Etude de la libération de principes actifs depuis les émulsions concentrées : caractérisation et modélisation

Abstract : In the field of controlled release technology for new drugs, models that can predict its delivery during application are important for device design. The main objective of this work is to develop a predictive model able to describe the drug delivery from highly concentrated water-in-oil emulsions. These systems consist of deformed droplets dispersed in a continuous film. Their structure's characteristics make them favourable for their use as releasing devices. A combination of different transfer mechanisms has been implemented in a mathematical model in order to simulate release experiments under different operating conditions (volume fraction, oil/surfactant ratio). A sensitivity analysis has been performed to point out the most relevant parameters affecting the drug's release: drug partition and diffusion coefficients. Partition coefficient of the drug for different surfactant concentrations has been obtained through a predictive thermodynamic model UNIFAC, and the diffusion coefficient using Chang and Wilke equations in addition to the Stefan- Maxwell development. An original and simple technique has been used to determine indirectly the mean droplet size of the concentrated emulsions, through measurements of continuous phase's thickness by analysis of incoherent polarized steady light transport through emulsion samples. In a general view, the diffusion model proposed for small drug diffusion in concentrated emulsions, which was first proposed for diluted emulsions, predicts successfully the evolution of mandelic acid concentrations during release experiments undertaken in perfect sink conditions
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Hala Fersadou. Etude de la libération de principes actifs depuis les émulsions concentrées : caractérisation et modélisation. Sciences agricoles. Institut National Polytechnique de Lorraine, 2011. Français. ⟨NNT : 2011INPL083N⟩. ⟨tel-01749492⟩

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