E. Arikan and S. Sen, Endothelial Damage and Hemostatic Markers in Patients with Uncomplicated Mild-to-Moderate Hypertension and Relationship with Risk Factors, Clinical and Applied Thrombosis/Hemostasis, vol.70, issue.3, pp.147-159, 2005.
DOI : 10.1016/S0021-9150(98)00163-4

R. Junker, J. Heinrich, H. Schulte, M. Erren, and G. Assmann, Hemostasis in normotensive and hypertensive men, Journal of Hypertension, vol.16, issue.7, pp.917-923, 1998.
DOI : 10.1097/00004872-199816070-00004

G. Lip and F. Li-saw-hee, Does hypertension confer a hypercoagulable state?, Journal of Hypertension, vol.16, issue.7, pp.913-916, 1998.
DOI : 10.1097/00004872-199816070-00003

D. Corseaux, V. Ollivier, V. Fontaine, M. Huisse, P. M. Louedec et al., Hemostasis imbalance in experimental hypertension, stroke but not with coronary heart disease in the elderly: the Three-City cohort study, pp.169-178, 2002.

C. Esmon and N. Esmon, The Link Between Vascular Features and Thrombosis, Annual Review of Physiology, vol.73, issue.1, pp.503-514, 2011.
DOI : 10.1146/annurev-physiol-012110-142300

R. Campbell, K. Overmyer, C. Selzman, B. Sheridan, and A. Wolberg, Contributions of extravascular and intravascular cells to fibrin network formation, structure, and stability, Blood, vol.114, issue.23, pp.4886-4896, 2009.
DOI : 10.1182/blood-2009-06-228940

P. Flynn, C. Byrne, T. Baglin, P. Weissberg, and M. Bennett, Thrombin generation by apoptotic vascular smooth muscle cells, Blood, vol.89, pp.4378-4384, 1997.

A. Pathak, R. Zhao, D. Monroe, H. Roberts, B. Sheridan et al., Thrombin generation in vascular tissue, Journal of Thrombosis and Haemostasis, vol.18, issue.Suppl. 1, pp.60-67, 2006.
DOI : 10.1161/01.ATV.18.2.250

V. Regnault, C. Perret-guillaume, A. Kearney-schwartz, J. Max, C. Labat et al., Tissue Factor Pathway Inhibitor: A New Link Among Arterial Stiffness, Pulse Pressure, and Coagulation in Postmenopausal Women, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.31, issue.5, pp.1226-1232, 2011.
DOI : 10.1161/ATVBAHA.110.221911

T. Battle, J. Arnal, M. Challah, and J. Michel, Selective isolation of rat aortic wall layers and their cell types in culture???Application to converting enzyme activity measurement, Tissue and Cell, vol.26, issue.6
DOI : 10.1016/0040-8166(94)90043-4

H. Hemker, P. Giesen, A. Dieri, R. Regnault, V. De-smedt et al., Calibrated Automated Thrombin Generation Measurement in Clotting Plasma, Pathophysiology of Haemostasis and Thrombosis, vol.33, issue.1, pp.4-15, 2003.
DOI : 10.1159/000071636

V. Regnault, H. Hemker, D. Wahl, and T. Lecompte, Phenotyping the haemostatic system by thrombography???potential for the estimation of thrombotic risk, Thrombosis Research, vol.114, issue.5-6, pp.539-545, 2004.
DOI : 10.1016/j.thromres.2004.06.017

. Gonzalez-navarro, Pathophysiology of the proatherothrombotic state in the metabolic syndrome, Frontiers in Bioscience, vol.2, issue.1, pp.194-208, 2010.
DOI : 10.2741/s57

M. Franchini, G. Targher, M. Montagnana, and G. Lippi, The metabolic syndrome and the risk of arterial and venous thrombosis, Thrombosis Research, vol.122, issue.6, pp.727-762, 2008.
DOI : 10.1016/j.thromres.2007.09.010

A. A. Akintunde, O. E. Ayodele, P. O. Akinwusi, and G. O. Opadijo, Metabolic Syndrome: Comparison of Occurrence Using Three Definitions in Hypertensive Patients, Clinical Medicine & Research, vol.9, issue.1, pp.26-31, 2010.
DOI : 10.3121/cmr.2010.902

E. Bog-hansen, U. Lindblad, B. Gullberg, A. Melander, and L. Rastam, Metabolic disorders associated with uncontrolled hypertension. Skaraborg hypertension and diabetes project, Diabetes, Obesity and Metabolism, vol.96, issue.6, pp.379-87, 2003.
DOI : 10.1016/S0002-9149(99)80444-5

N. D. Wong, J. R. Pio, S. S. Franklin, G. J. L-'italien, T. V. Kamath et al., Preventing coronary events by optimal control of blood pressure and lipids in patients with the metabolic syndrome, The American Journal of Cardiology, vol.91, issue.12, pp.91-1421, 2003.
DOI : 10.1016/S0002-9149(03)00392-8

C. H. Tseng, C. K. Chong, C. P. Tseng, W. Y. Shau, and T. Y. Tai, Hypertension is the Most Important Component of Metabolic Syndrome in the Association With Ischemic Heart Disease in Taiwanese Type 2 Diabetic Patients, Circulation Journal, vol.72, issue.9, pp.72-1419, 2008.
DOI : 10.1253/circj.CJ-08-0009

R. Rossi, A. Nuzzo, G. Origliani, and M. G. Modena, Metabolic Syndrome Affects Cardiovascular Risk Profile and Response to Treatment in Hypertensive Postmenopausal Women, Hypertension, vol.52, issue.5, pp.52-865, 2008.
DOI : 10.1161/HYPERTENSIONAHA.108.110478

W. Zidek, L. Naditch-brule, S. Perlini, C. Farsang, and S. E. Kjeldsen, Blood pressure control and components of the metabolic syndrome: the GOOD survey, Cardiovascular Diabetology, vol.8, issue.1, p.51, 2009.
DOI : 10.1186/1475-2840-8-51

M. Aizawa-abe, Y. Ogawa, H. Masuzaki, K. Ebihara, N. Satoh et al., Pathophysiological role of leptin in obesity-related hypertension, Journal of Clinical Investigation, vol.105, issue.9, pp.105-1243, 2000.
DOI : 10.1172/JCI8341

. Haynes, Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice, J Hypertens, vol.17, pp.1949-53, 1999.

. Zoccoli, Sleep modulates hypertension in leptin-deficient obese mice, Hypertension, pp.53-251, 2009.

M. G. Wickenheiser, J. Myers, and D. T. Eitzman, Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance, Arterioscler Thromb Vasc Biol, pp.27-70, 2007.

W. Su, Z. Guo, D. C. Randall, L. Cassis, D. R. Brown et al., mice, American Journal of Physiology-Heart and Circulatory Physiology, vol.295, issue.4, pp.295-1634, 2008.
DOI : 10.1097/00041552-200301000-00016

URL : https://hal.archives-ouvertes.fr/hal-01341519

H. Katagiri, T. Yamada, and Y. Oka, Adiposity and Cardiovascular Disorders: Disturbance of the Regulatory System Consisting of Humoral and Neuronal Signals, Circulation Research, vol.101, issue.1, pp.27-39, 2007.
DOI : 10.1161/CIRCRESAHA.107.151621

L. A. Sechi, Mechanisms of insulin resistance in rat models of hypertension and their relationships with salt sensitivity, Journal of Hypertension, vol.17, issue.9, pp.1229-1266, 1999.
DOI : 10.1097/00004872-199917090-00001

P. A. Sarafidis and G. L. Bakris, Review: Insulin and endothelin: an interplay contributing to hypertension development?, J Clin Endocrinol Metab, pp.92-379, 2007.

C. C. Juan, Y. W. Shen, Y. Chien, Y. J. Lin, S. F. Chang et al., Insulin infusion induces endothelin-1-dependent hypertension in rats, American Journal of Physiology-Endocrinology and Metabolism, vol.287, issue.5, pp.287-948, 2004.
DOI : 10.1006/jmcc.2002.2111

S. Deloach, Y. Huan, C. Daskalakis, and B. Falkner, Endothelin-1 response to glucose and insulin among African Americans, Journal of the American Society of Hypertension, vol.4, issue.5, pp.227-262, 2010.
DOI : 10.1016/j.jash.2010.07.004

M. Nakayama, M. Makishima, I. Matsuda, and . Shimomura, Increased oxidative stress in obesity and its impact on metabolic syndrome, J Clin Invest, vol.114, pp.1752-61, 2004.

C. K. Roberts, R. J. Barnard, R. K. Sindhu, M. Jurczak, A. Ehdaie et al., A high-fat, refined-carbohydrate diet induces endothelial dysfunction and oxidant/antioxidant imbalance and depresses NOS protein expression, Journal of Applied Physiology, vol.98, issue.1, pp.98-203, 2005.
DOI : 10.1016/S0895-7061(98)00238-6

J. E. Hall, Pathophysiology of obesity hypertension, Current Hypertension Reports, vol.44, issue.2, pp.139-186, 2000.
DOI : 10.1161/01.HYP.25.4.888

P. Lacolley, M. E. Safar, V. Regnault, and E. D. Frohlich, Angiotensin II, mechanotransduction, and pulsatile arterial hemodynamics in hypertension, American Journal of Physiology-Heart and Circulatory Physiology, vol.276, issue.5, pp.297-1567, 2009.
DOI : 10.1159/000102955

J. R. Sowers, Insulin resistance and hypertension, American Journal of Physiology-Heart and Circulatory Physiology, vol.286, issue.5, pp.1597-602, 2004.
DOI : 10.1161/01.CIR.101.13.1539

M. Pravenec and T. W. Kurtz, Molecular Genetics of Experimental Hypertension and the Metabolic Syndrome: From Gene Pathways to New Therapies, Hypertension, vol.49, issue.5, pp.49-941, 2007.
DOI : 10.1161/HYPERTENSIONAHA.107.086900

S. Makita, A. Abiko, Y. Naganuma, Y. Moriai, and M. Nakamura, Effects of telmisartan on adiponectin levels and body weight in hypertensive patients with glucose intolerance, Metabolism, vol.57, issue.10, pp.57-1473, 2008.
DOI : 10.1016/j.metabol.2008.05.019

S. Engeli, R. Negrel, and A. M. Sharma, Physiology and Pathophysiology of the Adipose Tissue Renin-Angiotensin System, Hypertension, vol.35, issue.6, pp.35-1270, 2000.
DOI : 10.1161/01.HYP.35.6.1270

L. A. Cassis, J. Saye, and M. J. Peach, Location and regulation of rat angiotensinogen messenger RNA., Hypertension, vol.11, issue.6_Pt_2, pp.11-591, 1988.
DOI : 10.1161/01.HYP.11.6.591

P. Schling, H. Mallow, A. Trindl, and G. Loffler, Evidence for a local renin angiotensin system in primary cultured human preadipocytes, International Journal of Obesity, vol.23, issue.4, pp.336-377, 1999.
DOI : 10.1038/sj.ijo.0800821

U. Shenoy and L. Cassis, Characterization of renin activity in brown adipose tissue, American Journal of Physiology-Cell Physiology, vol.34, issue.3, pp.989-99, 1997.
DOI : 10.1210/edrv-1-4-365

L. A. Cassis, M. J. Fettinger, A. L. Roe, U. R. Shenoy, and G. Howard, Characterization and regulation of angiotensin II receptors in rat adipose tissue. Angiotensin receptors in adipose tissue, Adv Exp Med Biol, pp.396-435, 1996.

A. Whaley-connell, M. S. Johnson, and J. R. Sowers, Aldosterone: Role in the Cardiometabolic Syndrome and Resistant Hypertension, Progress in Cardiovascular Diseases, vol.52, issue.5, pp.52-401, 2010.
DOI : 10.1016/j.pcad.2009.12.004

A. E. Schutte, H. W. Huisman, R. Schutte, J. M. Van-rooyen, L. Malan et al., Adipokines and cardiometabolic function: How are they interlinked?, Regulatory Peptides, vol.164, issue.2-3, pp.164-133, 2010.
DOI : 10.1016/j.regpep.2010.06.008

Y. Tomiyama and . Kanakura, Adiponectin acts as an endogenous antithrombotic factor, Arterioscler Thromb Vasc Biol, vol.26, pp.224-254, 2006.

P. Restituto, I. Colina, J. J. Varo, and N. Varo, Adiponectin diminishes platelet aggregation and sCD40L release. Potential role in the metabolic syndrome, American Journal of Physiology-Endocrinology and Metabolism, vol.91, issue.5, pp.298-1072, 2011.
DOI : 10.1097/00005344-199200193-00006

R. Lichnovska, S. Gwozdziewiczova, R. Chlup, and J. Hrebicek, Serum leptin in the development of insulin resistance and other disorders in the metabolic syndrome, Biomedical Papers, vol.149, issue.1, pp.149-119, 2005.
DOI : 10.5507/bp.2005.014

S. Stork, M. L. Bots, P. Angerer, C. Von-schacky, D. E. Grobbee et al., Low levels of adiponectin predict worsening of arterial morphology and function, Atherosclerosis, vol.194, issue.2, pp.194-147, 2007.
DOI : 10.1016/j.atherosclerosis.2006.11.044

Y. Kusama, H. Atarashi, and K. Mizuno, Upregulation of monocyte tissue factor activity is significantly associated with carotid intima-media thickness in patients with metabolic syndrome, J Atheroscler Thromb, vol.18, pp.475-86, 2011.

F. Samad, M. Pandey, and D. J. Loskutoff, Regulation of tissue factor gene expression in obesity, Blood, vol.98, issue.12, pp.98-3353, 2001.
DOI : 10.1182/blood.V98.12.3353

O. F. Arici and N. Cetin, Protective role of ghrelin against carbon tetrachloride (CCl4)-induced coagulation disturbances in rats, Regulatory Peptides, vol.166, issue.1-3, pp.139-181, 2011.
DOI : 10.1016/j.regpep.2010.10.009

H. Amagasa, M. Okazaki, S. Iwai, T. Kumai, S. Kobayashi et al., Enhancement of the Coagulation System in Spontaneously Hypertensive and Hyperlipidemic Rats, Journal of Atherosclerosis and Thrombosis, vol.12, issue.4, pp.12-191, 2005.
DOI : 10.5551/jat.12.191

A. M. Carter, C. M. Cymbalista, T. D. Spector, and P. J. Grant, Heritability of Clot Formation, Morphology, and Lysis: The EuroCLOT Study, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.27, issue.12, pp.27-2783, 2007.
DOI : 10.1161/ATVBAHA.107.153221

G. E. Sonnenberg, G. R. Krakower, and A. H. Kissebah, A Novel Pathway to the Manifestations of Metabolic Syndrome, Obesity Research, vol.107, issue.Suppl 3, pp.180-186, 2004.
DOI : 10.1161/01.CIR.0000066907.83923.32

H. S. Lim, G. Y. Lip, and A. D. Blann, Plasma von Willebrand Factor and the Development of the Metabolic Syndrome in Patients with Hypertension, The Journal of Clinical Endocrinology & Metabolism, vol.89, issue.11, pp.89-5377, 2004.
DOI : 10.1210/jc.2004-0616

A. J. Lansbury, P. J. Grant, and A. J. Catto, Atherothrombotic Risk Factors in Subjects with a Family History of Stroke, Cerebrovascular Diseases, vol.14, issue.3-4, pp.153-60, 2002.
DOI : 10.1159/000065677

P. J. Grant, Diabetes mellitus as a prothrombotic condition, Journal of Internal Medicine, vol.96, issue.2, pp.157-72, 2007.
DOI : 10.1161/01.CIR.99.2.224

C. Mineo, H. Deguchi, J. H. Griffin, and P. W. Shaul, Endothelial and Antithrombotic Actions of HDL, Circulation Research, vol.98, issue.11, pp.98-1352, 2006.
DOI : 10.1161/01.RES.0000225982.01988.93

F. Vitacolonna, A. Capani, and . Consoli, Plasminogen activator inhibitor type 1 is increased in the arterial wall of type II diabetic subjects, Arterioscler Thromb Vasc Biol, vol.21, pp.1378-82, 2001.

J. E. Mittleman, R. B. Muller, P. W. D-'agostino, D. Wilson, and . Levy, Association of blood pressure with fibrinolytic potential in the Framingham offspring population, Circulation, pp.101-264, 2000.

T. Hoekstra, J. M. Geleijnse, E. G. Schouten, and C. Kluft, Plasminogen activator inhibitor-type 1: its plasma determinants and relation with cardiovascular risk, Thrombosis and Haemostasis, pp.91-861, 2004.
DOI : 10.1160/TH03-08-0546

. Tremoli, Very low density lipoprotein-mediated signal transduction and plasminogen activator inhibitor type 1 in cultured HepG2 cells, Circ Res, vol.85, pp.208-225, 1999.

F. Samad, M. Pandey, P. A. Bell, and D. J. Loskutoff, Insulin continues to induce plasminogen activator inhibitor 1 gene expression in insulin-resistant mice and adipocytes, Mol Med, vol.6, pp.680-92, 2000.

A. Suehiro, I. Wakabayashi, K. Uchida, T. Yamashita, and J. Yamamoto, Impaired spontaneous thrombolytic activity measured by global thrombosis test in males with metabolic syndrome, Thrombosis Research, vol.129, issue.4, 2011.
DOI : 10.1016/j.thromres.2011.06.019

M. Kjalke, A. Silveira, A. Hamsten, U. Hedner, and M. Ezban, Plasma Lipoproteins Enhance Tissue Factor-Independent Factor VII Activation, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.20, issue.7, pp.1835-1876, 2000.
DOI : 10.1161/01.ATV.20.7.1835

C. J. Doggen, R. N. Lemaitre, N. L. Smith, S. R. Heckbert, and B. M. Psaty, HMG CoA reductase inhibitors and the risk of venous thrombosis among postmenopausal women, Journal of Thrombosis and Haemostasis, vol.103, issue.5, pp.700-701, 2004.
DOI : 10.1161/01.CIR.103.18.2248

A. D. Baron and . Vascular-reactivity, Vascular reactivity, The American Journal of Cardiology, vol.84, issue.1, pp.25-27, 1999.
DOI : 10.1016/S0002-9149(99)00354-9

H. O. Steinberg, G. Brechtel, A. Johnson, N. Fineberg, and A. D. Baron, Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release., Journal of Clinical Investigation, vol.94, issue.3, pp.94-1172, 1994.
DOI : 10.1172/JCI117433

URL : http://www.jci.org/articles/view/117433/files/pdf

J. W. Heemskerk and . Akkerman, Platelet inhibition by insulin is absent in type 2 diabetes mellitus, Arterioscler Thromb Vasc Biol, vol.26, pp.417-439, 2006.

N. A. Englyst, J. M. Taube, T. J. Aitman, T. P. Baglin, and C. D. Byrne, A Novel Role for CD36 in VLDL-Enhanced Platelet Activation, Diabetes, vol.52, issue.5, pp.52-1248, 2003.
DOI : 10.2337/diabetes.52.5.1248

R. M. Hamsten and . Fisher, Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance, Diabetologia, pp.47-1118, 2004.

G. E. Jarvis, B. T. Atkinson, D. C. Snell, and S. P. Watson, Distinct roles of GPVI and integrin alpha(2)beta(1) in platelet shape change and aggregation induced by different collagens, Br J Pharmacol, pp.137-107, 2002.

M. Mesri and D. C. Altieri, Leukocyte Microparticles Stimulate Endothelial Cell Cytokine Release and Tissue Factor Induction in a JNK1 Signaling Pathway, Journal of Biological Chemistry, vol.89, issue.3, pp.274-23111, 1999.
DOI : 10.1038/380075a0

A. Agouni, A. H. Lagrue-lak-hal, P. H. Ducluzeau, H. A. Mostefai, C. Draunet-busson et al., Endothelial Dysfunction Caused by Circulating Microparticles from Patients with Metabolic Syndrome, The American Journal of Pathology, vol.173, issue.4, pp.173-1210, 2008.
DOI : 10.2353/ajpath.2008.080228

. Freyssinet, Procoagulant microparticles: disrupting the vascular homeostasis equation?, Arterioscler Thromb Vasc Biol, vol.26, pp.2594-604, 2006.

M. J. Alkhatatbeh, N. M. Mhaidat, A. K. Enjeti, L. F. Lincz, and R. F. Thorne, The putative diabetic plasma marker, soluble CD36, is non-cleaved, non-soluble and entirely associated with microparticles, Journal of Thrombosis and Haemostasis, vol.56, issue.Suppl. 2, pp.9-844, 2011.
DOI : 10.2337/db07-0394

M. S. Phillips, Q. Liu, H. A. Hammond, V. Dugan, P. J. Hey et al., Leptin receptor missense mutation in the fatty Zucker rat, Nature Genetics, vol.254, issue.1, pp.13-18, 1996.
DOI : 10.1016/0092-8674(94)90333-6

R. Subramanian and K. M. Macleod, Age-dependent changes in blood pressure and arterial reactivity in obese Zucker rats, European Journal of Pharmacology, vol.477, issue.2, pp.477-143, 2003.
DOI : 10.1016/j.ejphar.2003.08.003

E. Cosson, P. Valensi, D. Laude, D. Mesangeau, and H. Dabire, Arterial stiffness and the autonomic nervous system during the development of Zucker diabetic fatty rats, Diabetes & Metabolism, vol.35, issue.5, pp.35-364, 2009.
DOI : 10.1016/j.diabet.2009.02.007

J. Hiraoka-yamamoto, Y. Nara, N. Yasui, Y. Onobayashi, S. Tsuchikura et al., Establishment of a new animal model of metabolic syndrome: SHRSP fatty (fa/fa) rats, Clinical and Experimental Pharmacology and Physiology, vol.52, issue.1-2, pp.31-107, 2004.
DOI : 10.1006/bbrc.1995.2631

M. Connell, G. W. Gould, and A. F. Dominiczak, Cd36 and molecular mechanisms of insulin resistance in the stroke-prone spontaneously hypertensive rat, Diabetes, pp.49-2222, 2000.

T. Koshiba, K. Masuyama, and . Shinozuka, Characterization of cardiac size and function in SHRSP.Z-Lepr(fa)/IzmDmcr rats, a new animal model of metabolic syndrome, Biol Pharm Bull, pp.33-1971, 2010.

Y. Anini and P. L. Brubaker, Role of Leptin in the Regulation of Glucagon-Like Peptide-1 Secretion, Diabetes, vol.52, issue.2, pp.52-252, 2003.
DOI : 10.2337/diabetes.52.2.252

T. Abumiya, J. Masuda, J. Kawai, T. Suzuki, and J. Ogata, Heterogeneity in the appearance and distribution of macrophage subsets and their possible involvement in hypertensive vascular lesions in rats, Lab Invest, pp.75-125, 1996.

T. Abumiya, T. Sakata, K. Enjyoji, H. Kato, J. Kawai et al., Does hypertension confer a hypercoagulable state in stroke-prone spontaneously hypertensive rats?, Journal of Hypertension, vol.18, issue.7, pp.18-901, 2000.
DOI : 10.1097/00004872-200018070-00012

. Friedman, Phenotypic consequences of a nonsense mutation in the leptin receptor gene (fak) in obese spontaneously hypertensive Koletsky rats (SHROB), J Nutr, vol.128, pp.2299-306, 1998.

S. Koletsky, Pathologic findings and laboratory data in a new strain of obese hypertensive rats, Am J Pathol, vol.80, pp.129-171, 1975.

P. Ernsberger, R. J. Koletsky, D. D. Kline, D. M. Bedol, and J. E. Friedman, The SHROB Model of Syndrome X: Effects of Excess Dietary Sucrose, Annals of the New York Academy of Sciences, vol.119, issue.1 THE METABOLIC, pp.892-315, 1999.
DOI : 10.1161/01.HYP.24.6.699

T. Kumai, S. Oonuma, Y. Kitaoka, M. Tadokoro, and S. Kobayashi, Biochemical and morphological characterization of spontaneously hypertensive hyperlipidaemic rats, Clinical and Experimental Pharmacology and Physiology, vol.88, issue.8, pp.537-581, 2003.
DOI : 10.1016/0021-9150(91)90255-2

K. Okamoto, S. Nosaka, Y. Yamori, and M. Matsumoto, Participation of Neural Factor in the Pathogenesis of Hypertension in the Spontaneously Hypertensive Rat, Japanese Heart Journal, vol.8, issue.2, pp.168-80, 1967.
DOI : 10.1536/ihj.8.168

Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold et al., Positional cloning of the mouse obese gene and its human homologue, Nature, pp.372-425, 1994.

A. J. Kennedy, K. L. Ellacott, V. L. King, and A. H. Hasty, Mouse models of the metabolic syndrome, Disease Models & Mechanisms, vol.3, issue.3-4, pp.156-66, 2010.
DOI : 10.1242/dmm.003467

H. Hyogo, S. Roy, and D. E. Cohen, Restoration of gallstone susceptibility by leptin in C57BL/6J ob/ob mice, J Lipid Res, pp.44-1232, 2003.

D. L. Silver, X. C. Jiang, and A. R. , Mice, Journal of Biological Chemistry, vol.271, issue.7, pp.274-4140, 1999.
DOI : 10.1073/pnas.95.13.7385

J. D. Olearzcyk and . Imig, Obesity induced renal oxidative stress contributes to renal injury in salt-sensitive hypertension, Clin Exp Pharmacol Physiol, vol.36, pp.724-732, 2009.

L. B. Andersen and . Nielsen, Cardiac lipid accumulation associated with diastolic dysfunction in obese mice, Endocrinology, pp.144-3483, 2003.

F. Dong, X. Zhang, X. Yang, L. B. Esberg, H. Yang et al., Impaired cardiac contractile function in ventricular myocytes from leptin-deficient ob/ob obese mice, Journal of Endocrinology, vol.188, issue.1, pp.188-213, 2006.
DOI : 10.1677/joe.1.06241

S. J. Swoap, Altered leptin signaling is sufficient, but not required, for hypotension associated with caloric restriction, American Journal of Physiology-Heart and Circulatory Physiology, vol.269, issue.6, pp.281-2473, 2001.
DOI : 10.1038/372425a0

P. F. Bodary, R. J. Westrick, K. J. Wickenheiser, Y. Shen, and D. T. Eitzman, Effect of Leptin on Arterial Thrombosis Following Vascular Injury in Mice, JAMA, vol.287, issue.13, pp.287-1706, 2002.
DOI : 10.1001/jama.287.13.1706

P. F. Bodary, S. Gu, Y. Shen, A. H. Hasty, J. M. Buckler et al., Recombinant Leptin Promotes Atherosclerosis and Thrombosis in Apolipoprotein E-Deficient Mice, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.25, issue.8, pp.25-119, 2005.
DOI : 10.1161/01.ATV.0000173306.47722.ec

R. A. Kaufman, M. M. Lindberg, and . Veniant, Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr, Am J Physiol Endocrinol Metab, pp.294-496, 2008.

J. R. Ortlepp, R. Kluge, K. Giesen, L. Plum, P. Radke et al., A metabolic syndrome of hypertension, hyperinsulinaemia and hypercholesterolaemia in the New Zealand obese mouse, European Journal of Clinical Investigation, vol.31, issue.2, pp.30-195, 2000.
DOI : 10.1007/s001250050832

C. Marchesi, T. Ebrahimian, O. Angulo, P. Paradis, and E. L. Schiffrin, Endothelial Nitric Oxide Synthase Uncoupling and Perivascular Adipose Oxidative Stress and Inflammation Contribute to Vascular Dysfunction in a Rodent Model of Metabolic Syndrome, Hypertension, vol.54, issue.6, pp.54-1384, 2009.
DOI : 10.1161/HYPERTENSIONAHA.109.138305

M. A. Miller, C. R. Spillert, R. Ponnudurai, S. Bonthu, and E. J. Lazaro, Are hypertensives hypercoagulable?, J Natl Med Assoc, vol.87, pp.71-73, 1995.

M. Diamant, R. Nieuwland, R. F. Pablo, A. Sturk, J. W. Smit et al., Elevated Numbers of Tissue-Factor Exposing Microparticles Correlate With Components of the Metabolic Syndrome in Uncomplicated Type 2 Diabetes Mellitus, Circulation, vol.106, issue.19, pp.106-2442, 2002.
DOI : 10.1161/01.CIR.0000036596.59665.C6

. Lacolley, Tissue factor pathway inhibitor: a new link among arterial stiffness, pulse pressure, and coagulation in postmenopausal women, Arterioscler Thromb Vasc Biol, pp.31-1226, 2011.

A. A. Ajayi, H. Hercule, J. Cory, B. E. Hayes, and A. O. Oyekan, Gender difference in vascular and platelet reactivity to thromboxane A2-mimetic U46619 and to endothelial dependent vasodilation in Zucker fatty (hypertensive, hyperinsulinemic) diabetic rats, Diabetes Research and Clinical Practice, vol.59, issue.1, pp.59-70, 2003.
DOI : 10.1016/S0168-8227(02)00180-8

H. Gomibuchi, M. Okazaki, S. Iwai, T. Kumai, S. Kobayashi et al., Development of Hyperfibrinogenemia in Spontaneously Hypertensive and Hyperlipidemic Rats: A Potentially Useful Animal Model as a Complication of Hypertension and Hyperlipidemia, Experimental Animals, vol.56, issue.1, pp.56-57, 2007.
DOI : 10.1538/expanim.56.1

A. Borca, C. Uzzau, and . Catena, Relationship of plasma renin with a prothrombotic state in hypertension: relevance for organ damage, Am J Hypertens, vol.21, pp.1347-53, 2008.

S. Montague and . Yusuf, Relationship of metabolic syndrome and fibrinolytic dysfunction to cardiovascular disease, Circulation, vol.108, pp.420-425, 2003.

E. Buczko and . Chabielska, Angiotensin II via AT1 receptor accelerates arterial thrombosis in renovascular hypertensive rats, J Physiol Pharmacol, vol.56, pp.571-85, 2005.

H. Van-gilst, The Association of the Metabolic Syndrome with PAI-1 and t-PA Levels, Cardiol Res Pract, pp.2011-541467, 2011.

P. Sawathiparnich, L. J. Murphey, S. Kumar, D. E. Vaughan, and N. J. Brown, Effect of combined AT1 receptor and aldosterone receptor antagonism on plasminogen activator inhibitor-1, J Clin Endocrinol Metab, pp.88-3867, 2003.

T. Cate and P. W. De-leeuw, Changes in fibrinolytic activity after angiotensin II receptor blockade in therapy-resistant hypertensive patients, J Thromb Haemost, vol.5, pp.1509-1524, 2007.

J. Chaoui and . Scholze, Agonistic AT(1) receptor autoantibodies and monocyte stimulation in hypertensive patients, Am J Hypertens, vol.16, pp.827-860, 2003.

T. W. Kurtz, R. C. Morris, and H. A. Pershadsingh, The Zucker fatty rat as a genetic model of obesity and hypertension., Hypertension, vol.13, issue.6_Pt_2, pp.13-896, 1989.
DOI : 10.1161/01.HYP.13.6.896

W. Paul, L. R. Queen, C. P. Page, and A. Ferro, Increased platelet aggregation in vivo in the Zucker Diabetic Fatty rat: differences from the streptozotocin diabetic rat, British Journal of Pharmacology, vol.41, issue.(Suppl), pp.150-105, 2007.
DOI : 10.2337/diab.41.2.S26

E. A. Glassford, C. A. Schwartz, G. M. Taylor, P. S. Reaven, and . Tsao, Increased aortic stiffness in the insulin-resistant Zucker fa/fa rat, Am J Physiol Heart Circ Physiol, pp.289-845, 2005.

S. Koletsky, Animal model: obese hypertensive rat, Am J Pathol, vol.81, pp.463-469, 1975.