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Nanoparticules fonctionnalisées pour une vectorisation médicale active

Abstract : The first part of this work describes the preparation of new organic/inorganic naanohybrids which are intended to be used for the detection and the selective destruction of cancer cells. We describe the synthetic methodology for covalent attachment of folie acid (organic moiety) to gold nanoparticles (inorganic moiety) sized between 5 and 20 mn. Aminothiols spacers were used for the linking of folic acid with gold particles. The second part describes the preparation of size-controlled gold clusters by reduction of gold (+3) bromide with an alkoxide activated hydride. We have demonstrated that an appropriate choice of hydride (NaH or LiH) end / or of the solvent used for the reduction allows either the preparation of 2 nm sized spherical gold clusters or gold nanoprisms (nanowires and polygonal shapes).
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https://hal.univ-lorraine.fr/tel-01750154
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Submitted on : Thursday, March 29, 2018 - 12:39:23 PM
Last modification on : Thursday, March 25, 2021 - 3:01:41 AM

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  • HAL Id : tel-01750154, version 1

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Xavier Jurvilliers. Nanoparticules fonctionnalisées pour une vectorisation médicale active. Autre [cond-mat.other]. Institut National Polytechnique de Lorraine, 2003. Français. ⟨NNT : 2003INPL085N⟩. ⟨tel-01750154⟩

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