S. Abdelmoumen, Etude théorique et expérimentale d'un nouveau procédé multicolonnes continu de chromatographie preparative intégrant une étape de concentration, 2005.

S. Abel, M. Mazzotti, and M. Morbidelli, Solvent gradient operation of simulated moving beds, Journal of Chromatography A, vol.944, issue.1-2, pp.23-39, 2002.
DOI : 10.1016/S0021-9673(01)01087-1

S. Abel, M. Mazzotti, and M. Morbidelli, Solvent gradient operation of simulated moving beds, Journal of Chromatography A, vol.1026, issue.1-2, pp.47-55, 2004.
DOI : 10.1016/j.chroma.2003.11.054

D. Antos and A. Seidel-morgenstern, Application of gradients in the simulated moving bed process, Chemical Engineering Science, vol.56, issue.23, pp.6667-6682, 2001.
DOI : 10.1016/S0009-2509(01)00342-6

D. Antos and A. Seidel-morgenstern, Two-step solvent gradients in simulated moving bed chromatography, Journal of Chromatography A, vol.944, issue.1-2, pp.77-91, 2002.
DOI : 10.1016/S0021-9673(01)01365-6

L. Aumann and M. Morbidelli, Method and device for chromatographic purification". City: Eidgenoessische Technische Hochschule Zuerich, Switz, p.55, 2006.

L. Aumann and M. Morbidelli, A continuous multicolumn countercurrent solvent gradient purification (MCSGP) process, Biotechnology and Bioengineering, vol.21, issue.5, pp.1043-1055, 2007.
DOI : 10.1002/bit.21527

L. Aumann and M. Morbidelli, A semicontinuous 3-column countercurrent solvent gradient purification (MCSGP) process, Biotechnology and Bioengineering, vol.99, issue.3, pp.728-733, 2008.
DOI : 10.1002/bit.21585

L. Aumann, G. Stroehlein, and M. Morbidelli, Parametric study of a 6-column countercurrent solvent gradient purification (MCSGP) unit, Biotechnology and Bioengineering, vol.34, issue.5, pp.98-1029, 2007.
DOI : 10.1002/bit.21529

M. Bailly, N. Inpl, M. Bailly, P. Adam, O. Ludemann-hombourger et al., Contribution à l'étude de nouvelles méthodes de séparation: -Chromatographie avec inversion du sens découlement -Thermofractionnement en lit mobileLiquid chromatography method and device with variable-length separation zones, Thèse de doctorat ès sciences physiques City: Institut Francais du Petrole, p.30, 1977.

M. P. Bartolomeo and F. Maisano, Validation of a reversed-phase HPLC method for quantitative amino acid analysis, Journal of biomolecular techniques : JBT, vol.17, issue.2, pp.131-138, 2006.

E. Bayer, E. Grom, B. Kaltenegger, and R. Uhmann, Separation of amino acids by high performance liquid chromatography, Analytical Chemistry, vol.48, issue.8, pp.48-1106, 1976.
DOI : 10.1021/ac50002a010

G. Bergeot, Extension du concept "One-column" au lit mobile simulé réactif application à la séparation réactive des C8 aromatiques, 2010.

R. Bhushan and R. Agarwal, Liquid chromatographic separation of some PTH-amino acids, Biomedical Chromatography, vol.104, issue.6, pp.322-325, 1998.
DOI : 10.1002/(SICI)1099-0801(199811/12)12:6<322::AID-BMC754>3.0.CO;2-0

J. Blehaut and R. Nicoud, Recent aspects in simulated moving bed, Analusis, vol.26, issue.7, pp.60-70, 1998.
DOI : 10.1051/analusis:199826070060

D. B. Broughton and C. G. Gerhold, Continuous sorption process employing fixed bed of sorbent and moving inlets ". City: United States, Universal Oil Products Co, 1961.

S. Brunauer, L. S. Deming, W. E. Deming, and E. Teller, On a Theory of the van der Waals Adsorption of Gases, Journal of the American Chemical Society, vol.62, issue.7, pp.62-1723, 1940.
DOI : 10.1021/ja01864a025

S. Budavari, The Merck index : an encyclopedia of chemicals, drugs, and biologicals, 1989.

G. Carta and A. Jungbauer, Downstream Processing of Biotechnology Products, Protein Chromatography, pp.1-55, 2010.
DOI : 10.1002/9783527630158.ch1

G. Carta and A. Jungbauer, Gradient Elution Chromatography, Protein Chromatography, pp.277-308, 2010.
DOI : 10.1002/9783527630158.ch9

E. Cavoy, M. F. Deltent, S. Lehoucq, and D. Miggiano, Laboratory-developed simulated moving bed for chiral drug separations, Journal of Chromatography A, vol.769, issue.1, pp.49-57, 1997.
DOI : 10.1016/S0021-9673(96)00964-8

P. Chaimbault, Analyse d'acides amines non dérivés par chromatographie en phase liquide avec le détecteur évaporatif à diffusion de la lumière et couplage avec la spectrométrie de masse, 2000.

P. Chaimbault, K. Petritis, C. Elfakir, and M. Dreux, Ion-pair chromatography on a porous graphitic carbon stationary phase for the analysis of twenty underivatized protein amino acids, Journal of Chromatography A, vol.870, issue.1-2, pp.245-254, 2000.
DOI : 10.1016/S0021-9673(99)00863-8

F. Charton and R. Nicoud, Complete design of a simulated moving bed, Journal of Chromatography A, vol.702, issue.1-2, pp.97-112, 1995.
DOI : 10.1016/0021-9673(94)01026-B

M. G. Chernobrovkin, I. A. Anan-'eva, E. N. Shapovalova, and O. A. Shpigun, Determination of Amino Acid Enantiomers in Pharmaceuticals by Reversed-Phase High-Performance Liquid Chromatography, Journal of Analytical Chemistry, vol.59, issue.1, pp.55-63, 2004.
DOI : 10.1023/B:JANC.0000011669.08932.d8

C. B. Ching, D. M. Ruthven, and K. Hidajat, Experimental study of a simulated counter-current adsorption system???III. Sorbex operation, Chemical Engineering Science, vol.40, issue.8, pp.40-1411, 1985.
DOI : 10.1016/0009-2509(85)80081-6

V. Concha-herrera, J. R. Torres-lapasió, G. Vivó-truyols, and M. C. García-Álvarez-coque, A comparative study of the performance of acetonitrile and methanol in the multi-linear gradient separation of proteic primary amino acids, Analytica Chimica Acta, vol.582, issue.2, pp.250-258, 2007.
DOI : 10.1016/j.aca.2006.09.015

V. Concha-herrera, G. Vivo-truyols, J. R. Torres-lapasio, G. , and M. C. , Limits of multi-linear gradient optimisation in reversed-phase liquid chromatography, Journal of Chromatography A, vol.1063, issue.1-2, 2005.
DOI : 10.1016/j.chroma.2004.12.001

M. A. Cremasco, B. J. Hritzko, Y. Xie, W. , and N. H. , Parameters estimation for amino acids adsorption in a fixed bed by moment analysis, Brazilian Journal of Chemical Engineering, vol.37, issue.6, pp.181-194, 2001.
DOI : 10.1021/ie9801711

G. Crétier, M. Khabchi, R. , and J. L. , Preparative liquid chromatography, Journal of Chromatography A, vol.596, issue.1, pp.15-25, 1992.
DOI : 10.1016/0021-9673(92)80198-4

G. Crétier, L. Macherel, R. , and J. L. , Preparative liquid chromatography I. Influence of column efficiency on optimum injection conditions under isocratic elution, Journal of Chromatography A, vol.590, issue.2, pp.175-188, 1992.
DOI : 10.1016/0021-9673(92)85380-C

A. C. Da-silva, A. G. Salles, R. F. Perna, C. R. Correia, and C. C. Santana, Chromatographic Separation and Purification of Mitotane Racemate in a Varicol Multicolumn Continuous Process, Chemical Engineering & Technology, vol.1037, issue.12, pp.83-90, 2012.
DOI : 10.1016/j.chroma.2003.11.108

A. Damtew, B. Sreedhar, and A. Seidel-morgenstern, Evaluation of the potential of nonlinear gradients for separating a ternary mixture, Journal of Chromatography A, vol.1216, issue.28, pp.1216-5355, 2009.
DOI : 10.1016/j.chroma.2009.05.026

N. Dejardin, Commande prédictive du lit mobile simulé, 2006.

E. Khabchi and M. , Chromatographie en phase liquide : contribution a l'optimisation d'une séparation preparative en gradient d'élution, 1993.

E. R. Francotte, R. , and P. , Applications of simulated moving-bed chromatography to the separation of the enantiomers of chiral drugs, Journal of Chromatography A, vol.769, issue.1, pp.101-107, 1997.
DOI : 10.1016/S0021-9673(97)00172-6

S. R. Gallant, S. Vunnum, and S. M. Cramer, Optimization of preparative ion-exchange chromatography of proteins: linear gradient separations, Journal of Chromatography A, vol.725, issue.2, pp.295-314, 1996.
DOI : 10.1016/0021-9673(95)00909-4

A. T. Georgios and N. P. Ioannis, Amino Acids: HPLC Analysis, Encyclopedia of Chromatography, pp.67-72, 2009.

E. Glueckauf, Theory of chromatography. VII. The general theory of two solutes following non-linear isotherms, Discussions of the Faraday Society, vol.7, 1949.
DOI : 10.1039/df9490700012

P. S. Gomes, M. Minceva, and A. E. Rodrigues, Operation of an industrial SMB unit for p-xylene separation accounting for adsorbent ageing problems, Sep. Sci. Technol. Separation Science and Technology, issue.8, pp.43-1974, 2008.

F. Gritti and G. Guiochon, Role of the buffer in retention and adsorption mechanism of ionic species in reversed-phase liquid chromatography, Journal of Chromatography A, vol.1038, issue.1-2, pp.53-66, 2004.
DOI : 10.1016/j.chroma.2004.03.036

F. Gritti and G. Guiochon, The bandwidth in gradient elution chromatography with a retained organic modifier, Journal of Chromatography A, vol.1145, issue.1-2, pp.67-82, 2007.
DOI : 10.1016/j.chroma.2007.01.056

C. Grossmann, G. Strohlein, M. Morari, and M. Morbidelli, Optimizing model predictive control of the chromatographic multi-column solvent gradient purification (MCSGP) process, Journal of Process Control, vol.20, issue.5, pp.618-629, 2010.
DOI : 10.1016/j.jprocont.2010.02.013

L. Gueorguieva, S. Palani, U. Rinas, G. Jayaraman, and A. Seidel-morgenstern, Recombinant protein purification using gradient assisted simulated moving bed hydrophobic interaction chromatography. Part II: Process design and experimental validation, Journal of Chromatography A, vol.1218, issue.37, pp.1218-6402, 2011.
DOI : 10.1016/j.chroma.2011.07.008

G. Guiochon, Preparative liquid chromatography, Journal of Chromatography A, vol.965, issue.1-2, pp.129-161, 2002.
DOI : 10.1016/S0021-9673(01)01471-6

K. Hashimoto, S. Adachi, H. Noujima, and H. Maruyama, Models for the separation of glucose/fructose mixture using a simulated moving-bed adsorber., Journal of Chemical Engineering of Japan, vol.16, issue.5, pp.400-406, 1983.
DOI : 10.1252/jcej.16.400

F. G. Helfferich and P. W. Carr, Non-linear waves in chromatography, Journal of Chromatography A, vol.629, issue.2, p.97, 1993.
DOI : 10.1016/0021-9673(93)87026-I

T. Hessa, H. Kim, K. Bihlmaier, C. Lundin, J. Boekel et al., Recognition of transmembrane helices by the endoplasmic reticulum translocon, Nature, vol.65, issue.7024, pp.433-377, 2005.
DOI : 10.1038/nbt1291-1356

C. Heuer, P. Hugo, G. Mann, and A. Seidel-morgenstern, Scale up in preparative chromatography, Journal of Chromatography A, vol.752, issue.1-2, pp.19-29, 1996.
DOI : 10.1016/S0021-9673(96)00496-7

K. Hidajat, C. B. Ching, and D. M. And-ruthven, Numerical simulation of a semi-continuous counter-current adsorption unit for fructose-glucose separation, The Chemical Engineering Journal, vol.33, issue.3, pp.55-61, 1986.
DOI : 10.1016/0300-9467(86)80021-1

C. Horvath, High-Performance Liquid Chromatography: Advances and Perspectives, 1980.

F. Ibrahim, Commande prédictive non linéaire d'un lit mobile simulé, 2006.

T. Ishihara, T. Kadoya, and S. Yamamoto, Application of a chromatography model with linear gradient elution experimental data to the rapid scale-up in ion-exchange process chromatography of proteins, Journal of Chromatography A, vol.1162, issue.1, pp.1162-1196, 2007.
DOI : 10.1016/j.chroma.2007.03.016

P. Jandera, Can the theory of gradient liquid chromatography be useful in solving practical problems?, Journal of Chromatography A, vol.1126, issue.1-2, pp.195-218, 2006.
DOI : 10.1016/j.chroma.2006.04.094

T. J. Janjic, G. Vuckovic, and M. B. Celap, Influence of the composition of the stationary and mobile phase on the retention factors and solvent strength parameters in RP chromatographic systems in which the Everett equation is valid, pp.66-79, 2001.

T. B. Jensen, T. G. Reijns, H. A. Billiet, and L. A. Van-der-wielen, Novel simulated moving-bed method for reduced solvent consumption, Journal of Chromatography A, vol.873, issue.2, pp.149-162, 2000.
DOI : 10.1016/S0021-9673(99)01352-7

S. Jo, H. Nam, and S. Mun, Optimal design and experimental validation of a modified four-zone SMB process for the separation of a ternary amino acid mixture, Process Biochemistry, vol.45, issue.8, pp.45-1288, 2010.
DOI : 10.1016/j.procbio.2010.04.016

H. Kaspar, K. Dettmer, W. Gronwald, and P. Oefner, Advances in amino acid analysis, Analytical and Bioanalytical Chemistry, vol.104, issue.2, pp.445-452, 2009.
DOI : 10.1007/s00216-008-2421-1

B. Kim and A. Velayudhan, Preparative gradient elution chromatography of chemotactic peptides, Journal of Chromatography A, vol.796, issue.1, pp.195-209, 1998.
DOI : 10.1016/S0021-9673(97)01142-4

A. Kostova and H. Bart, Preparative chromatographic separation of amino acid racemic mixturesI. Adsorption isotherms, Separation and Purification Technology, vol.54, issue.3, pp.340-348, 2007.
DOI : 10.1016/j.seppur.2006.10.005

A. Kostova and H. Bart, Preparative chromatographic separation of amino acid racemic mixturesII. Modelling of the separation process, Separation and Purification Technology, vol.54, issue.3, pp.315-321, 2007.
DOI : 10.1016/j.seppur.2006.10.002

A. S. Kurup, K. Hidajat, R. Ajay, and K. , Comparative Study of Modified Simulated Moving Bed Systems at Optimal Conditions for the Separation of Ternary Mixtures of Xylene Isomers, Industrial & Engineering Chemistry Research, vol.45, issue.18, pp.45-6251, 2006.
DOI : 10.1021/ie0505413

J. Kyte and R. F. Doolittle, A simple method for displaying the hydropathic character of a protein, Journal of Molecular Biology, vol.157, issue.1, pp.105-132, 1982.
DOI : 10.1016/0022-2836(82)90515-0

J. W. Lee, R. , and K. H. , Method to predict the bandwidth of elution profile under the linear gradient elution in reversed-phase HPLC, Journal of Separation Science, vol.1178, issue.2, pp.221-230, 2009.
DOI : 10.1002/jssc.200800535

D. R. Lide, CRC handbook of chemistry and physics, Boca Raton, 1993.

W. Lin, F. Wang, L. , and W. , Model Simulation and Optimization in Preparative Liquid Chromatography Using a Combination of Perturbation and Modified Collocation Methods, Industrial & Engineering Chemistry Research, vol.37, issue.11, pp.4399-4407, 1998.
DOI : 10.1021/ie980153j

O. Ludemann-hombourger, Optimisation des procédés de chromatographie préparative, application au procédé multicolonne continu Varicol, 2001.

O. Ludemann-hombourger, M. Bailly, and R. M. Nicoud, Design of a Simulated Moving Bed: Optimal Particle Size of the Stationary Phase, Separation Science and Technology, vol.33, issue.9, pp.1285-1305, 2000.
DOI : 10.1002/aic.690010222

O. Ludemann-hombourger, R. M. Nicoud, and M. Bailly, The ???VARICOL??? Process: A New Multicolumn Continuous Chromatographic Process, Separation Science and Technology, vol.5, issue.12, pp.35-1829, 2000.
DOI : 10.1016/S0021-9673(97)00048-4

O. Ludemann-hombourger, G. Pigorini, R. M. Nicoud, D. S. Ross, and G. Terfloth, Application of the ???VARICOL??? process to the separation of the isomers of the SB-553261 racemate, Journal of Chromatography A, vol.947, issue.1, pp.59-68, 2002.
DOI : 10.1016/S0021-9673(01)01568-0

S. Makart, M. Bechtold, and S. Panke, Separation of amino acids by simulated moving bed under solvent constrained conditions for the integration of continuous chromatography and biotransformation, Chemical Engineering Science, vol.63, issue.21, pp.63-5347, 2008.
DOI : 10.1016/j.ces.2008.07.019

D. Martinez, E. Postaire, P. Prognon, C. Ricour, O. Corriol et al., Dosage des acides amin??s en chromatographie liquide sur phase inverse par paire d'ions et d??tection directe dans l'ultraviolet. Application au contr??le de m??langes binaires pour nutrition parent??rale, Nutrition Clinique et M??tabolisme, vol.2, issue.1, pp.29-32, 1988.
DOI : 10.1016/S0985-0562(88)80006-2

L. Matija?evi? and ?. Vasi?-ra?ki, Separation of glucose/fructose mixtures: counter-current adsorption system, Biochemical Engineering Journal, vol.4, issue.2, pp.101-106, 2000.
DOI : 10.1016/S1369-703X(99)00040-6

M. Mazzotti, G. Storti, and M. Morbidelli, Optimal operation of simulated moving bed units for nonlinear chromatographic separations, Journal of Chromatography A, vol.769, issue.1, pp.3-24, 1997.
DOI : 10.1016/S0021-9673(97)00048-4

M. Morbidelli, Purification of monoclonal antibodies by continuous chromatography (MCSGP), New Biotechnology, vol.25, issue.0, pp.172-173, 2009.
DOI : 10.1016/j.nbt.2009.06.704

M. J. Moreira and L. M. Gando-ferreira, Separation of phenylalanine and tyrosine by ion-exchange using a strong-base anionic resin. I. Breakthrough curves analysis, Biochemical Engineering Journal, vol.67, issue.0, pp.67-231, 2012.
DOI : 10.1016/j.bej.2012.06.009

T. Müller-späth, L. Aumann, L. Melter, G. Strohlein, and M. Morbidelli, Chromatographic separation of three monoclonal antibody variants using multicolumn countercurrent solvent gradient purification (MCSGP), Biotechnology and Bioengineering, vol.30, issue.11, pp.1166-1177, 2008.
DOI : 10.1002/bit.21843

T. Müller-späth and M. Morbidelli, Continuous Chromatography for the Purification of Monoclonal Antibodies, Process Scale Purification of Antibodies, pp.223-238, 2008.
DOI : 10.1002/9780470444894.ch11

S. Nagamatsu, K. Murazumi, and S. Makino, Chiral separation of a pharmaceutical intermediate by a simulated moving bed process, Journal of Chromatography A, vol.832, issue.1-2, pp.55-65, 1999.
DOI : 10.1016/S0021-9673(98)01004-8

A. Nicolaos, Comparaison d'architectures de type lit mobile simule multi-composant application au cas de la séparation d'un mélange industriel, 2000.

R. M. Nicoud and M. Perrut, Hydrodynamics of preparative chromatography Columns Preparative and production scale chromatography, New York, pp.47-77, 1993.

P. Nikitas and A. Pappa-louisi, New approach to linear gradient elution used for optimisation in reversed-phase liquid chromatography, Journal of Chromatography A, vol.1068, issue.2, pp.1068-279, 2005.
DOI : 10.1016/j.chroma.2005.02.004

P. Nikitas and A. Pappa-louisi, Retention models for isocratic and gradient elution in reversed-phase liquid chromatography, Journal of Chromatography A, vol.1216, issue.10, pp.1216-1737, 2009.
DOI : 10.1016/j.chroma.2008.09.051

P. Nikitas, A. Pappa-louisi, and P. Agrafiotou, Multilinear gradient elution optimisation in reversed-phase liquid chromatography using genetic algorithms, Journal of Chromatography A, vol.1120, issue.1-2, pp.299-307, 2006.
DOI : 10.1016/j.chroma.2006.01.005

P. Oravec and D. Podhradský, High-performance liquid chromatography of amino acids after derivatization with 9-isothiocyanatoacridine, Journal of Biochemical and Biophysical Methods, vol.30, issue.2-3, pp.2-3, 1995.
DOI : 10.1016/0165-022X(94)00073-M

L. S. Pais, J. Loureiro, and A. E. Rodrigues, Separation of 1,1???-bi-2-naphthol enantiomers by continuous chromatography in simulated moving bed, Chemical Engineering Science, vol.52, issue.2, pp.245-257, 1997.
DOI : 10.1016/S0009-2509(96)00398-3

A. Pappa-louisi, P. Agrafiotou, P. , and K. , Retention modeling under organic modifier gradient conditions in ion-pair reversed-phase chromatography. Application to the separation of a set of underivatized amino acids, Analytical and Bioanalytical Chemistry, vol.1157, issue.6, pp.397-2151, 2010.
DOI : 10.1007/BF01244287

A. Pappa-louisi, P. Nikitas, K. Papachristos, and P. Balkatzopoulou, Multimode Gradient Elution in Reversed-Phase Liquid Chromatography: Application to Retention Prediction and Separation Optimization of a Set of Amino Acids in Gradient Runs Involving Simultaneous Variations of Mobile-Phase Composition, Flow Rate, and Temperature, Analytical Chemistry, vol.81, issue.3, pp.81-1217, 2009.
DOI : 10.1021/ac801896n

A. Pappa-louisi, P. Nikitas, and A. Papageorgiou, Optimisation of multilinear gradient elutions in reversed-phase liquid chromatography using ternary solvent mixtures, Journal of Chromatography A, vol.1166, issue.1-2, pp.126-134, 2007.
DOI : 10.1016/j.chroma.2007.08.016

M. Pugniere, H. Mattras, B. Castro, and A. Previero, Adsorption liquid chromatography on silica for the chiral separation of amino acids and asymmetric amines derivatized with optically active N-??-9-fluorenylmethyloxycarbonyl-amino acid-N-carboxyanhydrides, Journal of Chromatography A, vol.767, issue.1-2, pp.69-75, 1997.
DOI : 10.1016/S0021-9673(97)00021-6

A. Rajendran, Recent developments in preparative chromatographic processes, Current Opinion in Chemical Engineering, vol.2, issue.2, pp.263-270, 2013.
DOI : 10.1016/j.coche.2013.04.001

A. Rajendran, G. Paredes, and M. Mazzotti, Simulated moving bed chromatography for the separation of enantiomers, Journal of Chromatography A, vol.1216, issue.4, pp.1216-709, 2009.
DOI : 10.1016/j.chroma.2008.10.075

H. Rhee, R. Aris, and N. R. Amundson, On the Theory of Multicomponent Chromatography, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol.267, issue.1182, pp.267-419, 1182.
DOI : 10.1098/rsta.1970.0050

H. Rhee, R. Aris, and N. R. Amundson, Multicomponent adsorption in continuous counter-current exchangers, 1971.

R. C. Rodrigues, R. J. Silva, and J. P. Mota, Streamlined, two-column, simulated countercurrent chromatography for binary separation, Journal of Chromatography A, vol.1217, issue.20, pp.1217-3382, 2010.
DOI : 10.1016/j.chroma.2010.03.009

R. Rosset, M. Caude, and A. Jardy, Practical Manual of Liquid-Phase Chromatography, 1975.

F. Rouessac, A. Rouessac, C. , and D. , Analyse chimique : méthodes et techniques instrumentales modernes : cours et exercices corrigés, 2004.

D. M. Ruthven, Principles of Adsorption and Adsorption Processes, 1984.

J. Saurina and S. Hernández-cassou, Determination of amino acids by ion-pair liquid chromatography with post-column derivatization using 1,2-naphthoquinone-4-sulfonate, Journal of Chromatography A, vol.676, issue.2, pp.311-319, 1994.
DOI : 10.1016/0021-9673(94)80431-1

A. P. Schellinger and P. W. Carr, Isocratic and gradient elution chromatography: A comparison in terms of speed, retention reproducibility and quantitation, Journal of Chromatography A, vol.1109, issue.2, pp.1109-253, 2006.
DOI : 10.1016/j.chroma.2006.01.047

H. Schramm, H. Kniep, and A. Seidel-morgenstern, Optimization of Solvent Gradients for Chromatographic Separations, Chemical Engineering & Technology, vol.24, issue.2, pp.133-138, 2001.
DOI : 10.1002/1521-4125(200102)24:2<133::AID-CEAT133>3.0.CO;2-W

A. Seidel-morgenstern, Preparative Gradient Chromatography, Chemical Engineering & Technology, vol.865, issue.11, pp.1265-1273, 2005.
DOI : 10.1002/ceat.200500125

A. Seidel-morgenstern, L. C. Keßler, and M. Kaspereit, New Developments in Simulated Moving Bed Chromatography, Chemical Engineering & Technology, vol.12, issue.6, pp.31-826, 2008.
DOI : 10.1016/j.cep.2006.06.026

L. Shampine and M. Reichelt, The MATLAB ODE Suite, SIAM Journal on Scientific Computing, vol.18, issue.1, pp.1-22, 1997.
DOI : 10.1137/S1064827594276424

URL : https://hal.archives-ouvertes.fr/hal-01333731

L. F. Shampine, I. Gladwell, and S. Thompson, Solving ODEs with MATLAB". City, 2003.

Y. Shan and A. Seidel-morgenstern, Optimization of gradient elution conditions in multicomponent preparative liquid chromatography, Journal of Chromatography A, vol.1093, issue.1-2, pp.1-2, 2005.
DOI : 10.1016/j.chroma.2005.07.047

B. Shen, M. Chen, H. Jiang, Y. Zhao, W. et al., Modeling Study on a Three-Zone Simulated Moving Bed without Zone I, Separation Science and Technology, vol.34, issue.5, pp.695-701, 2011.
DOI : 10.1016/S0021-9673(98)00643-8

R. J. Silva, R. C. Rodrigues, H. Osuna-sanchez, M. Bailly, E. Valéry et al., A new multicolumn, open-loop process for center-cut separation by solvent-gradient chromatography, Journal of Chromatography A, vol.1217, issue.52, pp.1217-8257, 2010.
DOI : 10.1016/j.chroma.2010.11.005

URL : https://hal.archives-ouvertes.fr/hal-00609795

J. Sine, Séparation et analyse des biomolécules : méthodes physicochimiques : cours et exercices, 2003.

K. S. Sing, D. H. Everett, R. A. Haul, L. Moscou, R. A. Pierotti et al., Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity (Recommendations 1984), Pure and Applied Chemistry, vol.57, issue.4, pp.603-619, 1984.
DOI : 10.1351/pac198557040603

L. R. Snyder and J. W. Dolan, Gradient Elution Fundamentals", High- Performance Gradient Elution: The Practical Application of the Linear-Solvent- Strength Model, pp.23-73, 2006.

L. R. Snyder and J. W. Dolan, Introduction: The " general elution problem " and the need for gradient elution, High-Performance Gradient Elution, pp.1-22, 2006.

L. R. Snyder, J. , and W. D. , High-performance gradient elution. The practical application of the linear-solvent-strength model, Analytical and Bioanalytical Chemistry, vol.389, issue.6, pp.1659-1660, 2007.

L. R. Snyder, J. J. Kirkland, and J. W. Dolan, Introduction to modern liquid chromatography, 2009.
DOI : 10.1002/9780470508183

L. R. Snyder, J. J. Kirkland, and J. W. Dolan, Appendix I: Properties of HPLC Solvents", Introduction to Modern Liquid Chromatography, pp.879-886, 2010.

B. Sreedhar and A. Seidel-morgenstern, Preparative separation of multi-component mixtures using stationary phase gradients, Journal of Chromatography A, vol.1215, issue.1-2, pp.133-144, 2008.
DOI : 10.1016/j.chroma.2008.11.003

J. Ståhlberg, The thermodynamic limit of linear gradient chromatography, Journal of Chromatography A, vol.1217, issue.19, pp.1217-3172, 2010.
DOI : 10.1016/j.chroma.2010.02.035

G. Ströhlein, L. Aumann, M. Mazzotti, and M. Morbidelli, A continuous, counter-current multi-column chromatographic process incorporating modifier gradients for ternary separations, Journal of Chromatography A, vol.1126, issue.1-2, pp.338-346, 2006.
DOI : 10.1016/j.chroma.2006.05.011

G. Ströhlein, T. Müller-späth, and L. Aumann, Continuous Chromatography (Multicolumn Countercurrent Solvent Gradient Purification) for Protein Purification, pp.107-137, 2012.
DOI : 10.1081/SS-120002732

A. Tarafder, G. Strohlein, L. Aumann, and M. Morbidelli, Role of recycling in improving the performance of chromatographic solvent gradient purifications, Journal of Chromatography A, vol.1183, issue.1-2, pp.87-99, 2008.
DOI : 10.1016/j.chroma.2008.01.025

K. Tobal, Développement de nouvelles phases stationnaires monolithiques pour la nano-chromatographie et l'analyse protéomique, 2008.

D. Tondeur, Théorie des colonnes d'échange d'ions, Thèse de doctorat Physique [Texte imprimé], Faculté des sciences, 1969.

D. Tondeur and M. Bailly, Unifying concepts in non-linear unsteady processes part II: Multicomponent waves, competition and diffusion, Chemical Engineering and Processing: Process Intensification Chemical Engineering and Processing: Process Intensification, pp.91-105, 1987.
DOI : 10.1016/0255-2701(87)80035-1

A. Toumi, S. Engell, O. Ludemann-hombourger, R. M. Nicoud, and M. Bailly, Optimization of simulated moving bed and Varicol processes, Journal of Chromatography A, vol.1006, issue.1-2, pp.15-31, 2003.
DOI : 10.1016/S0021-9673(03)00430-8

K. K. Unger, R. Ditz, E. Machtejevas, and R. Skudas, Liquid Chromatography-Its Development and Key Role in Life Science Applications, Angewandte Chemie International Edition, vol.19, issue.2, pp.49-2300, 2010.
DOI : 10.1038/85686

E. Valery, S. H. Osuna, and M. Bailly, Gradient-elution multi-column separation method". City: Novasep, Fr, p.34, 2009.

S. Wang, Y. Liang, and S. Zheng, Separation of epigallocatechin gallate from tea polyphenol by simulated moving bed chromatography, Journal of Chromatography A, vol.1265, issue.0, pp.1265-1311, 2012.
DOI : 10.1016/j.chroma.2012.09.098

R. C. Weast, CRC Handbook of chemistry and physics : a ready-reference book of chemical and physical data, 1977.

F. Wei, M. Li, F. Huang, M. Chen, H. Jiang et al., A novel pseudo simulated moving bed with solvent gradient for ternary separations, Journal of Chromatography A, vol.1218, issue.20, pp.1218-2906, 2011.
DOI : 10.1016/j.chroma.2011.03.001

F. Wei, B. Shen, M. Chen, and Y. Zhao, Study on a pseudo-simulated moving bed with solvent gradient for ternary separations, Journal of Chromatography A, vol.1225, issue.0, pp.1225-99, 2012.
DOI : 10.1016/j.chroma.2011.12.080

M. J. Wells, C. , and C. R. , Liquid chromatographic elution characteristics of some solutes used to measure column void volume on C18 bonded phases, Analytical Chemistry, vol.53, issue.9, pp.1341-1345, 1981.
DOI : 10.1021/ac00232a009

A. Wiesel, H. Schmidt-traub, J. Lenz, and J. Strube, Modelling gradient elution of bioactive multicomponent systems in non-linear ion-exchange chromatography, Journal of Chromatography A, vol.1006, issue.1-2, pp.1-2, 2003.
DOI : 10.1016/S0021-9673(03)00554-5

M. C. Wilce, M. Aguilar, and M. T. Hearn, Physicochemical Basis of Amino Acid Hydrophobicity Scales: Evaluation of Four New Scales of Amino Acid Hydrophobicity Coefficients Derived from RP-HPLC of Peptides, Analytical Chemistry, vol.67, issue.7, pp.67-1210, 1995.
DOI : 10.1021/ac00103a012

W. C. Wimley and S. H. White, Experimentally determined hydrophobicity scale for proteins at membrane interfaces, Nature Structural & Molecular Biology, vol.1, issue.10, pp.842-848, 1996.
DOI : 10.1016/0005-2736(86)90302-0

C. Wohlfarth and B. Wohlfahrt, 3 Mixtures of Water and Organic Compounds Pure Organometallic and Organononmetallic Liquids, Binary Liquid Mixtures, pp.198-328, 2001.

D. J. Wu, Y. Xie, Z. Ma, W. , and N. H. , Design of Simulated Moving Bed Chromatography for Amino Acid Separations, Industrial & Engineering Chemistry Research, vol.37, issue.10, pp.4023-4035, 1998.
DOI : 10.1021/ie9801711

Y. Yokoyama, T. Amaki, S. Horikoshi, and H. Sato, Optimum Combination of Reversed-Phase Column Type and Mobile-Phase Composition for Gradient Elution Ion Pair Chromatography of Amino Acids., Analytical Sciences, vol.13, issue.6, pp.963-967, 1997.
DOI : 10.2116/analsci.13.963

A. Zammouri, Chromatographie de déplacement des acides amines sur des colonnes de résines anioniques fortes. Etude d'un déplaceur propre : dioxyde de carbone sous pression dans l'eau, 1998.

?. Composé and B. , Dihydrogénophosphate de sodium cristallisé (NaH 2 PO 4 , H 2 O) La masse molaire est de 137

?. Composé and C. , Acide phosphorique (H 3 PO 4 ) Sa masse molaire est de 98 g, p.1