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, Annexe 2 : Questionnaire EQ-5D

, Veuillez indiquer, pour chacune des rubriques suivantes, l'affirmation qui décrit le mieux votre état de santé aujourd'hui, en cochant la case appropriée (X)

, %L'utilité%permet%de%valoriser%simultanément%le%résultat%clinique%et%son%impact%sur%l'état% de%santé%du%patient,%et%d'exprimer%ainsi%la%qualité%de%vie%liée%à%la%santé.%Nous%nous%sommes%intéressés%à% l'approche%indirecte%d'estimation%d'utilité%dérivée%à%partir%des%échelles%psychométriques%de%mesure%de% l'état%de%santé.%CelleDci%permet%de%répéter%la%mesure%dans%le%temps%et%ouvre%les%perspectives%d'analyses% à% l'évaluation%du%changement%d'utilité% au% cours%du%temps.% Les%objectifs% étaient% de%définir%un% seuil% de% changement%pour%l'utilité%dérivée%des%instruments%de%mesure%psychométrique%de%la%qualité%de%vie,%et% de%prendre%en%compte%dans%l'interprétation%du%seuil%la%présence%des%comorbidités%ou%d'un%phénomène% de% responseDshift.% Afin% de% répondre% à% nos% objectifs,% nous% avons% étudié,% d'une% part,% le% changement% d'utilité%mesurée%par%le%SFD6D%dans%une%cohorte%de%patients%atteints%d'arthrose%des%membres%inférieurs% (cohorte%KHOALA)%et%l'effet%des%comorbidités%sur%l'utilité%et%son%changement.%D'autre%part,%nous%avons% estimé%l'utilité%de%donneur%vivant%de%rein%à%partir%des%questionnaires%EQD5D%et%SFD6D%avant%et%3%mois% après%le%prélèvement%du%rein.%Un%seuil%de%changement%a%été%estimé%et%un%phénomène%de%responseDshift% a% été% recherché.% Les% résultats% ont% montré% l'effet% délétère% des% comorbidités% sur% la% mesure% d'utilité,% et% mis%en%évidence%l'importance%de%la%sévérité%fonctionnelle%de%l'arthrose%dans%l'expression%de%l'utilité%et% son%changement.%Chez%les%donneurs%vivants%nous%avons%mis%en%évidence%une%diminution%significative% de% l'utilité% à% court% terme,% avec% une% proportion% de% plus% de% 30%% de% donneurs% ayant%atteint% le% seuil% de% changement.% L'estimation% du% seuil% diffère% selon% la% population% étudiée,% l'instrument% de% mesure% de% l'utilité,%et%la%méthodologie%appliquée%pour%définir%ce%seuil.%En%conclusion,%l'évaluation%du%changement% d'utilité% doit% tenir% compte% de% l'existence% des% comorbidités% ainsi% que% de% l'adaptation% du% jugement% de% valeur%que%l'individu%porte%sur%son%état%de%santé%lorsque%celuiDci%évolue, Dans% le% domaine% de% la% santé,% la% mesure% d'utilité% permet% d'exprimer% la% valeur% que% peut% donner% un% individu% à% un% état% de% santé,% comprise% généralement% entre% 0% (la% mort)% et% 1% (meilleur% état% de% santé% envisageable)