Attachment of columnar airway epithelial cells in asthma, Tissue and Cell, vol.37, issue.2, pp.145-52, 2005. ,
DOI : 10.1016/j.tice.2004.12.002
Airway secretions: new concepts and functions, Eur Respir J, vol.5, pp.3-4, 1992. ,
The immotile cilia syndrome: radiological manifestations., Radiology, vol.154, issue.3, pp.651-656, 1985. ,
DOI : 10.1148/radiology.154.3.3969467
Dog Tracheal Epithelial Cells in Culture Synthesize Sulfated Macromolecular Glycoconjugates and Release Them from the Cell Surface upon Exposure to Extracellular Proteinases, Experimental Lung Research, vol.127, issue.2, pp.157-84, 1987. ,
DOI : 10.1016/B978-0-12-356104-6.50011-8
Two transpallidal pathways originating in the rat nucleus accumbens, The Journal of Comparative Neurology, vol.255, issue.3, pp.437-483, 1990. ,
DOI : 10.1146/annurev.ne.09.030186.002041
Human ciliary beat frequency in epithelium from intrathoracic and extrathoracic airways, Am Rev Respir Dis, vol.125, pp.100-105, 1982. ,
Goblet Cells Secretion and Mucogenesis, Annual Review of Physiology, vol.52, issue.1, pp.157-76, 1990. ,
DOI : 10.1146/annurev.ph.52.030190.001105
Morphologic features of airway surface epithelial cells and glands, Am Rev Respir Dis, vol.128, pp.14-20, 1983. ,
Ultrastructural evidence of transport of secretory IgA across bronchial epithelium, Am Rev Respir Dis, vol.123, pp.115-124, 1981. ,
PATHOLOGY OF CHRONIC BRONCHITIS, The Lancet, vol.263, issue.6806, pp.275-278 ,
DOI : 10.1016/S0140-6736(54)91030-2
Proliferation and differentiation in mammalian airway epithelium, Eur Respir J, vol.1, pp.58-80, 1988. ,
Airway mucosa: secretory cells, mucus and mucin genes, European Respiratory Journal, vol.10, issue.7, pp.1655-62, 1997. ,
DOI : 10.1183/09031936.97.10071655
URL : http://erj.ersjournals.com/content/erj/10/7/1655.full.pdf
Tracheal epithelium: cell kinetics and differentiation in normal rat tissue, Cell Proliferation, vol.3, issue.2, pp.119-149, 1982. ,
DOI : 10.1016/B978-1-4832-3151-8.50011-7
Number and Proliferation of Basal and Parabasal Cells in Normal Human Airway Epithelium, American Journal of Respiratory and Critical Care Medicine, vol.133, issue.6, pp.2000-2006, 1998. ,
DOI : 10.1136/jcp.43.3.184
Respiratory Tract Mucin Genes and Mucin Glycoproteins in Health and Disease, Physiological Reviews, vol.86, issue.1 ,
DOI : 10.1172/JCI118372
Physiology and pathology of tracheobronchial glands, Respiration Physiology, vol.118, issue.2-3, pp.77-83, 1999. ,
DOI : 10.1016/S0034-5687(99)00080-8
Tissue distribution of antileukoprotease and lysozyme in humans J Histochem Cytochem, pp.493-501, 1989. ,
Imaging of airway cells, European Respiratory Journal, vol.12, issue.1, pp.3-5, 1998. ,
DOI : 10.1183/09031936.98.12010003
Comparative morphologic features of bronchiolar epithelial cells. The Clara cell, Am Rev Respir Dis, vol.128, pp.37-41, 1983. ,
The Clara cell, Eur J Respir Dis, vol.63, pp.202-222, 1982. ,
Uteroglobin: a novel cytokine?, Cellular and Molecular Life Sciences CMLS, vol.55, issue.5, pp.771-87, 1999. ,
DOI : 10.1007/s000180050331
The cytochrome P-450 monooxygenase system of rabbit lung enzyme components, activities, and induction in the nonciliated bronchialor epithelial (clara) cell, alveolar type 2 cell, and alveolar macrophage, Mol. Pharmacol, vol.30, pp.296-303, 1986. ,
A confocal microscopic study of solitary pulmonary neuroendocrine cells in human airway epithelium, Respiratory Research, vol.150, issue.1, p.115, 2005. ,
DOI : 10.1002/ar.a.10007
Bombesin, calcitonin and leu-enkephalin immunoreactivity in endocrine cells of human lung, Experientia, vol.28, issue.7, pp.765-772, 1981. ,
DOI : 10.1177/28.8.6160182
Differentiation of human alveolar epithelial cells in primary culture: morphological characterization and synthesis of caveolin-1 and surfactant protein-C, Cell and Tissue Research, vol.311, issue.1, pp.31-45, 2003. ,
DOI : 10.1007/s00441-002-0653-5
Molecular and cellular processing of lung surfactant., The FASEB Journal, vol.8, issue.12, pp.957-67, 1994. ,
DOI : 10.1096/fasebj.8.12.8088461
Bull Localization of a low molecular weight protease inhibitor in the respiratory tract, Eur Physiopathol Respir, vol.16, pp.231-237, 1980. ,
Antileukoprotease-containing Bronchiolar Cells: Relationship with Morphologic Disease of Small Airways and Parenchyma, American Review of Respiratory Disease, vol.238, issue.5, pp.1244-50, 1989. ,
DOI : 10.1111/j.1365-2362.1980.tb00048.x
Antibacterial activity of antileukoprotease, Infect Immun, vol.64, pp.4520-4524, 1996. ,
Antimicrobial activity of antiproteinases, Biochemical Society Transactions, vol.30, issue.2, pp.111-116, 2002. ,
DOI : 10.1042/bst0300111
Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitro., Journal of Clinical Investigation, vol.96, issue.1, pp.456-64, 1995. ,
DOI : 10.1172/JCI118056
Expression of the secretory leukoprotease inhibitor gene in epithelial cells., Journal of Clinical Investigation, vol.87, issue.6, pp.2207-151, 1991. ,
DOI : 10.1172/JCI115255
Effect of Menstrual Status on Antibacterial Activity and Secretory Leukocyte Protease Inhibitor Production by Human Uterine Epithelial Cells in Culture, The Journal of Infectious Diseases, vol.185, issue.11, pp.1606-1619, 2002. ,
DOI : 10.1086/340512
Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitro., Journal of Clinical Investigation, vol.96, issue.1, pp.456-464, 1995. ,
DOI : 10.1172/JCI118056
Secretory leukocyte protease inhibitor mediates non-redundant functionsnecessary for normal wound healing, Nature Medicine, vol.161, issue.10, pp.1147-53, 2000. ,
DOI : 10.1007/BF00491759
Antibacterial activity of antileukoprotease, Infect Immun, vol.64, pp.4520-4524, 1996. ,
Elevated ?-defensin levels in plasma of patients with pulmonary sarcoidosis, Respirology, vol.305, issue.3, pp.339-384, 2007. ,
DOI : 10.1007/PL00000282
Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA., Proceedings of the National Academy of Sciences, vol.88, issue.9, pp.3952-3958, 1991. ,
DOI : 10.1073/pnas.88.9.3952
Mammalian ?-defensins in mucosal defences.. Mammalian host defence peptides, pp.111-138, 2004. ,
Neutrophils, from Marrow to Microbes, Immunity, vol.33, issue.5, pp.657-70 ,
DOI : 10.1016/j.immuni.2010.11.011
Neutrophil granules: a library of innate immunity proteins, Trends in Immunology, vol.28, issue.8, pp.340-345, 2007. ,
DOI : 10.1016/j.it.2007.06.002
The role of neutrophils in autoimmune diseases, Immunology Letters, vol.143, issue.1, pp.9-19, 2012. ,
DOI : 10.1016/j.imlet.2012.01.013
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo, pp.819-854, 2012. ,
Peculiarities of cell death mechanisms in neutrophils, Cell Death & Differentiation, vol.62, issue.9, pp.1457-69, 2011. ,
DOI : 10.1074/jbc.M604051200
Regulating neutrophil apoptosis: new players enter the game, Trends in Immunology, vol.32, issue.3, pp.117-141, 2011. ,
DOI : 10.1016/j.it.2011.01.001
Phagocytosing neutrophils produce and release high amounts of the neutrophil-activating peptide 1/interleukin 8, Journal of Experimental Medicine, vol.173, issue.3, pp.771-775, 1991. ,
DOI : 10.1084/jem.173.3.771
Neutrophil clearance: when the party is over, clean-up begins, Trends in Immunology, vol.32, issue.8, pp.350-357, 2011. ,
DOI : 10.1016/j.it.2011.04.009
Phagocyte partnership during the onset and resolution of inflammation, Nature Reviews Immunology, vol.8, issue.6, pp.427-466, 2010. ,
DOI : 10.4049/jimmunol.180.10.6868
Immunological decision-making: how does the immune system decide to mount a helper T-cell response?, Immunology, vol.177, issue.3, pp.326-364, 2008. ,
DOI : 10.1074/jbc.M207577200
Th2 balance: the hypothesis, its limitations, and implications for health and disease, Altern Med Rev, vol.8, pp.223-269, 2003. ,
Macrophages in Inflammation, Current Drug Target -Inflammation & Allergy, vol.4, issue.3, pp.281-287, 2005. ,
DOI : 10.2174/1568010054022024
The biological activity of macrophages in health and disease, Post??py Higieny i Medycyny Do??wiadczalnej, vol.66, pp.507-527, 2012. ,
DOI : 10.5604/17322693.1004080
Regulation of immunologic homeostasis in peripheral tissues by dendritic cells: The respiratory tract as a paradigm, Journal of Allergy and Clinical Immunology, vol.105, issue.3, pp.421-429, 2000. ,
DOI : 10.1067/mai.2000.105010
Dendritic cell regulation of TH1-TH2 development, Nature Immunology, vol.9, issue.3, pp.199-205, 2000. ,
DOI : 10.1016/S1074-7613(00)80671-8
in MCII mast cells mediated by high-affinity Fc receptor for IgE, Biochemical Journal, vol.304, issue.3, pp.923-931, 1994. ,
DOI : 10.1042/bj3040923
Mast-Cell Infiltration of Airway Smooth Muscle in Asthma, New England Journal of Medicine, vol.346, issue.22, pp.1699-1705, 2002. ,
DOI : 10.1056/NEJMoa012705
Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2, American Journal of Physiology-Lung Cellular and Molecular Physiology, vol.129, issue.1, pp.193-201, 2000. ,
DOI : 10.1073/pnas.95.12.6642
The diverse potential effector and immunoregulatory roles of mast cells in allergic disease, Journal of Allergy and Clinical Immunology, vol.105, issue.5, pp.847-859, 2000. ,
DOI : 10.1067/mai.2000.106485
Reducing IgE levels as a strategy for the treatment of asthma, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.162, issue.2, pp.16-21, 2000. ,
DOI : 10.1164/ajrccm.158.6.9712073
Treatment of Allergic Asthma with Monoclonal Anti-IgE Antibody, New England Journal of Medicine, vol.341, issue.26 ,
DOI : 10.1056/NEJM199912233412603
Genomic structure, induction, and production of TNF-alpha, Immunol Ser, vol.56, pp.3-34, 1992. ,
Regulation of IL-8 production and the characteristics of the receptors for IL-8, Cytokines, vol.4, pp.41-53, 1992. ,
Tumor necrosis factor signaling, Cell Death and Differentiation, vol.10, issue.1, pp.45-65, 2003. ,
DOI : 10.1038/sj.cdd.4401189
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection, Cell, vol.73, pp.457-467, 1993. ,
The Tumor Necrosis Factor Ligand and Receptor Families, New England Journal of Medicine, vol.334, issue.26, pp.1717-1742, 1996. ,
DOI : 10.1056/NEJM199606273342607
Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo., Proceedings of the National Academy of Sciences, vol.89, issue.11, pp.4845-4894, 1992. ,
DOI : 10.1073/pnas.89.11.4845
Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors, Journal of Experimental Medicine, vol.172, issue.5 ,
DOI : 10.1084/jem.172.5.1517
Creation of TNFR1-selective Antagonist and Its Therapeutic Effects, YAKUGAKU ZASSHI, vol.130, issue.1, pp.63-71, 2010. ,
DOI : 10.1248/yakushi.130.63
A Tangled Web of Ubiquitin Chains: Breaking News in TNF-R1 Signaling, Molecular Cell, vol.36, issue.5, pp.736-778, 2009. ,
DOI : 10.1016/j.molcel.2009.11.029
Anatomy of TRAF2, Journal of Biological Chemistry, vol.148, issue.33, pp.19935-19977, 1996. ,
DOI : 10.1016/S0962-8924(00)89088-1
The two different receptors for tumor necrosis factor mediate distinct cellular responses., Proceedings of the National Academy of Sciences, vol.88, issue.20, pp.9292-96, 1991. ,
DOI : 10.1073/pnas.88.20.9292
The p70 tumor necrosis factor receptor mediates cytotoxicity, Cell, vol.70, issue.1, pp.47-56, 1992. ,
DOI : 10.1016/0092-8674(92)90532-H
Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin, Nature, vol.16, issue.6092, pp.73-79, 1986. ,
DOI : 10.1016/B978-0-12-057550-3.50033-8
Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor, Science, vol.241, issue.4867, pp.825-833, 1988. ,
DOI : 10.1126/science.3136546
Role of IL-6 and Its Soluble Receptor in Induction of Chemokines and Leukocyte Recruitment, Immunity, vol.6, issue.3, pp.315-340, 1997. ,
DOI : 10.1016/S1074-7613(00)80334-9
Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line, Journal of Experimental Medicine, vol.169, issue.4, pp.1485-90, 1988. ,
DOI : 10.1084/jem.169.4.1485
A newly discovered chemotactic factor for neutrophil: interleukin 8, Rinsho Byori, vol.40, pp.371-380, 1992. ,
Mechanisms involved in Helicobacter pyloriinduced interleukin-8 production by a gastric cancer cell line, MKN45. Infect Immun, vol.65, pp.3218-3242, 1997. ,
Interleukin 8 (monocyte-derived neutrophil chemotactic factor) dynamically regulates its own receptor expression on human neutrophils, J Biol Chem, vol.265, pp.183-189, 1990. ,
Chemotaxis and IL-8 receptor expression in B cells from normal and HIV-infected subjects, J Immunol, vol.158, pp.475-484, 1997. ,
Granulocyte-macrophage colony-stimulating factor, eosinophils and eosinophil cationic protein in subjects with and without mild, stable, atopic asthma, European Respiratory Journal, vol.7, issue.9, pp.1576-84, 1994. ,
DOI : 10.1183/09031936.94.07091576
The Response of a Human Bronchial Epithelial Cell Line to Histamine: Intracellular Calcium Changes and Extracellular Release of Inflammatory Mediators, American Journal of Respiratory Cell and Molecular Biology, vol.1, issue.5, pp.484-492, 1991. ,
DOI : 10.1073/pnas.82.14.4633
Histamine-Induced Production of Interleukin-6 and Interleukin-8 by Human Coronary Artery Endothelial Cells Is Enhanced by Endotoxin and Tumor Necrosis Factor-??, Microvascular Research, vol.61, issue.3, pp.253-62, 2001. ,
DOI : 10.1006/mvre.2001.2304
Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-?? and IL-4 in human keratinocytes, Journal of Dermatological Science, vol.28, issue.1, pp.34-41, 2002. ,
DOI : 10.1016/S0923-1811(01)00147-5
Inhibition by glucocorticoids of mitogen dependent histamine biosynthesis caused by histidine decaroboxylase incultured mouse spleen cells and peritoneal adherent cells, Immunology, vol.65, pp.433-439, 1988. ,
Regulation of histamine synthesis in mouse CD4+ and CD8+ T lymphocytes, Inflammation Research, vol.48, issue.3, pp.149-53, 1999. ,
DOI : 10.1007/s000110050438
Effect of glucocorticoid on upregulation of histamine H1 receptor mRNA in nasal mucosa of rats sensitized by exposure to toluene diisocyanate ,
Receptor mRNA Levels by Dexamethasone in Cerebral Endothelial Cells, Journal of Cerebral Blood Flow & Metabolism, vol.269, issue.3, pp.321-351, 1999. ,
DOI : 10.1111/j.1471-4159.1989.tb02509.x
Role of calcium and phosphorylation of cytosolic phospholipase A2 In regulating arachidonic acid release in macrophages, J ,
Diversity of group types, regulation, and function of phospholipase A2, J Biol Chem, vol.269, pp.13057-60, 1994. ,
Extracellular phospholipase A2 expression and inflammation : the relationship with associated disease states, J Lipid Mediat, vol.8, pp.1-30, 1993. ,
Identification and properties of very high affinity brain membranebinding sites for a neurotoxic phospholipase from the taipan venom, J Biol Chem, vol.264, pp.11503-11513, 1989. ,
Identification and purification of a very high affinity binding protein for toxic phospholipases A2 in skeletal muscle, J. Biol Chem, vol.265, pp.9526-9558, 1990. ,
Increasing molecular diversity of secreted phospholipases A2 and their receptors and binding proteins, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol.1488, issue.1-2, pp.59-70, 2000. ,
DOI : 10.1016/S1388-1981(00)00110-4
Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophages., Proceedings of the National Academy of Sciences, vol.92, issue.18, pp.8527-8558, 1995. ,
DOI : 10.1073/pnas.92.18.8527
Mediates Lymphocyte Proliferation, Journal of Biological Chemistry, vol.92, issue.46, pp.35692-35700, 2000. ,
DOI : 10.1074/jbc.270.25.14855
SYMPOSIUM REVIEW: Phosphoinositides: lipid regulators of membrane proteins, The Journal of Physiology, vol.37, issue.17, pp.3179-85, 2010. ,
DOI : 10.1016/S0896-6273(03)00125-9
Phosphatidylcholine-Specific Phospholipase C Activation in Epithelial Ovarian Cancer Cells, Cancer Research, vol.68, issue.16, pp.6541-6550, 2008. ,
DOI : 10.1158/0008-5472.CAN-07-6763
Lipopolysaccharide activated phosphatidylcholine-specific phospholipase C and induced IL-8 and MCP-1 production in vascular endothelial cells, Journal of Cellular Physiology, vol.30, issue.6, pp.1694-701, 2011. ,
DOI : 10.1161/ATVBAHA.109.195768
Phosphatidylcholine-specific phospholipase C in mitogen-stimulated fibroblasts, Experimental Cell Research, vol.299, issue.2, pp.370-82, 2004. ,
DOI : 10.1016/j.yexcr.2004.05.037
Tricyclodecan-9-yl-xanthogenate (D609) mechanism of actions ,
Compound D609 inhibits phorbol ester-stimulated phospholipase D activity and phospholipase C-mediated phosphatidylethanolamine hydrolysis, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol.1259, issue.1, pp.105-113, 1995. ,
DOI : 10.1016/0005-2760(95)00148-6
Phosphatidylcholine-specific phospholipases inhibitor D609 differentially affects MAP kinases and immediate-early genes in PC12 cells. Verity AN.Cell Signal, 1998. ,
Involvement of Phosphatidylcholine-specific Phospholipase C in Platelet-derived Growth Factor-induced Activation of the Mitogen-activated Protein Kinase Pathway in Rat-1 Fibroblasts, Journal of Biological Chemistry, vol.265, issue.17, pp.11011-11017, 1997. ,
DOI : 10.1073/pnas.83.18.6785
Cellular Localization and Functional Role of Phosphatidylcholine-Specific Phospholipase C in NK Cells, The Journal of Immunology, vol.167, issue.5, pp.2642-50, 2001. ,
DOI : 10.4049/jimmunol.167.5.2642
The phosphorus-containing lipides of the carrot, J. Biol. Chem, vol.168, pp.233-240, 1947. ,
On the nature of the phosphorus-containing lipides of cabbage leaves and their relation to a phospholipide-splitting enzyme contained in these leaves, Biol. Chem, vol.172, pp.191-198, 1948. ,
ADP-ribosylation-factor-regulated phospholipase D activity localizes to secretory vesicles and mobilizes to the plasma membrane following N-formylmethionyl-leucyl-phenylalanine stimulation of human neutrophils, Biochemical Journal, vol.325, issue.3, pp.581-586, 1997. ,
DOI : 10.1042/bj3250581
Differential regulation of phospholipase D and phospholipase A2 by protein kinase C in P388D1 macrophages, Biochemical Journal, vol.321, issue.3, pp.805-814, 1997. ,
DOI : 10.1042/bj3210805
Role and regulation of cyclooxygenase-2 during inflammation, The American Journal of Medicine, vol.106, issue.5, pp.37-42, 1999. ,
DOI : 10.1016/S0002-9343(99)00115-1
Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes, Nature, vol.32, issue.5770, pp.264-269, 1980. ,
DOI : 10.1111/j.2042-7158.1980.tb12946.x
The accumulation of 111In-eosinophils induced by inflammatory mediators, in vivo, Immunology, vol.73, pp.222-229, 1991. ,
Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues, Nature Immunology, vol.188, issue.10, pp.965-73, 2003. ,
DOI : 10.1084/jem.188.6.1063
Cystic fibrosis., American Journal of Respiratory and Critical Care Medicine, vol.154, issue.5, pp.1229-12561, 1996. ,
DOI : 10.1164/ajrccm.154.5.8912731
The Role of Inflammation in the Pathophysiology of CF Lung Disease, Clinical Reviews in Allergy & Immunology, vol.23, issue.1, pp.5-27, 2002. ,
DOI : 10.1385/CRIAI:23:1:005
Inhibition of airway proteases in cystic fibrosis lung disease, European Respiratory Journal, vol.32, issue.3, pp.783-95, 2008. ,
DOI : 10.1183/09031936.00146807
Pharmacological approaches for the discovery and development of new anti-inflammatory agents for the treatment of cystic fibrosis, Advanced Drug Delivery Reviews, vol.54, issue.11, pp.1409-1432, 2002. ,
DOI : 10.1016/S0169-409X(02)00146-1
Differential adaptation of microbial pathogens to airways of patients with cystic fibrosis and chronic obstructive pulmonary disease, FEMS Microbiology Reviews, vol.64, issue.1, pp.124-146, 2011. ,
DOI : 10.1111/j.1469-0691.2008.02659.x
Airway epithelial cell inflammatory signalling in cystic fibrosis, The International Journal of Biochemistry & Cell Biology, vol.40, issue.9, pp.1703-1718, 2008. ,
DOI : 10.1016/j.biocel.2008.02.002
Innate immune activation and cystic fibrosis, Paediatric Respiratory Reviews, vol.9, issue.4, pp.271-279, 2008. ,
DOI : 10.1016/j.prrv.2008.05.008
Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface., Proceedings of the National Academy of Sciences, vol.92, issue.7, pp.3019-3042, 1995. ,
DOI : 10.1073/pnas.92.7.3019
Mucus structure and properties in cystic fibrosis, Paediatric Respiratory Reviews, vol.8, issue.1, pp.4-7, 2007. ,
DOI : 10.1016/j.prrv.2007.02.004
Diagnosis, screening and management of cystic fibrosis related diabetes mellitus, Diabetes Research and Clinical Practice, vol.45, issue.1, pp.61-73, 1999. ,
DOI : 10.1016/S0168-8227(99)00058-3
Cystic fibrosis: molecular biology and therapeutic implications, Science, vol.256, issue.5058, pp.774-783, 1992. ,
DOI : 10.1126/science.1375392
Cystic Fibrosis, New England Journal of Medicine, vol.352, issue.19, pp.1992-2001, 2005. ,
DOI : 10.1056/NEJMra043184
La mucoviscidose ; de la théorie à la pratique. 2 em edition, 2001. ,
Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells, Nature, vol.347, pp.358-63, 1990. ,
Generation of cAMP-activated chloride currents by expression of CFTR, Science, vol.251, issue.4994, pp.679-82, 1991. ,
DOI : 10.1126/science.1704151
Demonstration that CFTR is a chloride channel by alteration of its anion selectiVity, pp.202-204, 1991. ,
Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR), Cell, vol.68, issue.4, pp.809-827 ,
DOI : 10.1016/0092-8674(92)90155-6
Mutations and sequence variations detected in the cystic fibrosis transmembrane conductance regulator (CFTR) gene: A report from the cystic fibrosis genetic analysis consortium, Human Mutation, vol.49, issue.3 ,
DOI : 10.1007/978-1-4684-5934-0_48
Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel, Cell, vol.66, issue.5, pp.1027-1063, 1991. ,
DOI : 10.1016/0092-8674(91)90446-6
Cystic fibrosis: channel, catalytic, and folding properties of the CFTR protein, Journal of Bioenergetics and Biomembranes, vol.29, issue.5, pp.429-471, 1997. ,
DOI : 10.1023/A:1022478822214
Structure and Function of the CFTR Chloride Channel, Physiological Reviews, vol.14, issue.1, pp.23-45, 1999. ,
DOI : 10.1126/science.2122520
CFTR as a cAMP-dependent regulator of sodium channels, Science, vol.261, issue.2, pp.847-50, 1995. ,
DOI : 10.1089/hum.1992.3.3-253
Cystic fibrosis: a disease of vulnerability to airway surface dehydration, Trends in Molecular Medicine, vol.13, issue.6, pp.231-271, 2007. ,
DOI : 10.1016/j.molmed.2007.05.001
The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease, Journal of Cystic Fibrosis, vol.10, pp.172-82, 2011. ,
DOI : 10.1016/S1569-1993(11)60021-0
CFTR regulates phagosome acidification in macrophages and alters bactericidal activity, Nat Cell Biol, vol.8, pp.933-977, 2006. ,
CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship, Nature, vol.363, issue.6426, pp.263-271, 1993. ,
DOI : 10.1038/363263a0
CFTR Is a Conductance Regulator as well as a Chloride Channel, Physiological Reviews, vol.266, issue.1, pp.145-66, 1999. ,
DOI : 10.1152/ajpcell.1994.266.3.C809
G protein G alpha i-2 inhibits outwardly rectifying chloride channels in human airway epithelial cells, American Journal of Physiology-Cell Physiology, vol.265, issue.2, pp.451-457, 1995. ,
DOI : 10.1073/pnas.88.12.5277
Expression of CFTR controls cAMP-dependent activation of epithelial K+ currents, American Journal of Physiology-Cell Physiology, vol.142, issue.5, pp.1565-73, 1996. ,
DOI : 10.1093/hmg/2.8.1253
Glutathione permeability of CFTR, American Journal of Physiology-Cell Physiology, vol.4, issue.40, pp.323-329, 1998. ,
DOI : 10.1085/jgp.61.6.687
AEROSOL CARBENICILLIN AND GENTAMICIN TREATMENT OF PSEUDOMONAS AERUGINOSA INFECTION IN PATIENTS WITH CYSTIC FIBROSIS, The Lancet, vol.318, issue.8256, pp.1137-1146, 1981. ,
DOI : 10.1016/S0140-6736(81)90588-2
Endotracheal and aerosol administrations of ceftazidime in patients with nosocomial pneumonia: pharmacokinetics and absolute bioavailability., Antimicrobial Agents and Chemotherapy, vol.36, issue.7, 1992. ,
DOI : 10.1128/AAC.36.7.1404
Antibiotic prophylaxis in cystic fibrosis: Inhaled cephaloridine as an adjunct to oral cloxacillin, The Journal of Pediatrics, vol.101, issue.4, pp.626-656, 1982. ,
DOI : 10.1016/S0022-3476(82)80726-9
Clinical Significance of Antibiotic Tissue Penetration, Clinical Pharmacokinetics, vol.16, issue.Supplement 1, pp.25-31, 1989. ,
DOI : 10.2165/00003088-198900161-00005
Gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts, Lab Invest, vol.40, pp.481-93, 1979. ,
Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-?B transcription factors, Antimicrob. Chemother, vol.49, pp.745-755, 2002. ,
Effects of roxithromycin and erythromycin on interleukin 8-induced neutrophil recruitment and goblet cell secretion in guinea pig tracheas ,
Cystic fibrosis pathogenesis and the role of biofilms in persistent infection, Trends in Microbiology, vol.9, issue.2, pp.50-52, 2001. ,
DOI : 10.1016/S0966-842X(00)01918-1
MucoidPseudomonas aeruginosa is a marker of poor survival in cystic fibrosis, Pediatric Pulmonology, vol.96, issue.3, pp.158-161, 1992. ,
DOI : 10.1001/archpedi.1958.02060060008002
Ueber Bronchiolitis exsudative und ihr Verhaltniss zum Asthma nervosum, Dtsch Arch Klin Med, vol.32, pp.1-34, 1882. ,
Asthma, New England Journal of Medicine, vol.344, issue.5, pp.350-62, 2001. ,
DOI : 10.1056/NEJM200102013440507
URL : https://hal.archives-ouvertes.fr/inserm-00796149
Eosinophil apoptosis and the resolution of airway inflammation in asthma., American Journal of Respiratory and Critical Care Medicine, vol.154, issue.1, pp.237-280, 1996. ,
DOI : 10.1164/ajrccm.154.1.8680686
Proinflammatory potential of the airway epithelium in bronchial asthma, European Respiratory Journal, vol.7, issue.12, pp.2226-2259, 1994. ,
DOI : 10.1183/09031936.94.07122226
Modulation of glucocorticoid receptor expression in human bronchial epithelial cell lines by IL- 1 beta, TNF-a and LPS, Eur Respir J, vol.9, pp.2036-2079, 1996. ,
Glucocorticoid receptor signaling in a bronchial epithelial cell line, American Journal of Physiology-Lung Cellular and Molecular Physiology, vol.272, issue.5, pp.838-843, 1997. ,
DOI : 10.1152/ajplung.1997.272.5.L838
Pharmacological characterization of glucocorticoid receptors in primary human bronchial epithelial cells, Biochemical Pharmacology, vol.57, issue.9, pp.1003-1012, 1999. ,
DOI : 10.1016/S0006-2952(99)00008-8
Glucocorticoid receptor localization in normal and asthmatic lung., American Journal of Respiratory and Critical Care Medicine, vol.154, issue.3, pp.771-82, 1996. ,
DOI : 10.1164/ajrccm.154.3.8810618
Expression of glucocorticoid receptor ??- and ??-isoforms in human cells and tissues, American Journal of Physiology-Cell Physiology, vol.266, issue.4, pp.1324-1355, 2002. ,
DOI : 10.1111/j.1365-2222.1994.tb00240.x
The Human Glucocorticoid Receptor b ,
Expression, biochemical properties, and putative function. The journal of biological, chemistry, vol.16, pp.9550-9559, 1996. ,
The Non-Ligand Binding f3-Isoform of the Human Glucocorticoid Receptor (hGRf): Tissue Levels, Mechanism of Action, and Potential Physiologic Role, Mol Med, vol.2, pp.597-607, 1996. ,
The Dominant Negative Activity of the Human Glucocorticoid Receptor ?? Isoform, Journal of Biological Chemistry, vol.2, issue.39, pp.27857-66, 1999. ,
DOI : 10.1210/mend-5-11-1707
Post-transcriptional and Nongenomic Effects of Glucocorticoids, Proceedings of the American Thoracic Society, vol.1, issue.3, pp.255-63, 2004. ,
DOI : 10.1513/pats.200402-015MS
Identification of Target Genes Involved in the Antiproliferative Effect of Glucocorticoids Reveals a Role for Nuclear Factor-??B Repression, Molecular Endocrinology, vol.19, issue.3, pp.632-675, 2005. ,
DOI : 10.1210/me.2004-0294
T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation, Nature Medicine, vol.21, issue.10, pp.1318-1340, 2003. ,
DOI : 10.1002/eji.1830211009
Anti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms, Clinical Science, vol.94, issue.6, pp.557-72, 1998. ,
DOI : 10.1042/cs0940557
Molecular mechanisms of corticosteroids in all_ergic diseases., Allergy, vol.166, issue.10, pp.928-964, 2001. ,
DOI : 10.4049/jimmunol.166.3.1975
The Epithelium as a Target of Glucocorticoid Action in the Treatment of Asthma, American Journal of Respiratory and Critical Care Medicine, vol.150, issue.2_pt_2, pp.16-25, 1996. ,
DOI : 10.1172/JCI112937
Dysregulation of IL-2 and IL-8 production in circulating T lymphocytes from young cystic fibrosis patients, Clinical and Experimental Immunology, vol.152, issue.3, pp.528-562, 2004. ,
DOI : 10.1128/IAI.68.4.2142-2147.2000
URL : https://hal.archives-ouvertes.fr/inserm-00145671
Modulation of airway inflammation in cystic fibrosis In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor, J Clin Invest, vol.90, pp.1296-301, 1992. ,
Innate immune response in CF airway epithelia: hyperinflammatory?, American Journal of Physiology-Cell Physiology, vol.291, issue.2, pp.218-248, 2006. ,
DOI : 10.1128/IAI.73.11.7151-7160.2005
Interleukin-8: an important chemoattractant in sputum of patients with chronic inflammatory airway diseases, American Journal of Physiology-Lung Cellular and Molecular Physiology, vol.264, issue.4, pp.413-421, 1993. ,
DOI : 10.1152/ajplung.1993.264.4.L413
Nitric oxide and interleukin-8 as inflammatory components of cystic fibrosis, Inflammation, vol.107, issue.8457, pp.587-98, 1995. ,
DOI : 10.1007/BF01539138
Nasal and Bronchoalveolar Lavage Fluid Cytokines in Early Cystic Fibrosis, Journal of Infectious Diseases, vol.175, issue.3, pp.638-685, 1997. ,
DOI : 10.1093/infdis/175.3.638
Inflammation and Infection in Naive Human Cystic Fibrosis Airway Grafts, American Journal of Respiratory Cell and Molecular Biology, vol.156, issue.2, pp.121-128, 2000. ,
DOI : 10.1164/ajrccm.152.3.7663805
Influence of Cystic Fibrosis Transmembrane Conductance Regulator on Gene Expression in Response to Pseudomonas aeruginosa Infection of Human Bronchial Epithelial Cells, Infection and Immunity, vol.73, issue.10 ,
DOI : 10.1128/IAI.73.10.6822-6830.2005
Long-Term Cultures of Polarized Airway Epithelial Cells from Patients with Cystic Fibrosis, American Journal of Respiratory Cell and Molecular Biology, vol.34, issue.1, pp.39-48, 2006. ,
DOI : 10.1128/IAI.72.7.4188-4199.2004
Inflammation in cystic fibrosis airways: relationship to increased bacterial adherence, European Respiratory Journal, vol.17, issue.1, pp.27-35, 2001. ,
DOI : 10.1183/09031936.01.17100270
Reduced Interleukin-8 Production by Cystic Fibrosis Airway Epithelial Cells, American Journal of Respiratory Cell and Molecular Biology, vol.267, issue.5, pp.1073-80, 1999. ,
DOI : 10.1126/science.2472008
Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 ,
Markedly Elevated in the Epithelial Lining Fluid of Patients with Cystic Fibrosis, American Review of Respiratory Disease, vol.256, issue.11, pp.896-901, 1993. ,
DOI : 10.1172/JCI111570
Prostaglandins E2 and E2 alpha are elevated in saliva of cystic fibrosis patients, Am J Gastroenterol, vol.84, pp.1408-1420, 1989. ,
positive feedback loop in inflammation, Journal of Cellular Physiology, vol.11, issue.6, pp.2759-66, 2012. ,
DOI : 10.1186/1465-9921-11-49
Pathological regulation of arachidonic acid release in cystic fibrosis: the putative basic defect., Proceedings of the National Academy of Sciences, vol.83, issue.23, pp.9202-9208, 1986. ,
DOI : 10.1073/pnas.83.23.9202
A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr-/- mice, Proceedings of the National Academy of Sciences, vol.26, issue.9, pp.13995-4000, 1999. ,
DOI : 10.1159/000177530
Pathological regulation of arachidonic acid release in cystic fibrosis: the putative basic defect., Proceedings of the National Academy of Sciences, vol.83, issue.23, pp.9202-9208, 1986. ,
DOI : 10.1073/pnas.83.23.9202
A cytosolic phospholipase in human neutrophils that hydrolyzes arachidonoyl-containing phosphatidylcholine, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol.878, issue.2, pp.273-80, 1986. ,
DOI : 10.1016/0005-2760(86)90156-6
Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12 hydroxyeicosa-tetraenoic acid by calcium ionophore-challenged platelets, J Biol Chem, vol.269, pp.15619-15643, 1994. ,
Cystic fibrosis gene mutation (deltaF508) is associated with an intrinsic abnormality in Ca2+-induced arachidonic acid release by epithelial cells, DNA Cell Biol, vol.16, pp.749-59, 1997. ,
A Cystic Fibrosis Tracheal Gland Cell Line, CF-KM4, American Journal of Respiratory Cell and Molecular Biology, vol.15, issue.4, pp.684-691, 1999. ,
DOI : 10.1006/bbrc.1997.7720
A macromolecular complex of ?2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA ,
Abnormal adrenergic and cholinergic sensitivity in cystic fibrosis, N Eng J Med, vol.302, pp.1453-1459, 1980. ,
Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors ,
Synergistic Regulation of m2 Muscarinic Acetylcholine Receptor Desensitization and Sequestration by G Protein-coupled Receptor Kinase-2 and ??-Arrestin-1, Journal of Biological Chemistry, vol.12, issue.30, pp.18882-90, 1997. ,
DOI : 10.1016/0306-4522(92)90253-X
Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor, J Biol Chem, vol.271, pp.5049-58, 1996. ,
Phosphorylation of Human m1 Muscarinic Acetylcholine Receptors by G Protein-coupled Receptor Kinase 2 and Protein Kinase C, Journal of Biological Chemistry, vol.271, issue.5, pp.2776-82, 1996. ,
DOI : 10.1074/jbc.271.5.2776
beta-Arrestin: a protein that regulates beta-adrenergic receptor function, Science, vol.248, issue.4962, pp.1547-50, 1990. ,
DOI : 10.1126/science.2163110
expression by pulmonary epithelial cells, American Journal of Physiology-Lung Cellular and Molecular Physiology, vol.289, issue.5, 2005. ,
DOI : 10.1165/ajrcmb/4.4.313
Compound D609 inhibits phorbol ester-stimulated phospholipase D activity and phospholipase C-mediated phosphatidylethanolamine hydrolysis, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol.1259, issue.1, pp.105-113, 1995. ,
DOI : 10.1016/0005-2760(95)00148-6
Prostaglandin E2 enhances interleukin 8 (IL-8) and IL-6 but inhibits GMCSF production by IL-1 stimulated human synovial fibroblasts in vitro, J Rheumatol, vol.23, pp.862-870, 1996. ,
Distribution of peptide transporter PEPT2 mRNA in the rat nervous system, Anatomy and Embryology, vol.199, issue.5 ,
DOI : 10.1007/s004290050242
Peptide transport in the mammary gland: expression and distribution of PEPT2 mRNA and protein, American Journal of Physiology-Endocrinology and Metabolism, vol.277, issue.5, pp.1172-1181, 2002. ,
DOI : 10.1111/j.1476-5381.1995.tb15958.x
Tissue distribution and thyroid hormone regulation of Pept1 and Pept2 mRNA in rodents, Peptides, vol.27, issue.4, pp.850-857, 2006. ,
DOI : 10.1016/j.peptides.2005.08.012
Differential recognition of ACE inhibitors in Xenopus laevis oocytes expressing rat PEPT1 and PEPT2, Pharmaceutical Research, vol.17, issue.5, pp.526-528, 2000. ,
DOI : 10.1023/A:1007556630189
Intestinal peptide transport systems and oral drug availability, Pharmaceutical Research, vol.16, issue.9, pp.1331-1374, 1999. ,
DOI : 10.1023/A:1018982505021
Molecular Mechanisms of Pulmonary Peptidomimetic Drug and Peptide Transport, American Journal of Respiratory Cell and Molecular Biology, vol.30, issue.3, pp.251-260, 2004. ,
DOI : 10.1124/jpet.102.040295
Pharmaceutical and pharmacological importance of peptide transporters, Journal of Pharmacy and Pharmacology, vol.12, issue.5, pp.543-85, 2008. ,
DOI : 10.1023/A:1016254514167
The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology, Pflugers Arch, vol.447, pp.610-618, 2004. ,
Functional analysis of a chimeric mammalian peptide transporter derived from the intestinal and renal isoforms., The Journal of Physiology, vol.497, issue.3, pp.773-782, 1996. ,
DOI : 10.1113/jphysiol.1996.sp021808
Identification of a Potential Substrate Binding Domain in the Mammalian Peptide Transporters PEPT1 and PEPT2 Using PEPT1-PEPT2 and PEPT2-PEPT1 Chimeras, Biochemical and Biophysical Research Communications, vol.246, issue.1, pp.39-44, 1998. ,
DOI : 10.1006/bbrc.1998.8566
N-terminal halves of rat H+/peptide transporters are responsible for their substrate recognition, Pharmaceutical Research, vol.17, issue.1, pp.15-20, 2000. ,
DOI : 10.1023/A:1007554105597
Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2, The EMBO Journal, vol.105, issue.2, pp.417-443, 2011. ,
DOI : 10.1073/pnas.0800825105
Molecular Modeling of PepT1 ??? Towards a Structure, Journal of Membrane Biology, vol.250, issue.Suppl, pp.79-88, 2006. ,
DOI : 10.1007/s00232-006-0876-6
Oligopeptide transport by epithelial cells, The Journal of Membrane Biology, vol.145, issue.1, pp.1-12, 1995. ,
DOI : 10.1007/BF00233302
First insights into the operational mode of epithelial peptide transporters., The Journal of Physiology, vol.498, issue.3, p.561, 1997. ,
DOI : 10.1113/jphysiol.1997.sp021882
Substrate-charge dependence of stoichiometry shows membrane potential is the driving force for proton-peptide cotransport in rat renal cortex, Pfl???gers Archiv European Journal of Physiology, vol.19, issue.5, pp.825-834, 1995. ,
DOI : 10.1007/BF00386182
Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications., Journal of Clinical Investigation, vol.101, issue.12, pp.2761-67, 1998. ,
DOI : 10.1172/JCI1909
Tissue distribution and thyroid hormone regulation of Pept1 and Pept2 mRNA in rodents, Peptides, vol.27, issue.4, pp.850-857, 2006. ,
DOI : 10.1016/j.peptides.2005.08.012
Cloning and Characterization of the Gene Encoding the Mouse Peptide Transporter PEPT2, Biochemical and Biophysical Research Communications, vol.276, issue.2, pp.734-775, 2000. ,
DOI : 10.1006/bbrc.2000.3546
hPEPT1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3, Pfl??gers Archiv - European Journal of Physiology, vol.47, issue.3, pp.611-613, 2008. ,
DOI : 10.1016/S0002-9440(10)64013-8
RT-PCR analysis of ABC, SLC and SLCO drug transporters in human lung epithelial cell models, Journal of Pharmacy and Pharmacology, vol.vol. VII, issue.5, pp.583-591, 2009. ,
DOI : 10.1053/gast.2001.21176
Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition, Xenobiotica, vol.33, issue.2, pp.963-88, 2006. ,
DOI : 10.1124/dmd.104.001354
Molecular cloning and tissue distribution of rat peptide transporter PEPT2, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1280, issue.2, pp.173-180, 1996. ,
DOI : 10.1016/0005-2736(96)00024-7
PepT1 expressed in immune cells has an important role in promoting the immune response during experimentally induced colitis, Laboratory Investigation, vol.32, issue.8, pp.888-899, 2013. ,
DOI : 10.1016/j.it.2011.02.002
Expression cloning of a mammalian proton-coupled oligopeptide transporter, Nature, vol.368, issue.6471, pp.563-566, 1994. ,
DOI : 10.1038/368563a0
Interaction of 31 ??-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1, European Journal of Pharmaceutics and Biopharmaceutics, vol.59, issue.1, pp.17-24, 2005. ,
DOI : 10.1016/j.ejpb.2004.07.008
Regulation of angiotensin I-converting enzyme in cultured bovine bronchial epithelial cells, Journal of Cellular Biochemistry, vol.1, issue.4, pp.352-361, 1993. ,
DOI : 10.1165/ajrcmb/2.3.245
Altered cytokine production by cystic fibrosis tracheal gland serous cells, Infect Immun, vol.65, pp.5176-83, 1997. ,
High lysosomal activities in cystic fibrosis tracheal gland cells corrected by adenovirus-mediated CFTR gene transfer, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1453, issue.1, pp.14-22, 1999. ,
DOI : 10.1016/S0925-4439(98)00084-2
Lactoperoxidase and human airway host defense, Am J Respir Cell Mol Biol, vol.29, pp.206-218, 2003. ,
Deficiency, New England Journal of Medicine, vol.368, issue.2, pp.149-60, 2013. ,
DOI : 10.1056/NEJMcp1113996
Serum levels of interleukin-6 type cytokines and soluble interleukin-6 receptor in patients with rheumatoid arthritis, Mediators of Inflammation, vol.7, issue.5, pp.347-353, 1998. ,
DOI : 10.1080/09629359890875
Cytokines in acute and chronic inflammation, Front Biosci, vol.1, pp.12-26, 1997. ,
Hypomethylation of interleukin-4 and -6 promoters in T cells from systemic lupus erythematosus patients, Acta Pharmacologica Sinica, vol.29, issue.1, pp.105-107, 2008. ,
Atypical methylation of the interleukin-8 gene correlates strongly with the metastatic potential of breast carcinoma cells, PNAS, vol.100, pp.24-13988, 2003. ,
Atherosclerosis ??? An Inflammatory Disease, New England Journal of Medicine, vol.340, issue.2, pp.115-141, 1999. ,
DOI : 10.1056/NEJM199901143400207
Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model, Journal of Clinical Investigation, vol.107, issue.6, pp.675-83, 2001. ,
DOI : 10.1172/JCI10588
RAGE Mediates a Novel Proinflammatory Axis, Cell, vol.97, issue.7, pp.889-901, 1999. ,
DOI : 10.1016/S0092-8674(00)80801-6
The return of the Scarlet Pimpernel: cobalamin in inflammation II ??? cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS, Journal of Nutritional & Environmental Medicine, vol.44, issue.3, pp.181-211, 2007. ,
DOI : 10.1073/pnas.95.13.7631
Metabolic response to injury and sepsis: changes in protein metabolism, Nutrition, vol.13, issue.9, pp.52-57, 1997. ,
DOI : 10.1016/S0899-9007(97)83044-4
Metabolic bases of amino acid requirements in acute diseases, Current Opinion in Clinical Nutrition and Metabolic Care, vol.5, issue.2, pp.189-97, 2002. ,
DOI : 10.1097/00075197-200203000-00012
The amino acid requirements of disease, Clinical Nutrition, vol.20, pp.15-22, 2001. ,
DOI : 10.1054/clnu.2001.0402
Quantitative study in vivo of methionine cycle in humans using [methyl-2H3]- and [1-13C]methionine, American Journal of Physiology-Endocrinology and Metabolism, vol.101, issue.3, pp.322-331, 1988. ,
DOI : 10.1152/jappl.1984.56.1.230
Compositions de cobalamine et procedes destines au traitement ou a la prevention de la mucosite, 2007. ,
Compositions pour application externe contenant de l'adenosyl cobalamine, destinees au traitement des maladies de la peau, 2007. ,
Lack of Association between Plasma Homocysteine and Inflammation in Psychogeriatric Patients, Dementia and Geriatric Cognitive Disorders, vol.14, issue.3, pp.151-156, 2002. ,
DOI : 10.1159/000063602
Method for treating generalized and focal peripheral neuropathies locales, 2008. ,
Effect of Cobalamin on the Allergic Response in Mice, Bioscience, Biotechnology, and Biochemistry, vol.64, issue.10, pp.2053-58, 2000. ,
DOI : 10.1271/bbb.64.2053
Endogenous and Exogenous IL-6 Inhibit Aeroallergen-Induced Th2 Inflammation, The Journal of Immunology, vol.165, issue.7, pp.4051-61, 2000. ,
DOI : 10.4049/jimmunol.165.7.4051
URL : http://www.jimmunol.org/content/jimmunol/165/7/4051.full.pdf
asthma, and lung function in relation to folate and vitamin B12 in adults, Allergy, vol.65, pp.1446-54, 2010. ,
Interleukin-4 and tumour necrosis factor-?? inhibit transforming growth factor-?? production in a human bronchial epithelial cell line: Possible relevance to inflammatory mechanisms in chronic obstructive pulmonary disease, Respirology, vol.176, issue.3, pp.205-216, 2001. ,
DOI : 10.1084/jem.176.5.1381
Histamine Activates Bronchial Epithelial Cells to Release Inflammatory Cytokines in vitro, International Archives of Allergy and Immunology, vol.108, issue.3, pp.260-267, 1995. ,
DOI : 10.1159/000237162
Leukotriene B4 mediates histamine induction of NF-kappaB and IL-8 ,
Histamine-Induced Production of Interleukin-6 and Interleukin-8 by Human Coronary Artery Endothelial Cells Is Enhanced by Endotoxin and Tumor Necrosis Factor-??, Microvascular Research, vol.61, issue.3, pp.253-62, 2001. ,
DOI : 10.1006/mvre.2001.2304
Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA., Proceedings of the National Academy of Sciences, vol.85, issue.4, pp.1204-1212, 1988. ,
DOI : 10.1073/pnas.85.4.1204
Dex-mediated inhibition of human T cell growth factor and gammainterferon messenger RNA, J Immunol, vol.133, pp.273-279, 1984. ,
Molecular analysis of the inhibition of interleukin-8 production by dexamethasone in a human fibrosarcoma cell line ,
Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression, J Biol Chem, vol.269, pp.13289-95, 1994. ,
On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (Inr motif) occlusion., Molecular and Cellular Biology, vol.10, issue.11, pp.5736-5782, 1990. ,
DOI : 10.1128/MCB.10.11.5736
Determinants of Cell- and Gene-Specific Transcriptional Regulation by the Glucocorticoid Receptor, PLoS Genetics, vol.32, issue.6, p.94, 2007. ,
DOI : 10.1371/journal.pgen.0030094.st004
Ligand-independent Activation of the Glucocorticoid Receptor by b2-Adrenergic Receptor Agonists in Primary Human Lung Fibroblasts and Vascular Smooth Muscle Cells, THE JOURNAL OF BIOLOGICAL CHEMISTRY, pp.1005-1015, 1999. ,
Molecular Endocrinology. Minireview: Latest Perspectives on Antiinflammatory Actions of Glucocorticoids, pp.281-310, 2009. ,
Mouse Glucocorticoid Receptor Phosphorylation Status Influences Multiple Functions of the Receptor Protein, Journal of Biological Chemistry, vol.260, issue.14 ,
DOI : 10.1210/mend-2-12-1256
Differential recruitment of glucocorticoid receptor phospho-isoforms to glucocorticoid-induced genes, The Journal of Steroid Biochemistry and Molecular Biology, vol.109, issue.1-2, pp.150-157, 2008. ,
DOI : 10.1016/j.jsbmb.2008.01.002
Glucocorticoid Receptor Phosphorylation Differentially Affects Target Gene Expression, Molecular Endocrinology, vol.22, issue.8 ,
DOI : 10.1210/me.2007-0219
URL : https://academic.oup.com/mend/article-pdf/22/8/1754/8941373/mend1754.pdf
Modulation of Glucocorticoid Receptor Phosphorylation and Transcriptional Activity by a C-Terminal-Associated Protein Phosphatase, Molecular Endocrinology, vol.21, issue.3, pp.625-659, 2007. ,
DOI : 10.1210/me.2005-0338
Epidermal growth factor stimulates tyrosine phosphorylation of human glucocorticoid receptor in cultured cells, Proc. Natl. Acad. Sci, pp.10762-67, 1987. ,
DOI : 10.1016/S0006-291X(87)80539-9
Vitamin B12 deficiency reduces proliferation and promotes differentiation of neuroblastoma cells and up-regulates PP2A, proNGF, and TACE, Proceedings of the National Academy of Sciences, vol.391, issue.1, pp.21930-21935, 2009. ,
DOI : 10.1007/s00216-008-1953-8
Defects of Protein Phosphatase 2A Causes Corticosteroid Insensitivity in Severe Asthma, PLoS ONE, vol.6, issue.12, p.27627, 2011. ,
DOI : 10.1371/journal.pone.0027627.s002
Ligand-selective transactivation and transrepression via the glucocorticoid receptor: Role of cofactor interaction, Molecular and Cellular Endocrinology, vol.299, issue.2, pp.219-250, 2009. ,
DOI : 10.1016/j.mce.2008.10.008
Phosphatidylcholine and lysophosphatidylcholine excretion is increased in children with cystic fibrosis and is associated with plasma homocysteine, S-adenosylhomocysteine, and S-adenosylmethionine, The American Journal of Clinical Nutrition, vol.16, issue.suppl, pp.686-91, 2005. ,
DOI : 10.1007/BF02534900
Phospholipase D activation mediates cobalamin-induced downregulation of Multidrug Resistance-1 gene and increase in sensitivity to vinblastine in HepG2 cells, The International Journal of Biochemistry & Cell Biology, vol.45, issue.2, pp.213-233, 2013. ,
DOI : 10.1016/j.biocel.2012.09.018
Toutes les réactions de PCR ont été réalisées dans un volume final de 25 ?L contenant : 0,2 mM de chacun des désoxyribonucléotides (dNTP), le tampon de la Taq concentré une fois 5 ?L de la solution d'ADN (diluée 8 fois pour les Input) et 1 ?M de chacune des amorces sens et antisens, p.2 ,
Les ADN amplifiés sont migrés sur un gel d'agarose à 2% contenant 0,05 ?g/mL de bromure d'éthidium. Le gel est alors scanné. Les bandes ont été quantifiées par densitométrie et analysées avec le logiciel « Image J » developpé par « National Institutes of Health ». L'enrichissement en ADN immunoprécipité (IP) est déterminé en divisant la densité des produits de PCR IP par celle des inputs (INP), pour les échantillons contrôles et traités puis en comparant le rapport entre les valeurs obtenues. La PCR est réalisée selon le protocole suivant : une incubation à 94°C pendant 3 min, pp.585-586 ,