C. Burge and S. Karlin, Prediction of complete gene structures in human genomic DNA, Journal of Molecular Biology, vol.268, issue.1, pp.78-94, 1997.
DOI : 10.1006/jmbi.1997.0951

F. Cabello-hurtado, F. Durst, J. V. Jorrín, and D. Werck-reichhart, Coumarins in helianthus tuberosus : characterization, induced accumulation and biosynthesis, Phytochemistry, vol.49, issue.4, pp.1029-1036, 1998.
DOI : 10.1016/S0031-9422(97)01036-4

J. Cadet, C. Anselmino, T. Douki, and L. Voituriez, New trends in photobiology, Journal of Photochemistry and Photobiology B: Biology, vol.15, issue.4, pp.277-298, 1992.
DOI : 10.1016/1011-1344(92)85135-H

S. Caffieri, Furocoumarin photolysis: chemical and biological aspects, Photochemical & Photobiological Sciences, vol.1, issue.3, 2002.
DOI : 10.1039/b107329j

J. J. Caoe, S. Suaaaia, M. N. Shae, J. R. Collett, L. M. Souza et al., The comparative RNA web (CRW) site: an online database of comparative sequence and structure information for ribosomal, intron, and other RNAs, BMC Bioinformatics, vol.3, issue.2, 2002.

E. M. Cappelletti, G. Innocenti, C. , and G. , Furocoumarins localization in the fruit and seed of Psoralea corylifolia L, Pl Med Phytother, vol.18, pp.181-190, 1984.

M. C. Carpinella, C. G. Ferrayoli, and S. M. Palacios, L. Fruits, Journal of Agricultural and Food Chemistry, vol.53, issue.8, pp.2922-2927, 2005.
DOI : 10.1021/jf0482461

M. J. Casadaban and S. N. Cohen, Analysis of gene control signals by DNA fusion and cloning in Escherichia coli, Journal of Molecular Biology, vol.138, issue.2, pp.179-207, 1980.
DOI : 10.1016/0022-2836(80)90283-1

R. Caspi, H. Foerster, C. A. Fulcher, P. Kaipa, M. Krummenacker et al., The MetaCyc Database of metabolic pathways and enzymes and the BioCyc collection of Pathway/Genome Databases, Nucleic Acids Research, vol.5, issue.1, pp.623-631, 2008.
DOI : 10.1186/1471-2105-5-76

. Goanno, GO annotation based on multiple alignment, Bioinformatics, vol.21, pp.2095-2096

C. Chapple, MOLECULAR-GENETIC ANALYSIS OF PLANT CYTOCHROME P450-DEPENDENT MONOOXYGENASES, Annual Review of Plant Physiology and Plant Molecular Biology, vol.49, issue.1, pp.311-343, 1998.
DOI : 10.1146/annurev.arplant.49.1.311

C. Chen and B. Kemper, Different Structural Requirements at Specific Proline Residue Positions in the Conserved Proline-rich Region of Cytochrome P450 2C2, Journal of Biological Chemistry, vol.10, issue.45, pp.28607-28611, 1996.
DOI : 10.1016/0167-4838(93)90205-6

G. Gattuso, D. Barreca, C. Caristi, C. Gargiulli, and U. Leuzzi, Risso, Journal of Agricultural and Food Chemistry, vol.55, issue.24, pp.9921-9927, 2007.
DOI : 10.1021/jf072065s

G. Calzavara-pinton, P. Zane, C. Carlino, A. , D. Panfilis et al., Bath-5-methoxypsoralen-UVA therapy for psoriasis, Journal of the American Academy of Dermatology, vol.36, issue.6, pp.945-949, 1997.
DOI : 10.1016/S0190-9622(97)80278-2

A. Gierl and M. Frey, Evolution of benzoxazinone biosynthesis and indole production in maize, Planta, vol.213, issue.4, pp.493-498, 2001.
DOI : 10.1007/s004250100594

K. Gion, H. Inui, K. Takakuma, T. Yamada, Y. Kambara et al., Molecular mechanisms of herbicide-inducible gene expression of tobacco CYP71AH11 metabolizing the herbicide chlorotoluron. Pestic, Biochem. Physiol, 2014.

B. Girennavar, G. K. Jayaprakasha, and B. S. Patil, Potent Inhibition of Human Cytochrome P450 3A4, 2D6, and 2C9 Isoenzymes by Grapefruit Juice and Its Furocoumarins, Journal of Food Science, vol.5, issue.8, pp.417-421, 2007.
DOI : 10.1124/dmd.104.001594

B. Girennavar, M. L. Cepeda, K. A. Soni, A. Vikram, P. Jesudhasan et al., Grapefruit juice and its furocoumarins inhibits autoinducer signaling and biofilm formation in bacteria, International Journal of Food Microbiology, vol.125, issue.2, pp.204-208, 2008.
DOI : 10.1016/j.ijfoodmicro.2008.03.028

E. Glawischnig, S. Grün, M. Frey, and A. Gierl, Cytochrome P450 monooxygenases of DIBOA biosynthesis: Specificity and conservation among grasses, Phytochemistry, vol.50, issue.6, pp.925-930, 1999.
DOI : 10.1016/S0031-9422(98)00318-5

A. Gliszz?ska and P. E. Bodelius, Sesquiterpene coumarins, Phytochemistry Reviews, vol.53, issue.1, pp.77-96, 2012.
DOI : 10.1016/S0031-9422(99)00554-3

D. E. Godar, UVA1 Radiation Triggers Two Different Final Apoptotic Pathways, Journal of Investigative Dermatology, vol.112, issue.1, pp.3-12, 1999.
DOI : 10.1046/j.1523-1747.1999.00474.x

URL : https://doi.org/10.1046/j.1523-1747.1999.00474.x

E. Gontier, M. A. Fliniaux, J. N. Barbotin, and B. S. Sangwan-norreel, Plants, Planta Medica, vol.59, issue.05, pp.432-435, 1993.
DOI : 10.1055/s-2006-959726

URL : https://hal.archives-ouvertes.fr/hal-01738259

P. R. Gordon and B. A. Gilchrest, Human Melanogenesis is Stimulated by Diacylglycerol, Journal of Investigative Dermatology, vol.93, issue.5, 1989.
DOI : 10.1111/1523-1747.ep12319900

H. J. Gorz and F. A. Haskins, Translocation of Coumarin Across a Graft Union m Sweetclover, 1962.

O. Gotoh, Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences, J. Biol. Chem, vol.267, pp.83-90, 1992.

C. A. Helliwell, P. M. Chandler, A. Poole, E. S. Dennis, and W. J. Peacock, The CYP88A cytochrome P450, ent-kaurenoic acid oxidase, catalyzes three steps of the gibberellin biosynthesis pathway, Proc. Natl. Acad. Sci. 98, pp.2065-2070, 2001.
DOI : 10.1105/tpc.12.6.901

G. M. Helmkamp, R. R. Rando, D. J. Brock, and K. Bloch, ?-Hydroxydecanoyl thioester dehydrase specificity of substrates and acetylenic inhibitors, J. Biol. Chem, vol.243, pp.3229-3231, 1968.

M. Hivelin, M. Siemionow, P. Grimbert, and L. Lantieri, Extracorporeal photopheresis: From solid organs to face transplantation, Transplant Immunology, vol.21, issue.3, pp.117-128, 2009.
DOI : 10.1016/j.trim.2009.04.005

R. Höfer, I. Briesen, M. Beck, F. Pinot, L. Schreiber et al., The Arabidopsis cytochrome P450 CYP86A1 encodes a fatty acid ??-hydroxylase involved in suberin monomer biosynthesis, Journal of Experimental Botany, vol.136, issue.9, pp.2347-2360, 2008.
DOI : 10.1104/pp.104.046367

D. W. Huang, B. T. Sherman, and R. A. Lempicki, Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources, Nature Protocols, vol.99, issue.1, pp.44-57, 2008.
DOI : 10.6026/97320630002428

S. Hübner, M. Hehmann, S. Scheie, S. Matees, R. Luka?i et al., Functional expression of cinnamate 4-hydroxylase from Ammi majus L., Phytochemistry, vol.64, issue.2, pp.445-452, 2003.
DOI : 10.1016/S0031-9422(03)00265-6

N. Hulo, A. Bairoch, V. Bulliard, L. Cerutti, B. A. Cuche et al., The 20 years of PROSITE, Nucleic Acids Research, vol.5, issue.suppl_1, pp.245-249, 2008.
DOI : 10.1186/1471-2105-5-56

J. M. Humphreys, M. R. Hemm, C. , and C. , New routes for lignin biosynthesis defined by biochemical characterization of recombinant ferulate 5-hydroxylase, a multifunctional cytochrome P450-dependent monooxygenase, Proc. Natl. Acad. Sci. 96, pp.10045-10050, 1999.
DOI : 10.1146/annurev.arplant.49.1.311

C. Hung, H. Prapaipong, M. R. Berenbaum, and M. A. Schuler, Differential induction of cytochrome P450 transcripts in Papilio polyxenes by linear and angular furanocoumarins, Insect Biochemistry and Molecular Biology, vol.25, issue.1, pp.89-99, 1995.
DOI : 10.1016/0965-1748(94)00038-J

S. Hunter, R. Apweiler, T. K. Attwood, A. Bairoch, A. Bateman et al., InterPro: the integrative protein signature database, Nucleic Acids Research, vol.24, issue.18, pp.211-215, 2009.
DOI : 10.1093/bioinformatics/btn387

URL : https://hal.archives-ouvertes.fr/hal-01214141

S. Irmler, G. Schröder, B. St-pierre, N. P. Crouch, M. Hotze et al., Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase, The Plant Journal, vol.34, issue.6, pp.797-804, 2000.
DOI : 10.1515/DMDI.1995.12.3-4.189

M. H. Jagasia, B. N. Savani, G. Stricklin, B. Engelhardt, A. Kassim et al., Classic and Overlap Chronic Graft-versus-Host Disease (cGVHD) Is Associated with Superior Outcome after Extracorporeal Photopheresis (ECP), Biology of Blood and Marrow Transplantation, vol.15, issue.10, pp.1288-1295, 2009.
DOI : 10.1016/j.bbmt.2009.06.007

E. D. Kharasch, D. C. Hankins, and J. K. Taraday, Single-dose methoxsalen effects on human cytochrome P-450 2A6 activity, Drug Metab. Dispos, vol.28, pp.28-33, 2000.

C. Arabidopsis and P. Cytochrome, Mediates the Baeyer-Villiger Oxidation of Castasterone to Brassinolide in Brassinosteroid Biosynthesis, Plant Cell Online, vol.17, pp.2397-2412

Y. Kim, Y. S. Kim, and S. Y. Ryu, Antiproliferative Effect of Furanocoumarins from the Root ofAngelica dahurica on Cultured Human Tumor Cell Lines, Phytotherapy Research, vol.82, issue.3, pp.288-290, 2007.
DOI : 10.1142/3041

N. Kitamura, S. Kohtani, and R. Nakagaki, Molecular aspects of furocoumarin reactions: Photophysics, photochemistry, photobiology, and structural analysis, Journal of Photochemistry and Photobiology C: Photochemistry Reviews, vol.6, issue.2-3, pp.168-185, 2005.
DOI : 10.1016/j.jphotochemrev.2005.08.002

Y. Kitamura, T. Ikenaga, Y. Ooe, N. Hiraoka, and H. Mizukami, Induction of furanocoumarin biosynthesis in Glehnia littoralis cell suspension cultures by elicitor treatment, Phytochemistry, vol.48, issue.1, pp.113-117, 1998.
DOI : 10.1016/S0031-9422(97)00849-2

M. Klingenberg, Pigments of rat liver microsomes, Archives of Biochemistry and Biophysics, vol.75, issue.2, pp.376-386, 1958.
DOI : 10.1016/0003-9861(58)90436-3

L. L. Koenigs, R. M. Peter, S. J. Thompson, A. E. Rettie, and W. F. Trager, Mechanism-based inactivation of human liver cytochrome P450 2A6 by 8-methoxypsoralen, Drug Metab. Dispos, vol.25, pp.1407-1415, 1997.

R. Koes, W. Verweij, and F. Quattrocchio, Flavonoids: a colorful model for the regulation and evolution of biochemical pathways, Trends in Plant Science, vol.10, issue.5, pp.236-242, 2005.
DOI : 10.1016/j.tplants.2005.03.002

L. G. Korkina, Phenylpropanoids as naturally occurring antioxidants: from plant defense to human health, Cell Mol Biol, vol.53, pp.15-25, 2007.

A. Krogh, B. Larsson, G. Von-heijne, and E. L. Sonnhammer, Predicting transmembrane protein topology with a hidden markov model: application to complete genomes11Edited by F. Cohen, Journal of Molecular Biology, vol.305, issue.3, pp.567-580, 2001.
DOI : 10.1006/jmbi.2000.4315

J. G. Krueger, The immunologic basis for the treatment of psoriasis with new biologic agents, Journal of the American Academy of Dermatology, vol.46, issue.1, 2002.
DOI : 10.1067/mjd.2002.120568

T. Kruse, K. Ho, H. Yoo, T. Johnson, M. Hippely et al., In Planta Biocatalysis Screen of P450s Identifies 8-Methoxypsoralen as a Substrate for the CYP82C Subfamily, Yielding Original Chemical Structures, Chemistry & Biology, vol.15, issue.2, pp.149-156, 2008.
DOI : 10.1016/j.chembiol.2008.01.008

A. Kumar, E. , and B. E. , The Phenylalanine Ammonia-Lyase Gene Family in Raspberry, 2001.

A. C. Kung, M. B. Stephens, and T. Darling, Phytophotodermatitis: Bulla Formation and Hyperpigmentation During Spring Break, Military Medicine, vol.174, issue.6, pp.657-661, 2009.
DOI : 10.7205/MILMED-D-01-7208

M. Marí and A. I. Cederbaum, Induction of catalase, alpha, and microsomal glutathione S-transferase in CYP2E1 overexpressing HepG2 cells and protection against short-term oxidative stress, Hepatology, vol.33, issue.3, pp.652-661, 2001.
DOI : 10.1053/jhep.2001.22521

C. Marzano, A. Chilin, F. Bordin, F. Baccichetti, and A. Guiotto, DNA damage and biological effects induced by photosensitization with new N1-unsubstituted furo, pp.3-5, 2002.

B. Massot, S. Milesi, E. Gontier, F. Bourgaud, and A. Guckert, Optimized culture conditions for the production of furanocoumarins by micropropagated shoots of Ruta graveolens, Plant Cell, Tissue and Organ Culture, vol.62, issue.1, pp.11-19, 2000.
DOI : 10.1023/A:1006430508169

O. Matern, H. Strasser, H. Wendorff, and D. Hamerski, Coumarins and Furanocoumarins, 1988.
DOI : 10.1016/B978-0-12-715005-5.50008-X

T. Matsubara, J. Baron, L. L. Peterson, and J. A. Peterson, NADPH-cytochrome P450 reductase, Archives of Biochemistry and Biophysics, vol.172, issue.2, pp.463-469, 1976.
DOI : 10.1016/0003-9861(76)90099-0

S. Matsumoto, M. Mizutani, K. Sakata, and B. Shimizu, Molecular cloning and functional analysis of the ortho-hydroxylases of p-coumaroyl coenzyme A/feruloyl coenzyme A involved in formation of umbelliferone and scopoletin in sweet potato, Ipomoea batatas (L.) Lam., Phytochemistry, vol.74, pp.49-57, 2012.
DOI : 10.1016/j.phytochem.2011.11.009

L. Matthews, G. Gopinath, M. Gillespie, M. Caudy, D. Croft et al., Reactome knowledgebase of human biological pathways and processes, Nucleic Acids Research, vol.2, issue.4, pp.619-622, 2009.
DOI : 10.1093/bioinformatics/btg015

E. S. Mccloud, M. R. Berenbaum, and R. W. Tuveson, Furanocoumarin content and phototoxicity of rough lemon (Citrus jambhiri) foliage exposed to enhanced ultraviolet-B (UVB) irradiation, Journal of Chemical Ecology, vol.17, issue.7, pp.1125-1137, 1992.
DOI : 10.1007/BF00980068

D. Mckey, Adaptive Patterns in Alkaloid Physiology, The American Naturalist, vol.108, issue.961, pp.305-320, 1974.
DOI : 10.1086/282909

H. Meng, J. Xu, W. Guo, Q. Xu, D. Li et al., A protocol for rapid isolation of flanking regions from short known sequences, Plant Molecular Biology Reporter, vol.23, issue.1, pp.75-75, 2005.
DOI : 10.1007/BF02772649

K. Meyer, J. C. Cusumano, C. Somerville, C. , and C. C. , Ferulate-5-hydroxylase from Arabidopsis thaliana defines a new family of cytochrome P450-dependent monooxygenases., Proceedings of the National Academy of Sciences, vol.93, issue.14, 1996.
DOI : 10.1073/pnas.93.14.6869

P. Michalak, Coexpression, coregulation, and cofunctionality of neighboring genes in eukaryotic genomes, Genomics, vol.91, issue.3, pp.243-248, 2008.
DOI : 10.1016/j.ygeno.2007.11.002

B. Mignotte and J. Vayssiere, Mitochondria and apoptosis, European Journal of Biochemistry, vol.252, issue.1, pp.1-15, 1998.
DOI : 10.1046/j.1432-1327.1998.2520001.x

S. Milesi, B. Massot, E. Gontier, F. Bourgaud, and A. Guckert, Ruta graveolens L.: a promising species for the production of furanocoumarins, Plant Science, vol.161, issue.1, pp.189-199, 2001.
DOI : 10.1016/S0168-9452(01)00413-7

URL : https://hal.archives-ouvertes.fr/tel-01749831

M. Mizutani and D. Ohta, Diversification of P450 Genes During Land Plant Evolution, Annual Review of Plant Biology, vol.61, issue.1, pp.291-315, 2010.
DOI : 10.1146/annurev-arplant-042809-112305

M. Mizutani, E. Ward, J. Dimaio, D. Ohta, J. Ryals et al., Molecular Cloning and Sequencing of a cDNA Encoding Mung Bean Cytochrome P450 (P450C4H) Possessing Cinnamate 4-Hydroxylase Activity, Biochemical and Biophysical Research Communications, vol.190, issue.3, pp.875-880, 1993.
DOI : 10.1006/bbrc.1993.1130

A. C. Moor and F. P. Gasparro, Biochemical aspects of psoralen photochemotherapy, Clinics in Dermatology, vol.14, issue.4, pp.353-365, 1996.
DOI : 10.1016/0738-081X(96)00065-X

M. Morant, A. Hehn, and D. Werck-reichhart, Conservation and diversity of gene families explored using the CODEHOP strategy in higher plants, BMC Plant Biology, vol.2, issue.1, p.7, 2002.
DOI : 10.1186/1471-2229-2-7

URL : https://hal.archives-ouvertes.fr/hal-01738040

A. I. Moreira, I. Leite, R. Guedes, A. Baptista, and E. O. Ferreira, Phytophotodermatitis: an occupational and recreational skin disease, Revista da Associa????o M??dica Brasileira, vol.56, issue.3, pp.269-270, 2010.
DOI : 10.1590/S0104-42302010000300008

T. Morikawa, M. Mizutani, N. Aoki, B. Watanabe, H. Saga et al., Cytochrome P450 CYP710A Encodes the Sterol C-22 Desaturase in Arabidopsis and Tomato, THE PLANT CELL ONLINE, vol.18, issue.4, pp.1008-1022, 2006.
DOI : 10.1105/tpc.105.036012

N. Mulder and R. Apweiler, InterPro and InterProScan, Comparative Genomics, pp.59-70, 2007.
DOI : 10.1007/978-1-59745-515-2_5

M. Murray, Mechanisms of Inhibitory and Regulatory Effects of Methylenedioxyphenyl Compounds on Cytochrome P450-Dependent Drug Oxidation, Current Drug Metabolism, vol.1, issue.1, pp.67-84, 2000.
DOI : 10.2174/1389200003339270

R. D. Murray, J. Méndez, and S. A. Brown, The natura, coumarins: Occurrence, Chemistry and Biochemistry, 1982.

L. Musajo, G. Rodighieo, G. Coloo, V. Toloe, and F. Aua, Photosensitizing furocoumarins: Interaction with DNA and photo-inactivation of DNA containing viruses, Experientia, vol.21, issue.1, pp.22-24, 1965.
DOI : 10.1038/bjc.1962.40

M. Nafisi, S. Goregaoker, C. J. Botanga, E. Glawischnig, C. E. Olsen et al., Cytochrome P450 Monooxygenase 71A13 Catalyzes the Conversion of Indole-3-Acetaldoxime in Camalexin Synthesis, The Plant Cell, vol.19, issue.6, pp.2039-2052, 2007.
DOI : 10.1105/tpc.107.051383

R. B. Nair, Q. Xia, C. J. Kartha, E. Kurylo, R. N. Hirji et al., Arabidopsis CYP98A3 Mediating Aromatic 3-Hydroxylation. Developmental Regulation of the Gene, and Expression in Yeast, PLANT PHYSIOLOGY, vol.130, issue.1, pp.210-220, 2002.
DOI : 10.1104/pp.008649

J. J. Neal and D. Wu, Inhibition of Insect Cytochromes P450 by Furanocoumarins, Pesticide Biochemistry and Physiology, vol.50, issue.1, pp.43-50, 1994.
DOI : 10.1006/pest.1994.1056

A. Okada, K. Okada, K. Miyamoto, J. Koga, N. Shibuya et al., OsTGAP1, a bZIP Transcription Factor, Coordinately Regulates the Inductive Production of Diterpenoid Phytoalexins in Rice, Journal of Biological Chemistry, vol.15, issue.39, pp.26510-26518, 2009.
DOI : 10.1105/tpc.012849

K. M. Olsen, U. S. Lea, R. Slimestad, M. Verheul, and C. Lillo, Differential expression of four Arabidopsis PAL genes; PAL1 and PAL2 have functional specialization in abiotic environmental-triggered flavonoid synthesis, Journal of Plant Physiology, vol.165, issue.14, pp.1491-1499, 2008.
DOI : 10.1016/j.jplph.2007.11.005

T. Omura and R. Sato, The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature, J Biol Chem, vol.239, pp.2370-2378, 1964.

A. Orlita, M. Sidwa-gorycka, E. Malinski, M. Czerwicka, J. Kumirska et al., Effective biotic elicitation of Ruta graveolens L. shoot cultures by lysates from Pectobacterium atrosepticum and Bacillus sp., Biotechnology Letters, vol.43, issue.4, pp.541-545, 2008.
DOI : 10.5586/asbp.1997.039

A. Orlita, M. Sidwa-gorycka, J. Kuiska, E. Mali?ski, E. M. Siedleka et al., Identification of Ruta graveolens L. Metabolites Accumulated in the Presence of Abiotic Elicitors, Biotechnology Progress, vol.24, issue.1, pp.128-133, 2008.
DOI : 10.1021/bp070261d

A. E. Osbourn and B. Field, Operons, Cellular and Molecular Life Sciences, vol.18, issue.7, pp.3755-3775, 2009.
DOI : 10.4161/rna.5.3.6676

R. Ooeeek, M. Fostei, M. D-'souza, G. D. Push, and N. Ad-maltse, The use of gene clusters to infer functional coupling, Proc. Natl. Acad. Sci. 96, pp.2896-2901, 1999.

H. Pae, H. Oh, Y. Yun, G. Oh, S. I. Jang et al., Imperatorin, a Furanocoumarin from Angelica dahurica (Umbelliferae), Induces Cytochrome c-Dependent Apoptosis in Human Promyelocytic Leukaemia, HL-60 Cells, Imperatorin, a Furanocoumarin from Angelica dahurica (Umbelliferae), Induces Cytochrome c-Dependent Apoptosis in Human Promyelocytic Leukaemia, HL-60 Cells, pp.40-48, 2002.
DOI : 10.1089/15230860050192314

N. A. Page, R. E. Wall, S. J. Darbyshire, and G. A. Mulligan, Sommier & Levier, Canadian Journal of Plant Science, vol.86, issue.2, pp.569-589, 2006.
DOI : 10.4141/P05-158

J. H. Park, N. I. Park, H. Xu, and S. U. Park, Cloning and Characterization of Phenylalanine Ammonia-Lyase and Cinnamate 4-Hydroxylase and Pyranocoumarin Biosynthesis in Angelica gigas, J, 2010.

X. Qi, S. Bakht, B. Qin, M. Leggett, A. Hemmings et al., A different function for a member of an ancient and highly conserved cytochrome P450 family: From essential sterols to plant defense, Proc. Natl. Acad. Sci. 103, pp.18848-18853, 2006.
DOI : 10.1093/bioinformatics/bti315

URL : https://hal.archives-ouvertes.fr/hal-00123829

R. F. Quinlan, M. Shumskaya, L. M. Bradbury, J. Beltrán, C. Ma et al., Synergistic Interactions between Carotene Ring Hydroxylases Drive Lutein Formation in Plant Carotenoid Biosynthesis, PLANT PHYSIOLOGY, vol.160, issue.1, pp.204-214, 2012.
DOI : 10.1104/pp.112.198556

J. A. Ranea, C. Yeats, A. Grant, and C. A. Orengo, Predicting Protein Function with Hierarchical Phylogenetic Profiles: The Gene3D Phylo-Tuner Method Applied to Eukaryotic Genomes, PLoS Computational Biology, vol.19, issue.11, p.237, 2007.
DOI : 10.1371/journal.pcbi.0030237.st004

A. Rani, K. Singh, P. Sood, S. Kumar, and P. S. Ahuja, p-Coumarate:CoA ligase as a key gene in the yield of catechins in tea [Camellia sinensis (L.) O. Kuntze], Functional & Integrative Genomics, vol.1, issue.2, pp.271-275, 2009.
DOI : 10.1093/treephys/28.9.1349

C. A. Rice-evans, N. J. Miller, and G. Paganga, Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic, Biol. Med, vol.20, pp.933-956, 1996.

D. K. Ro, N. Mah, B. E. Ellis, D. , and C. J. , Functional Characterization and Subcellular Localization of Poplar (Populus trichocarpa x Populus deltoides) Cinnamate 4-Hydroxylase, PLANT PHYSIOLOGY, vol.126, issue.1, pp.317-329, 2001.
DOI : 10.1104/pp.126.1.317

E. S. Roberts, N. E. Hopkins, W. L. Alworth, and P. F. Hollenberg, Mechanism-based inactivation of cytochrome P450 2B1 by 2-ethynylnaphthalene: Identification of an active-site peptide, Chemical Research in Toxicology, vol.6, issue.4, 1993.
DOI : 10.1021/tx00034a013

T. Robineau, Y. Batard, S. Nedelkina, F. Cabello-hurtado, M. Leret et al., The Chemically Inducible Plant Cytochrome P450 CYP76B1 Actively Metabolizes Phenylureas and Other Xenobiotics, Plant Physiology, vol.118, issue.3, pp.1049-1056, 1998.
DOI : 10.1104/pp.118.3.1049

S. Rojas-lia, R. L. Satilla, M. Doíguez, and A. Gutiérrez, Furocoumarins of three species of the genus Dorstenia, Phytochemistry, vol.50, issue.5, pp.863-868, 1999.
DOI : 10.1016/S0031-9422(98)00520-2

M. Ronaghi, M. Uhlén, and P. Nyren, DNA SEQUENCING:A Sequencing Method Based on Real-Time Pyrophosphate, Science, vol.281, issue.5375, pp.363-365, 1998.
DOI : 10.1126/science.281.5375.363

J. Rosler, F. Krekel, N. Amrhein, and J. Schmid, Maize Phenylalanine Ammonia-Lyase Has Tyrosine Ammonia-Lyase Activity, Plant Physiology, vol.113, issue.1, pp.175-179, 1997.
DOI : 10.1104/pp.113.1.175

G. J. Rouwendal, O. Mendes, E. J. Wolbert, and A. D. De-boer, Enhanced expression in tobacco of the gene encoding green fluorescent protein by modification of its codon usage, Plant Molecular Biology, vol.33, issue.6, pp.989-999, 1997.
DOI : 10.1023/A:1005740823703

N. Rusk, Cheap third-generation sequencing, Nature Methods, vol.6, issue.4, pp.244-244, 2009.
DOI : 10.1038/nmeth0409-244a

Y. Sahali-sahly, S. K. Balani, J. H. Lin, B. , and T. A. , Studies on the Metabolic Activation of the Furanopyridine L-754,394, a Highly Potent and Selective Mechanism-Based Inhibitor of Cytochrome P450 3A4, Chemical Research in Toxicology, vol.9, issue.6, pp.1007-1012, 1996.
DOI : 10.1021/tx960060b

S. Jr and H. , Plant metabolism of xenobiotics, Trends Biochem. Sci, vol.17, pp.82-84, 1992.

F. Sanger, S. Nicklen, and A. R. Coulson, DNA sequencing with chain-terminating inhibitors, Proceedings of the National Academy of Sciences, vol.74, issue.12, 1977.
DOI : 10.1073/pnas.74.12.5463

K. Santosh, Cytochrome P450-mediated phytoremediation using transgenic plants: a need for engineered cytochrome P450 enzymes, J. Pet. Environ. Biotechnol, 2012.

S. Sardari, Y. Mori, K. Horita, R. G. Micetich, S. Nishibe et al., Synthesis and antifungal activity of coumarins and angular furanocoumarins, Bioorganic & Medicinal Chemistry, vol.7, issue.9, 1933.
DOI : 10.1016/S0968-0896(99)00138-8

M. Sasaki, F. Meguro, E. Kumazawa, H. Fujita, H. Kakishima et al., Evidence for uptake of 8-methoxypsoralen and 5-methoxypsoralen by cellular nuclei, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.197, issue.1, pp.51-58, 1988.
DOI : 10.1016/0027-5107(88)90139-X

S. S. Sastry, Isolation and Partial Characterization of a Novel Psoralen-Tyrosine Photoconjugate from a Photoreaction of Psoralen with a Natural Protein, Photochemistry and Photobiology, vol.33, issue.6, pp.937-944, 1997.
DOI : 10.1016/0005-2787(77)90093-4

R. M. Sayre and J. C. Dowdy, The increase in melanoma: Are dietary furocoumarins responsible?, Medical Hypotheses, vol.70, issue.4, pp.855-859, 2008.
DOI : 10.1016/j.mehy.2007.07.029

M. Schalk, F. Cabello-hurtado, M. Pierrel, R. Atanassova, P. Saindrenan et al., -Cinnamate 4-Hydroxylase: A New Tool to Control the Flux of Metabolites in the Phenylpropanoid Pathway, Plant Physiology, vol.118, issue.1, pp.209-218, 1998.
DOI : 10.1104/pp.118.1.209

O. Schimmer and I. Kühne, Mutagenic compounds in an extract from Rutae Herba (Ruta graveolens L.) II. UV-A mediated mutagenicity in the green alga Chlamydomonas reinhardtii by furoquinoline alkaloids and furocoumarins present in a commercial tincture from Rutae Herba, Mutation Research Letters, vol.243, issue.1, 1990.
DOI : 10.1016/0165-7992(90)90123-2

I. M. Schmitt, V. M. Maxwell, G. A. Olack, R. L. Edelson, S. Chimenti et al., The specific effects of 8-methoxypsoralen photoadducts on cell growth: HPLC analysis of monoadduct and crosslink formation in cells exposed to split-dose treatment, Journal of Photochemistry and Photobiology B: Biology, vol.22, issue.1, pp.17-21, 1994.
DOI : 10.1016/1011-1344(93)06946-Z

I. M. Schmitt, S. Chimenti, and F. P. Gasparro, Psoralen-protein photochemistry ??? a forgotten field, Journal of Photochemistry and Photobiology B: Biology, vol.27, issue.2, pp.101-107, 1995.
DOI : 10.1016/1011-1344(94)07101-S

G. Schoch, S. Goepfert, M. Morant, A. Hehn, D. Meyer et al., Is a 3???-Hydroxylase of Phenolic Esters, a Missing Link in the Phenylpropanoid Pathway, Journal of Biological Chemistry, vol.1526, issue.39, pp.36566-36574, 2001.
DOI : 10.1016/S0031-9422(00)91451-1

URL : https://hal.archives-ouvertes.fr/hal-01738074

G. A. Schoch, J. K. Yano, M. R. Wester, K. J. Griffin, C. D. Stout et al., Structure of human microsomal cytochrome P450 2C8 Evidence for a peripheral fatty acid binding site, J. Biol, 2004.

S. A. Shoodeoed, G. M. Heegoue, C. C. Pesos, S. Caffieei, and F. Aua, Photobinding of 8-ethopsoralee, , ?-trimethylangelicin and chlorpromazine to Wistar rat epidermal biomacromolecules in vivo, J. Photochem. Photobiol. B, vol.10, pp.257-268, 1991.

C. R. Schopfer and J. Ebel, Identification of elicitor-induced cytochrome P450s of soybean ( Glycine max L.) using differential display of mRNA, Molecular and General Genetics MGG, vol.258, issue.4, pp.315-322, 1998.
DOI : 10.1007/s004380050736

J. Schröder, H. Schröder, S. J. Puglisi, R. Sinha, and B. Schmidt, SHREC: a short-read error correction method, Bioinformatics, vol.18, issue.5, pp.2157-2163, 2009.
DOI : 10.1101/gr.074492.107

M. A. Schuler, The Role of Cytochrome P450 Monooxygenases in Plant-Insect Interactions, Plant Physiology, vol.112, issue.4, 1411.
DOI : 10.1104/pp.112.4.1411

M. A. Schuler, P450s in plant???insect interactions, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1814, issue.1, pp.36-45, 2011.
DOI : 10.1016/j.bbapap.2010.09.012

C. Seitz, S. Ameres, and G. Forkmann, Identification of the molecular basis for the functional difference between flavonoid 3???-hydroxylase and flavonoid 3???,5???-hydroxylase, FEBS Letters, vol.391, issue.18, pp.3429-3434, 2007.
DOI : 10.1002/0470867302.ch14

J. D. Selengut, D. H. Haft, T. Davidsen, A. Ganapathy, M. Gwinn-giglio et al., TIGRFAMs and Genome Properties: tools for the assignment of molecular function and biological process in prokaryotic genomes, Nucleic Acids Research, vol.35, issue.Database, pp.260-264, 2007.
DOI : 10.1093/nar/gkl1043

J. J. Serrano-pérez, M. Merchan, and L. Serrano-andres, Photoreactivity of Furocoumarins and DNA in PUVA Therapy: Formation of Psoralen???Thymine Adducts, The Journal of Physical Chemistry B, vol.112, issue.44, pp.14002-14010, 2008.
DOI : 10.1021/jp805523d

D. G. Shilling, J. A. Dusky, M. A. Mossier, and T. A. Bewick, Allelopathic potential of celery residues on lettuce, J. Am. Soc. Hortic. Sci, vol.117, pp.308-312, 1992.

Y. Shimada, S. Fujioka, N. Miyauchi, M. Kushiro, S. Takatsuto et al., Brassinosteroid-6-Oxidases from Arabidopsis and Tomato Catalyze Multiple C-6 Oxidations in Brassinosteroid Biosynthesis, PLANT PHYSIOLOGY, vol.126, issue.2, pp.770-779, 2001.
DOI : 10.1104/pp.126.2.770

K. Shimura, A. Okada, K. Okada, Y. Jikumaru, K. Ko et al., Identification of a Biosynthetic Gene Cluster in Rice for Momilactones, Journal of Biological Chemistry, vol.282, issue.47, pp.34013-34018, 2007.
DOI : 10.1074/jbc.M703344200

O. Sibbesen, B. Koch, B. A. Halkier, and B. L. Møller, (L.) Moench, Journal of Biological Chemistry, vol.267, issue.8, pp.3506-3511, 1995.
DOI : 10.1016/0003-9861(89)90514-6

M. Sidwa-gorycka, A. Krolicka, A. Orlita, E. Malinski, M. Golebiowski et al., Genetic transformation of Ruta??graveolens L. by Agrobacterium??rhizogenes: hairy root cultures a promising approach for production of coumarins and furanocoumarins, Plant Cell, Tissue and Organ Culture (PCTOC), vol.44, issue.3, pp.59-69, 2009.
DOI : 10.1007/BF00234375

S. Sigurdsson, H. M. Ogmundsdottir, and S. Gudbjarnason, Abstract, Zeitschrift f??r Naturforschung C, vol.59, issue.7-8, pp.523-527, 2004.
DOI : 10.1515/znc-2004-7-813

C. Sinkel, M. C. Schwarzer, G. Frenking, A. Greiner, and S. Agarwal, Polymer-bound 4-methylcoumarin/1-heptanoyl-5-fluorouracil photodimers: NMR elucidation of dimer structure, Magnetic Resonance in Chemistry, vol.33, issue.17, pp.70-75, 2011.
DOI : 10.1103/PhysRevB.33.8822

K. Sjölander, Phylogenomic inference of protein molecular function: advances and challenges, Bioinformatics, vol.20, issue.2, pp.170-179, 2004.
DOI : 10.1093/bioinformatics/bth021

I. A. Sparkes, J. Runions, A. Kearns, and C. Hawes, Rapid, transient expression of fluorescent fusion proteins in tobacco plants and generation of stably transformed plants, Nature Protocols, vol.15, issue.4, pp.2019-2025, 2006.
DOI : 10.1038/nprot.2006.286

R. Staden, K. F. Beal, and J. K. Bonfield, The staden package, Bioinformatics Methods and Protocols, pp.115-130, 1998.

S. B. Stanfill, C. R. Brown, X. Yan, . Jane, C. H. Watson et al., Quantification of Flavor-Related Compounds in the Unburned Contents of Bidi and Clove Cigarettes, Journal of Agricultural and Food Chemistry, vol.54, issue.22, pp.8580-8588, 2006.
DOI : 10.1021/jf060733o

S. Jr, R. R. Sims, J. J. Midland, S. L. Mcdonald, and R. E. , Isolation of a phytoalexin, transp-coumaryl aldehyde, from Cucurbita maxima, Cucurbitaceae, Phytochemistry, vol.52, pp.41-43, 1999.

E. E. Stasheko, R. Aosta, and J. R. Ad-matíez, High-resolution gas-chromatographic analysis of the secondary metabolites obtained by subcritical-fluid extraction from Colombian rue (Ruta graveolens L.), Journal of Biochemical and Biophysical Methods, vol.43, issue.1-3, pp.379-390, 2000.
DOI : 10.1016/S0165-022X(00)00079-8

W. Steck and S. A. Brown, Biosynthesis of angular furanocoumarins, Canadian Journal of Biochemistry, vol.48, issue.8, pp.872-880, 1970.
DOI : 10.1139/o70-137

R. S. Stern, K. T. Nichols, and L. H. Väkevä, Malignant Melanoma in Patients Treated for Psoriasis with Methoxsalen (Psoralen) and Ultraviolet A Radiation (PUVA), New England Journal of Medicine, vol.336, issue.15, pp.1041-1045, 1997.
DOI : 10.1056/NEJM199704103361501

J. Sturm and J. G. Sturm, Deutschlands Flora in Abbildungen, 1796.

M. Sumiyoshi, M. Sakanaka, M. Taniguchi, K. Baba, and Y. Kimura, Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation, Journal of Natural Medicines, vol.5, issue.1, pp.83-94, 2014.
DOI : 10.1091/mbc.5.9.989

A. Szopa, H. Ekiert, A. Szewczyk, and E. Fugas, Production of bioactive phenolic acids and furanocoumarins in in vitro cultures of Ruta graveolens L. and Ruta graveolens ssp. divaricata (Tenore) Gams. under different light conditions, Plant Cell, Tissue and Organ Culture (PCTOC), vol.102, issue.3, pp.329-336, 2012.
DOI : 10.1007/s11240-010-9710-z

G. Taguchi, S. Fujikawa, T. Yazawa, R. Kodaira, N. Hayashida et al., Scopoletin uptake from culture medium and accumulation in the vacuoles after conversion to scopolin in 2,4-D-treated tobacco cells, Plant Science, vol.151, issue.2, pp.153-161, 2000.
DOI : 10.1016/S0168-9452(99)00212-5

B. Tal and D. J. And-robeson, The induction, by fungal inoculation, of ayapin and scopoletin biosynthesis in Helianthus annuus, Phytochemistry, vol.25, issue.1, pp.77-79, 1985.
DOI : 10.1016/S0031-9422(00)94505-9

B. Tal and D. J. And-robeson, The Metabolism of Sunflower Phytoalexins Ayapin and Scopoletin: Plant-Fungus Interactions, PLANT PHYSIOLOGY, vol.82, issue.1, pp.167-172, 1986.
DOI : 10.1104/pp.82.1.167

W. Tassaneeyakul, L. Guo, K. Fukuda, T. Ohta, Y. et al., Inhibition Selectivity of Grapefruit Juice Components on Human Cytochromes P450, Archives of Biochemistry and Biophysics, vol.378, issue.2, pp.356-363, 2000.
DOI : 10.1006/abbi.2000.1835

L. P. Taylor and E. Grotewold, Flavonoids as developmental regulators, Current Opinion in Plant Biology, vol.8, issue.3, pp.317-323, 2005.
DOI : 10.1016/j.pbi.2005.03.005

O. W. Thomé, Flora von Deutschland. Österr. Schweiz Wort Bild Für Sch, 1885.

H. J. Thompson, S. K. Sharma, and S. A. Brown, O-methyltransferases of furanocoumarin biosynthesis, Archives of Biochemistry and Biophysics, vol.188, issue.2, pp.272-281, 1978.
DOI : 10.1016/S0003-9861(78)80009-5

W. Tian and J. Skolnick, How Well is Enzyme Function Conserved as a Function of Pairwise Sequence Identity?, Journal of Molecular Biology, vol.333, issue.4, pp.863-882, 2003.
DOI : 10.1016/j.jmb.2003.08.057

K. G. Tietjen, D. Hunkler, and U. Matern, Differential Response of Cultured Parsley Cells to Elicitors from Two Non-pathogenic Strains of Fungi. 1. Identification of Induced Products as Coumarin Derivatives, European Journal of Biochemistry, vol.67, issue.2, pp.401-407, 1983.
DOI : 10.1271/bbb1961.34.395

R. Adam, M. Dobias, P. A. Eisner, and . K. Ventura, Extraction of antioxidants from plants using ultrasonic methods and the ir antioxidant capacity, 20091.

T. Akashi, T. Aoki, and S. Ayabe, 1199811dentification of a cytochrome P450 eDNA encoding (25)-flavanone 2-hydroxylase of licorice IGiycyrrhi za echinata L ; Fabaceae} which represents licodione synthase and flavone synthase Il, FEBS Lett, vol.431121, pp.287-290

D. Anzelotti and I. R. , 120041 Molecular characterization and functional expression of flavonol 6-hydroxylase, BMC Plant Biol, vol.4, issue.20

R. C. Beier and E. H. Oertli, Psoralen and other linear furocoumarins as phytoalexins in celery, Phytochemistry, vol.22, issue.11, pp.22-2595, 1983.
DOI : 10.1016/0031-9422(83)80173-3

F. Bourgaud, A. Hehn, . R. Larbat, S. Doerper, E. Gontier et al., Biosynthesis ofcoumarins in plants: a major pathway still ta be unravelled for cytochrome P450 enzymes, Phytochem. Rev, vol.5, pp.2-31, 2006.

M. Bredebach, U. Matern, and S. Martens, 12011) Three 2-oxoglutarate- dependentdioxygenase activities of Equisetum arvense L forming flavone and flavonol from (25)-naringenin, Phytochemistry, pp.72-79

S. A. Brown, Biosynthesis of Coumarin and Herniarin in Lavender, Science, vol.137, issue.3534, pp.977-978
DOI : 10.1126/science.137.3534.977

S. A. Brown, G. H. Towers, and D. Wright, BIOSYNTHESIS OF THE COUMARINS. TRACER STUDIES ON COUMARIN FORMATION IN HIEROCHLO?? ODORATA AND MELILOTUS OFFICINALIS, Canadian Journal of Biochemistry and Physiology, vol.74, issue.1, pp.143-156, 1960.
DOI : 10.1021/ja01129a060

J. Chong, R. Baltz, C. Schmitt, R. Bef-!-a, B. Fritig et al., 12002) Downregulation of a pathogen-responsive tobacco UDP-Gic: phenylpropanoid glucosyltransferase reduces scopoletin glucoside accumulation, enhances oxidative stress, and weakens virus resistance, pp.1415-1093

L. Costet, B. Fritig, and S. Kauffmann, Scopoletin expression in elicitor-treated and tobacco mosaic virus-infected tobacco plants, Physiologia Plantarum, vol.10, issue.2, pp.228-235, 2002.
DOI : 10.1146/annurev.arplant.49.1.585

G. Vialart, A. Hehn, A. Olry, K. Ito, C. Krieger et al., A 2-oxoglutarate-dependent dioxygenase from Ruta graveolens L. exhibits p-coumaroyl CoA 2???-hydroxylase activity (C2???H): a missing step in the synthesis of umbelliferone in plants, Via, pp.460-470, 2012.
DOI : 10.1007/BF00992529

URL : https://hal.archives-ouvertes.fr/hal-01738253

F. Daii-'acqua, D. Vedaldl, and M. Recher, The photoreaction between furocoumarins and various DNA with different base compositions, Photochem. Photobiol, vol.27, pp.3-36

U. Eilert, Elicitor induction ofsecondary metabolism in dedifferentiated in vitro system of Ruta graveo/ens. ln Primary and Secondary Metabolism of Plant Cel, pp.219-228

B. E. Ellis and N. Amrhein, The 'NIH-Shift' during aromatic ortho-hydroxylation in higher plants, Phytochemistry, vol.10, issue.12, pp.3069-3072
DOI : 10.1016/S0031-9422(00)97354-0

A. Endler, S. Martens, F. Wellmann, and U. Matern, 120081 Unusually divergent 4-coumarate: CoA-ligases from Ruta graveo/ens L, Plant Mol. Biol, vol.6714, pp.335-346

J. Fliegmann, K. Furtwangler, G. Malterer, C. Cantarello, G. Schuler et al., 120101 Flavone synthase IIICYP93B161 from soybean !Glycine max l, Phytochemistry, pp.711-50

M. Frey, K. Huber, W. J. Park, . Sicker, P. Undberg et al., 12003) A2-oxoglutarate-dependent dioxygenase is integrated in DIMBOA-biosynthesis, Phytochemistry, pp.62131-371

B. Gestetner and E. Conn, The 2-hydroxylation of trans-cinnamic acid by chloroplasts from Melilotus alba desr, Archives of Biochemistry and Biophysics, vol.163, issue.2, pp.617-624
DOI : 10.1016/0003-9861(74)90522-0

M. Gutierrez, A. Parry, M. Tena, J. Jorrin, and R. Edwards, 119951 Abiotic elicitation of coumarin phytoalexins in sunflower, Phytochemistry, pp.3815-1185

J. M. Hagel and P. J. Facchini, 12010) Dioxygenases catalyse the O.demethylation steps of morphine biosynthesis in opium poppy, Nat. Chem. Biol, vol.6, issue.41, pp.27-275

O. Hamerski and U. Matern, Elicitor-induced biosynthesis of psoralens in Ammi majus L. suspension cultures. Microsomal conversion of demethylsuberosin into ltlmarmesin and psoralen, Eur. J. Biochem, pp.17111-17113, 19881.

J. Haseloff, K. R. Siemering, D. C. Prasher, and S. Hodge, l19971 Removal of a cryptic intron and subcellular localization of green fluorescent protein are required to mark transgenic Arabidopsis plants brightly, Proc. Natl Acad

K. Kai, B. !. Shimizu, M. Mizutani, K. Watanabe, and K. Sakata, Accumulation of coumarins in Arabidopsis thaliana, Phytochemistry, vol.67, issue.4, pp.379-386
DOI : 10.1016/j.phytochem.2005.11.006

K. Kai, M. Mizutani, N. Kawamura, R. Yamamoto, M. Tamai et al., 120081 Scopoletin is biosynthesized via ortho-hydroxylation of feruloyl CoA by a 2-oxoglutarate-dependent dioxygenase in Arabidopsis thaliana, Plant J, vol.5516, pp.989-999

J. Kùc, l1982) Phytoalexins from the Solanaceae, pp.81-105

. R. Larbat, S. Kellner, S. Specker, A. Hehn, E. Gontier et al., 12007) Molecular cloning and functional characterization of psoralen synthase, the firstcommitted monooxygenase offuranocoumarin biosynthesis, J. Biol. Chem, pp.28211-542

D. Lee, Two divergent members of a tobacco 4-coumarate: Coenzyme A ligase I4CL) gene family, Plant Physiol, vol.112205, 11996.

R. Lukacin, F. Wellmanna, L. Britsch, S. Martens, and U. Matern, 12003) Flavonol synthase from Citrus unshiu is a bifunctional dioxygenase, Phytochemistry, pp.6213-287

S. Martens, G. Forkmann, U. Matem, and R. Lukacin, 120011 Cloning of parsley flavone synthase 1, Phytochemistry, pp.58111-58115

J. Matsuda, S. Okabe, T. Hashimoto, and Y. Vamada, 11991) Molecular cloning of hyoscyamine 6~·hydroxylase, a 2-oxoglutarate-dependent dioxygenase, from cultured roots of Hyoscyamus niger, J. Biol. Chem, pp.266115-9460

S. Milesi, B. Massot, E. Gontier, F. Bourgaud, and A. Guckert, 120011 Ruta graveolens L.: a promising species for the production of furocoumarins, pp.189-199

M. Paszkiewicz, A. Orlita, A. Dziabas, M. Golebiowski, E. Lojkowska et al., Simplex Optimized LC Analysis of Plant Coumarins and Furanocoumarins, Chromatographia, vol.20, issue.1, pp.120081-67
DOI : 10.1515/znc-2004-7-817

. 1. Puhl, F. Stadler, and D. Treutter, 120081 Alterations of flavonoid biosyn· thesis in young grapevine 1 Vitis vinifera LI leaves, flowers, and berri es induced by the dioxygenase inhibitor prohexadione-Ca, J. Agric. Food. Chem, vol.5617, pp.2498-2504

M. A. Schuler and M. R. Berenbaum, I2003) Diversification of furanocoumarin· metabolizing cytochrome P450 monooxygenases in two papilionids: specificity and substrate encounter rate, Proc. Natl Acad. Sei. USA. 1001 Suppl, pp.14593-14598

W. Schwab, 12003) Metabolome diversity: too few genes, toc many metabolites?, Phytochemistry, vol.6216, pp.837-849

W. Steck, B. K. Bailey, J. P. Shyluk, and O. L. Gamborg, 119711 Coumarins and alkaloids from cell cultures of Ruta graveolens, Phytochemistry, pp.10111-191

F. Vazquez-fiota, E. De-carolis, A. M. Alarco, D. Luca, and V. , 11997) Molecular cloning and characterization of desacetoxyvindoline·4·hydroxylase, a 2-oxoglutarate dependent·dioxygenase involved in the biosynthesis of vindoline in Catharanthus roseus IL) G. Don, Plant Mol. Biol, vol.34161, pp.935-948

0. Voinnet, S. Rivas, P. Mestre, and D. Baulcombe, Retracted: An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus, The Plant Journal, vol.240, issue.5, pp.51-949, 2003.
DOI : 10.1016/S0092-8674(00)81749-3

A. M. Zobel and S. A. Brown, 11993) Influence of low-intensity ultraviolet radiation on extrusion of furanocoumarins to the leal surface, J. Chem

A. M. Zobel, A. Zalewski, K. W. Renke, and K. Growniak, 119981 Influence of UV-radiation on xanthotoxin and bergapten contents in Ruta graveolens L. and Angelica arachangelica l . seedlings, 18J..189

J. M. Bushakra, C. Krieger, D. Deng, M. J. Stephens, A. C. Allan et al., QTL involved in the modification of cyanidin compounds in black and red raspberry fruit, Theoretical and Applied Genetics, pp.847-865, 2013.
DOI : 10.1093/jhered/93.1.77

D. Chagné, C. Krieger, M. Rassam, M. Sullivan, J. Fraser et al., QTL and candidate gene mapping for polyphenolic composition in apple fruit, BMC Plant Biology, vol.12, issue.1, p.12, 2012.
DOI : 10.1016/j.ygeno.2008.07.008

G. Vialart, A. Hehn, A. Olry, K. Ito, C. Krieger et al., A 2-oxoglutarate-dependent dioxygenase from Ruta graveolens L. exhibits p-coumaroyle CoA 2'-hydroxylase activity (C2'H): a missing step in the synthesis of umbelliferone in plants, The plant Journal, vol.70, issue.3, p.460470, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01738253

C. Krieger, A. Hehn, A. Olry, B. Dueholm, C. Weitzel et al., Identification de gènes codants pour des cytochromes P450 à partir de trois banques d'ADNc de plantes produisant des furanocoumarines et caractérisation fonctionnelle de la sous-famille CYP71AZ chez Pastinaca sativa. Séminaire de recherche inter-unités labellisé par le labex Arbre de l

C. Krieger, A. Hehn, A. Olry, B. Menin, H. T. Simonsen et al., Identification des chaînons moléculaires manquants dans la voie de biosynthèse des furocoumarines chez le panais (Pastinaca sativa) Ecole doctorale RP2E, 2012.