E. Adams and A. Luoma, The Adaptable Major Histocompatibility Complex (MHC) Fold: Structure and Function of Nonclassical and MHC Class I???Like Molecules, Annual Review of Immunology, vol.31, issue.1, pp.529-561, 2013.
DOI : 10.1146/annurev-immunol-032712-095912

A. Alfirevic and M. Pirmohamed, Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future, Pharmacogenomics, vol.11, issue.4, pp.497-499, 2010.
DOI : 10.1111/j.1365-2133.2006.07284.x

S. Almal and H. Padh, Implications of gene copy-number variation in health and diseases, Journal of Human Genetics, vol.437, issue.1, pp.6-13, 2012.
DOI : 10.1073/pnas.0602318103

U. Amstutz, C. Ross, L. Castro-pastrana, M. Rieder, N. Shear et al., HLA-A*31:01 and HLA-B*15:02 as Genetic Markers for Carbamazepine Hypersensitivity in Children, Clinical Pharmacology & Therapeutics, vol.10, issue.1, pp.142-149, 2013.
DOI : 10.1111/j.1399-0039.1997.tb02857.x

A. Apter, H. Schelleman, A. Walker, K. Addya, and T. Rebbeck, Clinical and genetic risk factors of self-reported penicillin allergy, Journal of Allergy and Clinical Immunology, vol.122, issue.1, pp.152-158, 2008.
DOI : 10.1016/j.jaci.2008.03.037

L. Arlettaz, J. Villard, C. De-rham, S. Degermann, B. Chapuis et al., Activating CD94:NKG2C and inhibitory CD94:NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR ?? lymphocytes, European Journal of Immunology, vol.101, issue.12, pp.3456-3464, 2004.
DOI : 10.1615/CritRevImmunol.v20.i6.30

M. Arlt, T. Wilson, and T. Glover, Replication stress and mechanisms of CNV formation, Current Opinion in Genetics & Development, vol.22, issue.3, pp.204-210, 2012.
DOI : 10.1016/j.gde.2012.01.009

K. Bansal and K. Balaji, Intracellular Pathogen Sensor NOD2 Programs Macrophages to Trigger Notch1 Activation, Journal of Biological Chemistry, vol.176, issue.7, pp.5823-5835, 2011.
DOI : 10.1016/j.molimm.2009.06.019

A. Barbaud, S. Reichert-penetrat, P. Tréchot, M. Jacquin-petit, A. Ehlinger et al., The use of skin testing in the investigation of cutaneous adverse drug reactions, British Journal of Dermatology, vol.13, issue.1, pp.49-58, 1998.
DOI : 10.1111/j.1600-0536.1992.tb00132.x

A. Barbaud, Skin Testing in Delayed Reactions to Drugs, Immunology and Allergy Clinics of North America, vol.29, issue.3, pp.517-535, 2009.
DOI : 10.1016/j.iac.2009.04.010

A. Barbaud, E. Collet, B. Milpied, H. Assier, and D. Staumont, A multicentre study to determine the value and safety of drug patch tests for the three main classes of severe cutaneous adverse drug reactions, British Journal of Dermatology, vol.33, issue.3, pp.555-562, 2013.
DOI : 10.1111/j.1600-0536.1995.tb02099.x

S. Billmann-born, A. Till, A. Arlt, S. Lipinski, C. Sina et al., Genome-Wide Expression Profiling Identifies an Impairment of Negative Feedback Signals in the Crohn???s Disease-Associated NOD2 Variant L1007fsinsC, The Journal of Immunology, vol.186, issue.7, pp.4027-4038, 2011.
DOI : 10.4049/jimmunol.1000085

D. Blais, R. Lyn, M. Joyce, Y. Rouleau, R. Steenbergen et al., Activity-based Protein Profiling Identifies a Host Enzyme, Carboxylesterase 1, Which Is Differentially Active during Hepatitis C Virus Replication, Journal of Biological Chemistry, vol.83, issue.33, pp.25602-25612, 2010.
DOI : 10.1096/fj.02-0728fje

S. Bouvresse, L. Valeyrie-allanore, N. Ortonne, M. Konstantinou, S. Kardaun et al., Toxic epidermal necrolysis, DRESS, AGEP: Do overlap cases exist?, Orphanet Journal of Rare Diseases, vol.7, issue.1, p.72, 2012.
DOI : 10.1097/01.fpc.0000199500.46842.4a

M. Britschgi, U. Steiner, S. Schmid, J. Depta, G. Senti et al., T-cell involvement in drug-induced acute generalized exanthematous pustulosis, Journal of Clinical Investigation, vol.107, issue.11, pp.1433-1474, 2001.
DOI : 10.1172/JCI12118

K. Brockow, A. Romano, M. Blanca, J. Ring, W. Pichler et al., General considerations for skin test procedures in the diagnosis of drug hypersensitivity, Allergy, vol.57, pp.45-51, 2002.

L. Calligaris, G. Stocco, S. De-ludicibus, S. Marino, G. Decorti et al., Carbamazepine Hypersensitivity Syndrome Triggered by a Human Herpes Virus Reactivation in a Genetically Predisposed Patient, International Archives of Allergy and Immunology, vol.149, issue.2, pp.173-177, 2009.
DOI : 10.1159/000189202

X. Camous, S. Calbo, D. Picard, and P. Musette, Drug Reaction with Eosinophilia and Systemic Symptoms: an update on pathogenesis, Current Opinion in Immunology, vol.24, issue.6, pp.730-735, 2012.
DOI : 10.1016/j.coi.2012.07.010

S. Cantsilieris and S. White, Correlating Multiallelic Copy Number Polymorphisms with Disease Susceptibility, Human Mutation, vol.25, issue.1, pp.1-13, 2013.
DOI : 10.1093/bioinformatics/btp394

L. Carneiro, J. Magalhaes, I. Tattoli, D. Philpott, and L. Travassos, Nod-like proteins in inflammation and disease, The Journal of Pathology, vol.80, issue.10, pp.136-148, 2008.
DOI : 10.4049/jimmunol.178.12.8022

S. Chantarangsu, T. Mushiroda, S. Mahasirimongkol, S. Kiertiburanakul, S. Sungkanuparph et al., HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients, Pharmacogenetics and Genomics, vol.19, issue.2, pp.139-146, 2009.
DOI : 10.1097/FPC.0b013e32831d0faf

J. Cheong, S. Cho, H. Il, S. Yoon, J. Lee et al., Association between chronic hepatitis B virus infection and interleukin-10, tumor necrosis factor-alpha gene promoter polymorphisms, Journal of Gastroenterology and Hepatology, vol.266, issue.7, pp.1163-1169, 2006.
DOI : 10.1073/pnas.94.26.14620

D. Chessman, L. Kostenko, T. Lethborg, A. Purcell, N. Williamson et al., Human Leukocyte Antigen Class I-Restricted Activation of CD8+ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity, Immunity, vol.28, issue.6, pp.822-832, 2008.
DOI : 10.1016/j.immuni.2008.04.020

W. Chung, S. Hung, H. Hong, M. Hsih, L. Yang et al., Medical genetics: A marker for Stevens???Johnson syndrome, Nature, vol.428, issue.6982, p.486, 2004.
DOI : 10.1038/428486a

J. Cornejo-garcia, R. Gueant-rodriguez, M. Torres, N. Blanca-lopez, D. Tramoy et al., Biological and genetic determinants of atopy are predictors of immediate-type allergy to betalactams, in Spain, Allergy, vol.27, issue.Suppl 58, pp.1181-1185, 2012.
DOI : 10.1111/j.1365-2222.1997.tb00671.x

R. Correa, S. Milutinovic, and J. Reed, Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases, Bioscience Reports, vol.181, issue.6, pp.597-608, 2012.
DOI : 10.1371/journal.pone.0017414

D. Daley, M. Lemire, L. Akhabir, M. Chan-yeung, J. He et al., Analyses of associations with asthma in four asthma population samples from Canada and Australia, Human Genetics, vol.4, issue.4, pp.445-459, 2009.
DOI : 10.1016/j.mrfmmm.2004.07.022

P. Demoly, M. Viola, E. Gomes, and A. Romano, Epidemiology and Causes of Drug Hypersensitivity
DOI : 10.1159/000104184

P. Demoly, D. Hillaire-buys, N. Raison-peyron, P. Godard, F. Michel et al., Identifier et comprendre les allergies m??dicamenteuses, m??decine/sciences, vol.19, issue.3, pp.327-336, 2003.
DOI : 10.1051/medsci/2003193327

URL : http://www.medecinesciences.org/articles/medsci/pdf/2003/03/medsci2003193p327.pdf

V. Descamps, A. Valance, C. Edlinger, A. Fillet, M. Grossin et al., Association of Human herpesvirus 6 infection with drug reaction with eosinophilia and systemic symptoms, Arch Dermatol, vol.137, pp.301-304, 2001.

V. Descamps, E. Mahé, N. Houhou, L. Abramowitz, F. Rozenberg et al., Drug-induced hypersensitivity syndrome associated with Epstein-Barr virus infection, British Journal of Dermatology, vol.285, issue.5, pp.1032-1034, 2003.
DOI : 10.1001/jama.285.9.1153

V. Descamps, B. Saïd, B. Sassolas, B. Truchetet, F. Avenel-audran et al., Prise en charge du drug reaction with eosinophilia and systemic symptoms (DRESS), Annales de Dermatologie et de V??n??r??ologie, vol.137, issue.11, pp.703-708, 2010.
DOI : 10.1016/j.annder.2010.04.024

J. Descotes and G. Choquet-kastylevsky, Gell and Coombs's classification: is it still valid?, Toxicology, vol.158, issue.1-2, pp.43-49, 2001.
DOI : 10.1016/S0300-483X(00)00400-5

C. De-jongh, S. John, D. Bruynzeel, F. Calkoen, F. Van-dijk et al., Cytokine gene polymorphisms and susceptibility to chronic irritant contact dermatitis, Contact Dermatitis, vol.58, issue.5, pp.267-277, 2008.
DOI : 10.1038/sj.jid.5700750

C. Dinarello, Immunological and Inflammatory Functions of the Interleukin-1 Family, Annual Review of Immunology, vol.27, issue.1, pp.519-550, 2009.
DOI : 10.1146/annurev.immunol.021908.132612

W. Duan, A. Mehta, J. Magalhaes, S. Ziegler, C. Dong et al., Innate signals from Nod2 block respiratory tolerance and program TH2-driven allergic inflammation, Journal of Allergy and Clinical Immunology, vol.126, issue.6, pp.1284-1293, 2010.
DOI : 10.1016/j.jaci.2010.09.021

W. Eder, W. Klimecki, L. Yu, E. Von-mutius, J. Riedler et al., Association between exposure to farming, allergies and genetic variation in CARD4/NOD1, Allergy, vol.33, issue.9, pp.1117-1124, 2006.
DOI : 10.1111/j.1365-2222.2004.01873.x

J. Fritz, L. Bourhis, L. Sellge, G. Magalhaes, J. Fsihi et al., Nod1-Mediated Innate Immune Recognition of Peptidoglycan Contributes to the Onset of Adaptive Immunity, Immunity, vol.26, issue.4, pp.445-459, 2007.
DOI : 10.1016/j.immuni.2007.03.009

N. Fujiyama, M. Miura, S. Kato, T. Sone, M. Isobe et al., Involvement of Carboxylesterase 1 and 2 in the Hydrolysis of Mycophenolate Mofetil, Drug Metabolism and Disposition, vol.38, issue.12, pp.2210-2217, 2010.
DOI : 10.1124/dmd.110.034249

T. Fukami, M. Nakajima, T. Maruichi, S. Takahashi, M. Takamiya et al., Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes, Pharmacogenetics and Genomics, vol.18, issue.10, pp.911-920, 2008.
DOI : 10.1097/FPC.0b013e32830b0c5e

T. Fukami, S. Takahashi, N. Nakagawa, T. Maruichi, M. Nakajima et al., In Vitro Evaluation of Inhibitory Effects of Antidiabetic and Antihyperlipidemic Drugs on Human Carboxylesterase Activities, Drug Metabolism and Disposition, vol.38, issue.12, pp.2174-2178, 2010.
DOI : 10.1124/dmd.110.034454

N. Gao, H. Qiao, L. Jia, X. Tian, and Y. Zhang, Relationships between specific serum IgE, IgG, IFN-?? level and IFN-??, IFNR1 polymorphisms in patients with penicillin allergy, European Journal of Clinical Pharmacology, vol.26, issue.Suppl 1, pp.971-977, 2008.
DOI : 10.1590/S0074-02762005000900024

S. Galluzzo, G. Patti, G. Dicuonzo, D. Sciascio, G. Tonini et al., Association between NOD2/CARD15 polymorphisms and coronary artery disease: a case???control study, Human Immunology, vol.72, issue.8, pp.636-640, 2011.
DOI : 10.1016/j.humimm.2011.04.005

H. Gatanaga, H. Yazaki, J. Tanuma, M. Honda, I. Genka et al., HLA-Cw8 primarily associated with hypersensitivity to nevirapine, AIDS, vol.21, issue.2, pp.264-265, 2007.
DOI : 10.1097/QAD.0b013e32801199d9

E. Génin, M. Schumacher, J. Roujeau, L. Naldi, Y. Liss et al., Genome-wide association study of Steven-Johnson syndrome and toxic epidermal necrolysis in Europe

M. Gennis, R. Vemuri, E. Burns, J. Hill, M. Miller et al., Familial occurrence of hypersensitivity to phenytoin, The American Journal of Medicine, vol.91, issue.6, pp.631-634, 1991.
DOI : 10.1016/0002-9343(91)90216-K

B. Gerber and W. Pichler, Cellular mechanisms of T cell mediated drug hypersensitivity, Current Opinion in Immunology, vol.16, issue.6, pp.732-737, 2004.
DOI : 10.1016/j.coi.2004.09.016

M. Gonçalo, I. Coutinho, V. Teixeira, A. Gameiro, M. Brites et al., is a risk factor for allopurinol induced DRESS and SJS/TEN in a Portuguese population, Br J Dermatol, vol.58, p.1, 2013.

V. Green, M. Pirrmohamed, N. Kitteringham, A. Gaedigk, D. Grant et al., Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity, Biochemical Pharmacology, vol.50, issue.9, pp.1353-1359, 1995.
DOI : 10.1016/0006-2952(95)02009-8

R. Gueant-rodriguez, A. Romano, M. Beri-derxheimer, M. Viola, F. Gaeta et al., Gene???gene interactions of IL13 and IL4RA variants in immediate allergic reactions to betalactam antibiotics, Pharmacogenetics and Genomics, vol.16, issue.10, pp.713-719, 2006.
DOI : 10.1097/01.fpc.0000230409.00276.44

R. Gueant-rodriguez, J. Gueant, M. Viola, D. Tramoy, F. Gaeta et al., Association of tumor necrosis factor-?? ???308G>A polymorphism with IgE-mediated allergy to betalactams in an Italian population, The Pharmacogenomics Journal, vol.46, issue.2, pp.162-168, 2008.
DOI : 10.1111/j.1398-9995.1991.tb04224.x

L. Guglielmi, C. Fontaine, C. Gougat, O. Avinens, J. Eliaou et al., IL-10 promoter and IL4-Ralpha gene SNPs are associated with immediate beta-lactam allergy in atopic women, Allergy, vol.80, issue.4, pp.921-927, 2006.
DOI : 10.1038/nri1589

M. Guma, C. Cabrera, I. Erkizia, M. Bofill, B. Clotet et al., Human Cytomegalovirus Infection Is Associated with Increased Proportions of NK Cells That Express the CD94/NKG2C Receptor in Aviremic HIV???1???Positive Patients, The Journal of Infectious Diseases, vol.194, issue.1, pp.38-41, 2006.
DOI : 10.1086/504719

S. Hetherington, A. Hughes, M. Mosteller, D. Shortino, K. Baker et al., Genetic variations in HLA-B region and hypersensitivity reactions to abacavir, The Lancet, vol.359, issue.9312, pp.1121-1122, 2002.
DOI : 10.1016/S0140-6736(02)08158-8

E. Holler, G. Rogler, H. Herfarth, J. Brenmoehl, P. Wild et al., Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation, Blood, vol.104, issue.3, pp.889-894, 2004.
DOI : 10.1182/blood-2003-10-3543

A. Hislop, G. Taylor, D. Sauce, and A. Rickinson, Cellular Responses to Viral Infection in Humans: Lessons from Epstein-Barr Virus, Annual Review of Immunology, vol.25, issue.1, pp.587-617, 2007.
DOI : 10.1146/annurev.immunol.25.022106.141553

C. Huang, J. Yang, H. Qiao, and L. Jia, Polymorphisms and haplotype analysis of IL-4R?? Q576R and I75V in patients with penicillin allergy, European Journal of Clinical Pharmacology, vol.60, issue.9, pp.895-902, 2009.
DOI : 10.1007/s00228-009-0659-y

C. Huang, D. Zou, J. Yang, and H. Qiao, Polymorphisms of STAT6 and specific serum IgE levels in patients with penicillin allergy, Int. Journal of Clinical Pharmacology and Therapeutics, vol.50, issue.07, pp.461-467, 2012.
DOI : 10.5414/CP201691

J. Hugot, M. Chamaillard, H. Zouali, S. Lesage, J. Cézard et al., Association of NOD2-leucine rich repeat variants with susceptibility to Crohn's disease, Nature, vol.441, pp.599-602, 2001.

S. Hung, W. Chung, L. Liou, C. Chu, M. Lin et al., HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol, Proceedings of the National Academy of Sciences, vol.63, issue.21, pp.4134-4139, 2005.
DOI : 10.1016/S0002-9440(10)64284-8

M. Hurme and M. Helminen, resistance to human cytomegalovirus infection may be influenced by genetic polymorphisms of the tumor necrosis factor-alpha and interleukin-1 receptor antagonist genes, Scand J Infect Dis, vol.30, pp.447-449, 1998.

M. Hurme, M. Haanpää, T. Nurmikko, X. Wang, M. Virta et al., IL-10 gene polymorphism and herpesvirus infections, Journal of Medical Virology, vol.24, issue.S1, pp.48-50, 2003.
DOI : 10.1111/j.1365-2370.1997.tb00001.x

P. Hysi, M. Kabesch, M. Moffatt, M. Schedel, D. Carr et al., NOD1 variation, immunoglobulin E and asthma, Human Molecular Genetics, vol.14, issue.7, pp.935-941, 2005.
DOI : 10.1086/338007

URL : https://academic.oup.com/hmg/article-pdf/14/7/935/17242188/ddi087.pdf

P. Illing, J. Vivian, N. Dudek, L. Kostenko, Z. Chen et al., Immune self-reactivity triggered by drug-modified HLA-peptide repertoire, Nature, vol.22, issue.7404, pp.554-558, 2012.
DOI : 10.1038/nbt957

S. Johansson, J. Hourihane, J. Bousquet, C. Bruijnzeel-koomen, S. Dreborg et al., A revised nomenclature for allergy: An EAACI position statement from the EAACI nomenclature task force, Allergy, vol.55, issue.206, pp.813-824, 2001.
DOI : 10.1007/978-3-662-02671-7_6

S. Johansson, T. Bieber, R. Dahl, P. Friedmann, B. Lanier et al., Revised Nomenclature for Allergy for Global Use, Allergy & Clinical Immunology International - Journal of the World Allergy Organization, vol.17, issue.01, pp.832-836, 2003.
DOI : 10.1027/0838-1925.17.1.4

L. Johnson-reagan and S. Bahna, Severe drug rashes in three siblings simultaneously, Allergy, vol.115, issue.5, pp.445-447, 2003.
DOI : 10.1001/archderm.127.6.839

R. Jones, A. Taylor, E. Tong, and J. Repa, Carboxylesterases Are Uniquely Expressed among Tissues and Regulated by Nuclear Hormone Receptors in the Mouse, Drug Metabolism and Disposition, vol.41, issue.1, pp.40-49, 2013.
DOI : 10.1124/dmd.112.048397

S. Jost and M. Atfeld, Control of Human Viral Infections by Natural Killer Cells, Annual Review of Immunology, vol.31, issue.1, pp.163-194, 2013.
DOI : 10.1146/annurev-immunol-032712-100001

M. Kabesch, W. Peters, D. Carr, W. Leupold, S. Weiland et al., Association between polymorphisms in caspase recruitment domain containing protein 15 and allergy in two German populations, Journal of Allergy and Clinical Immunology, vol.111, issue.4, pp.813-817, 2003.
DOI : 10.1067/mai.2003.1336

H. Kang, Y. Jee, Y. Kim, C. Lee, J. Jung et al., Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans, Pharmacogenetics and Genomics, vol.21, issue.5, pp.303-307, 2011.
DOI : 10.1097/FPC.0b013e32834282b8

N. Kaniwa, Y. Saito, M. Aihara, K. Matsunaga, M. Tohkin et al., HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens???Johnson syndrome and toxic epidermal necrolysis, Pharmacogenomics, vol.42, issue.11, pp.1617-1622, 2008.
DOI : 10.1086/529382

T. Kanneganti, M. Lamkanfi, and G. Nunez, Intracellular NOD-like Receptors in Host Defense and Disease, Immunity, vol.27, issue.4, pp.549-559, 2007.
DOI : 10.1016/j.immuni.2007.10.002

S. Kardaun, A. Sidoroff, L. Valeyrie-allanore, S. Halevy, B. Davidovici et al., Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?, British Journal of Dermatology, vol.156, issue.3, pp.609-611, 2007.
DOI : 10.1111/j.1365-2133.2006.07332.x

S. Kardaun, P. Sekula, L. Valeyrie-allanore, Y. Liss, C. Chu et al., Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study, British Journal of Dermatology, vol.333, issue.5, 2013.
DOI : 10.1056/NEJM199512143332404

J. Kidd, G. Cooper, W. Donahue, H. Hayden, N. Sampas et al., Mapping and sequencing of structural variation from eight human genomes, Nature, vol.94, issue.7191, pp.56-64, 2008.
DOI : 10.3748/wjg.v12.i37.6021

S. Kim, S. Lee, S. Kim, H. Park, Y. Chang et al., Antituberculosis drug-induced hypersensitivity syndrome and its association with human leukocyte antigen, Tuberculosis, vol.93, issue.2, pp.270-274, 2013.
DOI : 10.1016/j.tube.2012.10.010

C. Ku, E. Tan, and D. Cooper, From the periphery to centre stage: de novo single nucleotide variants play a key role in human genetic disease, Journal of Medical Genetics, vol.50, issue.4, pp.203-211, 2013.
DOI : 10.1136/jmedgenet-2013-101519

S. Laizure, V. Herring, Z. Hu, K. Witbrodt, and R. Parker, The Role of Human Carboxylesterases in Drug Metabolism: Have We Overlooked Their Importance?, Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, vol.30, issue.Suppl 2, pp.210-222, 2013.
DOI : 10.1124/dmd.30.6.731

L. Bourhis, L. Benko, S. Girardin, and S. , Nod1 and Nod2 in innate immunity and human inflammatory disorders, Biochemical Society Transactions, vol.35, issue.6, pp.1479-1484, 2007.
DOI : 10.1042/BST0351479

J. Lewis, R. Horenstein, K. Ryan, O. Connel, J. Gibson et al., The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response, Pharmacogenetics and Genomics, vol.23, issue.1, pp.1-8, 2013.
DOI : 10.1097/FPC.0b013e32835aa8a2

G. Lilja and M. Wickman, Allergy ? atopy ? hypersensitivity ? a matter of definition, Allergy, vol.7, issue.11, pp.1011-1012, 1998.
DOI : 10.1016/0091-6749(81)90132-9

R. Littera, C. Carcassi, A. Masala, P. Piano, P. Serra et al., HLA-dependent hypersensitivity to nevirapine in Sardinian HIV patients, AIDS, vol.20, issue.12, pp.1621-1626, 2006.
DOI : 10.1097/01.aids.0000238408.82947.09

C. Lonjou, L. Thomas, N. Borot, N. Ledger, C. De-toma et al., A marker for Stevens-Johnson syndrome ???: ethnicity matters, The Pharmacogenomics Journal, vol.102, issue.4, pp.265-268, 2006.
DOI : 10.1073/pnas.0409500102

C. Lonjou, N. Borot, P. Sekula, N. Ledger, L. Thomas et al., A European study of HLA-B in Stevens???Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs, Pharmacogenetics and Genomics, vol.18, issue.2, pp.99-107, 2008.
DOI : 10.1097/FPC.0b013e3282f3ef9c

F. Macaluso, M. Nothnagel, Q. Parwez, E. Petrasch-parwez, F. Bechara et al., Polymorphisms in NACHT-LRR (NLR) genes in atopic dermatitis, Experimental Dermatology, vol.65, issue.4, pp.692-698, 2007.
DOI : 10.1016/j.intimp.2006.02.005

S. Mallal, S. Nolan, C. Witt, G. Masel, A. Martin et al., Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir, The Lancet, vol.359, issue.9308, pp.727-732, 2002.
DOI : 10.1016/S0140-6736(02)07873-X

W. Manuyakorn, K. Siripool, W. Kamchaisatian, S. Pakakasama, A. Visudtibhan et al., Phenobarbital-induced severe cutaneous adverse drug reactions are associated with CYP2C19*2 in Thai children, Pediatric Allergy and Immunology, vol.31, issue.Suppl. 3, pp.299-303, 2013.
DOI : 10.1159/000104186

L. Mardivirin, V. Descamps, A. Lacroix, and S. Delebassée, Early effects of drugs responsible for DRESS on HHV-6 replication in vitro, Journal of Clinical Virology, vol.46, issue.3, pp.300-302, 2009.
DOI : 10.1016/j.jcv.2009.08.006

D. Mauri-hellweg, F. Bettens, D. Mauri, C. Brander, T. Hunziker et al., Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine, J Immunol, vol.155, pp.462-472, 1995.

M. Mccormack, A. Alfirevic, S. Bourgeois, J. Farrell, D. Kasperaviciute et al., HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans, New England Journal of Medicine, vol.364, issue.12, pp.1134-1143, 2011.
DOI : 10.1056/NEJMoa1013297

B. Meresse, S. Curran, C. Ciszewski, G. Orbelyan, M. Setty et al., Reprogramming of CTLs into natural killer???like cells in celiac disease, The Journal of Experimental Medicine, vol.42, issue.5, pp.1343-1455, 2006.
DOI : 10.1093/nar/gki065

URL : https://hal.archives-ouvertes.fr/hal-00166286

C. Micelli-richard, S. Lesage, M. Rybojad, A. Prieur, S. Manouvrier-hanu et al., CARD15 mutations in Blau syndrome, CARD15 mutations in Blau syndrome, pp.19-20, 2001.
DOI : 10.1016/S0022-3476(86)80411-5

L. Ming, Q. Wen, H. Qiao, and Z. Dong, ???607A/C and ???137G/C Gene Polymorphisms in Patients with Penicillin Allergy, Journal of International Medical Research, vol.162, issue.2, pp.388-398, 2011.
DOI : 10.1016/S1359-6101(00)00015-0

E. Morel, S. Escamochero, R. Cabanas, R. Diaz, A. Fiandor et al., CD94/NKG2C is a killer effector molecule in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis, Journal of Allergy and Clinical Immunology, vol.125, issue.3, pp.703-710, 2010.
DOI : 10.1016/j.jaci.2009.10.030

D. Mosser and X. Zhang, Interleukin-10: new perspectives on an old cytokine, Immunological Reviews, vol.226, issue.1, pp.205-218, 2008.
DOI : 10.1111/j.1600-065X.2008.00706.x

D. Naisbitt, S. Gordon, M. Pirmohamed, and K. Park, Immunological Principles of Adverse Drug Reactions, Drug Safety, vol.282, issue.6, pp.483-507, 2000.
DOI : 10.1111/j.1346-8138.1999.tb02082.x

M. Nelson, S. Bacanu, M. Mosteller, L. Li, C. Bowman et al., Genome-wide approaches to identify pharmacogenetic contributions to adverse drug reactions, The Pharmacogenomics Journal, vol.78, issue.1, pp.23-33, 2009.
DOI : 10.2307/2336502

C. Nemos, A. Bursztejn, and P. Jonveaux, Gestion des variations du nombre de s??quences g??nomiques (CNV) en g??n??tique humaine constitutionnelle utilisant l???hybridation g??nomique comparative en micror??seau d???ADN (HGCM), Pathologie Biologie, vol.56, issue.6, pp.354-361, 2008.
DOI : 10.1016/j.patbio.2008.03.015

M. Netea, G. Ferwerda, D. De-jong, C. Werts, I. Boneca et al., Results in Unresponsiveness Not Only to Nod2- but Also Nod1-activating Peptidoglycan Agonists, Journal of Biological Chemistry, vol.174, issue.43, pp.35859-35867, 2005.
DOI : 10.1093/hmg/ddi135

H. Niihira, T. Kakamu, Y. Fujita, S. Kaneko, and E. Morita, HLA-A31 strongly associates with carbamazepine-induced adverse drug reactions but not with carbamazepine-induced lymphocyte proliferation in a Japanese population, The Journal of Dermatology, vol.72, issue.7, pp.594-601, 2012.
DOI : 10.1111/j.1399-0039.2008.01111.x

Y. Ogura, D. Bonen, N. Inohara, D. Nicolae, F. Chen et al., A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease, Nature, vol.411, issue.6837, pp.603-606, 2001.
DOI : 10.1038/35079114

H. Onuma, M. Tohyama, A. Imagawa, T. Hanafusa, T. Kobayashi et al., High Frequency of HLA B62 in Fulminant Type 1 Diabetes with the Drug-Induced Hypersensitivity Syndrome, The Journal of Clinical Endocrinology & Metabolism, vol.97, issue.12, pp.2277-2281, 2012.
DOI : 10.1210/jc.2012-2054

T. Ozeki, T. Mushiroda, A. Yowang, A. Takahashi, M. Kubo et al., Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population, Human Molecular Genetics, vol.155, issue.5, pp.1034-1041, 2011.
DOI : 10.1093/aje/155.5.478

E. Phillips and S. Mallal, Pharmacogenetics of drug hypersensitivity, Pharmacogenomics, vol.10, issue.7, pp.973-987, 2010.
DOI : 10.1038/gene.2009.58

D. Picard, J. B. Descamps, V. , D. 'incan, M. Courville et al., Drug reaction with eosinophilia and systemic cymptoms (DRESS): a multiorgan antiviral T cell response, Sci Transl Med, vol.2, pp.46-62, 2010.

W. Pichler, Delayed Drug Hypersensitivity Reactions, Annals of Internal Medicine, vol.139, issue.8, pp.683-693, 2003.
DOI : 10.7326/0003-4819-139-8-200310210-00012

W. Pichler, Direct T-cell stimulations by drugs???bypassing the innate immune system, Toxicology, vol.209, issue.2, pp.95-100, 2005.
DOI : 10.1016/j.tox.2004.12.014

W. Pichler, D. Naisbitt, and K. Park, Immune pathomechanism of drug hypersensitivity reactions, Journal of Allergy and Clinical Immunology, vol.127, issue.3, pp.74-81, 2011.
DOI : 10.1016/j.jaci.2010.11.048

G. Pietra, C. Romagnani, P. Mazzarino, M. Falco, E. Millo et al., HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8+ cytolytic T lymphocytes, Proceedings of the National Academy of Sciences, vol.45, issue.90003, pp.10896-10901, 2003.
DOI : 10.1093/jac/45.suppl_4.29

M. Pirmohamed, Genetic factors in the predisposition to drug-induced hypersensitivity reactions, The AAPS Journal, vol.8, issue.1, pp.20-26, 2006.
DOI : 10.1208/aapsj080103

H. Poeck and J. Ruland, From virus to inflammation: Mechanisms of RIG-I-induced IL-1?? production, European Journal of Cell Biology, vol.91, issue.1, pp.59-64, 2012.
DOI : 10.1016/j.ejcb.2011.01.013

Y. Pompeu, J. Stewart, S. Mallal, E. Philipps, B. Peters et al., The structural basis of HLA-associated drug hypersensitivity syndromes, Immunological Reviews, vol.359, issue.Suppl, pp.158-166, 2012.
DOI : 10.1016/S0140-6736(02)08158-8

C. Ponvert, Y. Perrin, A. Bados-albiero, L. Bourgeois, M. Karila et al., Allergy to betalactam antibiotics in children: results of a 20-year study based on clinical history, skin and challenge tests, Pediatric Allergy and Immunology, vol.127, issue.4, pp.411-418, 2011.
DOI : 10.1016/j.jaci.2010.08.025

J. Prusakiewicz, C. Ackermann, and . Voorman, Comparison of Skin Esterase Activities from Different Species, Pharmaceutical Research, vol.18, issue.7, pp.1517-1524, 2006.
DOI : 10.1016/j.bcp.2005.09.002

H. Qiao, Y. J. Zhang, and Y. , Specific serum IgE levels and FceRIbeta genetic polymorphism in patients with penicillins allergy, Allergy, vol.273, issue.12, pp.1326-1332, 2004.
DOI : 10.4049/jimmunol.165.7.3917

H. Qiao, Y. J. Zhang, and Y. , Relationships between specific serum IgE, cytokines and polymorphisms in the IL-4, IL-4Ralpha in patients with penicillins allergy, Allergy, vol.113, issue.2, pp.1053-1059, 2005.
DOI : 10.1006/clim.2001.5082

H. Qiao, Q. Wen, N. Gao, X. Tian, and L. Jia, Association of IL-10 level and IL-10 promoter SNPs with specific antibodies in penicillin-allergic patients, European Journal of Clinical Pharmacology, vol.15, issue.11, pp.263-269, 2007.
DOI : 10.4049/jimmunol.171.4.2080

A. Rebane, M. Zimmermann, A. Aab, H. Baurecht, A. Koreck et al., Mechanisms of IFN-?????induced apoptosis of human skin keratinocytes in patients with atopic dermatitis, Journal of Allergy and Clinical Immunology, vol.129, issue.5, pp.1297-1306, 2012.
DOI : 10.1016/j.jaci.2012.02.020

R. Redon, S. Ishikawa, K. Fitch, L. Feuk, G. Perry et al., Global variation in copy number in the human genome, Nature, vol.38, issue.7118, pp.444-454, 2006.
DOI : 10.1126/science.1117196

N. Reijmerink, R. Bottema, M. Kerkhof, J. Gerritsen, F. Stelma et al., TLR-related pathway analysis: novel gene??????gene interactions in the development of asthma and atopy, Allergy, vol.25, issue.Suppl. 7, pp.199-207, 2010.
DOI : 10.4049/jimmunol.171.4.1630

A. Romano, M. Blanca, M. Torres, A. Bircher, W. Aberer et al., Diagnosis of nonimmediate reactions to beta-lactam antibiotics, Allergy, vol.2, issue.4, pp.1153-60, 2004.
DOI : 10.1001/jama.220.8.1098

A. Romano and P. Demoly, Recent advances in the diagnosis of drug allergy, Current Opinion in Allergy and Clinical Immunology, vol.7, issue.4, pp.299-303, 2007.
DOI : 10.1097/ACI.0b013e328216f4d4

A. Rozières, M. Vocanson, K. Rodet, J. Benetiere, J. Bienvenu et al., CD8+ T cells mediate skin allergy to amoxicillin in a mouse model, Allergy, vol.7, issue.8, pp.996-1003, 2010.
DOI : 10.1016/S0002-9440(10)64410-0

J. Sacco, M. Abouraya, A. Motsinger-reif, S. Yale, M. Carty et al., Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity, Pharmacogenetics and Genomics, vol.22, issue.10, pp.733-740, 2012.
DOI : 10.1097/FPC.0b013e328357a735

N. Saito, N. Yoshioka, R. Abe, H. Qiao, Y. Fujita et al., Stevens-Johnson syndrome/toxic epidermal necrolysis mouse model generated by using PBMCs and the skin of patients, Journal of Allergy and Clinical Immunology, vol.131, issue.2, pp.434-441, 2013.
DOI : 10.1016/j.jaci.2012.09.014

C. Schlapabach, A. Zawodniak, A. Irla, J. Adam, R. Hunger et al., NKp46+ cells express granulysin in multiple cutaneous adverse drug reactions, Allergy, vol.235, issue.11, pp.1469-1476, 2011.
DOI : 10.1111/j.0105-2896.2010.00906.x

A. Schnuch, G. Westphal, R. Mössner, W. Uter, and K. Reich, Genetic factors in contact allergyreview and future goals, Contact Dermatitis, vol.6, pp.2-23, 2011.

B. Schnyder and W. Pichler, Mechanisms of Drug-Induced Allergy, Mayo Clinic Proceedings, vol.84, issue.3, pp.268-272, 2009.
DOI : 10.4065/84.3.268

Y. Sergerie, S. Rivest, and G. Boivin, Tumor Necrosis Factor????? and Interleukin???1?? Play a Critical Role in the Resistance against Lethal Herpes Simplex Virus Encephalitis, The Journal of Infectious Diseases, vol.196, issue.6, pp.853-860, 2007.
DOI : 10.1086/520094

Y. Shen, P. Nicoletti, A. Floratos, M. Pirrmohamed, M. Molokhia et al., Genome-wide association study of serious blistering skin rash caused by drugs, The Pharmacogenomics Journal, vol.328, issue.2, pp.96-104, 2012.
DOI : 10.1126/science.1186802

T. Shiohara, M. Ijima, Z. Ikezawa, and K. Hashimoto, The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations, British Journal of Dermatology, vol.156, issue.5, pp.1083-1084, 2007.
DOI : 10.1016/j.jaad.2005.03.057

J. Staudinger, C. Xu, Y. Cui, and C. Klaassen, Nuclear receptor-mediated regulation of carboxylesterase expression and activity, Expert Opinion on Drug Metabolism & Toxicology, vol.41, issue.3, pp.261-271, 2010.
DOI : 10.1016/j.tem.2009.03.003

Y. Sundström, C. Nilsson, G. Lilja, K. Kärre, M. Troye-blomberg et al., The Expression of Human Natural Killer Cell Receptors in Early Life, Scandinavian Journal of Immunology, vol.107, issue.2-3, pp.335-344, 2007.
DOI : 10.1002/eji.200324141

H. Tada, S. Aiba, K. Shibata, T. Ohteki, and H. Takada, Synergistic Effect of Nod1 and Nod2 Agonists with Toll-Like Receptor Agonists on Human Dendritic Cells To Generate Interleukin-12 and T Helper Type 1 Cells, Infection and Immunity, vol.73, issue.12, pp.7967-7976, 2005.
DOI : 10.1128/IAI.73.12.7967-7976.2005

Y. Tang and A. Amon, Gene Copy-Number Alterations: A Cost-Benefit Analysis, Cell, vol.152, issue.3, pp.394-405, 2013.
DOI : 10.1016/j.cell.2012.11.043

W. Tassaneevakul, T. Jantararougtong, P. Chen, P. Lin, S. Tiamkao et al., Strong association between HLA-B*5801 and allopurinol-induced Stevens???Johnson syndrome and toxic epidermal necrolysis in a Thai population, Pharmacogenetics and Genomics, vol.19, issue.9, pp.704-709, 2009.
DOI : 10.1097/FPC.0b013e328330a3b8

Y. Teraki, H. Murota, and S. Izaki, Toxic epidermal necrolysis due to zonisamise associated with reactivation of human herpesvirus 6, Arch Dermatol, vol.144, pp.232-234, 2008.

Y. Teraki, M. Shibuya, and S. Izaki, Stevens-Johnson syndrome and toxic epidermal necrolysis due to anticonvulsants share certain clinical and laboratory features with drug-induced hypersensitivity syndrome, despite differences in cutaneous presentations, Clinical and Experimental Dermatology, vol.140, issue.7, pp.723-728, 2009.
DOI : 10.7861/clinmedicine.5-6-555

P. Thomas, R. Klinger, L. Furlong, M. Homann-apitius, and C. Friedrich, Challenges in the association of human single nucleotide polymorphism mentions with unique database identifiers, BMC Bioinformatics, vol.12, issue.Suppl 4, p.4, 2011.
DOI : 10.1161/01.STR.0000185389.59049.75

J. Tigno-aranjuez and D. Abbott, Ubiquitination and phosphorylation in the regulation of NOD2 signaling and NOD2-mediated disease, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1823, issue.11, pp.2022-2028, 2012.
DOI : 10.1016/j.bbamcr.2012.03.017

M. Torres, M. Blanca, J. Fernandez, A. Romano, A. Weck et al., Diagnosis of immediate allergic reactions to beta-lactam antibiotics, Allergy, vol.104, issue.10, pp.961-72, 2003.
DOI : 10.1542/peds.104.4.e45

L. Tsurkan, M. Hatfield, C. Edwards, J. Hyatt, and P. Potter, Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors, Chemico-Biological Interactions, vol.203, issue.1, pp.226-230, 2013.
DOI : 10.1016/j.cbi.2012.10.018

L. Verneuil, C. Leboeuf, S. Vidal, P. Ratajczak, F. Comoz et al., Endothelial Damage in All Types of T-Lymphocyte???Mediated Drug-Induced Eruptions, Archives of Dermatology, vol.147, issue.5, pp.579-584, 2011.
DOI : 10.1001/archdermatol.2011.104

R. Wadkins, J. Lyatt, K. Yoon, C. Morton, R. Lee et al., Discovery of Novel Selective Inhibitors of Human Intestinal Carboxylesterase for the Amelioration of Irinotecan-Induced Diarrhea: Synthesis, Quantitative Structure-Activity Relationship Analysis, and Biological Activity, Molecular Pharmacology, vol.65, issue.6, pp.1336-1343, 2004.
DOI : 10.1124/mol.65.6.1336

J. Waton, P. Tréchot, C. Loss-ayav, J. Schmutz, and A. Barbaud, Negative predictive value of drug skin tests in investigating cutaneous adverse drug reactions, British Journal of Dermatology, vol.49, issue.4, pp.786-794, 2009.
DOI : 10.7326/0003-4819-141-1-200407060-00010

J. Waton, C. Pouget-jasson, C. Loos-ayav, P. Trechot, A. Bursztejn et al., Drug re-challenges in cutaneous adverse drug reactions: information and effectiveness in the long-term management of patients, Allergy, vol.100, issue.7, pp.941-947, 2011.
DOI : 10.1016/S1081-1206(10)60402-4

S. Weidinger, N. Klopp, L. Rümmler, S. Wagenpfeil, H. Baurecht et al., Association of CARD15 polymorphisms with atopy-related traits in a population-based cohort of Caucasian adults, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.9, issue.7, pp.866-872, 2005.
DOI : 10.1016/S1074-7613(01)00176-5

S. Weidinger, N. Klopp, L. Rümmler, S. Wagenpfeil, N. Novak et al., Association of NOD1 polymorphisms with atopic eczema and related phenotypes, Journal of Allergy and Clinical Immunology, vol.116, issue.1, pp.177-184, 2005.
DOI : 10.1016/j.jaci.2005.02.034

G. Westphal, A. Schnuch, R. Moessner, I. Konig, B. Kranke et al., Cytokine gene polymorphisms in allergiccontact dermatitis, Contact Dermatitis, vol.109, issue.2, pp.93-98, 2003.
DOI : 10.1046/j.0022-202x.2001.01642.x

J. Wu and R. Jiang, Prediction of Deleterious Nonsynonymous Single-Nucleotide Polymorphism for Human Diseases, The Scientific World Journal, vol.22, issue.12, p.67851, 2013.
DOI : 10.1086/302448

D. Yang, R. Pearce, X. Wang, R. Gaedigk, Y. Wan et al., Human carboxylesterases HCE1 and HCE2: Ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin, Biochemical Pharmacology, vol.77, issue.2, pp.238-247, 2009.
DOI : 10.1016/j.bcp.2008.10.005

J. Yang, H. Qiao, and Z. Dong, Polymorphisms of IL???13 and IL???4???IL???13???SNPs in patients with penicillins allergy, European Journal of Clinical Pharmacology, vol.32, issue.Suppl 2, pp.803-809, 2005.
DOI : 10.1165/ajrcmb.25.3.4483

J. Yang, H. Qiao, Y. Zhang, L. Jia, X. Tian et al., HLA-DRB genotype and specific IgE responses in patients with allergies to penicillins, Chin Med J, vol.119, pp.458-466, 2006.

N. Yawalkar, F. Egli, Y. Hari, H. Nievergelt, L. Braathen et al., Infiltration of cytotoxic T cells in drug-induced cutaneous eruptions, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.102, issue.6, pp.847-55, 2000.
DOI : 10.1172/JCI3544

M. Zanni, D. Mauri-hellweg, C. Brander, T. Wendland, B. Schnyder et al., Characterization of lidocaine-specific T cells, J Immunol, vol.158, pp.1139-1148, 1997.

M. Zanni, S. Von-greyerz, B. Schnyder, T. Wendland, and W. Pichler, Allele-unrestricted presentation of lidocaine by HLA-DR molecules to specific alphabeta+ T cell clones, International Immunology, vol.10, issue.4, pp.507-515, 1998.
DOI : 10.1093/intimm/10.4.507

J. Zhu, D. Appel, Y. Iang, and J. Markowitz, Age- and Sex-Related Expression and Activity of Carboxylesterase 1 and 2 in Mouse and Human Liver, Drug Metabolism and Disposition, vol.37, issue.9, pp.1819-1825, 2009.
DOI : 10.1124/dmd.109.028209

H. Zhu, D. Appel, Y. Peterson, Z. Wang, and J. Markowitz, Identification of selected therapeutic agents as inhibitors of carboxylesterase 1: Potential sources of metabolic drug interactions, Toxicology, vol.270, issue.2-3, pp.59-65, 2010.
DOI : 10.1016/j.tox.2010.01.009

H. Zhu, X. Wang, B. Gawronski, B. Brinda, D. Angiolillo et al., Carboxylesterase 1 as a Determinant of Clopidogrel Metabolism and Activation, Journal of Pharmacology and Experimental Therapeutics, vol.344, issue.3, pp.665-672, 2013.
DOI : 10.1124/jpet.112.201640

. Liste-des, A. Bursztejn, A. Romano, R. Guéant-rodriguez, I. Gastin et al., Allergy to betalactams and nucleotide-binding oligomerization domain (NOD) gene polymorphisms

@. Barbaud, A. Waton, J. Herbeth, B. Bursztejn, A. Bollaert et al., Aimone-Gastin I. Comparison of cytokine gene polymorphism in drug-induced maculopapular eruption, urticaria and drug reaction with eosinophilia and systemic symptoms (DRESS), J Eur Acad Dermatol Venereol

@. Bursztejn, A. Guéant, R. Gastin, I. Romano, A. Barbaud et al., Etude de polymorphismes de NOD2 dans des états d'hyperréactivité cutanée, Congrès Annuel de Recherche en Dermatologie, pp.21-22

@. Bursztejn, A. Guéant, R. Gastin, I. Corneo-garcia, J. Romano et al., NOD1 and NOD2 polymorphisms in cutaneous adverse drug reactions to betalactam antibiotics, 2010.

@. Bursztejn, A. Guéant, R. Gastin, I. Corneo-garcia, J. Romano et al., Etude des polymorphismes de NOD1 et NOD2 chez des patients ayant présenté une toxidermie aux bétalactamines, p.2010