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,
, induction pendant 15 minutes avec le mélange de l"isoflurane (3,5 vol%) et l"oxygène (2L/min), après la vérification de la profondeur d"anesthésie, l"intubation oro-trachéale est ensuite réalisée. Les paramètres du respirateur sont réglés tels que suivant : fréquence respiratoire 60/min, Les rats sont pré-anesthésiés dans le cage d
, Les rats sont mis en décubitus latéral droit ; la patte supérieure gauche est attachée avec un fil vert et tirée en avant
,
, Faire une incision de 2cm au scalpel 1cm du bord gauche de sternum au niveau de 5 e espace intercostale
, Mettre un écarteur Beckman pour exposer le coeur
,
, Avant de nouer le fil, retirer doucement le drain thoracique en aspirant avec une seringue de
, Injecter l"antibiotique (Cefamandole) 10mg en intramusculaire
imagerie par TEP permet d"obtenir les valeurs segmentaires de la captation du FDG, qui s"exprime en % du voxel ayant l"activité plus forte du FDG. Le coeur est réparti en 17 segments selon la segmentation du VG préconisée par the American Heart Association. Des segments présentant une captation du FDG inférieure à 50% sont considérés chez l"homme comme étant irréversiblement nécrotique ,
nous avons différencié des segments présentant une captation télé-systolique du FDG entre 50 et 70% et leur considéré comme des zones souffrant d"ischémie mais encore viable. Le TEP permet aussi d"obtenir le paramètre de contractilité qui est calculé selon l"augmentation (%) de l"épaisseur pariétale en télé-systole par rapport à celle en télé-diastole. L"enregistrement d"images synchronisées avec l"ECG permet d"acquérir les paramètres fonctionnels du VG tels que les volumes télé-diastolique et télé-systolique ,
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