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. Also, The microparticles characterization was done by scanning electron microscopy (SEM), X-ray diffraction (PXRD), infrared spectroscopy (FTIR) and in vitro release studies were performed in a phosphate buffer The microparticles were negatively charged with mean particle size ranging from 5 to 7 µm. The formulation was stable and was resistant to acidic pH but showed rapid release in basic pH. The polymeric microparticles were acid resistant; hence, they can be used as colon specific drug delivery systems for the treatment of Crohn's disease, 2004.

. Enfin, ) par spray drying. L'Eudragit ® FS 30D, qui est gastro-résistant, a été choisi comme polymère. La caractérisation de microparticules a été réalisée par microscopie électronique à balayage (SEM), par diffraction X (PXRD), par spectroscopie infrarouge à transformée de Fourrier (FTIR) Les essais de libération in vitro ont été réalisés dans un tampon phosphate (pH 1) Les microparticules étaient chargées négativement avec une taille moyenne allant de 5 à 7 µm. La formulation était stable à pH acide mais a montré une libération rapide à pH basique