Glutathione- and non-glutathione-based oxidant control in the endoplasmic reticulum, Journal of Cell Science, vol.124, issue.6, pp.847-855, 2011. ,
DOI : 10.1242/jcs.080895
Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine, Journal of Controlled Release, vol.71, issue.3, pp.277-285, 2001. ,
DOI : 10.1016/S0168-3659(01)00227-9
pH-sensitive microparticles for oral drug delivery based on alginate/oligochitosan/Eudragit?? L100-55 ???sandwich??? polyelectrolyte complex, Colloids and Surfaces B: Biointerfaces, vol.110, pp.395-402, 2013. ,
DOI : 10.1016/j.colsurfb.2013.05.016
Development of a sustained-release system for nitric oxide delivery using alginate/chitosan nanoparticles, Current Nanoscience, vol.9, pp.1-7, 2013. ,
-Nitrosoglutathione improves haemodynamics in early-onset pre-eclampsia, British Journal of Clinical Pharmacology, vol.114, issue.3, 2014. ,
DOI : 10.1152/japplphysiol.01302.2012
New biomaterials for the sustained release of nitric oxide: past, present and future, Expert Opinion on Drug Delivery, vol.15, issue.10, pp.1113-1122, 2009. ,
DOI : 10.1021/ja0201348
NO donor and MEK inhibitor synergistically inhibit proliferation and invasion of cancer cells, Int J Oncol, vol.40, pp.807-815, 2012. ,
Topical S-nitrosoglutathione-releasing hydrogel improves healing of rat ischaemic wounds, Journal of Tissue Engineering and Regenerative Medicine, vol.38, issue.8, pp.612-619, 2011. ,
DOI : 10.1016/j.freeradbiomed.2004.12.016
Peter Griess???Discoverer of diazo compounds, Journal of Chemical Education, vol.35, issue.4, 1958. ,
DOI : 10.1021/ed035p187
Increased stability of S-nitrosothiol solutions via pH modulations, Free Radical Research, vol.41, issue.3, pp.214-225, 2012. ,
DOI : 10.1016/j.freeradbiomed.2006.06.025
Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates, J Pharmacol Exp Ther, vol.218, pp.739-749, 1981. ,
Mechanism of action and biochemical effects of nitric oxide (NO), J Prev Med, vol.10, pp.35-45, 2002. ,
Electron spin resonance spin trapping of thiyl, radicals from the decomposition of thionitrites, Tetrahedron Letters, vol.25, issue.16, pp.1685-1688, 1984. ,
DOI : 10.1016/S0040-4039(01)81144-8
Physicochemical, tissue distribution, and vasodilation characteristics of nitrosated serum albumin: delivery of nitric oxide in vivo, Journal of Pharmaceutical Sciences, vol.93, issue.9, pp.2343-2352, 2004. ,
DOI : 10.1002/jps.20147
Development of Polyethylene Glycol-Conjugated Poly-S-Nitrosated Serum Albumin, a Novel S-Nitrosothiol for Prolonged Delivery of Nitric Oxide in the Blood Circulation in Vivo, Journal of Pharmacology and Experimental Therapeutics, vol.314, issue.3, pp.1117-1124, 2005. ,
DOI : 10.1124/jpet.105.087429
S-Nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats, Journal of Neuroinflammation, vol.8, issue.1, p.78, 2011. ,
DOI : 10.1016/j.neulet.2007.05.026
Nitric oxide: moving towards the clinic, Molecular Medicine Today, vol.2, issue.8, p.324, 1996. ,
DOI : 10.1016/1357-4310(96)81795-3
The nitrate???nitrite???nitric oxide pathway in physiology and therapeutics, Nature Reviews Drug Discovery, vol.336, issue.2, pp.156-167, 2008. ,
DOI : 10.7326/0003-4819-134-12-200106190-00010
On a Test of Whether one of Two Random Variables is Stochastically Larger than the Other, The Annals of Mathematical Statistics, vol.18, issue.1, pp.50-60, 1947. ,
DOI : 10.1214/aoms/1177730491
Nitric oxide: physiology, pathophysiology, and pharmacology, Pharmacol Rev, vol.43, pp.109-142, 1991. ,
Viability and gene expression responses to polymeric nanoparticles in human and rat cells, Cell Biol Toxicol, vol.30, pp.137-146, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01274268
-Nitrosoglutathione-Loaded Nanoparticles: Uptake, Viability, and Transcriptome, Molecular Pharmaceutics, vol.12, issue.2, pp.554-561, 2015. ,
DOI : 10.1021/mp5006382
Nanocarriers for Nitric Oxide Delivery, Journal of Drug Delivery, vol.6, issue.8, 2011. ,
DOI : 10.1039/b803441a
Enteric Glia Regulate Intestinal Barrier Function and Inflammation Via Release of S-Nitrosoglutathione, Gastroenterology, vol.132, issue.4, pp.1344-1358, 2007. ,
DOI : 10.1053/j.gastro.2007.01.051
A scheme for the colorimetric determination of microgram amounts of thiols, The Analyst, vol.83, issue.993, 1958. ,
DOI : 10.1039/an9588300670
Reevaluation of the Griess Method for Determining NO/NO???2 in Aqueous and Protein-Containing Samples, Nitric Oxide, vol.3, issue.3, pp.225-234, 1999. ,
DOI : 10.1006/niox.1999.0226
Polynitrosated Polyesters:?? Preparation, Characterization, and Potential Use for Topical Nitric Oxide Release, Biomacromolecules, vol.6, issue.5, pp.2512-2520, 2005. ,
DOI : 10.1021/bm050216z
The effect of S-nitrosoglutathione and L-cysteine on chloride efflux from cystic fibrosis airway epithelial cells, Experimental and Molecular Pathology, vol.90, issue.1, 2011. ,
DOI : 10.1016/j.yexmp.2010.10.005
-nitrosoglutathione-oligosaccharide-chitosan as a nitric oxide donor, Expert Opinion on Drug Delivery, vol.9, issue.8, 2015. ,
DOI : 10.1016/j.ejpb.2008.04.008
-nitrosoglutathione kinetics and transport in human airways, Journal of Applied Physiology, vol.276, issue.3, pp.777-788, 2001. ,
DOI : 10.1152/ajpheart.1994.266.5.H2108
-Nitrosothiols, Journal of Biological Chemistry, vol.24, issue.31, pp.18596-18603, 1996. ,
DOI : 10.1093/cvr/28.5.691
The chemistry of the S-nitrosoglutathione/glutathione system, Proceedings of the National Academy of Sciences, vol.26, issue.4, pp.14428-14433, 1996. ,
DOI : 10.1002/kin.550261208
Drug Transfer across Intact Rat Intestinal Mucosa Following Surgical Removal of Serosa and Muscularis Externa, Journal of Pharmaceutical Sciences, vol.62, issue.2, pp.200-205, 1973. ,
DOI : 10.1002/jps.2600620203
Preparation and comparison of chitosan nanoparticles with different degrees of glutathione thiolation, pp.367-375, 2011. ,
In vivo evaluation of a novel pH- and time-based multiunit colonic drug delivery system, Alimentary Pharmacology and Therapeutics, vol.93, issue.3, pp.347-353, 2004. ,
DOI : 10.1046/j.1365-2036.2000.00697.x
Enteric coated HPMC capsules designed to achieve intestinal targeting, International Journal of Pharmaceutics, vol.231, issue.1, pp.83-95, 2002. ,
DOI : 10.1016/S0378-5173(01)00871-7
Spray dried microparticles for controlled delivery of mupirocin calcium: Process???tailored modulation of drug release, Journal of Microencapsulation, vol.27, issue.2, pp.108-121, 2011. ,
DOI : 10.1007/BF02980037
Coated hard capsules as the pH-dependent drug transport systems to ileo-colonic compartment, Drug Development and Industrial Pharmacy, vol.6, issue.10, pp.1131-1140, 2011. ,
DOI : 10.1016/j.ijpharm.2005.08.025
Tissue sulfhydryl groups, Archives of Biochemistry and Biophysics, vol.82, issue.1, pp.70-77, 1959. ,
DOI : 10.1016/0003-9861(59)90090-6
Production of Eudragit Microparticles by Spray-Drying Technique: Influence of Experimental Parameters on Morphological and Dimensional Characteristics, Pharmaceutical Development and Technology, vol.12, issue.2, 2000. ,
DOI : 10.1016/0378-5173(89)90079-3
Spray-drying technique to prepare innovative nanoparticulated formulations for drug administration: a brief overview, Brazilian Journal of Physics, vol.39, issue.1a, pp.205-209, 2009. ,
DOI : 10.1590/S0103-97332009000200013
Peter Griess???Discoverer of diazo compounds, Journal of Chemical Education, vol.35, issue.4, p.187, 1958. ,
DOI : 10.1021/ed035p187
Prevention of ischemia/reperfusion injury by hepatic targeting of nitric oxide in mice, Journal of Controlled Release, vol.140, issue.1, pp.12-17, 2009. ,
DOI : 10.1016/j.jconrel.2009.07.013
Development of ethylcellulose-polyethylene glycol and ethylcellulose-polyvinyl pyrrolidone blend oral microspheres of ibuprofen, Journal of Drug Delivery Science and Technology, vol.20, issue.6, pp.439-444, 2010. ,
DOI : 10.1016/S1773-2247(10)50076-5
Continuous-flow encapsulation of ketoprofen in copolymer microbeads via co-axial microfluidic device: Influence of operating and material parameters on drug carrier properties, International Journal of Pharmaceutics, vol.441, issue.1-2, pp.809-817, 2013. ,
DOI : 10.1016/j.ijpharm.2012.12.024
Microfluidic conceived pH sensitive core???shell particles for dual drug delivery, International Journal of Pharmaceutics, vol.478, issue.1, pp.78-87, 2015. ,
DOI : 10.1016/j.ijpharm.2014.10.010
Release of diltiazem from Eudragit microparticles prepared by spray-drying, International Journal of Pharmaceutics, vol.137, issue.2, pp.159-165, 1996. ,
DOI : 10.1016/0378-5173(96)04509-7
The use of Eudragit?? RS 100/cyclodextrin nanoparticles for the transmucosal administration of glutathione, European Journal of Pharmaceutics and Biopharmaceutics, vol.72, issue.3, pp.509-520, 2009. ,
DOI : 10.1016/j.ejpb.2009.02.013
Formulation Optimization and Characterization of Spray Dried Microparticles for Inhalation Delivery of Doxycycline Hyclate, YAKUGAKU ZASSHI, vol.131, issue.12, pp.1813-1825, 2011. ,
DOI : 10.1248/yakushi.131.1813
On the use of the Weibull function for the discernment of drug release mechanisms, International Journal of Pharmaceutics, vol.309, issue.1-2, pp.44-50, 2006. ,
DOI : 10.1016/j.ijpharm.2005.10.044
Effect of polymeric blend on the dissolution behavior of spray-dried microparticles, Int J Res Pharm Chem, vol.1, issue.3, pp.690-701, 2011. ,
Spray dried microparticles for controlled delivery of Fluconazole using factorial Design ,
Properties of tolmetin-loaded Eudragit RL100 and Eudragit RS 100, 1997. ,
Ultraviolet and Infrared Spectra of Some Nitrosamines, 1963. ,
Encapsulation and characterization of flurbiprofen loaded poly(??-caprolactone)???poly(vinylpyrrolidone) blend micropheres by solvent evaporation method, Journal of Sol-Gel Science and Technology, vol.21, issue.1, pp.281-289, 2009. ,
DOI : 10.1208/pt040465
Ketoprofen Spray-dried Microspheres Based on Eudragit?? RS and RL: Study of the Manufacturing Parameters, Drug Development and Industrial Pharmacy, vol.7, issue.11, pp.1178-1187, 2008. ,
DOI : 10.1016/j.ejpb.2004.03.006
Nanocarriers for Nitric Oxide Delivery, Journal of Drug Delivery, vol.6, issue.8, 2011. ,
DOI : 10.1039/b803441a
Enteric Glia Regulate Intestinal Barrier Function and Inflammation Via Release of S-Nitrosoglutathione, Gastroenterology, vol.132, issue.4, pp.1344-1358, 2007. ,
DOI : 10.1053/j.gastro.2007.01.051
A scheme for the colorimetric determination of microgram amounts of thiols, The Analyst, vol.83, issue.993, pp.670-672, 1958. ,
DOI : 10.1039/an9588300670
Synthesis and characterization of S-nitrosoglutathioneoligosaccharide-chitosan as a nitric oxide donor, Exp Opin Drug Deliv, 2015. ,
Lack of correlation between the observed stability and pharmacological properties of S-nitroso derivatives of glutathione and cysteine-related peptides11Abbreviations: NO, nitric oxide; RSNO, S-nitrosothiol; CysH, cysteine; SNOGSH, S-nitrosoglutathione; SNOCys, S-nitrosocysteine; SNOGluCys, S-nitroso-l-??-glutamyl-l-cysteine; SNOCysGly, S-nitroso-l-cysteinylglycine; SNOPROPA, S-nitroso-3-mercaptopropionic acid; SNONAC, S-nitroso-N-acetyl-l-cysteine; DTPA, diethylenetriaminpentaacetic acid; and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide., Biochemical Pharmacology, vol.62, issue.9, pp.1239-1247, 2001. ,
DOI : 10.1016/S0006-2952(01)00750-X
Pharmaceutical Particle Engineering via Spray Drying, Pharmaceutical Research, vol.21, issue.5, pp.999-1022, 2008. ,
DOI : 10.14356/kona.2005014
15N NMR and electronic properties of S-nitrosothiols, Bioorganic & Medicinal Chemistry Letters, vol.9, issue.19, pp.2897-2902, 1999. ,
DOI : 10.1016/S0960-894X(99)00499-0
Time lasting S-nitrosoglutathione polymeric nanoparticles delay cellular protein S-nitrosation, European Journal of Pharmaceutics and Biopharmaceutics, vol.89, pp.1-8, 2015. ,
DOI : 10.1016/j.ejpb.2014.11.005
URL : https://hal.archives-ouvertes.fr/hal-01281136
Synthesis and Structural Analysis of Copper (II) Glutathione Complexes via Cu-S Linkage, World Appl Sci J, vol.29, pp.1357-1362, 2014. ,
S-Nitrosothiols: a class of nitric oxide-donor drugs, Clinical Science, vol.98, issue.5, pp.507-520, 2000. ,
DOI : 10.1042/cs0980507
Sustained-release of buspirone HCl by co spray-drying with aqueous polymeric dispersions, European Journal of Pharmaceutics and Biopharmaceutics, vol.69, issue.2, pp.735-742, 2008. ,
DOI : 10.1016/j.ejpb.2008.01.002
Applicability and Approaches of (Meth) Acrylate Copolymers (Eudragits) in Novel Drug Delivery Systems, Current Drug Therapy, vol.7, issue.4, pp.219-234, 2012. ,
DOI : 10.2174/157488512804999082
Influences of process and formulation parameters on powder flow properties and immunogenicity of spray dried polymer particles entrapping recombinant pneumococcal surface protein A, International Journal of Pharmaceutics, vol.466, issue.1-2, pp.198-210, 2014. ,
DOI : 10.1016/j.ijpharm.2014.03.025
Glutathione- and non-glutathione-based oxidant control in the endoplasmic reticulum, Journal of Cell Science, vol.124, issue.6, pp.847-855, 2011. ,
DOI : 10.1242/jcs.080895
Thiolated chitosan coated poly hydroxyethyl methacrylate nanoparticles: Synthesis and characterization, Carbohydrate Polymers, vol.74, issue.1, pp.59-67, 2008. ,
DOI : 10.1016/j.carbpol.2008.01.015
Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery, Molecular BioSystems, vol.48, issue.3, pp.242-250, 2005. ,
DOI : 10.1039/b500266d
Pr??paration des microsph??res de citrulline ?? ciblage colique par la technique de spray drying, Annales Pharmaceutiques Fran??aises, vol.72, issue.2, pp.132-140, 2014. ,
DOI : 10.1016/j.pharma.2013.12.002
Stability Testing of Pharmaceutical Products, J Appl Pharm Sci, vol.2, pp.129-138, 2012. ,
Stirring time effect of silver nanoparticles prepared in glutathione mediated by green method, Chemistry Central Journal, vol.8, issue.1, p.11, 2014. ,
DOI : 10.1021/la3003838
Thiolated polymers???thiomers: synthesis and in vitro evaluation of chitosan???2-iminothiolane conjugates, International Journal of Pharmaceutics, vol.260, issue.2, pp.229-237, 2003. ,
DOI : 10.1016/S0378-5173(03)00271-0
Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine, Journal of Controlled Release, vol.71, issue.3, pp.277-285, 2001. ,
DOI : 10.1016/S0168-3659(01)00227-9
Polymers with thiol groups: a new generation of mucoadhesive polymers?, Pharmaceutical Research, vol.16, issue.6, pp.876-881, 1999. ,
DOI : 10.1023/A:1018830204170
Polycarbophil???Cysteine Conjugates as Platforms for Oral Polypeptide Delivery Systems, Journal of Pharmaceutical Sciences, vol.89, issue.7, pp.901-909, 2000. ,
DOI : 10.1002/1520-6017(200007)89:7<901::AID-JPS7>3.0.CO;2-0
The effect of the ???heart-tonics??? and other drugs upon the heart-tone and coronary circulation, The Journal of Physiology, vol.64, issue.4, pp.365-387, 1928. ,
DOI : 10.1113/jphysiol.1928.sp002447
Nitric oxide and the immune response, Nature Immunology, vol.14, issue.11, pp.907-916, 2001. ,
DOI : 10.1096/fj.14.10.1447
Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance, Journal of Controlled Release, vol.70, issue.3, pp.329-339, 2001. ,
DOI : 10.1016/S0168-3659(00)00362-X
Endogenous nitric oxide synthesis: Biological functions and pathophysiology, Free Radical Research, vol.100, issue.6, pp.577-596, 1999. ,
DOI : 10.1172/JCI119783
2015. anatomy.<http://www.britannica.com/science/anatomy/images-videos>^acess date, 2015. ,
Nitric oxide: a physiologic mediator of penile erection, Science, vol.257, issue.5068, pp.401-403, 1992. ,
DOI : 10.1126/science.1378650
Review lecture. Neurotransmitters and trophic factors in the autonomic nervous system., The Journal of Physiology, vol.313, issue.1, pp.1-35, 1981. ,
DOI : 10.1113/jphysiol.1981.sp013648
pH-sensitive microparticles for oral drug delivery based on alginate/oligochitosan/Eudragit?? L100-55 ???sandwich??? polyelectrolyte complex, Colloids and Surfaces B: Biointerfaces, vol.110, pp.395-402, 2013. ,
DOI : 10.1016/j.colsurfb.2013.05.016
Nitric oxide and cancer: a review, World Journal of Surgical Oncology, vol.11, issue.1, 2013. ,
DOI : 10.1186/1477-7819-11-118
A porous defense: the leaky epithelial barrier in intestinal disease, Laboratory Investigation, vol.97, issue.3, pp.282-291, 2004. ,
DOI : 10.1016/0016-5085(89)91689-2
Enteric coated HPMC capsules designed to achieve intestinal targeting, International Journal of Pharmaceutics, vol.231, issue.1, pp.83-95, 2002. ,
DOI : 10.1016/S0378-5173(01)00871-7
Fecal microbiota transplantation as therapy for inflammatory bowel disease: A systematic review and meta-analysis, Journal of Crohn's and Colitis, vol.48, issue.12, pp.1569-1581, 2014. ,
DOI : 10.1097/MCG.0000000000000046
The safety profile of infliximab in patients with Crohn???s disease: The Mayo Clinic experience in 500 patients, Gastroenterology, vol.126, issue.1, pp.19-31, 2004. ,
DOI : 10.1053/j.gastro.2003.10.047
Development of a sustained-release system for nitric oxide delivery using alginate/chitosan nanoparticles, Curr Nanosci, vol.9, pp.1-7, 2013. ,
Effects of S-nitrosoglutathione in the human forearm circulation: evidence for selective inhibition of platelet activation, 1994. ,
Guanylate cyclase and the ???NO/cGMP signaling pathway, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1411, issue.2-3, pp.334-350, 1999. ,
DOI : 10.1016/S0005-2728(99)00024-9
Anatomical and physiological parameters affecting gastrointestinal absorption in humans and rats, Food and Chemical Toxicology, vol.39, issue.3, pp.209-228, 2001. ,
DOI : 10.1016/S0278-6915(00)00136-8
Spray dried microparticles for controlled delivery of mupirocin calcium: Process???tailored modulation of drug release, Journal of Microencapsulation, vol.27, issue.2, pp.108-121, 2011. ,
DOI : 10.1007/BF02980037
Coated hard capsules as the pH-dependent drug transport systems to ileo-colonic compartment, Drug Development and Industrial Pharmacy, vol.6, issue.10, pp.1131-1140, 2011. ,
DOI : 10.1016/j.ijpharm.2005.08.025
Inhibition of proximal tubular fluid absorption by nitric oxide and atrial natriuretic peptide in rat kidney, American Journal of Physiology-Cell Physiology, vol.267, issue.36, pp.1075-1080, 1998. ,
DOI : 10.1113/jphysiol.1992.sp019214
PREPARATION AND CHARACTERIZATION OF CHITOSAN/AGAR BLENDS: RHEOLOGICAL AND THERMAL STUDIES, Journal of the Chilean Chemical Society, vol.55, issue.1, pp.130-136, 2010. ,
DOI : 10.4067/S0717-97072010000100031
Biopolymeric Nanoparticles for Oral Protein Delivery: Design and In Vitro Evaluation, Journal of Nanomedicine & Nanotechnology, vol.02, issue.03, pp.110-4172, 2011. ,
DOI : 10.4172/2157-7439.1000110
Tissue sulfhydryl groups, Archives of Biochemistry and Biophysics, vol.82, issue.1, pp.70-77, 1959. ,
DOI : 10.1016/0003-9861(59)90090-6
Production of Eudragit Microparticles by Spray-Drying Technique: Influence of Experimental Parameters on Morphological and Dimensional Characteristics, Pharmaceutical Development and Technology, vol.12, issue.2, pp.267-278, 2000. ,
DOI : 10.1016/0378-5173(89)90079-3
-Nitrosoglutathione improves haemodynamics in early-onset pre-eclampsia, British Journal of Clinical Pharmacology, vol.114, issue.3, pp.660-669, 2014. ,
DOI : 10.1152/japplphysiol.01302.2012
<http://eudragit.evonik.com/product/eudragit/en/products- services/eudragit-products/enteric-formulations/fs-30-d/Pages/default.aspx>^acess date, pp.28-36, 2015. ,
Long-term follow-up of patients with Crohn's disease, Gastroenterology, vol.88, issue.6, pp.1818-1825, 1985. ,
DOI : 10.1016/0016-5085(85)90006-X
Mechanisms of Disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases, Nature Clinical Practice Gastroenterology & Hepatology, vol.41, issue.9, pp.416-422, 2005. ,
DOI : 10.1007/BF02100148
Effects of Adalimumab Therapy on Incidence of Hospitalization and Surgery in Crohn's Disease: Results From the CHARM Study, Gastroenterology, vol.135, issue.5, pp.1493-1499, 2008. ,
DOI : 10.1053/j.gastro.2008.07.069
The use of nitric oxide donors in pharmacological studies, Naunyn-Schmiedeberg's Archives of Pharmacology, vol.358, issue.1, pp.113-122, 1998. ,
DOI : 10.1007/PL00005231
Long-term natural history of Crohn???s disease, World Journal of Gastroenterology, vol.15, issue.11, pp.1315-1318, 2009. ,
DOI : 10.3748/wjg.15.1315
New biomaterials for the sustained release of nitric oxide: past, present and future, Expert Opinion on Drug Delivery, vol.15, issue.10, pp.1113-1122, 2009. ,
DOI : 10.1021/ja0201348
Sustained release nitric oxide releasing nanoparticles: Characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites, Nitric Oxide, vol.19, issue.1, pp.12-20, 2008. ,
DOI : 10.1016/j.niox.2008.04.003
NO donor and MEK inhibitor synergistically inhibit proliferation and invasion of cancer cells, Int J Oncol, vol.40, pp.807-815, 2012. ,
Smart polymers: applications in biotechnology and biomedicine, 2007. ,
DOI : 10.1201/NOE0415267984
Nitric oxide inhibits sodium/hydrogen exchange activity in the thick ascending limb, American Journal of Physiology-Renal Physiology, vol.257, issue.20, pp.377-382, 1999. ,
DOI : 10.1172/JCI115653
Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways., Proceedings of the National Academy of Sciences, vol.90, issue.23, pp.10957-10961, 1993. ,
DOI : 10.1073/pnas.90.23.10957
Topical S-nitrosoglutathione-releasing hydrogel improves healing of rat ischaemic wounds, Journal of Tissue Engineering and Regenerative Medicine, vol.38, issue.8, pp.612-619, 2011. ,
DOI : 10.1016/j.freeradbiomed.2004.12.016
Decomposition ofS-Nitrosoglutathione in the Presence of Copper Ions and Glutathione, Archives of Biochemistry and Biophysics, vol.330, issue.2, pp.219-228, 1996. ,
DOI : 10.1006/abbi.1996.0247
Therapeutic interventions targeting the nitric oxide system: Current and potential uses in obstetrics, bone disease and erectile dysfunction, Life Sciences, vol.74, issue.14, pp.1701-1721, 2004. ,
DOI : 10.1016/j.lfs.2003.08.029
Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine, J Cyclic Nucleotide Res, vol.5, pp.211-224, 1979. ,
The use of DSC curves to determine the acetylation degree of chitin/chitosan samples, Thermochimica Acta, vol.444, issue.2, pp.128-133, 2006. ,
DOI : 10.1016/j.tca.2006.03.003
Spray-drying technique to prepare innovative nanoparticulated formulations for drug administration: a brief overview, Brazilian Journal of Physics, vol.39, issue.1a, pp.205-209, 2009. ,
DOI : 10.1590/S0103-97332009000200013
Thiomers: A Blessing to Evaluating Era of Pharmaceuticals, International Journal of Polymer Science, vol.3, issue.1, 2015. ,
DOI : 10.1021/bm801058j
Peter Griess???Discoverer of diazo compounds, Journal of Chemical Education, vol.35, issue.4, 1958. ,
DOI : 10.1021/ed035p187
Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis, European Heart Journal, vol.26, issue.19, pp.1945-1955, 2005. ,
DOI : 10.1007/s00228-003-0597-z
Nitric Oxide in Hypertension, The Journal of Clinical Hypertension, vol.91, issue.suppl 3, pp.17-29, 2006. ,
DOI : 10.1161/01.CIR.91.5.1314
Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives, Annals of Internal Medicine, vol.105, issue.6, 1986. ,
DOI : 10.7326/0003-4819-105-6-883
Anti-inflammatory effect of augmented nitric oxide production in chronic lung infection, The Journal of Pathology, vol.158, issue.2, pp.198-205, 2006. ,
DOI : 10.1164/ajrccm.158.1.9707096
Increased stability of S-nitrosothiol solutions via pH modulations, Free Radical Research, vol.41, issue.3, pp.214-225, 2012. ,
DOI : 10.1016/j.freeradbiomed.2006.06.025
Nitric Oxide Generating Polymers (NOGPs). The University of Michigan, 2007. ,
Polyurethane with tethered copper(II)???cyclen complex: Preparation, characterization and catalytic generation of nitric oxide from S-nitrosothiols, Biomaterials, vol.29, issue.16, pp.2443-2452, 2008. ,
DOI : 10.1016/j.biomaterials.2008.02.004
Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis, British Journal of Pharmacology, vol.49, issue.Suppl 2, pp.618-625, 2004. ,
DOI : 10.4049/jimmunol.169.3.1467
Ionically Crosslinked Chitosan/Tripolyphosphate Microparticles for the Controlled Delivery of Pyrimethamine, Ibnosina J Med Biomed Sci, vol.3, 2011. ,
Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates, J Pharmacol Exp Ther, vol.218, pp.739-749, 1981. ,
Nitric Oxide Donors and Cardiovascular Agents Modulating the Bioactivity of Nitric Oxide: An Overview, Circulation Research, vol.90, issue.1, pp.21-28, 2002. ,
DOI : 10.1161/hh0102.102330
Controlled Drug Delivery by Biodegradable Poly(Ester) Devices: Different Preparative Approaches, Drug Development and Industrial Pharmacy, vol.23, issue.1, pp.703-727, 1998. ,
DOI : 10.1016/0168-3659(88)90054-5
Mechanism of action and biochemical effects of nitric oxide (NO), J Prev Med, vol.10, pp.35-45, 2002. ,
Electron spin resonance spin trapping of thiyl, radicals from the decomposition of thionitrites, Tetrahedron Letters, vol.25, issue.16, pp.1685-1688, 1984. ,
DOI : 10.1016/S0040-4039(01)81144-8
Synthesis and in Vitro Evaluation of a Novel Chitosan???Glutathione Conjugate, Pharmaceutical Research, vol.18, issue.1):, pp.1480-1488, 2005. ,
DOI : 10.1007/s11095-005-6248-6
Multifunctional polymeric excipients in no-invasive delivery of hydrophilic macromolecular drugs: the thiomer-technology. The drug delivery companies report Autumn, p.47, 2004. ,
Synthesis and in vitro evaluation of thiolated hyaluronic acid for mucoadhesive drug delivery, International Journal of Pharmaceutics, vol.343, issue.1-2, pp.48-58, 2007. ,
DOI : 10.1016/j.ijpharm.2007.04.019
PEGylated Polymer Micelle-based Nitric Oxide (NO) Photodonor with NO-mediated Antitumor Activity, Chemistry Letters, vol.39, issue.9, pp.1008-1009, 2010. ,
DOI : 10.1246/cl.2010.1008
Physicochemical, tissue distribution, and vasodilation characteristics of nitrosated serum albumin: delivery of nitric oxide in vivo, Journal of Pharmaceutical Sciences, vol.93, issue.9, 2004. ,
DOI : 10.1002/jps.20147
Development of Polyethylene Glycol-Conjugated Poly-S-Nitrosated Serum Albumin, a Novel S-Nitrosothiol for Prolonged Delivery of Nitric Oxide in the Blood Circulation in Vivo, Journal of Pharmacology and Experimental Therapeutics, vol.314, issue.3, pp.1117-1124, 2005. ,
DOI : 10.1124/jpet.105.087429
Prevention of ischemia/reperfusion injury by hepatic targeting of nitric oxide in mice, Journal of Controlled Release, vol.140, issue.1, pp.12-17, 2009. ,
DOI : 10.1016/j.jconrel.2009.07.013
Development of ethylcellulose-polyethylene glycol and ethylcellulose-polyvinyl pyrrolidone blend oral microspheres of ibuprofen, Journal of Drug Delivery Science and Technology, vol.20, issue.6, pp.439-444, 2010. ,
DOI : 10.1016/S1773-2247(10)50076-5
Continuous-flow encapsulation of ketoprofen in copolymer microbeads via co-axial microfluidic device: Influence of operating and material parameters on drug carrier properties, International Journal of Pharmaceutics, vol.441, issue.1-2, pp.809-817, 2013. ,
DOI : 10.1016/j.ijpharm.2012.12.024
Microfluidic conceived pH sensitive core???shell particles for dual drug delivery, International Journal of Pharmaceutics, vol.478, issue.1, pp.78-87, 2015. ,
DOI : 10.1016/j.ijpharm.2014.10.010
Administration of S-nitrosoglutathione after traumatic brain injury protects the neurovascular unit and reduces secondary injury in a rat model of controlled cortical impact, Journal of Neuroinflammation, vol.6, issue.1, p.32, 2009. ,
DOI : 10.1186/1742-2094-6-32
S-Nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats, Journal of Neuroinflammation, vol.8, issue.1, p.78, 2011. ,
DOI : 10.1016/j.neulet.2007.05.026
Nitric oxide: moving towards the clinic, Molecular Medicine Today, vol.2, issue.8, p.324, 1996. ,
DOI : 10.1016/1357-4310(96)81795-3
Intestine: Normal Development, Structure and Function Textbook of Clinical Pediatrics, pp.1811-1816, 2012. ,
The role of nitric oxide in hypertension and renal disease progression, Nephrology Dialysis Transplantation, vol.16, issue.suppl_1, pp.60-62, 2001. ,
DOI : 10.1093/ndt/16.suppl_1.60
A detailed description of synthetic and natural polymers which are used in the formulation of sustained release drug delivery system: a review, J Chem Pharm Sci, vol.6, pp.161-169 ,
Release of diltiazem from Eudragit microparticles prepared by spray-drying, International Journal of Pharmaceutics, vol.137, issue.2, pp.159-165, 1996. ,
DOI : 10.1016/0378-5173(96)04509-7
Thiomers: promising platform for macromolecular drug delivery, Future Medicinal Chemistry, vol.18, issue.17, pp.2205-2216, 2012. ,
DOI : 10.1016/S0939-6411(03)00061-4
Attenuation by nitrosothiol NO donors of acute intestinal microvascular dysfunction in the rat, British Journal of Pharmacology, vol.1, issue.3, pp.498-502, 1995. ,
DOI : 10.3109/10623329309100953
ON THE USE OF NITRITE OF AMYL IN ANGINA PECTORIS., The Lancet, vol.90, issue.2291, pp.97-98, 1867. ,
DOI : 10.1016/S0140-6736(02)51392-1
Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type, Brain Research Reviews, vol.35, issue.1, pp.73-96, 2001. ,
DOI : 10.1016/S0165-0173(00)00051-5
In vitro models of the intestinal barrier. The report and recommendations of ECVAM Workshop 46. European Centre for the Validation of Alternative methods, Altern Lab Anim, vol.29, pp.649-668, 2001. ,
Alginate: Properties and biomedical applications, Progress in Polymer Science, vol.37, issue.1, pp.106-126, 2012. ,
DOI : 10.1016/j.progpolymsci.2011.06.003
Role of nitric oxide in lysis of tumor cells by cytokineactivated endothelial cells, Cancer Res, vol.51, pp.2531-2535, 1991. ,
Serious Infections and Mortality in Association With Therapies for Crohn???s Disease: TREAT Registry, Clinical Gastroenterology and Hepatology, vol.4, issue.5, pp.621-630, 2006. ,
DOI : 10.1016/j.cgh.2006.03.002
Management of Crohn's Disease in Adults, The American Journal of Gastroenterology, vol.7, issue.2, pp.465-483, 2009. ,
DOI : 10.1002/ibd.20014
Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn???s disease, Gastroenterology, vol.128, issue.4, pp.862-869, 2005. ,
DOI : 10.1053/j.gastro.2005.01.048
The use of Eudragit?? RS 100/cyclodextrin nanoparticles for the transmucosal administration of glutathione, European Journal of Pharmaceutics and Biopharmaceutics, vol.72, issue.3, pp.509-520, 2009. ,
DOI : 10.1016/j.ejpb.2009.02.013
Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide, J Biol Chem, vol.268, pp.1908-1913, 1993. ,
Nitric Oxide: A Physiologic Messenger, Annals of Internal Medicine, vol.120, issue.3, pp.227-237, 1994. ,
DOI : 10.7326/0003-4819-120-3-199402010-00009
The nitrate???nitrite???nitric oxide pathway in physiology and therapeutics, Nature Reviews Drug Discovery, vol.336, issue.2, pp.156-167, 2008. ,
DOI : 10.7326/0003-4819-134-12-200106190-00010
Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine, Clinical & Experimental Immunology, vol.24, issue.2, pp.301-305, 1990. ,
DOI : 10.1016/0016-5085(87)90266-6
Effects of nitric oxide and nitrogen dioxide on bacterial growth, Appl Environ Microbiol, vol.46, pp.198-202, 1983. ,
On a Test of Whether one of Two Random Variables is Stochastically Larger than the Other, The Annals of Mathematical Statistics, vol.18, issue.1, pp.50-60, 1947. ,
DOI : 10.1214/aoms/1177730491
Development of nitrosyl ruthenium complex-loaded lipid carriers for topical administration: improvement in skin stability and in nitric oxide release by visible light irradiation, Journal of Pharmaceutical and Biomedical Analysis, vol.53, issue.4, pp.843-851, 2010. ,
DOI : 10.1016/j.jpba.2010.06.007
NO-Releasing Hybrids of Cardiovascular Drugs, Current Medicinal Chemistry, vol.13, issue.6, pp.609-625, 2006. ,
DOI : 10.2174/092986706776055634
Metal ion catalysis in nitrosothiol (RSNO) decomposition, Journal of the Chemical Society, Chemical Communications, issue.23, pp.1758-1759, 1993. ,
DOI : 10.1039/c39930001758
Methotrexate for treatment of active treatment resistant Crohn's disease, Health, 2014. ,
Anatomy and physiology of the bowel and urinary systems, 2005. ,
Nitric oxide donor drugs, Drugs of the Future, vol.25, issue.7, pp.587-601, 2002. ,
DOI : 10.1358/dof.2000.025.07.858691
Endothelial cell functions, Journal of Cellular Physiology, vol.416, issue.3, pp.430-443, 2003. ,
DOI : 10.1007/978-1-4899-0179-8_47
Recent developments in nitric oxide donor drugs, British Journal of Pharmacology, vol.110, issue.Suppl 7, pp.305-321, 2007. ,
DOI : 10.1172/JCI200419267
Formulation Optimization and Characterization of Spray Dried Microparticles for Inhalation Delivery of Doxycycline Hyclate, YAKUGAKU ZASSHI, vol.131, issue.12, pp.1813-1825, 2011. ,
DOI : 10.1248/yakushi.131.1813
Nitric oxide: physiology, pathophysiology, and pharmacology, Pharmacol Rev, vol.43, pp.109-142, 1991. ,
Antisense Oligonucleotide, and Crohn???s Disease, Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn's Disease, pp.1104-1113 ,
DOI : 10.1056/NEJMoa1407250
Soluble Guanylyl Cyclase: Physiological Role as an NO Receptor and the Potential Molecular Target for Therapeutic Application, Clinical Chemistry and Laboratory Medicine, vol.84, issue.7, pp.865-870, 2003. ,
DOI : 10.1038/sj.bjp.0703320
Nitric oxide as a secretory product of mammalian cells., The FASEB Journal, vol.6, issue.12, pp.3051-3064, 1992. ,
DOI : 10.1096/fasebj.6.12.1381691
Anatomy and Physiology For Dummies, 2011. ,
Nitrates and Nitrites in the Treatment of Ischemic Cardiac Disease, Cardiology in Review, vol.18, issue.4, pp.190-197, 2010. ,
DOI : 10.1097/CRD.0b013e3181c8e14a
A comparison of organic and inorganic nitrates/nitrites, Nitric Oxide, vol.26, issue.4, pp.229-240, 2012. ,
DOI : 10.1016/j.niox.2012.03.008
Micro and nano drug delivery systems in cancer therapy, Cancer Ther, vol.3, pp.131-138, 2005. ,
Biocompatibility of microcapsules for cell immobilization elaborated with different type of alginates, Biomaterials, vol.23, issue.18, pp.3825-3831, 2002. ,
DOI : 10.1016/S0142-9612(02)00118-7
Induction of Cytokine Production from Human Monocytes Stimulated with Alginate, Journal of Immunotherapy, vol.10, issue.4, pp.286-291, 1991. ,
DOI : 10.1097/00002371-199108000-00007
On the use of the Weibull function for the discernment of drug release mechanisms, International Journal of Pharmaceutics, vol.309, issue.1-2, pp.44-50, 2006. ,
DOI : 10.1016/j.ijpharm.2005.10.044
A Complete Physicochemical Identity Card of S-nitrosoglutathione, Curr Pharm Anal, vol.9, pp.31-42, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00807801
Effect of polymeric blend on the dissolution behavior of spray-dried microparticles, Int J Res Pharm Chem, vol.1, pp.690-701, 2011. ,
Spray dried microparticles for controlled delivery of Fluconazole using factorial Design, Int J Res Pharm Biomed Sci, vol.4, pp.582-589 ,
The effects of nitric oxide on the immune response during giardiasis, The Brazilian Journal of Infectious Diseases, vol.14, issue.6, pp.606-612, 2010. ,
DOI : 10.1016/S1413-8670(10)70119-7
Intestinal permeability in children with Crohn's disease and coeliac disease., BMJ, vol.285, issue.6334, pp.20-21, 1982. ,
DOI : 10.1136/bmj.285.6334.20
Properties of tolmetin-loaded Eudragit RL100 and Eudragit RS 100 microparticles prepared by different techniques, STP Pharma Sci, vol.7, pp.148-157, 1997. ,
Ultraviolet and Infrared Spectra of Some Nitrosamines, Bull Acad Pol Sci Ser Sci Chim, vol.11, p.607, 1963. ,
Water-Soluble Nitric Oxide-Releasing Gold Nanoparticles, Langmuir, vol.23, issue.9, pp.4938-4943, 2007. ,
DOI : 10.1021/la0633841
Chitosan nanoparticles: Preparation, size evolution and stability, International Journal of Pharmaceutics, vol.455, issue.1-2, pp.219-228, 2013. ,
DOI : 10.1016/j.ijpharm.2013.07.034
Encapsulation and characterization of flurbiprofen loaded poly(??-caprolactone)???poly(vinylpyrrolidone) blend micropheres by solvent evaporation method, Journal of Sol-Gel Science and Technology, vol.21, issue.1, pp.281-289, 2009. ,
DOI : 10.1208/pt040465
Ketoprofen Spray-dried Microspheres Based on Eudragit?? RS and RL: Study of the Manufacturing Parameters, Drug Development and Industrial Pharmacy, vol.7, issue.11, pp.1178-1187, 2008. ,
DOI : 10.1016/j.ejpb.2004.03.006
EDRF role in renal function and blood pressure of normal rats and rats with obstructive uropathy, Kidney International, vol.41, issue.2, pp.403-413, 1992. ,
DOI : 10.1038/ki.1992.56
The Small and Large Intestines <http://cnx.org/contents/430d8e5a-f699-4949-9849- 5b4ca1125fa2@4, 2015. ,
Nitroglycerin and Other Nitrites in the Treatment of Angina Pectoris: Comparison of Six Preparations and Four Routes of Administration, Circulation, vol.17, issue.1, 1958. ,
DOI : 10.1161/01.CIR.17.1.22
Intravenous immunoglobulin for the treatment of Crohn's disease, Autoimmunity Reviews, vol.12, issue.2, pp.275-280, 2012. ,
DOI : 10.1016/j.autrev.2012.04.006
Viability and gene expression responses to polymeric nanoparticles in human and rat cells, Cell Biology and Toxicology, vol.87, issue.6, pp.137-146, 2014. ,
DOI : 10.1007/s00204-012-0938-8
URL : https://hal.archives-ouvertes.fr/hal-01274268
Comparison of scheduled and episodic treatment strategies of infliximab in Crohn???s disease, Gastroenterology, vol.126, issue.2, pp.402-413, 2004. ,
DOI : 10.1053/j.gastro.2003.11.014
-Nitrosoglutathione-Loaded Nanoparticles: Uptake, Viability, and Transcriptome, Molecular Pharmaceutics, vol.12, issue.2, pp.554-561, 2015. ,
DOI : 10.1021/mp5006382
S-Nitrosoglutathione inhibits platelet activation and deposition in coronary artery saphenous vein grafts in vitro and in vivo, Heart, vol.80, issue.2, pp.146-150, 1998. ,
DOI : 10.1136/hrt.80.2.146
Nanocarriers for Nitric Oxide Delivery, Journal of Drug Delivery, vol.6, issue.8, 2011. ,
DOI : 10.1039/b803441a
Enteric Glia Regulate Intestinal Barrier Function and Inflammation Via Release of S-Nitrosoglutathione, Gastroenterology, vol.132, issue.4, pp.1344-1358, 2007. ,
DOI : 10.1053/j.gastro.2007.01.051
A scheme for the colorimetric determination of microgram amounts of thiols, The Analyst, vol.83, issue.993, pp.670-672, 1958. ,
DOI : 10.1039/an9588300670
Nitric Oxide Regulates Wound Healing, Journal of Surgical Research, vol.63, issue.1, pp.237-240, 1996. ,
DOI : 10.1006/jsre.1996.0254
Reevaluation of the Griess Method for Determining NO/NO???2 in Aqueous and Protein-Containing Samples, Nitric Oxide, vol.3, issue.3, pp.225-234, 1999. ,
DOI : 10.1006/niox.1999.0226
Nitric Oxide and Synaptic Function, Annual Review of Neuroscience, vol.17, issue.1, pp.153-183, 1994. ,
DOI : 10.1146/annurev.ne.17.030194.001101
Medical treatment of moderate to severe Crohn's disease, Alimentary Pharmacology and Therapeutics, vol.120, issue.s2, pp.23-30, 2003. ,
DOI : 10.1136/gut.51.1.30
Polynitrosated Polyesters:?? Preparation, Characterization, and Potential Use for Topical Nitric Oxide Release, Biomacromolecules, vol.6, issue.5, pp.2512-2520, 2005. ,
DOI : 10.1021/bm050216z
The effect of S-nitrosoglutathione and L-cysteine on chloride efflux from cystic fibrosis airway epithelial cells, Experimental and Molecular Pathology, vol.90, issue.1, pp.79-83, 2011. ,
DOI : 10.1016/j.yexmp.2010.10.005
-nitrosoglutathione-oligosaccharide-chitosan as a nitric oxide donor, Expert Opinion on Drug Delivery, vol.9, issue.8, pp.1209-1223, 2015. ,
DOI : 10.1016/j.ejpb.2008.04.008
Improving oral absorption via drug-loaded nanocarriers: absorption mechanisms, intestinal models and rational fabrication, Curr Drug Metab, vol.14, pp.28-56, 2013. ,
Expression of endothelial nitric oxide synthase and vascular endothelial growth factor in oral squamous cell carcinoma: its correlation with angiogenesis and disease progression, Journal of Oral Pathology and Medicine, vol.2, issue.3, pp.134-139, 2005. ,
DOI : 10.1074/jbc.M101371200
Nitric oxide and the kidney, Indian J Nephrol, vol.14, pp.77-84, 2004. ,
Endogenous nitric oxide release required for long-term synaptic depression
in the cerebellum, Nature, vol.349, issue.6307, pp.326-328, 1991. ,
DOI : 10.1038/349326a0
-nitrosoglutathione kinetics and transport in human airways, Journal of Applied Physiology, vol.276, issue.3, pp.777-788, 2001. ,
DOI : 10.1152/ajpheart.1994.266.5.H2108
-Nitrosothiols, Journal of Biological Chemistry, vol.24, issue.31, pp.18596-18603, 1996. ,
DOI : 10.1093/cvr/28.5.691
Nitric oxide: role in tumour biology and iNOS/NO-based anticancer therapies, Cancer Chemotherapy and Pharmacology, vol.12, issue.6, pp.1211-1224, 2011. ,
DOI : 10.1038/sj.cr.7290133
The chemistry of the S-nitrosoglutathione/glutathione system, Proceedings of the National Academy of Sciences, vol.26, issue.4, pp.14428-14433, 1996. ,
DOI : 10.1002/kin.550261208
Alginate Particles as Platform for Drug Delivery by the Oral Route: State-of-the-Art, ISRN Pharmaceutics, vol.6, issue.11, article 1894, 2014. ,
DOI : 10.1163/092050610X550359
National Cooperative Crohn's Disease Study: results of drug treatment, Gastroenterology, vol.77, pp.847-869, 1979. ,
Eudragit??: a technology evaluation, Expert Opinion on Drug Delivery, vol.2, issue.2, pp.131-149, 2013. ,
DOI : 10.3109/02652049709006822
A Comparison of Budesonide and Mesalamine for Active Crohn's Disease, New England Journal of Medicine, vol.339, issue.6, pp.370-374, 1998. ,
DOI : 10.1056/NEJM199808063390603
Alginate in Drug Delivery Systems, Drug Development and Industrial Pharmacy, vol.55, issue.6, pp.621-630, 2002. ,
DOI : 10.1248/cpb.45.1063
Principles of anatomy and physiology, 2011. ,
Lack of correlation between the observed stability and pharmacological properties of S-nitroso derivatives of glutathione and cysteine-related peptides11Abbreviations: NO, nitric oxide; RSNO, S-nitrosothiol; CysH, cysteine; SNOGSH, S-nitrosoglutathione; SNOCys, S-nitrosocysteine; SNOGluCys, S-nitroso-l-??-glutamyl-l-cysteine; SNOCysGly, S-nitroso-l-cysteinylglycine; SNOPROPA, S-nitroso-3-mercaptopropionic acid; SNONAC, S-nitroso-N-acetyl-l-cysteine; DTPA, diethylenetriaminpentaacetic acid; and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide., Biochemical Pharmacology, vol.62, issue.9, pp.1239-1247, 2001. ,
DOI : 10.1016/S0006-2952(01)00750-X
Formulation and physical characterization of large porous particles for inhalation, Pharmaceutical Research, vol.16, issue.11, pp.1735-1742, 1999. ,
DOI : 10.1023/A:1018910200420
Pharmaceutical Particle Engineering via Spray Drying, Pharmaceutical Research, vol.21, issue.5, pp.999-1022, 2008. ,
DOI : 10.14356/kona.2005014
Nitric oxide as a regulator of inflammatory processes. Memórias do Instituto Oswaldo Cruz, pp.5-9, 2005. ,
Enhanced anti-inflammatory effects of a nitric oxide???releasing derivative of mesalamine in rats, Gastroenterology, vol.117, issue.3, pp.557-566, 1999. ,
DOI : 10.1016/S0016-5085(99)70448-8
15N NMR and electronic properties of S-nitrosothiols, Bioorganic & Medicinal Chemistry Letters, vol.9, issue.19, pp.2897-2902, 1999. ,
DOI : 10.1016/S0960-894X(99)00499-0
Drug Transfer across Intact Rat Intestinal Mucosa Following Surgical Removal of Serosa and Muscularis Externa, Journal of Pharmaceutical Sciences, vol.62, issue.2, pp.200-205, 1973. ,
DOI : 10.1002/jps.2600620203
Time lasting S-nitrosoglutathione polymeric nanoparticles delay cellular protein S-nitrosation, European Journal of Pharmaceutics and Biopharmaceutics, vol.89, pp.1-8 ,
DOI : 10.1016/j.ejpb.2014.11.005
URL : https://hal.archives-ouvertes.fr/hal-01281136
Colon-specific drug delivery: new approaches and in vitro/in vivo evaluation, International Journal of Pharmaceutics, vol.235, issue.1-2, pp.1-15, 2002. ,
DOI : 10.1016/S0378-5173(02)00004-2
Characterization of nitric oxide-releasing microparticles for the mucosal delivery, Journal of Biomedical Materials Research Part A, vol.78, issue.2/3, pp.1233-1243, 2009. ,
DOI : 10.1016/0002-9378(59)90174-7
Preparation and comparison of chitosan nanoparticles with different degrees of glutathione thiolation, pp.367-375, 2011. ,
The microparticles characterization was done by scanning electron microscopy (SEM), X-ray diffraction (PXRD), infrared spectroscopy (FTIR) and in vitro release studies were performed in a phosphate buffer The microparticles were negatively charged with mean particle size ranging from 5 to 7 µm. The formulation was stable and was resistant to acidic pH but showed rapid release in basic pH. The polymeric microparticles were acid resistant; hence, they can be used as colon specific drug delivery systems for the treatment of Crohn's disease, 2004. ,
) par spray drying. L'Eudragit ® FS 30D, qui est gastro-résistant, a été choisi comme polymère. La caractérisation de microparticules a été réalisée par microscopie électronique à balayage (SEM), par diffraction X (PXRD), par spectroscopie infrarouge à transformée de Fourrier (FTIR) Les essais de libération in vitro ont été réalisés dans un tampon phosphate (pH 1) Les microparticules étaient chargées négativement avec une taille moyenne allant de 5 à 7 µm. La formulation était stable à pH acide mais a montré une libération rapide à pH basique ,