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Conception de nanocapsules biodégradables recouvertes de dextrane par réaction "click" interfaciale

Abstract : Biodegradable nanocapsules allowing encapsulation of active substances for environmental applications were produced by emulsion-evaporation method combined with a “click” reaction occurring at the liquid/liquid interface of emulsion droplets. Two types of “click” reaction were tested: (i) copper-catalyzed azide-alkyne cycloaddition (CuAAC) and (ii) thiol-ene reaction. The NCs are composed of a hydrophobic polymer shell (polylactide), a liquid core (Miglyol®810) and a hydrophilic polysaccharide coating (dextran). For comparison, nanospheres (without oily core) were also prepared. These nano-objects were characterized in terms of size distribution, dextran coverage density and thickness, “click” coupling efficiency and morphology. Colloidal stability in NaCl solutions as well as dextran coverage stability against an anionic competitive surfactant were also studied. Finally, an active substance was encapsulated and released from these nano-objects
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https://hal.univ-lorraine.fr/tel-01752028
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Katarzyna Poltorak. Conception de nanocapsules biodégradables recouvertes de dextrane par réaction "click" interfaciale. Alimentation et Nutrition. Université de Lorraine, 2015. Français. ⟨NNT : 2015LORR0134⟩. ⟨tel-01752028⟩

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