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Elaboration de NCs à coeur huileux par le procédé de polymérisation en chaîne en miniémulsion directe ,
2°) fonctionnalisation éventuelle de la surface du coeur, 3°) formation couche-par-couche de l'écorce polymère autour du template dur, 4°) élimination du coeur sacrificiel, 5°) remplissage du coeur par une solution contenant la SA par imprégnation, 6°) redispersion des NCs dans, Elaboration des NCs à coeur liquide par le procédé couche-par-couche à partir d'un coeur sacrificiel dur : 1°) synthèse d'un coeur dur ,
Synthèse de NCs vides par le procédé couche-par-couche par réaction de polymérisation RAFT à partir de la surface en utilisant des nanosphères de silice comme templates (adapté de la référence 125 ). tBMA = méthacrylate de tert-butyle, DMIPM = méthacrylate de 2,3diméthylimidopropyle, HPMA =N-(2-hydroxypropyle) méthacrylamide, vol.8 ,
Synthèse de NCs à coeur huileux par le procédé couche-par-couche à partir de la surface d'une nano-gouttelette d'émulsion chargée positivement (adapté de la rérérence 73 ) ,
Elaboration des NCs à coeur huileux par le procédé de dépôt d'une couche polymère (« polymer coating ») ,
Elaboration de NCs à coeur huileux par le procédé de polymérisation par étapes à l'interface d'une gouttelette de miniémulsion ,
Elaboration de NCs à coeur huileux par le procédé de polymérisation en chaîne à l'interface d'une gouttelette de miniémulsion ,
Elaboration des MCs à coeur CHCl3 par réaction « click, vol.13 ,
,
Elaboration des NCs à coeur aqueux par réaction « click » thiol-ène à l'interface eau/CH2Cl2 (adapté de la référence 166 ) ,
Elaboration des NCs vides par réaction « click » thiol-ène photo-amorcée à l'interface ,
, CHCl3/eau (adapté de la référence 167 )
Réactions de cycloaddition azide-alcyne : a) non-catalysée, b) catalysée par Cu(I), p.45 ,
Modification de D-glucose via une transformation « one-pot multi-step » impliquant la réaction de chimie « click ,
Mécanisme proposé de la réaction CuAAC 179 ,
Réaction de chimie « click » CuAAC entre des alcynes terminaux et un nucléoside (1(4'-azido-2'-deoxy-2'-fluoro-?-D-arabinofuranosyl) cytosine) 180 ,
Réaction de chimie « click » CuAAC réalisée à l'interface entre deux solvant nonmiscibles et catalysée par CuSO4/NaAsc (inspiré par 183 ) ,
, 22. Deux principaux mécanismes de la réaction thiol-ène: a) nucléophile ou basique, b) radicalaire
Mécanisme de la réaction thiol-ène catalysée par une molécule nucléophile (XR3) ,
Mécanisme de la réaction thiol-ène catalysée par une base 187. B correspond à une base et EWG aux groupes attracteurs d'électrons (ang. Electron Withdrawing Groups) ,
Mécanisme radicalaire de la réaction thiol-ène 190 ,
Mécanisme d'amorçage de la réaction thiol-ène en utilisant un photo-amorceur de type I, dans l'exemple du DMPA 189 ,
Mécanisme d'amorçage de la réaction thiol-ène en utilisant un photo-amorceur de type II ,
Mécanisme de formation de radicaux par un système BPO/amine tertiaire 206 ,
,
Synthèse du PLA ?-alcyne par polymérisation par ouverture de cycle du D,L-lactide catalysée par SnOct2 et amorcée par l'alcool propargylique ,
Synthèse du PLA ?-SH : I) Synthèse du PLA-SS-PLA par polymérisation par ouverture de cycle du D,L-lactide, II) Réduction des liaisons disulfure en thiol ,
ATRP : a) synthèse de l'amorceur fonctionnel, b) POC du D ,
Réduction d'une liaison disulfure à l'aide du DTT 13 ,
Synthèse du dextrane-azide (DexN3) par réaction entre le dextrane natif et l'acide 6-azidohexanoïque activé ,
, Synthèse du dextrane-méthacrylate (DexC=C) par réaction entre le dextrane natif et l'anhydride méthacrylique
Synthèse du dextrane-alcène (DexC6C=C) par réaction entre le dextrane natif et l'acide 5-hexenoïque activé, vol.8 ,
émulsion-évaporation de solvant couplé à une réaction de chimie « click » à l'interface de l'émulsion huile-dans-eau, Synthèse des NCs de PLA à coeur M810 et recouvertes de dextrane par le procédé d ,
10. Réaction « click » CuAAC entre un DexN3 et un PLA ?-alcyne ,
11. Réaction « click » thiol-ène nucéophile entre un DexC=C et un PLA ?-SH ,
, 12. Réaction « click » thiol-ène entre un DexC6C=C et un PLA ?-SH dans les conditions radicalaires
, Liste des Schémas 225
, Mécanismes principaux de libération prolongée de la SA à partir d'une capsule polymère
Synthèse du PLA ?-alcyne par polymérisation par ouverture de cycle du D,L-lactide catalysée par SnOct2 et amorcée par l'alcool propargylique ,
Synthèse du PLA-SS-PLA par polymérisation par ouverture de cycle du D,L-lactide catalysée par SnOct2 et amorcée par le 2-hydroxyéthyl disulfide ,
Synthèse de l'acide 6-azidohexanoïque ,
Synthèse de l'ester activé de l'acide 6-azidohexanoïque ,
Réaction du dextrane avec l'acide 6-azidohexanoïque activé ,
Réaction du dextrane avec l'anhydride méthacrylique ,
Synthèse de l'ester activé de l'acide hex-5-énoïque, vol.8 ,
Réaction du dextrane avec l'acide hex-5-énoïque activée ,
Préparation des NSs ou des NCs par le procédé d'émulsion-évaporation de solvant couplé à une réaction de chimie « click » CuAAC en utilisant différents catalyseurs: a) CuBr ou CuI, b) CuSO4 (±BPMODA)/AAsc ,
Préparation des NSs ou des NCs par le procédé d'émulsion-évaporation de solvant couplé à une réaction de chimie « click » thiol-ène dans des conditions nucléophiles ,
Préparation des NSs par le procédé d'émulsion-évaporation de solvant couplé à une réaction de chimie « click » thiol-ène dans les conditions radicalaires ,
, Liste des Schémas