R. 1. Siegel, R. Miller, K. Jemal, and A. , Cancer statistics, 2015, CA: A Cancer Journal for Clinicians, vol.61, issue.3, pp.5-29, 2015.
DOI : 10.3322/caac.20134

P. Rosenberg, F. Bray, and M. Gillison, Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers, J Clin Oncol, vol.31, issue.36, pp.4550-4559, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01261786

K. Looser, J. Shah, and E. Strong, The significance of ???positive??? margins in surgically resected epidermoid carcinomas, Head & Neck Surgery, vol.61, issue.2, pp.107-111, 1978.
DOI : 10.1148/95.1.185

R. Spiro, O. Guillamondegui, J. Paulino, A. Huvos, and A. , Pattern of invasion and margin assessment in patients with oral tongue cancer, Head & Neck, vol.148, issue.5, pp.408-413, 1999.
DOI : 10.1016/0002-9610(84)90368-4

C. Alix-panabieres and K. Pantel, Circulating Tumor Cells: Liquid Biopsy of Cancer, Clinical Chemistry, vol.59, issue.1, pp.110-118, 2013.
DOI : 10.1373/clinchem.2012.194258

E. Mitchell and M. Miller, Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer, J

J. Allard, W. Miller, and M. , Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer, J Clin Oncol, vol.23, issue.7, pp.1420-1430, 2005.

L. Schwartz, S. Larson, and M. Fleisher, Circulating tumor cell number and prognosis in progressive castration-resistant prostate cancer, Clin Cancer Res, vol.13, issue.23, pp.7053-7058, 2007.

S. Edge and C. Compton, The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM, Annals of Surgical Oncology, vol.17, issue.6, pp.1471-1474, 2010.
DOI : 10.1245/s10434-010-0985-4

J. Diagnostics, L. Nichols, A. Lowes, L. Szeto, C. Basmaji et al., CELLSEARCH® Circulating Tumor Cell Kit (Epithelial) Instructions for Use. 11

N. Venkatesan, V. Hammond, and A. , Detection of circulating tumor cells in advanced head and neck cancer using the CellSearch system, Head Neck, vol.34, issue.12, pp.1440-1444, 2012.

M. , C. D. Peyrade, and F. , Significance of circulating tumor cell detection using the Annexes 150

L. Kluwe, M. Heiland, and K. Pantel, Prognostic relevance of circulating tumor cells in blood and disseminated tumor cells in bone marrow of patients with squamous cell carcinoma of the oral cavity, Clin Cancer Res, vol.20, issue.2, pp.425-433, 2014.

C. Ciccarese, M. Mangoni, and L. Ferrari, Circulating tumor cells in patients with recurrent or metastatic head and neck carcinoma: prognostic and predictive significance, PLoS One, vol.9, issue.8, p.103918, 2014.

F. Paiar and N. Pasinetti, Circulating tumour cells in locally advanced head and neck cancer: preliminary report about their possible role in predicting response to non-surgical treatment and survival, Eur J Cancer, vol.48, issue.16, pp.3019-3026, 2012.

B. Negin and S. Cohen, Circulating Tumor Cells in Colorectal Cancer: Past, Present, and Future Challenges, Current Treatment Options in Oncology, vol.25, issue.13, pp.1-13, 2010.
DOI : 10.1007/s11864-010-0115-3

T. Yoshikawa and S. Matsuda, Clinical significance of circulating tumor cells in blood from patients with gastrointestinal cancers, Ann Surg Oncol, vol.15, issue.11, pp.3092-3100, 2008.

S. and T. Dj, Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival, J Natl Cancer Inst, vol.90, issue.21, pp.824-832, 1998.

M. Groot and L. Terstappen, Circulating tumor cells before and during follow-up after breast cancer surgery, Int J Oncol, vol.46, issue.1, pp.407-413, 2015.

D. Schuller and T. Teknos, Significance of circulating tumor cells in patients with squamous cell carcinoma of the head and neck: initial results, Arch Otolaryngol Head Neck Surg, vol.136, issue.12, pp.1274-1279, 2010.

V. Budach, Detection of circulating tumor cells for prediction of recurrence after adjuvant chemoradiation in locally advanced squamous cell carcinoma of the head and neck, Ann Oncol, vol.25, issue.10, pp.2042-2047, 2014.

A. Auricchio, D. Vita, F. , D. Vecchio, and L. , Postoperative detection of circulating tumor cells predicts tumor recurrence in colorectal cancer patients, J Gastrointest Surg, vol.17, issue.10, pp.1809-1818, 2013.

F. P. Andrea, Résistance de rayonnement intrinsèque des cellules souches mésenchymateuses cancéreuses et conséquences pour la réponse au traitement dans un modèle murin de sarcome, Dan. Med. J, pp.59-4388, 2012.

R. Arnaud, EMT: quand les cellules épithéliales décident de devenir des cellules mésenchymateuses, J. Clin. Investir, vol.119, pp.1417-1419, 2009.

S. Bao, Q. Wu, S. Sathornsumetee, Y. Hao, . Li-z et al., Cellules de gliome de cellules souches comme promouvoir l'angiogenèse tumorale par facteur de croissance endothélial vasculaire. Cancer res, pp.7843-7848, 2006.

C. Bardelle, D. Cross, S. Davenport, J. G. Kettle, E. J. Ko et al., Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines, Bioorganic & Medicinal Chemistry Letters, vol.18, issue.9, pp.2776-2780, 2008.
DOI : 10.1016/j.bmcl.2008.04.015

C. Bardelle, T. Coleman, D. Cross, S. Davenport, J. G. Kettle et al., Inhibitors of the tyrosine kinase EphB4. Part 2: Structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines, Bioorganic & Medicinal Chemistry Letters, vol.18, issue.21, pp.5717-5721, 2008.
DOI : 10.1016/j.bmcl.2008.09.087

M. T. Becker and C. G. Shores, Molecular Assay to Detect Metastatic Head and Neck Squamous Cell Carcinoma, Archives of Otolaryngology???Head & Neck Surgery, vol.130, issue.1, pp.21-28, 2004.
DOI : 10.1001/archotol.130.1.21

H. Benateau and E. Babin, D??tection du ganglion sentinelle dans les carcinomes ??pidermo??des de la cavit?? buccale et de l???oropharynx. ??tude pr??liminaire, Revue de Stomatologie et de Chirurgie Maxillo-faciale, vol.106, issue.5, pp.281-287, 2005.
DOI : 10.1016/S0035-1768(05)86042-5

F. Bidard, A. E. Saliba, L. Saias, A. Degeorges, P. De-cremoux et al., Cellules tumorales circulantes et cancer du sein : méthodes de détection et résultats cliniques, Bulletin du Cancer, vol.96, pp.73-86, 2009.

T. Brabletz, To differentiate or not ??? routes towards metastasis, Nature Reviews Cancer, vol.10, issue.6, pp.425-436, 2012.
DOI : 10.1158/1078-0432.CCR-04-1110

J. Cairns, Les cellules souches somatiques et la cinétique de la mutagenèse et cancérogenèse, États-Unis d'Amérique de Proc Natl. Acad. Sci, pp.10567-10570, 2002.

M. D. Cameron, E. E. De-schmidt, N. De, . Kerkvliet, V. K. De et al., Progression temporelle des métastases dans le poumon : cellule de survie, dormance et emplacement dépendance d'inefficacité métastatique. Cancer res, pp.2541-2546, 2000.

C. L. Chaffer, B. Dopheide, D. R. Mcculloch, . Lee, J. M. Moseley et al., Axe surexprimés MT1-MMP/TIMP-2 dans le modèle de TSU-Pr1-B1, pp.115-125, 2005.

C. L. Chaffer, E. W. Thompson, and E. D. Williams, Mesenchymal épithéliales transition en développement et de la maladie, Cellules tissus organes 185, pp.7-19, 2007.

A. F. Chambers, I. Macdonald, C. Schmidt, E. E. Morris, V. L. Marié et al., Clinical targets for anti-metastasis therapy, Adv. Cancer Res. De, vol.79, pp.91-121, 2000.
DOI : 10.1016/S0065-230X(00)79003-8

A. F. Chambers, G. N. Naumov, H. J. Venet, V. K. Nadkarni, I. Macdonald et al., Critique les étapes à la métastase hématogène : un aperçu, Surg. Oncol. Clin. N, 2001.

Q. Chang, C. Jorgensen, T. Pawson, and D. W. Hedley, Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer, British Journal of Cancer, vol.61, issue.7, pp.1074-1082, 2008.
DOI : 10.1038/ncb1045

S. Changxin, H. Lihua, X. Lin, and L. Yirong, The detection of circulating tumor cells of breast cancer patients by using multimarker (Survivin, hTERT and hMAM) quantitative real-time PCR, Clinical Biochemistry, vol.42, issue.3, pp.194-200, 2009.
DOI : 10.1016/j.clinbiochem.2008.10.016

Y. L. Chao and R. Shepard, Cellules de carcinome du sein ré-expriment E-cadhérine au cours de la transition rétablissement mésenchymateuse à épithéliale, Cancer, vol.9, 2010.

O. M. Cojocariu and F. Huguet, Prognosis and predictive factors in head-andneck cancers], Bull Cancer, vol.96, issue.4, pp.369-78, 2009.

A. K. Croker and A. L. Allan, Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDHhiCD44+ human breast cancer cells, Breast Cancer Research and Treatment, vol.100, issue.11, pp.75-87, 2012.
DOI : 10.1093/jnci/djn148

D. Gao, D. J. Nolan, S. A. De-mellick, K. Bambino, K. Mcdonnell et al., Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis, Science, vol.6, issue.11, pp.195-198, 2008.
DOI : 10.1038/nrc1971

A. Garcia, Notch : un régulateur clé de l'angiogenèse tumorale et les métastases, Histol. Histopathol, vol.27, pp.151-156, 2012.

R. Garrel and M. Dromard, The Diagnostic Accuracy of Reverse Transcription-PCR Quantification of Cytokeratin mRNA in the Detection of Sentinel Lymph Node Invasion in Oral and Oropharyngeal Squamous Cell Carcinoma: A Comparison with Immunohistochemistry, Clinical Cancer Research, vol.12, issue.8, pp.2498-505, 2006.
DOI : 10.1158/1078-0432.CCR-05-2136

R. A. Ghossein and S. Bhattacharya, Molecular detection and characterisation of circulating tumour cells and micrometastases in solid tumours, European Journal of Cancer, vol.36, issue.13, pp.1681-94, 2000.
DOI : 10.1016/S0959-8049(00)00152-0

R. A. Ghossein and L. Carusone, ChemInform Abstract: Molecular Detection of Micrometastases and Circulating Tumor Cells in Melanoma Prostatic and Breast Carcinomas, ChemInform, vol.14, issue.43, pp.237-50, 2000.
DOI : 10.1002/chin.200043288

H. Goda and K. I. Nakashiro, One-step nucleic acid amplification for detecting lymph node metastasis of head and neck squamous cell carcinoma, Oral Oncology, vol.48, issue.10, pp.211-214, 2012.
DOI : 10.1016/j.oraloncology.2012.03.026

L. R. Gomes, L. F. Terra, M. C. Sogayar, and L. Labriola, Transition épithéliales ? mésenchymateuse : implications dans la progression du cancer et des métastases, 2011.

P. A. Gregory, G. A. Bert, L. Paterson, E. L. Barry, S. C. Les-tsykin et al., The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1, Nature Cell Biology, vol.94, issue.5, pp.593-601, 2008.
DOI : 10.1126/science.1115079

J. S. Greenberg and R. Fowler, Extent of extracapsular spread, Cancer, vol.36, issue.6, pp.1464-70, 2003.
DOI : 10.1016/S0360-3016(96)00430-0

S. Guérin and F. Doyon, And Hill C. La fréquence des cancers en France en 2006 et les évolutions de la mortalité depuis 1950 et de l'incidence depuis 1980, Bulletin du Cancer, vol.96, pp.51-57, 2009.

H. Hamakawa and M. Fukuzumi, Keratin mRNA for detecting micrometastasis in cervical lymph nodes of oral cancer, Cancer Letters, vol.160, issue.1, pp.115-138, 2000.
DOI : 10.1016/S0304-3835(00)00574-7

H. Hamakawa and A. Onishi, Intraoperative real-time genetic diagnosis for sentinel node navigation surgery, International Journal of Oral and Maxillofacial Surgery, vol.33, issue.7, pp.670-675, 2004.
DOI : 10.1016/j.ijom.2004.01.009

D. Hanahan and R. A. Weinberg, The Hallmarks of Cancer, Cell, vol.100, issue.1, pp.57-70, 2000.
DOI : 10.1016/S0092-8674(00)81683-9

T. Hashimoto, Y. Kajiyama, Y. Tsutsumi-ishii, I. Nagaoka, and M. Tsurumaru, Circulating micrometastases of esophageal cancer detected by carcinoembryonic antigen mRNA reverse transcriptase-polymerase chain reaction: clinical implications, Diseases of the Esophagus, vol.30, issue.8, pp.690-696, 2008.
DOI : 10.1111/j.1442-2050.2008.00830.x

A. Jemal, R. Siegel, E. Ward, T. Murray, J. Xu et al., Cancer Statistics, 2006, CA: A Cancer Journal for Clinicians, vol.56, issue.2, pp.106-130, 2006.
DOI : 10.3322/canjclin.56.2.106

S. Kalyankrishna and J. R. Grandis, Epidermal Growth Factor Receptor Biology in Head and Neck Cancer, Journal of Clinical Oncology, vol.24, issue.17, pp.2666-72, 2006.
DOI : 10.1200/JCO.2005.04.8306

Y. Kang and J. Massague, Epithelial-Mesenchymal Transitions, Cell, vol.118, issue.3, pp.277-279, 2004.
DOI : 10.1016/j.cell.2004.07.011

M. Kano and Y. Shimada, Detection of lymph node metastasis of oesophageal cancer by RT-nested PCR for SCC antigen gene mRNA, British Journal of Cancer, vol.50, issue.2, pp.429-464, 2000.
DOI : 10.1097/00004347-198403000-00005

M. W. Karaman, S. Herrgard, D. K. Treiber, P. Gallant, C. E. Atteridge et al., A quantitative analysis of kinase inhibitor selectivity, Nature Biotechnology, vol.50, issue.1, pp.127-132, 2008.
DOI : 10.1021/jm070562u

P. N. Kelly, A. De-dakic, A. Nutt, S. L. , J. M. Strasser et al., La croissance tumorale n'a pas besoin d'être poussée par rare de cancer des cellules souches, Science, vol.317, p.33, 2007.

N. H. Kim, H. S. De-kim, X. Y. De-li, I. De-lee, H. S. De-choi et al., A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial???mesenchymal transition, The Journal of Cell Biology, vol.36, issue.3, pp.417-433, 2011.
DOI : 10.1038/ncb1173

G. Khair, R. John, J. Monson, and J. Greenman, Epithelial Molecular Markers in the Peripheral Blood of Patients with Colorectal Cancer, Diseases of the Colon & Rectum, vol.50, issue.8, pp.1188-1203, 2007.
DOI : 10.1007/s10350-006-0875-9

C. I. Kobayashi and T. De-suda, Regulation of reactive oxygen species in stem cells and cancer stem cells, Journal of Cellular Physiology, vol.99, issue.2, pp.421-430, 2012.
DOI : 10.1073/pnas.192276999

T. Koepke, Cellules souches cancéreuses lié à la résistance aux radiations, Cancer Biol Ther, vol.5, p.1428, 2006.

P. J. Kowalski, M. A. Rubin, and C. G. Kleer, E-cadherin expression in primary carcinomas of the breast and its distant metastases, Breast Cancer Research, vol.106, issue.6, pp.217-222, 2003.
DOI : 10.1002/ijc.11197

F. Li, B. Tiede, J. Massague, and Y. Kang, Au-delà de tumorigenèse : cellules souches cancéreuses à la métastase, pp.3-14, 2007.

L. Juge, G. Hurteau, J. A. Carlson, S. D. Spivack, and G. J. Brock, La surexpression de la micro-ARN a-miR -200c conduit à une expression réduite de facteur de transcription 8 et augmentation de l'expression de la E-cadhérine. Cancer res, pp.7972-7976, 2007.

H. Liu, P. M. Prescher, J. A. , A. Patsialou, and D. Qian, Lin j de type. facultatif, et coll Cellules souches cancéreuses des tumeurs du sein humaines sont impliqués dans les métastases spontanées dans des modèles murins orthotopique, États-Unis d'Amérique de Proc Natl. Acad. Sci, pp.18115-18120, 2010.

L. Liu, G. Liao, P. He, H. Zhu, P. Liu et al., Detection of circulating cancer cells in lung cancer patients with a panel of marker genes, Biochemical and Biophysical Research Communications, pp.756-760, 2008.
DOI : 10.1016/j.bbrc.2008.05.101

. Liu-s, C. Ginestier, U. S. Clouthier, S. G. Le-juge-patel, S. H. Monville et al., Les cellules souches cancéreuses du sein sont réglementés par des cellules souches mésenchymateuses à travers des réseaux de cytokine. Cancer res, pp.614-624, 2011.

Z. Liu, M. Jiang, F. Yan, L. Xu, J. Zhao et al., Multipoint quantification of multimarker genes in peripheral blood and micrometastasis characteristic in peri-operative esophageal cancer patients, Cancer Letters, vol.261, issue.1, pp.46-54, 2008.
DOI : 10.1016/j.canlet.2007.11.001

H. Lou and M. Dean, Targeted therapy for cancer stem cells: the patched pathway and ABC transporters, Oncogene, vol.8, issue.9, pp.1357-1360, 2007.
DOI : 10.1038/nm0901-1028

E. Louie, S. Nik, J. S. Chen, M. Schmidt, and C. B. Paquin-c, Identification d'une population de cellules souches en exposant des lignées de cellules cancéreuses du sein métastatique à cycles répétitifs de l'hypoxie et la réoxygénation, Breast Cancer Res, 2010.

M. G. Mack and J. Rieger, Cervical lymph nodes, European Journal of Radiology, vol.66, issue.3, pp.493-500, 2008.
DOI : 10.1016/j.ejrad.2008.01.019

G. Mamelle and S. Temam, Role and perspectives of sentinel node biopsy in head and neck tumors], Cancer Radiother, vol.10, pp.6-7, 2006.

S. A. Mathieu, . Guo, M. J. Liao, E. N. Eaton, A. Ayyanan et al., La transition épithéliale-mésenchymateuse génère des cellules avec des propriétés de cellules souches, Cellule, vol.133, pp.704-715, 2008.

L. L. Marotta and K. Polyak, Cellules souches cancéreuses : un modèle en gestation, 2009.

R. Masood and S. R. Kumar, EphB4 provides survival advantage to squamous cell carcinoma of the head and neck, International Journal of Cancer, vol.10, issue.6, pp.1236-1284, 2006.
DOI : 10.3109/10428199909058438

W. Mcbride, F. Vlashi, E. , and H. , Résistance de rayonnement des cellules souches cancéreuses : les 4 R de radiobiologie revisité, Cellules souches, vol.28, pp.639-648, 2010.

A. Meltzer, Dormancy and breast cancer, Journal of Surgical Oncology, vol.33, issue.3, pp.181-188, 1990.
DOI : 10.1001/archsurg.1988.01400330035004

S. D. Micalizzi, S. M. Farabaugh, and H. L. Ford, Transition épithéliales ? mésenchymateuses dans le cancer : parallèles entre le développement normal et la progression tumorale, J. Biol, vol.15, pp.117-134, 2010.

Y. Miyazaki, M. Nakano, H. Sato, A. T. Truesdale, J. D. Stuart et al., Design and effective synthesis of novel templates, 3,7-diphenyl-4-amino-thieno and furo-[3,2-c]pyridines as protein kinase inhibitors and in vitro evaluation targeting angiogenetic kinases, Bioorganic & Medicinal Chemistry Letters, vol.17, issue.1, pp.250-254, 2007.
DOI : 10.1016/j.bmcl.2006.09.050

K. Moitra, H. Lou, and M. Dean, Pompes d'efflux multirésistante et le cancer des cellules souches : aperçus de résistance multirésistante et développement thérapeutique, 2011.

T. J. Molloy, A. J. Bosma, and L. Veer, Towards an optimized platform for the detection, enrichment, and semi-quantitation circulating tumor cells, Breast Cancer Research and Treatment, vol.56, issue.2, pp.297-307, 2008.
DOI : 10.1007/978-1-4757-2440-0

R. Murakami and H. Uozumi, Impact of FDG-PET/CT Imaging on Nodal Staging for Head-And-Neck Squamous Cell Carcinoma, International Journal of Radiation Oncology*Biology*Physics, vol.68, issue.2, pp.377-82, 2007.
DOI : 10.1016/j.ijrobp.2006.12.032

J. T. Nauseef and M. D. Henry, Epithelial-to-mesenchymal transition in prostate cancer: paradigm or puzzle?, Nature Reviews Urology, vol.32, issue.8, pp.428-439, 2011.
DOI : 10.1053/hupa.2001.26463

B. Newman, Y. Liu, H. F. Lee, D. Sun, and Y. Wang, Inhibiteur de HSP90 17-AAG élimine sélectivement les cellules souches lymphome. Cancer res, pp.4551-4561, 2012.

C. A. Brien, A. De-kreso, and D. J. , Cancer Stem Cells in Solid Tumors: An Overview, Seminars in Radiation Oncology, vol.19, issue.2, pp.71-77, 2009.
DOI : 10.1016/j.semradonc.2008.11.001

T. Ogawa and Y. Tsurusako, Comparison of Tumor Markers in Patients with Squamous Cell Carcinoma of the Head and Neck, Acta Oto-Laryngologica, vol.119, issue.3, pp.72-78, 1999.
DOI : 10.1080/00016489950181242

V. Paleri and G. Rees, Sentinel node biopsy in squamous cell cancer of the oral cavity and oral pharynx: A diagnostic meta-analysis, Head & Neck, vol.21, issue.9, pp.739-786, 2005.
DOI : 10.1001/archotol.126.3.410

R. Pardal, M. F. Clarke, and S. J. Morrison, Applying the principles of stem-cell biology to cancer, Nature Reviews Cancer, vol.297, issue.12, pp.895-902, 2003.
DOI : 10.1126/science.1071489

P. Gerard, A. B. , E. Lengyel, S. M. Peter, and M. E. , La famille miR-200 détermine le phénotype épithélial des cellules cancéreuses en ciblant les répresseurs de E-cadhérine, pp.894-907, 2008.

Y. Parc and S. L. Gerson, DNA Repair Defects in Stem Cell Function and Aging, Annual Review of Medicine, vol.56, issue.1, pp.495-508, 2005.
DOI : 10.1146/annurev.med.56.082103.104546

S. A. Patel, J. R. Meyer, S. J. Greco, K. E. Corcoran, M. Bryan et al., Cellules souches mésenchymateuses protéger les cellules cancéreuses du sein par l'intermédiaire des cellules T régulatrices, 2010.

P. Paterlini-brechot and L. N. Benali, Circulating tumor cells (CTC) detection: Clinical impact and future directions, Cancer Letters, vol.253, issue.2, pp.180-204, 2007.
DOI : 10.1016/j.canlet.2006.12.014

C. Potten, G. Owen, and D. , Cellules souches intestinales protéger leur génome par ségrégation sélective des brins d'ADN modèle, J. Cell Sci, vol.115, pp.2381-2388, 2002.

A. Raza, M. J. Franklin, and A. Z. Dudek, Maturation péricytes et navire pendant l'angiogenèse tumorale et les métastases, Mod. J. Hematol, vol.85, pp.593-598, 2010.

T. Reya, S. J. Morrison, M. F. Clarke, and I. L. Weissman, Des cellules souches, le cancer et les cellules souches cancéreuses, Nature, vol.414, issue.6859, pp.105-111, 2001.
DOI : 10.1038/35102167

J. N. Rich, Cellules souches cancéreuses dans la résistance aux radiations. Cancer res, pp.8980-8984, 2007.

G. L. Ross and D. S. Soutar, Improved Staging of Cervical Metastases in Clinically Node-Negative Patients With Head and Neck Squamous Cell Carcinoma, Annals of Surgical Oncology, vol.19, issue.2, pp.213-221, 2004.
DOI : 10.1200/JCO.2001.19.16.3635

G. L. Ross and D. S. Soutar, Sentinel Node Biopsy in Head and Neck Cancer: Preliminary Results of a Multicenter Trial, Annals of Surgical Oncology, vol.176, issue.7, pp.690-696, 2004.
DOI : 10.1159/000064143

P. L. Saharinen, K. Eklund, P. Pulkki, . Bono, and K. Alitalo, VEGF et angiopoietin signalisation dans l'angiogenèse tumorale et les métastases. Les tendances mol med, p.17, 2011.

C. Schem and N. Maass, One-step nucleic acid amplification???a molecular method for the detection of lymph node metastases in breast cancer patients; results of the German study group, Virchows Archiv, vol.40, issue.2, pp.203-213, 2009.
DOI : 10.1016/j.ejso.2006.09.013

G. Schleiermacher and O. Delattre, [Detection of micrometastases and circulating tumour cells using molecular biology technics in solid tumours], Bull Cancer, vol.88, issue.6, pp.561-70, 2001.

M. Schneider, D??tection et implications cliniques des cellules tumorales circulantes dans le cancer du sein, Oncologie, vol.8, issue.3, pp.295-296, 2006.
DOI : 10.1007/s10269-006-0377-3

S. Seton-rogers, VEGF promotes stemness, Nature Reviews Cancer, vol.478, issue.12, p.831, 2011.
DOI : 10.1038/nature10525

H. Shi, Y. Zhang, J. Zheng, and J. Pan, Les espèces réactives de l'oxygène dans le cancer des cellules souches. Antioxid. Signal de redox, pp.1215-1228, 2012.

C. G. Shores and X. Yin, Clinical Evaluation of a New Molecular Method for Detection of Micrometastases in Head and Neck Squamous Cell Carcinoma, Archives of Otolaryngology???Head & Neck Surgery, vol.130, issue.8, pp.937-979, 2004.
DOI : 10.1001/archotol.130.8.937

V. Six, B. Gayraud-morel, D. De-gomes, and S. Tajbakhsh, Division asymétrique et coségrégation de modèle ADN chapelets en cellules satellites musculaires adultes, 2006.

H. Siemens, R. Jackstadt, S. Hunten, M. Kaller, A. Menssen et al., miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions, Cell Cycle, vol.10, issue.24, pp.4256-4271, 2011.
DOI : 10.4161/cc.10.24.18552

U. K. Sinha and A. Kundra, Expression of EphB4 in head and neck squamous cell carcinoma, Ear Nose Throat J, vol.82, issue.11, pp.866-869, 2003.

U. K. Sinha and K. Mazhar, The Association Between Elevated EphB4 Expression, Smoking Status, and Advanced-Stage Disease in Patients With Head and Neck Squamous Cell Carcinoma, Archives of Otolaryngology???Head & Neck Surgery, vol.132, issue.10, pp.1053-1062, 2006.
DOI : 10.1001/archotol.132.10.1053

J. Solassol and V. Burcia, Pemphigus vulgaris antigen mRNA quantification for the staging of sentinel lymph nodes in head and neck cancer, British Journal of Cancer, vol.8, issue.1, pp.181-188, 2010.
DOI : 10.1001/archotol.128.7.751

P. S. Steeg, Métastases tumorales : perspicacités mécanistes et défis cliniques, 2006.

S. J. Stoeckli and L. W. Alkureishi, Sentinel node biopsy for early oral and oropharyngeal squamous cell carcinoma, European Archives of Oto-Rhino-Laryngology, vol.26, issue.7, pp.787-93, 2009.
DOI : 10.1001/archotol.127.8.970

S. J. Stoeckli and M. Pfaltz, Histopathological Features of Occult Metastasis Detected by Sentinel Lymph Node Biopsy in Oral and Oropharyngeal Squamous Cell Carcinoma, The Laryngoscope, vol.437, issue.1, pp.111-116, 2002.
DOI : 10.1007/s004280000199

S. J. Stoeckli and M. Pfaltz, The Second International Conference on Sentinel Node Biopsy in Mucosal Head and Neck Cancer, Annals of Surgical Oncology, vol.86, issue.(9 Suppl), pp.919-943, 2005.
DOI : 10.1001/archotol.128.11.1287

J. W. Uhr, E. De-vitetta-scheuermann, R. H. , and N. E. , Cancer dormancy: Opportunities for new therapeutic approaches, Nature Medicine, vol.343, issue.5, pp.505-509, 1997.
DOI : 10.1038/nm0196-52

E. Vincan, T. Brabletz, M. C. Faux, and R. R. , Un modèle de ligne de cellules en trois dimensions humaines permet l'étude de transition épithéliale-mésenchymateuse et mésenchymateuses ? épithéliales dynamique et réversible qui sous, pp.20-28, 2007.

J. E. Visvader and G. J. Lefevre, Cancer stem cells in solid tumours: accumulating evidence and unresolved questions, Nature Reviews Cancer, vol.63, issue.10, pp.755-768, 2008.
DOI : 10.1158/0008-5472.CAN-06-3126

M. Vippman, S. Wang, D. Yang, and E. , Ciblant Bcl-2 et Bcl-XL avec ces petites molécules antagonistes, Semin. Oncol, vol.30, pp.133-142, 2003.

M. Visser and M. Jiwa, Intra-operative rapid diagnostic method based on CK19 mRNA expression for the detection of lymph node metastases in breast cancer, International Journal of Cancer, vol.80, issue.11, pp.2562-2569, 2008.
DOI : 10.1038/bjc.1997.516

Z. Wang, Y. Li, and F. H. Simon, Des espèces réactives de l'oxygène en transition épithéliale-mésenchymateuse réminiscence des cellules souches du cancer dans la progression tumorale ou les mécanismes de signalisation, pp.74-80, 2010.

P. J. Weigelt and L. J. Van-'t-veer, Breast cancer metastasis: markers and models, Nature Reviews Cancer, vol.9, issue.8, pp.591-602, 2005.
DOI : 10.1038/nm0803-999b

L. Weiss, Metastatic Inefficiency, Adv. Cancer Res, vol.54, pp.159-211, 1990.
DOI : 10.1016/S0065-230X(08)60811-8

L. Weiss, Commentaires sur les modèles métastatiques hématogène chez l'être humain telle que révélée par l'autopsie, Clin. Exp. métastases, 1992.

N. A. Williams and E. D. , Les facteurs de croissance dans l'induction de transition épithéliale-mésenchymateuse et métastase. Cellules tissus organes 193, pp.85-97, 2011.

J. K. Wu, Activation de Bmi1 par Twist1 direct : implications dans la stemness du cancer, transition épithéliale-mésenchymateuse et signification clinique, Chang Gung med J, vol.34, pp.229-238, 2011.

K. J. Wu and M. H. Yang, Epithelial???mesenchymal transition and cancer stemness: the Twist1???Bmi1 connection, Bioscience Reports, vol.62, issue.6, pp.449-455, 2011.
DOI : 10.1172/JCI39374

D. Yao, C. Dai, and S. Peng, Mécanisme de la transition mésenchymateuses ? épithéliales et sa relation avec la formation de tumeurs métastatiques, Mol Cancer Res, issue.9, 2011.

C. C. Yates, D. R. Shepard-c, B. Stolz, and A. , Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin, British Journal of Cancer, vol.92, issue.8, pp.1246-1252, 2007.
DOI : 10.1083/jcb.200212033

M. Yilmaz and G. Christofori, Invasion des cellules EMT, 2009.

M. H. Yoo and D. L. Hatfield, La théorie des cellules souches du cancer : est-ce correct?, 2008.

L. Xi, D. Nicastri, T. El-hefnawy, S. Hugues, J. Luketich et al., Optimal Markers for Real-Time Quantitative Reverse Transcription PCR Detection of Circulating Tumor Cells from Melanoma, Breast, Colon, Esophageal, Head and Neck, and Lung Cancers, Clinical Chemistry, vol.53, issue.7, 2007.
DOI : 10.1373/clinchem.2006.081828