Spectral, spatial and temporal properties of multilayered epithelial tissue in vivo in presence of metal nanoparticles in multimodal spectroscopy

Abstract : The thesis work is devoted to spatially-, temporally- and spectrally- resolved laser and biological tissue interactions. The aim of the present thesis was to investigate the influence of colloidal nanoparticles embedded into multilayered biological tissues on their optical properties in order to provide deeper and/or more precise probing. To do so, the integral spectroscopic parameters and lifetime of fluorophore in vicinity of metal nanoparticles were analyzed theoretically and experimentally. Another part of the study was to propose new algorithmic solutions for improving the performance of the estimation process of the optical properties values from spatially resolved spectroscopic measurements. The last part of the thesis was the experimental and theoretical modelling of fluorophore’s kinetics in presence of colloidal gold nanoparticles. The ultra-short pico-second component (around 100 ps) was resolved and correlated to strong nanoparticles dipole field which is compensating the molecule’s dipole
Complete list of metadatas

Cited literature [8 references]  Display  Hide  Download

https://hal.univ-lorraine.fr/tel-01752206
Contributor : Thèses Ul <>
Submitted on : Thursday, March 29, 2018 - 1:38:18 PM
Last modification on : Saturday, March 30, 2019 - 2:05:07 AM

File

DDOC_T_2016_0031_KHOLODTSOVA.p...
Files produced by the author(s)

Identifiers

  • HAL Id : tel-01752206, version 1

Citation

Maria Kholodtsova. Spectral, spatial and temporal properties of multilayered epithelial tissue in vivo in presence of metal nanoparticles in multimodal spectroscopy. Other. Université de Lorraine, 2016. English. ⟨NNT : 2016LORR0031⟩. ⟨tel-01752206v1⟩

Share

Metrics

Record views

50

Files downloads

14