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Synthèse de nanoparticules à propriétés de surface contrôlées par polymérisation en miniémulsion pour la vectorisation de molécules actives

Abstract : The aim of this study was the one-step synthesis via miniemulsion polymerization, of nanoparticles with a hydrophobic core based on poly(n-butyl cyanoacrylate) and a hydrophilic shell. Two families of amphiphilic polymers were used to stabilize the miniemulsion. The first one was constituted of three dextran derivatives synthesized in the laboratory: DexP11, DexP16 and DexP22. The other three stabilizers were commercial products based on PEO: Brij®78, Brij®700, and Tween®80. Their stability under the conditions used for miniemulsion polymerization was checked. Their adsorption at oil-water interface was studied by dynamic surface tension measurement. Despite the high reactivity of the monomer, nanoparticles of poly(n-butyl cyanoacrylate) were synthesized via anionic and/or radical miniemulsion polymerization. Particle size, surface coverage and hydrophilic layer thickness were controlled by the structure and the amount of the amphiphilic polymer in the continuous phase, while the molar mass of the poly(n-butyl cyanoacrylate) depending on the pH of the continuous phase and the polymerization mechanism (anionic or radical). Finally, the encapsulation and the release of a model compound were studied
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https://hal.univ-lorraine.fr/tel-01752832
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Man Wu. Synthèse de nanoparticules à propriétés de surface contrôlées par polymérisation en miniémulsion pour la vectorisation de molécules actives. Génie des procédés. Institut National Polytechnique de Lorraine, 2007. Français. ⟨NNT : 2007INPL101N⟩. ⟨tel-01752832⟩

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