M. Gütschow, L. Kuerschner, U. Neumann, M. Pietsch, R. Löser et al., 2-(Diethylamino)thieno[1,3]oxazin-4-ones as Stable Inhibitors of Human Leukocyte Elastase, Journal of Medicinal Chemistry, vol.42, issue.26, pp.5437-5447, 1999.
DOI : 10.1021/jm991108w

A. K. Mukerjee and R. Ashare, Isothiocyanates in the chemistry of heterocycles, Chemical Reviews, vol.91, issue.1, pp.1-24, 1991.
DOI : 10.1021/cr00001a001

R. D. Carpenter, K. S. Lam, and M. J. Kurth, )-ones, The Journal of Organic Chemistry, vol.72, issue.1, pp.284-287, 2007.
DOI : 10.1021/jo0618066

F. Delmas, A. Avellaneda, C. D. Giorgio, M. , R. et al., Synthesis and antileishmanial activity of (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone derivatives, European Journal of Medicinal Chemistry, vol.39, issue.8, pp.685-690, 2004.
DOI : 10.1016/j.ejmech.2004.04.006

E. ?imonová-;-m, . Henselová-;-p, and . Zahradník, Benzothiazole derivatives substituted in position 2 as biologically active substances with plant growth regulation activity, Plant, Soil and Environment, vol.51, issue.No. 11, pp.496-505, 2005.
DOI : 10.17221/3623-PSE

G. D. Wells-;-t, . Brdshaw-;-p, ;. A. Diana, . Seaton-;-d-f, and . Shi, Antitumour benzothiazoles. Part 10: The synthesis and antitumour activity of benzothiazole substituted quinol derivatives, Bioorganic & Medicinal Chemistry Letters, vol.10, issue.5, pp.513-515, 2000.
DOI : 10.1016/S0960-894X(00)00027-5

R. Alan, C. Katritzky, and W. , Comprehensive heterocyclic chemistry, p.302

P. Jacobsen, Ueber Bildung von Anhydroverbindungen des Orthoamidophenylmercaptans aus Thioaniliden, Berichte der deutschen chemischen Gesellschaft, vol.207, issue.1, p.1067
DOI : 10.1002/cber.188601901239

1. Dans-un-ballon-des, 1éq) de thio-urée sont dissous N -(4-Méthoxyphényl)-4,5-dihydronaphto[1,2-b]thiéno[3,2-d][1,3]thiazol-2-amine (141) Rendement: 62 % Aspect: solide brun Point de fusion: 135 °C RMN 1 H (250 MHz, Hz, vol.100, issue.9, pp.5-8632516191195

S. Karkola, A. Lilienkampf, and K. Wähälä, A 3D QSAR Model of 17??-HSD1 Inhibitors Based on a Thieno[2,3-d]pyrimidin-4(3H)-one Core Applying Molecular Dynamics Simulations and Ligand???Protein Docking, ChemMedChem, vol.18, issue.3, p.461, 2008.
DOI : 10.1007/s008940100045

R. W. Sabnis and D. W. Rangnekar, Synthesis of azo benzo[b]thiophene derivatives and their application as disperse dyes, Dyes and Pigments, vol.10, issue.4, p.295, 1989.
DOI : 10.1016/0143-7208(89)85017-X

K. Gewald, Heterocyclen aus CH-aciden Nitrilen, VII. 2-Amino-thiophene aus ??-Oxo-mercaptanen und methylenaktiven Nitrilen, Chemische Berichte, vol.659, issue.11, p.3571, 1965.
DOI : 10.1002/cber.19650981120

K. Gewald, E. Schinke, and . Botcher, Heterocyclen aus CH-aciden Nitrilen, VIII. 2-Amino-thiophene aus methylenaktiven Nitrilen, Carbonylverbindungen und Schwefel, Chemische Berichte, vol.1963, issue.1, p.94, 1966.
DOI : 10.1002/cber.19660990116

G. Kirsch, D. Cagniant, and P. Cagniant, Synth??se d'amino-3 thioph??nes a partir d'aryl-et d'h??taryl-ac??tonitrile, Journal of Heterocyclic Chemistry, vol.13, issue.3, p.443, 1982.
DOI : 10.1002/jhet.5570190248

K. Gewald and U. Hain, Substituted 3-amino-thiophenes and 3-amino-selenophenes from ?-chloro-?-cyano-cinnamonitrile, Monatshefte f???r Chemie Chemical Monthly, vol.95, issue.5, p.455, 1992.
DOI : 10.1007/BF00817601

K. Friedrich and K. Wallansfels, In the chemistry of cyano group; Rappoport, Z, 1979.

M. Aadil and G. Kirsch, phosphorus sulfur, and silicon, p.91, 1993.

G. Kirsch, D. Cagniant, and P. Cagniant, Synth??se d'amino-3 thioph??nes a partir d'aryl-et d'h??taryl-ac??tonitrile, Journal of Heterocyclic Chemistry, vol.13, issue.3, p.443, 1982.
DOI : 10.1002/jhet.5570190248

S. Karkola, A. Lilienkampf, and K. Wähälä, A 3D QSAR Model of 17??-HSD1 Inhibitors Based on a Thieno[2,3-d]pyrimidin-4(3H)-one Core Applying Molecular Dynamics Simulations and Ligand???Protein Docking, ChemMedChem, vol.18, issue.3, p.461, 2008.
DOI : 10.1007/s008940100045

R. J. Ife, T. H. Brown, P. Blurton, D. J. Keeling, C. A. Leach et al., Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 5. Substituted 2,4-Diaminoquinazolines and Thienopyrimidines, Journal of Medicinal Chemistry, vol.38, issue.14, p.2763, 1995.
DOI : 10.1021/jm00014a027

J. C. Jaén, E. V. Gregor, C. Lee, R. Davis, and M. Emmerling, Acetylcholinesterase inhibition by fused dihydroquinazoline compounds, Bioorganic & Medicinal Chemistry Letters, vol.6, issue.6, p.737, 1996.
DOI : 10.1016/0960-894X(96)00102-3

D. Luca, L. Giacomelli, G. Porcheddu, and A. , Beckmann Rearrangement of Oximes under Very Mild Conditions, The Journal of Organic Chemistry, vol.67, issue.17, p.6272, 2002.
DOI : 10.1021/jo025960d

R. D. Carpenter, K. S. Lam, and M. J. Kurth, )-ones, The Journal of Organic Chemistry, vol.72, issue.1, p.284, 2007.
DOI : 10.1021/jo0618066

W. H. Lunn, R. W. Harper, and R. L. Stone, Benzimidazo[2,1-b]quinazolin-12-ones. New class of potent immunosuppressive compounds, Journal of Medicinal Chemistry, vol.14, issue.11, p.1069, 1971.
DOI : 10.1021/jm00293a012

M. Gütschow, L. Kuerschner, U. Neumann, M. Pietsch, R. Löser et al., 2-(Diethylamino)thieno[1,3]oxazin-4-ones as Stable Inhibitors of Human Leukocyte Elastase, Journal of Medicinal Chemistry, vol.42, issue.26, p.5437, 1999.
DOI : 10.1021/jm991108w

A. Santagati, J. Longmore, S. Guccione, T. Langer, E. Tonnel et al., Building a model of interaction at the NK-2 receptors: Polycondensed heterocycles containing the pyrimidoindole skeleton, European Journal of Medicinal Chemistry, vol.32, issue.12, p.973, 1997.
DOI : 10.1016/S0223-5234(97)89641-9

P. Vicini, A. Geronikaki, K. Anastasia, M. Incerti, and F. Zani, Synthesis and antimicrobial activity of novel 2-thiazolylimino-5-arylidene-4-thiazolidinones, Bioorganic & Medicinal Chemistry, vol.14, issue.11, p.3859, 2006.
DOI : 10.1016/j.bmc.2006.01.043

F. Delmas, A. Avellaneda, C. Di-giorgio, M. Robin, E. De-clercq et al., Synthesis and antileishmanial activity of (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone derivatives, European Journal of Medicinal Chemistry, vol.39, issue.8, p.685, 2004.
DOI : 10.1016/j.ejmech.2004.04.006

G. Wells, T. D. Brdshaw, P. Diana, A. Seaton, and D. Shi, Antitumour benzothiazoles. Part 10: The synthesis and antitumour activity of benzothiazole substituted quinol derivatives, Bioorganic & Medicinal Chemistry Letters, vol.10, issue.5, p.513, 2000.
DOI : 10.1016/S0960-894X(00)00027-5

P. Jacobson, Ueber Bildung von Anhydroverbindungen des Orthoamidophenylmercaptans aus Thioaniliden, Berichte der deutschen chemischen Gesellschaft, vol.207, issue.1, p.1067
DOI : 10.1002/cber.188601901239

M. L. Xiao, F. H. Chen, Z. J. Chen, B. S. Guo, X. H. Lv et al., Facile synthesis of thiourea derivatives in ionic liquid, Chinese Chemical Letters, vol.18, issue.3, p.258, 2007.
DOI : 10.1016/j.cclet.2007.01.036

S. Saeed, N. Rashid, M. Ali, R. Hussain, and P. Jones, Synthesis, spectroscopic characterization, crystal structure and pharmacological properties of some novel thiophene-thiourea core derivatives, European Journal of Chemistry, vol.1, issue.3, p.221, 2010.
DOI : 10.5155/eurjchem.1.3.221-227.124

S. D. Bose and M. Idrees, A convenient access to substituted benzothiazole scaffolds via intramolecular cyclization of thioformanilides, Tetrahedron Letters, vol.48, issue.4, p.669, 2007.
DOI : 10.1016/j.tetlet.2006.11.105

. La-possibilité-d, accès à partir des dérivés amino-ester aux dérivés aminés nous a permis la construction de nouveaux systèmes hétérocycliques substituant du noyau thiophénique tels les 2-chloro N-(3-thiényl) acétamides, isothiocyanates et N-(3-thiényl) thio-urée, utilisés pour la synthèse des systèmes condensés tels les 1,3-thiazolidinones et les thiéno, p.3