M. Kappelman, S. Rifas-shiman, K. Kleinman, D. Ollendorf, A. Bousvaros et al., The Prevalence and Geographic Distribution of Crohn???s Disease and Ulcerative Colitis in the United States, Clinical Gastroenterology and Hepatology, vol.5, issue.12, 2007.
DOI : 10.1016/j.cgh.2007.07.012

C. Loftus, E. Loftus, W. Harmsen, A. Zinsmeister, W. Tremaine et al., Update on incidence and prevalence of Crohn's disease (CD) and ulcerative colitis (UC) in olmsted county, minnesota, Gastroenterology, vol.124, issue.4, pp.254-61, 1940.
DOI : 10.1016/S0016-5085(03)80177-4

A. Sonnenberg and J. Chang, Time trends of physician visits for Crohn??s disease and ulcerative colitis in the United States, 1960???2006, Inflammatory Bowel Diseases, vol.94, issue.2, pp.249-52, 1960.
DOI : 10.1016/S0140-6736(07)60751-X

G. Nguyen, A. Tuskey, T. Dassopoulos, M. Harris, and S. Brant, Rising hospitalization rates for inflammatory bowel disease in the United States between 1998 and 2004#, Inflammatory Bowel Diseases, vol.149, issue.12, pp.1529-1564, 1998.
DOI : 10.1053/j.gastro.2004.01.063

C. Bernstein and A. Nabalamba, Hospitalization, Surgery, and Readmission Rates of IBD in Canada: A Population-Based Study, The American Journal of Gastroenterology, vol.10, issue.1, pp.110-118, 2006.
DOI : 10.1016/S0016-5085(99)70549-4

W. Faubion, E. Loftus, W. Harmsen, A. Zinsmeister, and W. Sandborn, The natural history of corticosteroid therapy for inflammatory bowel disease: A population-based study, Gastroenterology, vol.121, issue.2, pp.255-60, 2001.
DOI : 10.1053/gast.2001.26279

L. Peyrin-biroulet, A. Cieza, W. Sandborn, M. Coenen, Y. Chowers et al., Development of the first disability index for inflammatory bowel disease based on the international classification of functioning, disability and health, Gut, vol.61, issue.2, pp.241-248, 2012.
DOI : 10.1136/gutjnl-2011-300049

URL : https://hal.archives-ouvertes.fr/hal-00683081

J. Cosnes, C. Gower-rousseau, P. Seksik, and A. Cortot, Epidemiology and Natural History of Inflammatory Bowel Diseases, Gastroenterology, vol.140, issue.6, pp.1785-94, 2011.
DOI : 10.1053/j.gastro.2011.01.055

URL : https://hal.archives-ouvertes.fr/hal-00631553

L. Peyrin-biroulet, E. Loftus, J. Colombel, and W. Sandborn, Long-term complications, extraintestinal manifestations, and mortality in adult Crohn??s disease in population-based cohorts, Inflammatory Bowel Diseases, vol.6, issue.1, pp.471-479, 2011.
DOI : 10.1016/j.cgh.2008.03.014

T. Yamamoto, R. Allan, and M. Keighley, Risk factors for intra-abdominal sepsis after surgery in Crohn??s disease, Diseases of the Colon & Rectum, vol.43, issue.8, pp.1141-1146, 2000.
DOI : 10.1007/BF02236563

V. Billioud, A. Ford, E. Tedesco, J. Colombel, X. Roblin et al., Preoperative use of anti-TNF therapy and postoperative complications in inflammatory bowel diseases: A meta-analysis, Journal of Crohn's and Colitis, vol.30, issue.11, pp.853-67, 2013.
DOI : 10.1016/S0016-5085(03)00883-7

URL : https://hal.archives-ouvertes.fr/hal-01706822

P. Rutgeerts, K. Geboes, G. Vantrappen, J. Beyls, R. Kerremans et al., Predictability of the postoperative course of Crohn's disease, Gastroenterology, vol.99, issue.4, pp.956-63, 1990.
DOI : 10.1016/0016-5085(90)90613-6

P. Rutgeerts, K. Geboes, G. Vantrappen, R. Kerremans, J. Coenegrachts et al., Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery. Gut, pp.665-72, 1984.

A. Buisson, J. Chevaux, P. Allen, G. Bommelaer, and L. Peyrin-biroulet, Review article: the natural history of postoperative Crohn's disease recurrence, Alimentary Pharmacology & Therapeutics, vol.152, issue.Suppl. 2, pp.625-658, 2012.
DOI : 10.1016/j.jss.2008.04.014

F. Michelassi, T. Balestracci, R. Chappell, and G. Block, Primary and Recurrent Crohn??s Disease, Annals of Surgery, vol.214, issue.3, pp.230-238, 1991.
DOI : 10.1097/00000658-199109000-00006

Y. Trnka, D. Glotzer, E. Kasdon, H. Goldman, M. Steer et al., The Long-term Outcome of resorative Operation in Crohn;s Disease, Annals of Surgery, vol.196, issue.3, pp.345-55, 1982.
DOI : 10.1097/00000658-198209000-00014

J. Hugot, M. Chamaillard, H. Zouali, S. Lesage, J. Cézard et al., Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease, Nature, vol.411, issue.6837, pp.599-603, 2001.
DOI : 10.1038/35079107

Y. Ogura, D. Bonen, N. Inohara, D. Nicolae, F. Chen et al., A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease, Nature, vol.411, issue.6837, pp.603-609, 2001.
DOI : 10.1038/35079114

S. Ng, C. Bernstein, M. Vatn, P. Lakatos, E. Loftus et al., Geographical variability and environmental risk factors in inflammatory bowel disease, Gut, vol.62, issue.4, p.2013
DOI : 10.1136/gutjnl-2012-303661

N. Molodecky, I. Soon, D. Rabi, W. Ghali, M. Ferris et al., Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review, Gastroenterology, vol.142, issue.1, pp.46-54, 2012.
DOI : 10.1053/j.gastro.2011.10.001

C. Gower-rousseau, F. Vasseur, M. Fumery, G. Savoye, J. Salleron et al., Epidemiology of inflammatory bowel diseases: new insights from a French populationbased registry (EPIMAD) Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver, Feb, vol.45, issue.2, pp.89-94, 2013.

K. Thia, W. Sandborn, W. Harmsen, A. Zinsmeister, and E. Loftus, Risk Factors Associated With Progression to Intestinal Complications of Crohn's Disease in a Population-Based Cohort, Gastroenterology, vol.139, issue.4, pp.1147-55, 2010.
DOI : 10.1053/j.gastro.2010.06.070

D. Schwartz, E. Loftus, W. Tremaine, R. Panaccione, W. Harmsen et al., The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota. Gastroenterology, pp.875-80, 2002.

A. Lapidus, Crohn???s disease in Stockholm County during 1990-2001: An epidemiological update, World Journal of Gastroenterology, vol.12, issue.1, pp.75-81, 2006.
DOI : 10.1136/gut.2004.047282

T. Jess, M. Gamborg, P. Matzen, P. Munkholm, and T. Sørensen, Increased Risk of Intestinal Cancer in Crohn's Disease: A Meta-Analysis of Population-Based Cohort Studies, The American Journal of Gastroenterology, vol.107, issue.2, pp.2724-2733, 2005.
DOI : 10.1111/j.1572-0241.2003.08671.x

T. Jess, L. Riis, I. Vind, K. Winther, S. Borg et al., Changes in Clinical Characteristics, Course, and Prognosis of Inflammatory Bowel Disease during the Last 5 Decades: A Population-Based Study from Copenhagen, Denmark, Inflammatory Bowel Diseases, vol.55, issue.4, 2007.
DOI : 10.1136/gut.2005.079350

V. Roon, A. Reese, G. Teare, J. Constantinides, V. Darzi et al., The risk of cancer in patients with Crohn's disease. Dis Colon Rectum, pp.839-55, 2007.

C. Canavan, K. Abrams, and J. Mayberry, Meta-analysis: mortality in Crohn???s disease, Alimentary Pharmacology & Therapeutics, vol.21, issue.7, pp.861-70, 2007.
DOI : 10.1111/j.1365-2036.2006.03132.x

D. Duricova, N. Pedersen, M. Elkjaer, M. Gamborg, P. Munkholm et al., Overall and cause-specific mortality in Crohn??s disease: A meta-analysis of population-based studies, Inflammatory Bowel Diseases, vol.309, issue.2, pp.347-53, 2010.
DOI : 10.1126/science.1114233

M. Silverberg, J. Satsangi, T. Ahmad, I. Arnott, C. Bernstein et al., Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology, Montreal World Congress of Gastroenterology, pp.5-36, 2005.
DOI : 10.1155/2005/269076

A. Kaser, S. Zeissig, and R. Blumberg, Inflammatory Bowel Disease, Annual Review of Immunology, vol.28, issue.1, pp.573-621, 2010.
DOI : 10.1146/annurev-immunol-030409-101225

M. Russel, A. Volovics, E. Schoon, E. Van-wijlick, R. Logan et al., Inflammatory bowel disease: is there any relation between smoking status and disease presentation? European Collaborative IBD Study Group, Inflamm Bowel Dis, 1998.

J. Cosnes, Tobacco and IBD: relevance in the understanding of disease mechanisms and clinical practice, Best Practice & Research Clinical Gastroenterology, vol.18, issue.3, pp.481-96, 2004.
DOI : 10.1016/j.bpg.2003.12.003

J. Cosnes, What is the link between the use of tobacco and IBD? Inflamm Bowel Dis, pp.14-19, 2008.

J. Cosnes, F. Carbonnel, F. Carrat, L. Beaugerie, S. Cattan et al., Effects of current and former cigarette smoking on the clinical course of Crohn's disease, Alimentary Pharmacology and Therapeutics, vol.30, issue.11, pp.1403-1414, 1999.
DOI : 10.1001/archinte.157.12.1371

S. Mahid, K. Minor, R. Soto, C. Hornung, and S. Galandiuk, Smoking and Inflammatory Bowel Disease: A Meta-analysis, Mayo Clinic Proceedings, vol.81, issue.11, pp.1462-71, 2006.
DOI : 10.4065/81.11.1462

V. Bergeron, V. Grondin, S. Rajca, M. Maubert, B. Pigneur et al., Current smoking differentially affects blood mononuclear cells from patients with Crohn's disease and ulcerative colitis: relevance to its adverse role in the disease, Inflamm Bowel Dis, 2012.

G. Kaplan, T. Jackson, B. Sands, M. Frisch, R. Andersson et al., The Risk of Developing Crohn's Disease After an Appendectomy: A Meta-Analysis, The American Journal of Gastroenterology, vol.344, issue.11, pp.2925-2956, 2008.
DOI : 10.3748/wjg.v12.i8.1235

L. García-rodríguez, A. González-pérez, S. Johansson, and M. Wallander, Risk factors for inflammatory bowel disease in the general population, Alimentary Pharmacology and Therapeutics, vol.37, issue.4, pp.309-324, 2005.
DOI : 10.1111/j.1365-2036.2004.02270.x

E. Klement, J. Lysy, M. Hoshen, M. Avitan, E. Goldin et al., Childhood Hygiene Is Associated With the Risk for Inflammatory Bowel Disease: A Population-Based Study, The American Journal of Gastroenterology, vol.299, issue.7, pp.1775-82, 2008.
DOI : 10.1111/j.1572-0241.2008.01905.x

D. Amre, D. Souza, S. Morgan, K. Seidman, G. Lambrette et al., Imbalances in Dietary Consumption of Fatty Acids, Vegetables, and Fruits Are Associated With Risk for Crohn's Disease in Children, The American Journal of Gastroenterology, vol.12, issue.170, pp.2016-2041, 2007.
DOI : 10.1136/gut.2004.054353

J. Hou, B. Abraham, and H. El-serag, Dietary Intake and Risk of Developing Inflammatory Bowel Disease: A Systematic Review of the Literature, The American Journal of Gastroenterology, vol.19, issue.4, pp.563-73
DOI : 10.1136/bmj.280.6210.293-a

S. Lesage, H. Zouali, J. Cézard, J. Colombel, J. Belaiche et al., CARD15/NOD2 Mutational Analysis and Genotype-Phenotype Correlation in 612 Patients with Inflammatory Bowel Disease, The American Journal of Human Genetics, vol.70, issue.4, pp.845-57, 2002.
DOI : 10.1086/339432

P. Rosenstiel, M. Fantini, K. Bräutigam, T. Kühbacher, G. Waetzig et al., TNF-?? and IFN-?? regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells, Gastroenterology, vol.124, issue.4, pp.1001-1010, 2003.
DOI : 10.1053/gast.2003.50157

M. Pierik, S. Joossens, K. Van-steen, V. Schuerbeek, N. Vlietinck et al., Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases, Inflammatory Bowel Diseases, vol.53, issue.1, pp.1-8, 2006.
DOI : 10.1136/gut.2003.034033

J. Wehkamp, M. Schmid, K. Fellermann, and E. Stange, Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn???s disease, Journal of Leukocyte Biology, vol.112, issue.Suppl. 3, pp.460-465, 2005.
DOI : 10.1016/j.clim.2004.03.002

R. Xavier and D. Podolsky, Unravelling the pathogenesis of inflammatory bowel disease, Nature, vol.124, issue.7152, pp.427-461, 2007.
DOI : 10.4049/jimmunol.176.2.705

R. Kastelein, C. Hunter, and D. Cua, Discovery and Biology of IL-23 and IL-27: Related but Functionally Distinct Regulators of Inflammation, Annual Review of Immunology, vol.25, issue.1, pp.221-263, 2007.
DOI : 10.1146/annurev.immunol.22.012703.104758

J. Barrett, S. Hansoul, D. Nicolae, J. Cho, R. Duerr et al., Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease, Nature Genetics, vol.179, issue.8, pp.955-62, 2008.
DOI : 10.1021/bi060570x

D. Yen, J. Cheung, H. Scheerens, F. Poulet, T. Mcclanahan et al., IL-23 is essential for T cell???mediated colitis and promotes inflammation via IL-17 and IL-6, Journal of Clinical Investigation, vol.116, issue.5, pp.1310-1316, 2006.
DOI : 10.1172/JCI21404

M. Orholm, V. Binder, T. Sørensen, L. Rasmussen, and K. Kyvik, Concordance of inflammatory bowel disease among Danish twins. Results of a nationwide study, Scand J Gastroenterol, vol.35, issue.10, pp.1075-81, 2000.

N. Thompson, R. Driscoll, R. Pounder, and A. Wakefield, Genetics versus environment in inflammatory bowel disease: results of a British twin study, BMJ, vol.312, issue.7023, pp.95-101, 1996.
DOI : 10.1136/bmj.312.7023.95

M. Russel, C. Pastoor, K. Janssen, C. Van-deursen, J. Muris et al., Familial aggregation of inflammatory bowel disease: a population-based study in South Limburg, The Netherlands. The South Limburg IBD Study Group, Scand J Gastroenterol Suppl, vol.223, pp.88-91, 1997.

U. Monsén, O. Bernell, C. Johansson, and G. Hellers, Prevalence of Inflammatory Bowel Disease among Relatives of Patients with Crohn's Disease, Scandinavian Journal of Gastroenterology, vol.36, issue.490, 1991.
DOI : 10.1136/gut.29.7.990

L. Jostins, S. Ripke, R. Weersma, R. Duerr, D. Mcgovern et al., Host???microbe interactions have shaped the genetic architecture of inflammatory bowel disease, Nature, vol.286, issue.7422, pp.119-143, 2012.
DOI : 10.1074/jbc.M111.291492

K. Kobayashi, M. Chamaillard, Y. Ogura, O. Henegariu, N. Inohara et al., Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract, Science, vol.307, issue.5710, pp.731-735, 2005.
DOI : 10.1126/science.1104911

C. Abraham and J. Cho, Functional consequences of NOD2 (CARD15) mutations, Inflammatory Bowel Diseases, vol.101, issue.7, pp.641-50, 2006.
DOI : 10.1073/pnas.0308680101

J. Yamamoto-furusho, N. Barnich, R. Xavier, T. Hisamatsu, and D. Podolsky, Centaurin ??1 Down-regulates Nucleotide-binding Oligomerization Domains 1- and 2-dependent NF-??B Activation, Journal of Biological Chemistry, vol.15, issue.47, pp.36060-70, 2006.
DOI : 10.1038/sj.emboj.7600588

L. Peyrin-biroulet, C. Vignal, R. Dessein, M. Simonet, P. Desreumaux et al., NODs in defence: from vulnerable antimicrobial peptides to chronic inflammation, Trends in Microbiology, vol.14, issue.10, pp.432-440, 2006.
DOI : 10.1016/j.tim.2006.08.008

S. Naser, M. Arce, A. Khaja, M. Fernandez, N. Naser et al., Role of ATG16L, NOD2 and IL23R in Crohn's disease pathogenesis, World J Gastroenterol WJG Feb, vol.718, issue.5, pp.412-436, 2012.

J. Rioux, R. Xavier, K. Taylor, M. Silverberg, P. Goyette et al., Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis, Nature Genetics, vol.19, issue.5, pp.596-604, 2007.
DOI : 10.4049/jimmunol.171.6.3010

M. Parkes, J. Barrett, N. Prescott, M. Tremelling, C. Anderson et al., Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility, Nature Genetics, vol.6, issue.7, pp.830-832, 2007.
DOI : 10.1038/ng1001-223

S. Singh, A. Davis, G. Taylor, and V. Deretic, Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria, Science, vol.119, issue.2, pp.1438-1479, 2006.
DOI : 10.1242/jcs.02735

E. Plowey, S. Cherra, Y. Liu, and C. Chu, Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells, Journal of Neurochemistry, vol.13, issue.3, pp.1048-56, 2008.
DOI : 10.1016/j.neuron.2004.11.005

R. Duerr, K. Taylor, S. Brant, J. Rioux, M. Silverberg et al., A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene, Science, vol.314, issue.5804, pp.1461-1464, 2006.
DOI : 10.1126/science.1135245

C. Parham, M. Chirica, J. Timans, E. Vaisberg, M. Travis et al., A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R, J Immunol Baltim Md, vol.168, issue.11, pp.5699-708, 1950.

L. Henckaerts, K. Nielsen, R. Steffensen, K. Van-steen, C. Mathieu et al., Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit*, Critical Care Medicine, vol.37, issue.1, pp.192-201, 2009.
DOI : 10.1097/CCM.0b013e31819263d8

T. Bruns, J. Peter, P. Reuken, D. Grabe, S. Schuldes et al., NOD2 gene variants are a risk factor for culture-positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis, Liver International, vol.77, issue.2, 2012.
DOI : 10.1128/IAI.00940-08

J. Cosnes, I. Nion-larmurier, L. Beaugerie, P. Afchain, E. Tiret et al., Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery, Gut, vol.54, issue.2, pp.237-278, 2005.
DOI : 10.1136/gut.2004.045294

A. Dignass, G. Van-assche, J. Lindsay, M. Lémann, J. Söderholm et al., The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management, Journal of Crohn's and Colitis, vol.136, issue.S1, pp.28-62, 2010.
DOI : 10.1007/s00384-008-0542-9

V. Fazio, F. Marchetti, M. Church, J. Goldblum, C. Lavery et al., Effect of Resection Margins on the Recurrence of Crohn's Disease in the Small Bowel, Annals of Surgery, vol.224, issue.4, pp.563-71, 1996.
DOI : 10.1097/00000658-199610000-00014

G. Van-assche, A. Dignass, W. Reinisch, C. Van-der-woude, A. Sturm et al., The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Special situations, Journal of Crohn's and Colitis, vol.1, issue.Suppl 2, pp.63-101, 2010.
DOI : 10.1001/jama.299.14.1690

T. Yamamoto, V. Fazio, and P. Tekkis, Safety and Efficacy of Strictureplasty for Crohn??s Disease: A Systematic Review and Meta-Analysis, Diseases of the Colon & Rectum, vol.50, issue.11, pp.1968-86, 2007.
DOI : 10.1007/s10350-007-0279-5

R. Caprilli, M. Gassull, J. Escher, G. Moser, P. Munkholm et al., European evidence based consensus on the diagnosis and management of Crohn's disease: special situations, Gut, vol.55, issue.suppl_1, pp.36-58, 2006.
DOI : 10.1136/gut.2005.081950c

T. Young-fadok, B. Wolff, A. Meagher, P. Benn, and R. Dozois, Surgical management of ileosigmoid fistulas in Crohn??s disease, Diseases of the Colon & Rectum, vol.40, issue.5, pp.558-61, 1997.
DOI : 10.1007/BF02055378

C. Solem, E. Loftus, W. Tremaine, J. Pemberton, B. Wolff et al., Fistulas to the urinary system in Crohn's disease: clinical features and outcomes, The American Journal of Gastroenterology, vol.114, issue.9, pp.2300-2305, 2002.
DOI : 10.1056/NEJM199905063401804

R. Kiran, P. Nisar, J. Church, and V. Fazio, The role of primary surgical procedure in maintaining intestinal continuity for patients with Crohn's colitis. Ann Surg, 2011.

P. Tekkis, S. Purkayastha, S. Lanitis, T. Athanasiou, A. Heriot et al., A comparison of segmental vs subtotal/total colectomy for colonic Crohn's disease: a meta-analysis, Colorectal Disease, vol.123, issue.2, pp.82-90, 2006.
DOI : 10.1002/sim.1186

Y. Panis, B. Poupard, J. Nemeth, A. Lavergne, P. Hautefeuille et al., Ileal pouch/anal anastomosis for Crohn's disease. Lancet Lond Engl, pp.854-861, 1996.

M. Prudhomme, N. Dehni, R. Dozois, E. Tiret, and R. Parc, Causes and outcomes of pouch excision after restorative proctocolectomy, British Journal of Surgery, vol.44, issue.1, pp.82-88, 2006.
DOI : 10.1046/j.1365-2168.2002.01983.x

J. Regimbeau, Y. Panis, M. Pocard, Y. Bouhnik, A. Lavergne-slove et al., Long-term results of ileal pouch-anal anastomosis for colorectal Crohn??s disease, Diseases of the Colon & Rectum, vol.44, issue.6, pp.769-78, 2001.
DOI : 10.1007/BF02234693

G. Reese, R. Lovegrove, H. Tilney, T. Yamamoto, A. Heriot et al., The effect of Crohn's disease on outcomes after restorative proctocolectomy, 2007.

D. Oca, J. Sánchez-santos, R. Ragué, J. Biondo, S. Parés et al., Long-term results of ileal pouch-anal anastomosis in Crohn's disease, Inflamm Bowel Dis, 2003.

A. Champault, S. Benoist, A. Alvès, and Y. Panis, Surgical therapy for Crohn's disease of the colon and rectum], Gastroentérologie Clin Biol, vol.10, issue.1, pp.882-92, 2004.

A. Alves, Y. Panis, Y. Bouhnik, M. Pocard, E. Vicaut et al., Risk Factors for Intra-Abdominal Septic Complications After a First Ileocecal Resection for Crohn??s Disease: A Multivariate Analysis in 161 Consecutive Patients, Diseases of the Colon & Rectum, vol.50, issue.3, pp.331-337, 2007.
DOI : 10.1007/s10350-006-0782-0

L. Peyrin-biroulet, A. Oussalah, N. Williet, C. Pillot, L. Bresler et al., Impact of azathioprine and tumour necrosis factor antagonists on the need for surgery in newly diagnosed Crohn's disease, Gut, vol.60, issue.7, pp.930-936, 2011.
DOI : 10.1136/gut.2010.227884

S. Post, M. Betzler, B. Von-ditfurth, G. Schürmann, P. Küppers et al., Risks of intestinal anastomoses in Crohn's disease. Ann Surg, pp.37-42, 1991.

G. Bouguen and L. Peyrin-biroulet, Surgery for adult Crohn's disease: what is the actual risk?, Gut, vol.60, issue.9, pp.1178-81, 2011.
DOI : 10.1136/gut.2010.234617

Z. Yang, Q. Wu, K. Wu, and D. Fan, Meta-analysis: pre-operative infliximab treatment and shortterm post-operative complications in patients with ulcerative colitis, Aliment Pharmacol Ther Feb, vol.1531, issue.4, pp.486-92, 2010.

U. Kopylov, S. Ben-horin, O. Zmora, R. Eliakim, and L. Katz, Anti-tumor necrosis factor and postoperative complications in Crohn??s disease: systematic review and meta-analysis, Inflammatory Bowel Diseases, vol.134, issue.12, pp.2404-2417, 2012.
DOI : 10.1016/j.cgh.2006.03.002

J. Lennard-jones, Classification of Inflammatory Bowel Disease, Scandinavian Journal of Gastroenterology, vol.284, issue.sup170, pp.2-6, 1989.
DOI : 10.1136/bmj.284.6309.91

W. Sandborn and S. Hanauer, Antitumor Necrosis Factor Therapy for Inflammatory Bowel Disease: A Review of Agents, Pharmacology, Clinical Results, and Safety, Inflammatory Bowel Diseases, vol.107, issue.2, pp.119-152, 1999.
DOI : 10.1016/0016-5085(94)90807-9

P. Zerbib, D. Koriche, S. Truant, A. Bouras, G. Vernier-massouille et al., Pre-operative management is associated with low rate of post-operative morbidity in penetrating Crohn???s disease, Alimentary Pharmacology & Therapeutics, vol.42, issue.3, pp.459-65, 2010.
DOI : 10.1007/DCR.0b013e3181a7ba96

G. Tay, D. Binion, D. Eastwood, and M. Otterson, Multivariate analysis suggests improved perioperative outcome in Crohn's disease patients receiving immunomodulator therapy after segmental resection and/or strictureplasty. Surgery, pp.565-72, 2003.

K. Appau, V. Fazio, B. Shen, J. Church, B. Lashner et al., Use of Infliximab within 3??Months of Ileocolonic Resection is Associated with Adverse Postoperative Outcomes in Crohn???s Patients, Journal of Gastrointestinal Surgery, vol.159, issue.12, 2008.
DOI : 10.1007/s11605-008-0646-0

J. Colombel, E. Loftus, W. Tremaine, J. Pemberton, B. Wolff et al., Early Postoperative Complications are not Increased in Patients with Crohn's Disease Treated Perioperatively with Infliximab or Immunosuppressive Therapy, The American Journal of Gastroenterology, vol.37, issue.5, pp.878-83, 2004.
DOI : 10.1097/00054725-200303000-00003

U. Mahadevan, E. Loftus, W. Tremaine, J. Pemberton, W. Harmsen et al., Azathioprine or 6-Mercaptopurine Before Colectomy for Ulcerative Colitis Is Not Associated With Increased Postoperative Complications, Inflammatory Bowel Diseases, vol.38, issue.5, pp.311-317, 2002.
DOI : 10.1007/BF02049146

V. Subramanian, S. Saxena, J. Kang, and R. Pollok, Preoperative Steroid Use and Risk of Postoperative Complications in Patients With Inflammatory Bowel Disease Undergoing Abdominal Surgery, The American Journal of Gastroenterology, vol.204, issue.Suppl 5, pp.2373-81, 2008.
DOI : 10.1136/bmj.315.7109.629

F. Aberra, J. Lewis, D. Hass, J. Rombeau, B. Osborne et al., Corticosteroids and immunomodulators: postoperative infectious complication risk in inflammatory bowel disease patients, Gastroenterology, vol.125, issue.2, pp.320-327, 2003.
DOI : 10.1016/S0016-5085(03)00883-7

D. Burger and S. Travis, Conventional Medical Management of Inflammatory Bowel Disease, Gastroenterology, vol.140, issue.6, pp.1827-1864, 2011.
DOI : 10.1053/j.gastro.2011.02.045

B. Nasir, E. Dozois, R. Cima, J. Pemberton, B. Wolff et al., Perioperative Anti-Tumor Necrosis Factor Therapy Does Not Increase the Rate of Early Postoperative Complications in Crohn???s Disease, Journal of Gastrointestinal Surgery, vol.103, issue.9, 2010.
DOI : 10.1007/s11605-010-1341-5

R. Lee, D. Efron, U. Tantry, C. Stuelten, L. Moldawer et al., Inhibition of tumor necrosis factor-alpha attenuates wound breaking strength in rats, Wound Repair and Regeneration, vol.81, issue.6, pp.547-53, 2000.
DOI : 10.1067/msy.1998.90578

L. Marchal, D. Haens, G. Van-assche, G. Vermeire, S. Noman et al., The risk of post-operative complications associated with infliximab therapy for Crohn's disease: a controlled cohort study, Alimentary Pharmacology and Therapeutics, vol.124, issue.4, pp.749-54, 2004.
DOI : 10.1016/S0016-5085(03)00883-7

M. Agrez, R. Valente, W. Pierce, L. Melton, J. Van-heerden et al., Surgical history of Crohn's disease in a well-defined population, Mayo Clin Proc, vol.57, issue.12, pp.747-52, 1982.

L. Sutherland, S. Ramcharan, H. Bryant, and G. Fick, Effect of Cigarette Smoking on Recurrence of Crohn's Disease, Gastroenterology, vol.98, issue.5, pp.1123-1131, 1990.
DOI : 10.1016/0016-5085(90)90324-T

M. Cottone, M. Rosselli, A. Orlando, L. Oliva, A. Puleo et al., Smoking habits and recurrence in Crohn's disease, Gastroenterology, vol.106, issue.3, pp.643-651, 1994.
DOI : 10.1016/0016-5085(94)90697-1

D. Sachar, E. Lemmer, C. Ibrahim, Y. Edden, T. Ullman et al., Recurrence patterns after first resection for stricturing or penetrating Crohn's disease, Inflamm Bowel Dis, 2009.

O. Bernell, A. Lapidus, and G. Hellers, Risk factors for surgery and recurrence in 907 patients with primary ileocaecal Crohn's disease, British Journal of Surgery, vol.84, issue.12, pp.1697-701, 2000.
DOI : 10.1002/bjs.1800840129

F. Parente, G. Sampietro, M. Molteni, S. Greco, A. Anderloni et al., Behaviour of the bowel wall during the first year after surgery is a strong predictor of symptomatic recurrence of Crohn's disease: a prospective study, Alimentary Pharmacology and Therapeutics, vol.1, issue.9, pp.959-68, 2004.
DOI : 10.1046/j.1365-2036.2003.01673.x

A. Bressenot, J. Chevaux, N. Williet, A. Oussalah, A. Germain et al., Submucosal Plexitis as a Predictor of Postoperative Surgical Recurrence in Crohn??s Disease, Inflammatory Bowel Diseases, vol.19, issue.8, pp.1654-61
DOI : 10.1097/MIB.0b013e318281f336

F. Collins, L. Brooks, and A. Chakravarti, A DNA Polymorphism Discovery Resource for Research on Human Genetic Variation: Table 1., Genome Research, vol.8, issue.12, pp.1229-1260, 1998.
DOI : 10.1126/science.280.5366.1077

N. Anwar, S. Lovestone, M. Cheetham, R. Levy, and J. Powell, Apolipoprotein E-epsilon 4 allele and Alzheimer's disease. Lancet, pp.1308-1317, 1993.

A. Gloyn, M. Weedon, K. Owen, M. Turner, B. Knight et al., Large-Scale Association Studies of Variants in Genes Encoding the Pancreatic ??-Cell KATP Channel Subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) Confirm That the KCNJ11 E23K Variant Is Associated With Type 2 Diabetes, Diabetes, vol.52, issue.2, pp.568-72, 2003.
DOI : 10.2337/diabetes.52.2.568

F. Kavvoura, T. Akamizu, T. Awata, Y. Ban, D. Chistiakov et al., Cytotoxic T-Lymphocyte Associated Antigen 4 Gene Polymorphisms and Autoimmune Thyroid Disease: A Meta-Analysis, The Journal of Clinical Endocrinology & Metabolism, vol.92, issue.8, pp.3162-70, 2007.
DOI : 10.1210/jc.2007-0147

J. Bland and D. Altman, Statistics notes: Multiple significance tests: the Bonferroni method, BMJ, vol.310, issue.6973, p.170, 1995.
DOI : 10.1136/bmj.310.6973.170

T. Rice, N. Schork, and D. Rao, Methods for Handling Multiple Testing, Adv Genet, vol.60, pp.293-308, 2008.
DOI : 10.1016/S0065-2660(07)00412-9

D. Clayton and P. Mckeigue, Epidemiological methods for studying genes and environmental factors in complex diseases, The Lancet, vol.358, issue.9290, pp.1356-60, 2001.
DOI : 10.1016/S0140-6736(01)06418-2

J. Solon, J. Burke, S. Walsh, and J. Coffey, The Effect of NOD2 Polymorphism on Postsurgical Recurrence in Crohn???s Disease, Inflammatory Bowel Diseases, vol.106, issue.5, pp.1099-105
DOI : 10.1038/ajg.2011.19

S. Fowler, A. Ananthakrishnan, A. Gardet, C. Stevens, J. Korzenik et al., SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease, Journal of Crohn's and Colitis, vol.163, issue.26, pp.845-51, 2014.
DOI : 10.1016/S0002-9440(10)63582-1

R. Sehgal, A. Berg, J. Polinski, J. Hegarty, Z. Lin et al., Mutations in IRGM Are Associated With More Frequent Need for Surgery in Patients With Ileocolonic Crohn??s Disease, Diseases of the Colon & Rectum, vol.55, issue.2, pp.115-136, 2012.
DOI : 10.1097/DCR.0b013e31823ccea8

C. Anderson, G. Boucher, C. Lees, A. Franke, D. Amato et al., Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47, Nature Genetics, vol.38, issue.3, pp.246-52, 2011.
DOI : 10.1046/j.1365-2036.2001.00981.x

D. Sachar, The problem of postoperative recurrence of Crohn's disease. Med Clin North Am, pp.183-191, 1990.

D. Sachar, Recurrence rates in Crohn's disease: predicting the future and predicting the past, Gut, vol.55, issue.8, pp.1069-70, 2006.
DOI : 10.1136/gut.2005.088658

E. Landsend, E. Johnson, H. Johannessen, and E. Carlsen, Long-term outcome after intestinal resection for Crohn's disease, Scandinavian Journal of Gastroenterology, vol.22, issue.10, pp.1204-1212, 2006.
DOI : 10.1097/00004836-199603000-00008

T. Ahmed, F. Rieder, C. Fiocchi, and J. Achkar, Pathogenesis of postoperative recurrence in Crohn's disease. Gut, pp.553-62, 2011.

M. Alvarez-lobos, J. Arostegui, M. Sans, D. Tassies, S. Plaza et al., Crohn??s Disease Patients Carrying Nod2/CARD15 Gene Variants Have an Increased and Early Need for First Surgery due to Stricturing Disease and Higher Rate of Surgical Recurrence, Annals of Surgery, vol.242, issue.5, pp.693-700, 2005.
DOI : 10.1097/01.sla.0000186173.14696.ea

C. Büning, J. Genschel, S. Bühner, S. Krüger, K. Kling et al., Mutations in the NOD2/CARD15 gene in Crohn's disease are associated with ileocecal resection and are a risk factor for reoperation, Alimentary Pharmacology and Therapeutics, vol.42, issue.10, pp.1073-1081, 2004.
DOI : 10.1053/gast.2003.50045

G. Maconi, E. Colombo, G. Sampietro, F. Lamboglia, D. Incà et al., CARD15 Gene Variants and Risk of Reoperation in Crohn's Disease Patients, The American Journal of Gastroenterology, vol.48, issue.10, 2009.
DOI : 10.1016/j.bpg.2003.12.008

M. Renda, A. Orlando, G. Civitavecchia, V. Criscuoli, A. Maggio et al., The Role of CARD15 Mutations and Smoking in the Course of Crohn's Disease in a Mediterranean Area, The American Journal of Gastroenterology, vol.12, issue.Suppl, pp.649-55, 2008.
DOI : 10.1016/0016-5085(94)90697-1

C. Onnie, S. Fisher, N. Prescott, M. Mirza, P. Green et al., Diverse effects of the CARD15 and IBD5 loci on clinical phenotype in 630 patients with Crohn's disease

T. Ahmad, A. Armuzzi, M. Bunce, K. Mulcahy-hawes, S. Marshall et al., The molecular classification of the clinical manifestations of Crohn's disease, Gastroenterology, vol.122, issue.4, pp.854-66, 2002.
DOI : 10.1053/gast.2002.32413

M. Razmara, S. Srinivasula, L. Wang, J. Poyet, B. Geddes et al., CARD-8 Protein, a New CARD Family Member That Regulates Caspase-1 Activation and Apoptosis, Journal of Biological Chemistry, vol.14, issue.16, pp.13952-13960, 2002.
DOI : 10.1074/jbc.M100433200

L. Bouchier-hayes, H. Conroy, H. Egan, C. Adrain, E. Creagh et al., CARDINAL, a Novel Caspase Recruitment Domain Protein, Is an Inhibitor of Multiple NF-??B Activation Pathways, Journal of Biological Chemistry, vol.276, issue.47, pp.44069-77, 2001.
DOI : 10.1074/jbc.M009853200

M. Yamamoto, T. Torigoe, K. Kamiguchi, Y. Hirohashi, K. Nakanishi et al., A Novel Isoform of TUCAN Is Overexpressed in Human Cancer Tissues and Suppresses Both Caspase-8??? and Caspase-9???Mediated Apoptosis, Cancer Research, vol.65, issue.19, pp.8706-8720, 2005.
DOI : 10.1158/0008-5472.CAN-04-4649

N. Pathan, H. Marusawa, M. Krajewska, S. Matsuzawa, H. Kim et al., TUCAN, an Antiapoptotic Caspase-associated Recruitment Domain Family Protein Overexpressed in Cancer, Journal of Biological Chemistry, vol.17, issue.34, pp.32220-32229, 2001.
DOI : 10.1126/science.284.5411.156

G. Chen and G. Núñez, Inflammasomes in Intestinal Inflammation and Cancer, Gastroenterology, vol.141, issue.6, pp.1986-99, 2011.
DOI : 10.1053/j.gastro.2011.10.002

O. Bernell, A. Lapidus, and G. Hellers, Risk Factors for Surgery and Postoperative Recurrence in Crohn???s Disease, Annals of Surgery, vol.231, issue.1, pp.38-45, 2000.
DOI : 10.1097/00000658-200001000-00006

D. Sachar, Patterns of Postoperative Recurrence in Crohn's Disease, Scandinavian Journal of Gastroenterology, vol.88, issue.sup172, pp.35-43, 1990.
DOI : 10.1007/BF02393571

G. Reese, T. Nanidis, C. Borysiewicz, T. Yamamoto, T. Orchard et al., The effect of smoking after surgery for Crohn???s disease: a meta-analysis of observational studies, International Journal of Colorectal Disease, vol.28, issue.1, pp.1213-1234, 2008.
DOI : 10.1111/j.1572-0241.2007.01548.x

R. Holzheimer, R. Molloy, and D. Wittmann, Postoperative complications predict recurrence of Crohn's disease, Eur J Surg Acta Chir. Feb, vol.161, issue.2, pp.129-164, 1995.

I. Iesalnieks, A. Kilger, H. Glass, R. Müller-wille, F. Klebl et al., Intraabdominal septic complications following bowel resection for Crohn???s disease: detrimental influence on long-term outcome, International Journal of Colorectal Disease, vol.66, issue.Suppl 1, pp.1167-74, 2008.
DOI : 10.7326/0003-4819-123-2-199507150-00009

L. Peyrin-biroulet, E. Loftus, J. Colombel, and W. Sandborn, The Natural History of Adult Crohn's Disease in Population-Based Cohorts, The American Journal of Gastroenterology, vol.132, issue.2, pp.289-97, 2009.
DOI : 10.1053/j.gastro.2008.09.053

T. Serradori, A. Germain, M. Scherrer, C. Ayav, M. Perez et al., The effect of immune therapy on surgical site infection following Crohn's Disease resection, British Journal of Surgery, vol.19, issue.Suppl, pp.1089-93
DOI : 10.1111/j.1365-2036.2004.01904.x

A. Franke, P. Rosenstiel, T. Balschun, V. Kampen, O. Schreiber et al., No Association Between the TUCAN (CARD8) Cys10Stop Mutation and Inflammatory Bowel Disease in a Large Retrospective German and a Clinically Well-Characterized Norwegian Sample, Gastroenterology, vol.132, issue.5, pp.2080-2081, 2007.
DOI : 10.1053/j.gastro.2007.03.087

A. Sharma, A. Deeb, J. Iannuzzi, A. Rickles, J. Monson et al., Tobacco Smoking and Postoperative Outcomes After Colorectal Surgery, Annals of Surgery, vol.258, issue.2, pp.296-300, 2013.
DOI : 10.1097/SLA.0b013e3182708cc5

S. Girardin, I. Boneca, J. Viala, M. Chamaillard, A. Labigne et al., Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection, Journal of Biological Chemistry, vol.65, issue.11, pp.8869-72, 2003.
DOI : 10.1016/0022-1759(91)90120-5

M. Spehlmann and L. Eckmann, Nuclear factor-kappa B in intestinal protection and destruction, Current Opinion in Gastroenterology, vol.25, issue.2, pp.92-101, 2009.
DOI : 10.1097/MOG.0b013e328324f857

C. Jakobsen, I. Cleynen, P. Andersen, S. Vermeire, P. Munkholm et al., Genetic susceptibility and genotype???phenotype association in 588 Danish children with inflammatory bowel disease, Journal of Crohn's and Colitis, vol.17, issue.Suppl. A, pp.678-85
DOI : 10.1002/ibd.21661

C. Büning, H. Schmidt, T. Molnár, J. Drenth, T. Fiedler et al., No association of the CARD8 (TUCAN) c.30T>A (p.C10X) variant with Crohn??s disease: A study in 3 independent European cohorts, Inflammatory Bowel Diseases, vol.33, issue.3, pp.332-339, 2008.
DOI : 10.1038/ng1071

S. Fisher, M. Mirza, C. Onnie, D. Soars, C. Lewis et al., Combined Evidence From Three Large British Association Studies Rejects TUCAN/CARD8 as an IBD Susceptibility Gene, Gastroenterology, vol.132, issue.5, pp.2078-80, 2007.
DOI : 10.1053/j.gastro.2007.03.086

S. Yang, H. Kim, M. Hong, J. Lim, E. Choi et al., Association of CARD8 with inflammatory bowel disease in Koreans, Journal of Human Genetics, vol.19, issue.3, pp.217-240, 2011.
DOI : 10.1007/BF02237231

J. Liu, Y. Liu, J. Liu, B. Li, H. Cen et al., Association between CARD8 rs2043211 Polymorphism and Inflammatory Bowel Disease: A Meta-Analysis, Immunological Investigations, vol.26, issue.2, pp.253-64, 2015.
DOI : 10.1038/jhg.2010.170