35 (s, 9H , CH 3 Boc), Val, vol.1, issue.2, p.45 ,
39 (q, J = 6.9Hz, ?CH Ala)57 (br s, 1H, Ala, vol.39, issue.721 2, p.3046 ,
REFERENCES (1) Advances in Drug Research, 145?286. (3) Bouillon, I.; Brosse, pp.127-159, 1991. ,
Liquid and solid phase syntheses of orthogonally protected ??-hydrazinoacid derivatives, Tetrahedron Letters, vol.45, issue.18, pp.3569-3572, 2004. ,
DOI : 10.1016/j.tetlet.2004.03.063
Solid phase synthesis of N-aminodipeptides in high optical purity, Tetrahedron Letters, vol.49, issue.1, pp.156-158, 2008. ,
DOI : 10.1016/j.tetlet.2007.10.152
Methods of organic chemistry (Houben?Weyl). E22, Synthesis of peptides and peptidomimetics. a?e, 2004. ,
Overhand Helv, Journal of the American Chemical Society Chim. Acta Acc. Chem. Res. Chem. Rev. Accounts of Chemical Research Nat. Chem. Biol. Chem. Commun. Chem. Commun. International Journal of Biological Macromolecules Journal of the American Chemical Society Journal of the American Chemical Society J. Am. Chem. Soc, vol.118, issue.123, pp.913-928, 1994. ,
-peptides, A New Class of Foldamers Relying on a Framework of Hydrazinoturns, The Journal of Organic Chemistry, vol.70, issue.16, pp.6499-6502, 2005. ,
DOI : 10.1021/jo050938g
-??-Asp(OMe) containing a 14-membered ring, Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry, vol.31, issue.2, pp.555-560, 1975. ,
DOI : 10.1107/S0567740875003226
-Cyclohexapeptides:?? Pseudopeptidic Macrocycles with Interesting Conformational and Configurational Properties Slow Pyramidal Nitrogen Inversion in 24-Membered Rings!, The Journal of Organic Chemistry, vol.71, issue.15, pp.5638-5645, 2006. ,
DOI : 10.1021/jo0608467
) Gustafsson H;Ragnarsson U Acta Pharm Suec, 493?494. (43) Achiwa, pp.3022-3062, 1896. ,
-alkyloxycarbonylaminophthalimide Using the Mitsunobu Protocol, The Journal of Organic Chemistry, vol.65, issue.14, pp.4370-4374, 2000. ,
DOI : 10.1021/jo000225s
(68) Declerck V. ; Aitken D, 1794?1797. (70) Suc J, pp.9678-9683, 1955. ,
-??-Aminoxy Acid Dimer, Journal of the American Chemical Society, vol.125, issue.47, pp.14452-14457, 2003. ,
DOI : 10.1021/ja029514j
A New Strategy to Induce ??-Turns:?? Peptides Composed of Alternating ??-Aminoxy Acids and ??-Amino Acids, Journal of the American Chemical Society, vol.125, issue.43, pp.13018-13019, 2003. ,
DOI : 10.1021/ja036136p
-cyclotetrapeptides, The Journal of Organic Chemistry, vol.73, issue.21, pp.8579-8582, 2008. ,
DOI : 10.1021/jo8013963
Hydrazino and N-Amino peptides. Chemical and structural aspects, Tetrahedron Letters, vol.32, issue.24, pp.2765-2768, 1991. ,
DOI : 10.1016/0040-4039(91)85080-O
URL : https://hal.archives-ouvertes.fr/tel-01752141
-Peptide Nanotubes as Artificial Transmembrane Ion Channels, Journal of the American Chemical Society, vol.120, issue.4, pp.651-656, 1998. ,
DOI : 10.1021/ja972786f
Submonomer Solution Synthesis of Hydrazinoazapeptoids, a New Class of Pseudopeptides, The Journal of Organic Chemistry, vol.64, issue.8, p.2924, 1999. ,
DOI : 10.1021/jo981487l
-??-Asp(OMe) containing a 14-membered ring, Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry, vol.31, issue.2, pp.555-560, 1975. ,
DOI : 10.1107/S0567740875003226
2101. (113) Martin, Journal of the American Chemical Society Angewandte Chemie International Edition Mol. Pharm. C. R.; Kohli, P. Nat. Rev. Drug Discov. Science Namba, K. Advances in Biophysics Angewandte Chemie ? International Edition J. Am. Chem. Soc. Helvetica Chimica Acta, vol.124, issue.80, pp.1625-1628, 1955. ,
Hydrogen-Bonded Self-Assembled Peptide Nanotubes from Cystine-Based Macrocyclic Bisureas, Journal of the American Chemical Society, vol.121, issue.26, pp.6103-6106, 1992. ,
DOI : 10.1021/ja9903025
élaboration de structures nanotubulaires, nous avons étudié une série de 1:1[?/?-N ? -Bn-hydrazino]peptides cycliques, et tout particulièrement les cyclotétramères. Dans ce contexte, nous avons cherché à mettre en lumière les différents paramètres pouvant influencer l'organisation nanotubulaires dans nos macrocycles, dans le but d'élaborer la meilleure stratégie afin d'obtenir cette nanostructuration en vues d'éventuelles applications. Les différents paramètres étudiés sont les suivants : la stratégie de synthèse, la chiralité ,