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Élaboration de copolymères biorésorbables pour endoprothèse

Abstract : This work describes the synthesis of biodegradable copolymer to design a bioabsorbable endoprosthesis. Lactide and glycolide-based copolymers were synthesized by ring opening polymerization. Experimental conditions were chosen to produce controlled structures. The study of mechanical properties was performed in dry and wet states. During the tensile experiments, the effect of strain rate was noticed and some characteristics parameters were determined. Hydrolytic degradation of materials was fast and revealed a heterogeneous mechanism. Addition of acidic molecules for plasticizing increased the degradation rate of the copolymers.Mechanical properties and degradation of the PDLGA copolymers are indeed in good agreement with the specifications of this biomedical application.
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Submitted on : Friday, July 23, 2021 - 10:27:24 AM
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  • HAL Id : tel-01754519, version 1


Charlotte Duval. Élaboration de copolymères biorésorbables pour endoprothèse. Autre. Institut National Polytechnique de Lorraine, 2011. Français. ⟨NNT : 2011INPL018N⟩. ⟨tel-01754519⟩



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