Optimisation des procédés chromatographiques multicolonnes continus : développement d'un système de contrôle avancé

Abstract : Multicolumn continuous chromatographic processes became a key separation technology in the areas of pharmaceutical industry thanks to high productivity and short process development times. Today, modeling, design, and optimization of SMB and Varicol, are well established. However a robust and optimized operation of processes is still an open issue. The common practice is to operate processes under suboptimal operating conditions in order to gain the necessary robustness. The operating parameters are tuned manually by experienced operators in order to maintain the product specifications. Therefore, as chromatographic applications spread, process control problem becomes increasingly important. Recently, several control methodologies of SMB process have been proposed. This thesis work introduces a new advanced control system approach. This system adjusts operating parameters thanks to two kinds of measurements : an in-line measurement and an at-line measurement. The performance of this control scheme is demonstrated through several experiments on Varicol. The reported results aim to demonstrate that the controller is able to deliver the products within the specifications, to optimize the process performance and to answer to disturbances while protecting the key product
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https://hal.univ-lorraine.fr/tel-01754559
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Céline Morey. Optimisation des procédés chromatographiques multicolonnes continus : développement d'un système de contrôle avancé. Autre. Institut National Polytechnique de Lorraine, 2009. Français. ⟨NNT : 2009INPL003N⟩. ⟨tel-01754559⟩

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