3 C-2, 3 C-2'), 48.2, 49.2, 49, C(CH 3 ) 2 ), pp.171-172 ,
55 (dd, 2H, J gem = 6.5 Hz81 (dd, 1H, J gem = 125 Hz, H-?), 3.17-3.21 (m, 2H, H-8), 3.52-3.70 (m, 3H, H-?, H-6), 3.74 (m, 1H10 (s, 2H, CH 2 -Ph), 5.47 (br s, 1H, NMR (CDCl 3 , 400 MHz): ? = 1.26 (s 7.61 (d, 1H, J = 8.0 Hz, H-Ar), 8.72 (br s, 1H, NH). 13 C NMR (CDCl 3 , 100 MHz): ? = 24.7 (CH 3CONH). ESI-HRMS [M+Na IR (NaCl) ? = 3312, pp.4150-4151 ,
04-5.06 (m, 4H, CH 2 - Ph), 5.11 (s, 2H, CH 2 -Ph), 6.20 (s, 2H, CH 2 -Ph), 26.4, 27.2, 28 122.5 (C-Ar), 123.7 (C-Ar), pp.50-52 ,
ESI-HRMS [M+Na, ). IR (NaCl)???? 1728, pp.1622-1623, 1638. ,
03 (s, 4H, CH 2 -Ph)10 (s, 2H, CH 2 -Ph), 5.19 (s, 2H, CH 2 -Ph), 2H, H-7), 3.74 (m, 1H, H-6), 3.84 (m, 1H, H-3), 4.59-4.64 (m, 2H, H-4, pp.26-27 ,
13 C NMR (CDCl 3 , 100 MHz): ? = 24, 4.61 (dd, 1H, J 4,5 = 6.0, J 5,6 = 3.5 Hz, H-5), 4.67 (dd, 1H (C(CH 3 ) 2 )C=O). ESI-HRMS [M+Na.1003). IR (NaCl)???? 3289, pp.6823-6826 ,
56 (m, 1H, H-A3), 3.68 (m, 1H, pp.13-16 ,
13 C NMR (D 2 O, 100 MHz): ? = 23 IR (pellets)???? 3360, 34.7 (C-2), 40.6 (C-A3) 112.8 (C(CH 3 ) 2 )C=O). ESI-HRMS [M+Na, pp.81-88, 1942. ,
46 (s, 3H, Ph-CH 370 (s, 3H, OCH 3 ), 4.00 (dd, 1H, J gem = 10, NMR (CDCl 3 , 250 MHz): ? = 1.31 (s, 3H, C(CH 3 ) 2 ) Hz, H-2), 2.74 (dd, 1H, J 2',3 = 7.0 Hz 1H, J 6,7' = 4.5 Hz, H-7'), 4.18 (m, 1H (d, 2H, H-Ar). 13 C NMR (CDCl 3 , 62.9 MHz): ? = 21, p.456380 ,
06 (ddd, 1H, J gem = 13.5, J = 8.0, J = 4.5 Hz, ), 3.47 (m, 1H, H-A3), 3.78 (s, 3H, OCH 3 ), 4.12 (m, 1H, pp.8931-8935 ,
08 (ddd, 1H, J 6,7' = 5.0, J 7',NH = 8.0 Hz, pp.71-75 ,
400 MHz): ? = 1.25 (s, 3H, C(CH 3 ) 2 ), 1.38 (s, 3H, C(CH 3 ) 2 ), pp.45-161 ,
77 (dd, 1H, CH 3 ) 2 ), 2.67 (dd, 1H, J gem = 17.0, J 2,3 = 7.0 Hz'), 2.91 (m, 1H, H-7), 3.09 (m, 1H, pp.1-4571, 2002. ,
53 (br s, 1H, COOH) 13 C NMR (CDCl 3 , 62.9 MHz): ? = 24, 40.8 (CH 2 -CO 2 CH 3 ), 42.7 (C-7), pp.4-7125 ,
13 C NMR (DMSO-d 6 , 62.9 MHz): ? = 25 IR (pellets)???? 3374, 29.1 (C-A1), 35.6 (C-2), 40.8 (C-A3), 41 112.0 (C(CH 3 ) 2 ), pp.52-81, 1718. ,
09 (ddd, 1H, J 6,7' = 5.0, J 7',NH = 8.0 Hz, p.73 ,
13 C NMR (D 2 O, 100 MHz): ? = 23 IR (pellets)???? 3350, 35.3 (C-2), 40.6 (C-A3) 112.9 (C(CH 3 ) 2 ) 178.5 (C=O). ESI-HRMS [M+Na, pp.574-3184, 1648. ,
100 mg) was then added to the solution and the suspension was stirred until the solution became colorless. The resin was filtered off and the solvent were removed under reduced pressure. The crude was purified by column chromatography (C-18 silica gel ,
59 (dd, 1H, J gem = 15, NMR (D 2 O, 400 MHz): ? = 1.31 (s, 3H, C(CH 3 ) 2 ).17 (m, 3H, 2 H-A3, H-7'), 3.26 (m, 1H, H-11), 3.42-3.59 (m, 3H, H-12, H-13 13 C NMR (D 2 O, 62.9 MHz): ? =, pp.59-60 ,
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