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Bioactivity of nacre water-soluble organic matrix from the bivalve mollusk Pinctada maxima in three mammalian cell types: fibroblasts, bone marrow stromal cells and osteoblasts, Comp Biochem Physiol B Biochem Mol Biol, vol.132, pp.217-246, 2002. ,
The water-soluble matrix fraction from the nacre of Pinctada maxima produces earlier mineralization of MC3T3-E1 mouse pre-osteoblasts, Comp Biochem Physiol B Biochem Mol Biol, vol.135, pp.1-7, 2003. ,
Characterization and in vitro mineralization function of a soluble protein complex P60 from the nacre of Pinctada fucata, Comp Biochem Physiol B Biochem Mol Biol, vol.148, pp.201-209, 2007. ,
A new method for the separation and purification of the osteogenic compounds of nacre ! 112! ,
, Ethanol Soluble Matrix. J Struct Biol, 2016.
Nacre, a natural, multi-use, and timely biomaterial for bone graft substitution, J Biomed Mater Res A, vol.105, pp.662-71, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01716482
The in vitro osteoclastic degradation of nacre, Biomaterials, vol.28, pp.2155-62, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00131756
Arthrodesis of lumbar spine transverse processes using nacre in rabbit, J Bone Miner Res, vol.16, pp.2232-2239, 2001. ,
Subchondral nacre implant in the articular zone of the sheep's knee: a pilot study, Biomed Mater Eng, vol.22, pp.227-261, 2012. ,
Low molecular weight molecules of oyster nacre induce mineralization of the, pp.3-3 ,
URL : https://hal.archives-ouvertes.fr/hal-00181010
, J Biomed Mater Res A, vol.85, pp.487-97, 2008.
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, Osteogenic differentiation of human bone marrow mesenchymal stem cells in hydrogel containing nacre powder, J Biomed Mater Res A, 2013.
BMP signaling components are expressed in human fracture callus, Bone, vol.33, pp.362-71, 2003. ,
Studies of bone morphogenetic protein-based surgical repair, Adv Drug Deliv Rev, vol.64, pp.1277-91, 2012. ,
A health economic analysis of the use of rhBMP-2 in Gustilo-Anderson grade III open tibial fractures for the UK, Injury, vol.40, pp.1269-75, 2009. ,
Adverse effects of posterior lumbar interbody fusion using rhBMP-2, Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc, vol.18, pp.920-923, 2009. ,
, Avec de nombreuses qualités exceptionnelles (biocompatible et ostéogénique), la nacre représente un biomatériau naturel comme substitut osseux. Mais les composés ostéogéniques dans la nacre ne sont pas encore connus. Nos travaux visent à l'identification des composés ostéogéniques de la nacre
, Grâce au couplage des cellules MC3T3-E1 et d'ostéoblastes humains arthrosiques, nous avons démontré que la partie cationique d'ESM est ostéogénique, sans interaction avec la partie anionique. Le calcium joue un rôle dans l'activité ostéogénique d'ESM. Ensuite, nous avons créé une lignée cellulaire exprimant de manière stable un plasmide contenant un gène rapporteur ostéogénique (ATDC5 pMetLuc2 ColX promoteur), L'ESM (éthanol soluble matrix) est un extrait de la nacre qui est démontré ostéogénique. A partir d'ESM, nous avons essayé plusieurs approches pour cibler et identifier ces composés
, Mots clés : Nacre, substitut osseux, éthanol soluble matrix, modèle cellulaire in vitro