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, RESULTS AND DISCUSSION 3.1. Chemical characterization FTIR spectra of bare, silanized and co-polymer modified Fe 3 O 4 NPs are displayed in Figure

, The signal corresponding to the Fe-O bonds was observed in the domain 520-570, p.1

. For-the-three, . Samples, and . Nps, The signals in the spectrum of Fe 3 O 4 (Figure 4.3.1.black line) between 1330 and 1630 cm -1 correspond to the symmetric and anti-symmetric stretching of COO -due to the presence of citrate ions at the surface of Fe 3 O 4 NPs. For the Fe 3 O 4 @Ph-Cl NPs, the signal at 1051 cm -1 is assigned to the Fe?O?Si stretching vibrations. The bands at 1200-1400 cm -1 are attributed to the C-C stretching in the silane structure

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N. , MA 60 -OEGMA 40 ) dispersions in water under UV light and the corresponding absorption and PL spectra of ZnO@P(MEO 2 MA 60 -OEGMA 40 ), ZnO@P, issue.2, p.141

.. , MEO 2 MA 75 -OEGMA 25 ) diameter with temperature; the drawing on the left illustrates the NPs in their dispersed state and the one on the right illustrates the aggregation of the NPs, Figure 3.3.10 Evolution of ZnO@P, p.142

.. , MEO 2 MA 60 -OEGMA 40 ) by following the 1 st derivative method, Figure 3.3.11 Obtaining the LCST of ZnO@P, p.143

L. , 12 Evolution of ZnO@P(MEO 2 MA 80 -OEGMA 20 ) and ZnO@P(MEO 2 MA 65 - OEGMA 35 ) diameter with temperature showing the shift of the, Figure 3.3, p.144

, Figure 3.3.13 Optical photograph of ZnO@P(MEO 2 MA 75 -OEGMA 25 ) at a) 20 °C and b), p.70

°. During, D. , and .. , , p.144

.. , MEO 2 MA 60 -OEGMA 40 ) NPs in water with successive heating and cooling cycles, p.145

.. , MEO 2 MA 65 -OEGMA 35 ) NPs diameter showing a shift in the LCST in CM (1) and increase in the aggregates size (2), Figure 3.3.15 Evolution of ZnO@P, p.147

.. , MEO 2 MA 60 -OEGMA 40 ) NPs in CM with successive heating and cooling cycles, Figure 3.3.16 Reversible diameter change of ZnO@P, p.147

X. , , p.148

2. Zn, and 72 h of exposure to ZnO@P(MEO 2 MA X - OEGMA 100-X ) NPs at 50 µg, Figure 3.3.18 Viability of HT29 cells after 24, p.149

.. , 19 Viability of HT29 cells after 24 or 5 h of exposure to A) ZnO@P(MEO 2 MA 65 - OEGMA 35 ) and ZnO@P(MEO 2 MA 65 -OEGMA 35 )-DOX NPs, and B) ZnO@P(MEO 2 MA 60 - OEGMA 40 ) and ZnO@P(MEO 2 MA 60 -OEGMA 40 )-DOX NPs, respectively, Figure 3.3, p.150

, Figure 3.3.20 Viability of HT29 cells after 5 h of exposure to free DOX, ZnO@P(MEO 2 MA 65 -OEGMA 35 )-DOX and ZnO@P(MEO 2 MA 60 -OEGMA 40 )-DOX NPs, p.151

, Figure 3.3.21 HT29 cell viability in presence of 2.6 µg/mL free DOX, ZnO@P(MEO 2 MA 65 - OEGMA 35 )-DOX and ZnO@P(MEO 2 MA 60 -OEGMA 40 )-DOX NPs at 37 or 41 °C for 5 h, p.152

, Figure 3.3.22 HT29 cell viability after incubation with A) ZnO@P

D. and B. , ZnO@P(MEO 2 MA 60 -OEGMA 40 )-DOX NPs and C) free DOX at 37 and 41 °C for 5

H. , , p.153

N. , Fe 3 O 4 @Ph-Cl (red) and Fe 3 O 4 @co-polymer (blue), p.171

.. , Low magnification TEM image and b) electron diffraction pattern of the core/shell MNPs with c) XRD spectra of Fe 3 O 4 derivatives, p.172

.. , Fe 3 O 4 @Ph-Cl NPs with their corresponding b) size distribution and c) Fe 3 O 4 @P(MEO 2 MA X -OEGMA 100-X ) NPs with d) their normal size distribution, p.173

.. , , p.174

.. , , p.175

.. , , p.175

, Figure 4.3.7 The magnetic behavior of Fe 3 O 4 derivatives as a function of temperature, p.176

.. Ma, O. , and R. , 177 TABLE OF SCHEMES Scheme 2.2.1 Schematic representation of the surface-initiated ARGET-ATRP polymerization of a) styrene from SiO 2 @Ph-Cl NPs and b) X MEO 2 MA with 100-X OEGMA from ZnO@Ph-Cl or Fe 3 O 4 @Ph-Cl NPs, where X and 100-X are the molar ratio of MEO 2

S. , Schematic illustration of the preparation procedure of ZnO@P(MEO 2 MA X - OEGMA 100-X ) NPs by, p.129

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