Transformation morphologique des cellules SHE et communication intercellulaire des V79 appliquées à la détection de cancérogènes non génotoxiques

Abstract : This work concerned the study of the performance of three in vitro assays to detect genotoxic and epigenetic carcinogenic potentialities of environmental contaminants : the inductionof point mutation on Salmonella typhimurium his- ; the inhibition of intercellular communication on V79 cells ; the morphological transformation on syrian hamster embryo cells (SHE). Two chlorinated pesticides, chlordane and chlorothalonil, carcinogenic in vivo but no mutagenic, were tested as well as hazardous leachates of solid waste and percolates from landfill to evaluate the performances of these bioassays in detecting carcinogens. The results demonstrate the highest sensitivity of the morphological transformation assay to detect genotoxic and epigenetic potentialities of environmental contaminants
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Halima Bessi. Transformation morphologique des cellules SHE et communication intercellulaire des V79 appliquées à la détection de cancérogènes non génotoxiques. Médecine humaine et pathologie. Université Paul Verlaine - Metz, 1993. Français. ⟨NNT : 1993METZ012S⟩. ⟨tel-01775478⟩

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