Propriétés cholérétiques, antihépatotoxiques et diuérétiques d'Eupatorium cannabinum L. : approche ethnopharmacologique

Abstract : The traditionnal properties of a medicinal plant, frequently occuring in Europe, Eupatorium cannabinum L. are studied by means of pharmacological techniques. After a bibliographic analysis of the botanical and chemical caracteristics of the species, we present the result of an identity check of the aquaeous extract of the plant used in the following. Pharmacological investigations are performed on two targets : liver and kidney, after checking the lack of toxocity of the extract. Choleretic properties are demonstrated in the rat, with time-dose-effect relations. A study of the mechanism of action identified the site of stimulated bile formation as canalicular and bile acid dependant. The antihepatotoxic properties are studied on a model producing an experimental hepatitis in the rat with an organic solvant. This model have been successfully transposed to the mouse. An approach of the mechanism of action using isolated rat hepatoxytes is presented. The impact of the aquaeous extract of the plant occurs at the later stages of the intoxication, preventing necrosis. Diuretic properties are investagated on two experimental models in the rat : a chronic per os administration of the extract, and an acute one with administration of an hydric hypotonic overland injection including the extract. The natural extract is salidiuretic and its mode of action is thiazidic like. According to the results, the traditionnal therapeutic indications of the plant used in hepatic disorders and as diuretic are confirmed. Moreover, we find a good correlation between pharmacological active doses and the traditionnal posology
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Annette Lexa-Robin. Propriétés cholérétiques, antihépatotoxiques et diuérétiques d'Eupatorium cannabinum L. : approche ethnopharmacologique. Médecine humaine et pathologie. Université Paul Verlaine - Metz, 1988. Français. ⟨NNT : 1988METZ006S⟩. ⟨tel-01775749⟩

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