Synthèse et réactivité de systèmes hétérocycliques à noyau isosélénazolinique, thieno et sélénopyridinique

Abstract : The syntesis and reactivity of new heterocyclic systems are described and discussed in this thesis. Two different subjects are investigated : synthesis of isoselenazolinics derivatives, synthesis of thieno and selenolopyridinics derivatives. All isoselenazolones described in the literature are benzo-condensed. With the aim to prepare non-benzocondensed isoselenazolones, we have used chloroacroleines as starting material. In one case, we are able to obtain the isoselenazolinic systems. Cyclisation of alkylidenemalonitriles by the Vilsmeier-Haack reagent afford 2-chloro-3-cyanopyridines. These compounds are used as starting material for the synthesis of new amino thieno and selenolo (2,3-b) pyridines, which are not described in the literature. The reactivity if the compounds have been studied in actylation, hydrolysis, decarboxylation and diazotation. In the same manner, cyclisation of some alkyldene cyanoacetates by the Vilsmeier-Haack reagent leads to esters of 2-chloro nicotinic acid. This route gives us the possibility to extend the synthesis to hydroxylated thieno and selenolopyridines
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Mina Aadil. Synthèse et réactivité de systèmes hétérocycliques à noyau isosélénazolinique, thieno et sélénopyridinique. Autre. Université Paul Verlaine - Metz, 1992. Français. ⟨NNT : 1992METZ024S⟩. ⟨tel-01775985⟩

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