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L. Diméthyl and -. , LTben(a)anthracène (DMBA) est un hydrocarbure polycyclique aromatique cancérogène dont les effets immunosupPresseurs chez la souris sont bien connus. Dans cette éhrde, nous avons éfudié les effets in oitro du DMBA sur I'activation lymphocytaire T, en s'intéressant plus particulièrement à I'interaction avec l'homéostasie calcique, une seconde partie, I'utilisation des 2

M. Le, inhibe pas la prolifération en réponse à la concanavaline A et ninduit pas d'augmentation significative du taux de C-a,Z+ic En revanche coûrme le DMBA, te M12BA provoque une augmentation de C*+ic, démontrant ainsi I'importance du méthyt en position 12 po.tr l'interaction du DMBA avec I'homéostasie calcique. lae DMBA inhibe la prolifération lymphocytaire T, la génération et la fonction de lymphocytes T cytotoxiques ainsi que la fonction NK de lymphocytes mwins ou humains, Des différences entre ces 2 systèmes cellulaires çxistent en ce qui concernent I'interaction du DMBA avec I'homéostasie calcique