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TiO2 Nanoparticles Coupled To Photosensitizers For Applications In Photocatalysis And Photodynamic Therapy

Abstract : This work addresses the development of dye-sensitized TiO2 and SiO2 nanoparticles (NPs) for application in photocatalysis and photodynamic therapy (PDT). The NPs were either coated with a polysiloxane shell or modified by aminopropyl triethoxysilane (APTES) alone. Monocarboxylic tetraphenyl porphyrin (P1-COOH) or chlorin e6 (Ce6) PSs were coupled to the NPs by amide bond. In photocatalysis, The APTES-modified sensitized NPs, particularly TiO2-APTES-Ce6, exhibit a superior activity towards the degradation of methylene blue and methyl orange over the core-shell systems under solar and visible light. For PDT, in vitro tests were conducted on the glioblastoma cell line U87 at different NPs’ concentrations illuminated at 652 nm. TiO2-APTES-Ce6 revealed a good phototoxicity as the cell viability decreased by 89% after illumination. The cellular uptake and localization of those NPs and their silica analogues were explored. The ROS involved in photocatalysis and PDT were investigated
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https://hal.univ-lorraine.fr/tel-01907765
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Zahraa Youssef. TiO2 Nanoparticles Coupled To Photosensitizers For Applications In Photocatalysis And Photodynamic Therapy. Chemical and Process Engineering. Université de Lorraine; Université libanaise, 2017. English. ⟨NNT : 2017LORR0231⟩. ⟨tel-01907765⟩

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