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, acrylonitrile (?99%) and acetonitrile (?99.9%) were purchased from Sigma-Aldrich. Molecular sieves (4 Å) were from Grace Davison. Nylon syringe filters (13-mm diameter, 0.22-?m pore size) were from Whatman Co, ?99%), isoproponaol (?99%), binzonitrile (?99%

, Dissolution rate experiments were performed in a 27-mL jacketed reactor (Chemspeed ASW 1000)

, Dissolution experiments and analysis

, Before each experiment, solvent (15 mL) was dried with 4-Å molecular sieves during 24 h at 50 °C and then transferred to the flavonoid (0.75 g). The solution was stirred at 50 °C under 500 rpm, using a Chemspeed vibration system

. °c, Dissolved flavonoids were analyzed by HPLC using LaChrom HPLC system (Merck) with UV detector (Merck) at 254 nm and with an Appolo C18 column (250 × 4.6 mm, Alltech). The eluent used was methanol. The elution flow rate was 1 mL/min, The filtrate (0.5 or 1 mL) was collected in a vial, and immediately analyzed by HPLC

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, Résultats et discussion Chapitre VI

. Vi, Développement d'une approche multiéchelle pour l'étude des assemblages PLGA/quercétine

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