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Étude des mécanismes de déformation de membranes polymères poreuses pour applications biomédicales

Abstract : The "bioartificial pancreas" (named MAILPAN for Macro-encapsulation d’ILots PANcréatiques) developed by the startup company Defymed is an implantable device for patients diagnosed with type I diabetes. The core element of the device is a porous membrane providing molecular selectivity. The emergence of cracking in this membrane would lead to the loss of its selective properties. As a consequence, it is crucial to study and understand the mechanical behavior of this material in order to ensure its integrity during the lifetime of the device. This thesis is a part of the FUI MECABARP project, gathering together SMEs and laboratories from the Lorraine and Alsace regions. The membrane is a unique material obtained by laminating several porous polymer materials. It is made of porous “track-etched” films as well as thermal-spot bonded nonwovens. The objective is to study its deformation mechanisms using time-resolved imaging and characterization techniques during a tensile test. X-ray micro-tomography and wide- and small-angle X-ray scattering experiments were performed on high energy beamlines. These results were supplemented with time-resolved scanning electron microscopy and Raman spectroscopy experiments during a tensile test. The synergy of the chosen techniques enables a multi-scale approach (from millimeter to angström) in order to obtain the most comprehensive analysis. Solutions are suggested to improve the mechanical properties of the membrane. Besides, a mechanical testing device by inflation (“bulge test”) has been designed to provide an equibiaxial mechanical path that is closer to the actual demands
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Submitted on : Friday, November 16, 2018 - 10:29:11 AM
Last modification on : Friday, January 7, 2022 - 3:47:14 AM


  • HAL Id : tel-01924651, version 1


Martin Donnay. Étude des mécanismes de déformation de membranes polymères poreuses pour applications biomédicales. Science des matériaux [cond-mat.mtrl-sci]. Université de Lorraine, 2017. Français. ⟨NNT : 2017LORR0228⟩. ⟨tel-01924651⟩



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