N. Townsend, L. Wilson, P. Bhatnagar, K. Wickramasinghe, M. Rayner et al., Cardiovascular disease in Europe: epidemiological update, vol.37, pp.3232-3245, 2016.

C. M. Dewey, K. M. Spitler, J. M. Ponce, D. D. Hall, and C. E. Grueter, Cardiac-secreted factors as peripheral metabolic regulators and potential disease biomarkers, J. Am. Heart Assoc, vol.5, issue.6, 2016.

P. Ponikowski, A. A. Voors, S. D. Anker, H. Bueno, J. G. Cleland et al., ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure, Eur. J. Heart Fail, vol.18, issue.8, pp.891-975, 2016.

F. J. Azuaje, S. Rodius, L. Zhang, Y. Devaux, and D. R. Wagner, Information encoded in a network of inflammation proteins predicts clinical outcome after myocardial infarction, BMC Med. Genomics, vol.4, p.59, 2011.

Y. Devaux, M. Bousquenaud, S. Rodius, P. Marie, F. Maskali et al., Transforming growth factor beta receptor 1 is a new candidate prognostic biomarker after acute myocardial infarction, BMC Med. Genet, vol.4, issue.1, p.83, 2011.

F. Azuaje, Y. Devaux, M. Vausort, C. Yvorra, and D. R. Wagner, Transcriptional networks characterize ventricular dysfunction after myocardial infarction: a proof-ofconcept investigation, J. Biomed. Inform, vol.43, issue.5, pp.812-819, 2010.

Y. Devaux, F. Azuaje, M. Vausort, C. Yvorra, and D. R. Wagner, Integrated protein network and microarray analysis to identify potential biomarkers after myocardial infarction, Funct. Integr. Genomics, vol.10, issue.3, pp.329-337, 2010.

F. Azuaje, Y. Devaux, and D. R. Wagner, Integrative pathway-centric modeling of ventricular dysfunction after myocardial infarction, PLoS One, vol.5, issue.3, p.9661, 2010.

F. J. Azuaje, F. E. Dewey, D. L. Brutsaert, Y. Devaux, E. A. Ashley et al., Systemsbased approaches to cardiovascular biomarker discovery, Circ. Cardiovasc. Genet, vol.5, issue.3, pp.360-367, 2012.

Y. Devaux, Transcriptome of blood cells as a reservoir of cardiovascular biomarkers, Biochim. Biophys. Acta, Mol. Cell Res, vol.1864, issue.1, pp.209-216, 2017.

M. Nahrendorf and F. K. Swirski, Innate immune cells in ischaemic heart disease: does myocardial infarction beget myocardial infarction?, Eur. Heart J, vol.37, issue.11, pp.868-872, 2016.

P. Libby, M. Nahrendorf, and F. K. Swirski, Leukocytes link local and systemic inflammation in ischemic cardiovascular disease: an expanded "cardiovascular continuum, J. Am. Coll. Cardiol, vol.67, issue.9, pp.1091-1103, 2016.

R. A. Frieler and R. M. Mortensen, Immune cell and other noncardiomyocyte regulation of cardiac hypertrophy and remodeling, Circulation, vol.131, issue.11, pp.1019-1030, 2015.

I. C. Gerling, R. A. Ahokas, G. Kamalov, W. Zhao, S. K. Bhattacharya et al., Gene expression profiles of peripheral blood mononuclear cells reveal transcriptional signatures as novel biomarkers of cardiac remodeling in rats with aldosteronism and hypertensive heart disease, JACC Heart Fail, vol.1, issue.6, pp.469-476, 2013.

J. A. Wingrove, S. E. Daniels, A. J. Sehnert, W. Tingley, M. R. Elashoff et al., Correlation of peripheral-blood gene expression with the extent of coronary artery stenosis, Circ. Cardiovasc. Genet, vol.1, issue.1, pp.31-38, 2008.

J. Vargas, J. A. Lima, W. E. Kraus, P. S. Douglas, and S. Rosenberg, Use of the Corus® CAD gene expression test for assessment of obstructive coronary artery disease likelihood in symptomatic non-diabetic patients, PLoS Curr, p.5, 2013.

D. R. Wagner, Y. Devaux, and O. Collignon, Door-to-balloon time and mortality, N. Engl. J. Med, vol.370, issue.2, pp.178-182, 2014.

M. Vausort, D. R. Wagner, and Y. Devaux, Long noncoding RNAs in patients with acute myocardial infarction, Circ. Res, vol.115, issue.7, pp.668-677, 2014.

Y. Gruenbaum and R. Foisner, Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation, Annu. Rev. Biochem, vol.84, pp.131-164, 2015.

M. Sadaie, R. Salama, T. Carroll, K. Tomimatsu, T. Chandra et al., Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence, Genes Dev, vol.27, issue.16, pp.1800-1808, 2013.

K. L. Reddy, J. M. Zullo, E. Bertolino, and H. Singh, Transcriptional repression mediated by repositioning of genes to the nuclear lamina, Nature, vol.452, issue.7184, pp.243-247, 2008.

K. Manju, B. Muralikrishna, and V. K. Parnaik, Expression of disease-causing lamin A mutants impairs the formation of DNA repair foci, J. Cell Sci, vol.119, pp.2704-2714, 2006.

M. Crisp, Q. Liu, K. Roux, J. B. Rattner, C. Shanahan et al., Coupling of the nucleus and cytoplasm: role of the LINC complex, J. Cell Biol, vol.172, issue.1, pp.41-53, 2006.

X. Wang, A. Zabell, W. Koh, and W. H. Tang, Lamin A/C cardiomyopathies: current understanding and novel treatment strategies, Curr. Treat. Options Cardiovasc. Med, vol.19, issue.3, p.21, 2017.

D. R. Wagner, C. Delagardelle, I. Ernens, D. Rouy, M. Vaillant et al., Matrix metalloproteinase-9 is a marker of heart failure after acute myocardial infarction, J. Card. Fail, vol.12, issue.1, pp.66-72, 2006.

D. Kelly, S. Q. Khan, M. Thompson, G. Cockerill, L. L. Ng et al., Plasma tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9: novel indicators of left ventricular remodelling and prognosis after acute myocardial infarction, Eur. Heart J, vol.29, issue.17, pp.2116-2124, 2008.

M. Bujak, G. Ren, H. J. Kweon, M. Dobaczewski, A. Reddy et al., Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling, Circulation, vol.116, issue.19, pp.2127-2138, 2007.

R. Giltay, G. Kostka, and R. Timpl, Sequence and expression of a novel member (LTBP-4) of the family of latent transforming growth factor-beta binding proteins, FEBS Lett, vol.411, issue.2-3, pp.164-168, 1997.

K. M. Lamar, T. Miller, L. Dellefave-castillo, and E. M. Mcnally, Genotype-specific interaction of latent TGFbeta binding protein 4 with TGFbeta, PLoS One, vol.11, issue.2, p.150358, 2016.

K. Miyazono, A. Olofsson, P. Colosetti, and C. H. Heldin, A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1, EMBO J, vol.10, issue.5, pp.1091-1101, 1991.

J. Bristow, M. K. Tee, S. E. Gitelman, S. H. Mellon, and W. L. Miller, Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B, J. Cell Biol, vol.122, issue.1, pp.265-278, 1993.

G. H. Burch, Y. Gong, W. Liu, R. W. Dettman, C. J. Curry et al., Tenascin-X deficiency is associated with Ehlers-Danlos syndrome, Nat. Genet, vol.17, issue.1, pp.104-108, 1997.

J. R. Mao, G. Taylor, W. B. Dean, D. R. Wagner, V. Afzal et al., Tenascin-X deficiency mimics Ehlers-Danlos syndrome in mice through alteration of collagen deposition, Nat. Genet, vol.30, issue.4, pp.421-425, 2002.

J. W. Petersen and J. Y. Douglas, Tenascin-X, collagen, and Ehlers-Danlos syndrome: tenascin-X gene defects can protect against adverse cardiovascular events, Med. Hypotheses, vol.81, issue.3, pp.443-447, 2013.

L. Jing, L. J. Zhou, F. M. Zhang, W. M. Li, and Y. Sang, Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming growth factor-beta1 and peroxisome proliferator-activated receptor gamma in alcoholic cardiomyopathy, Chin. Med. J, vol.124, issue.3, pp.390-395, 2011.

Y. Devaux, A. Salgado-somoza, J. Dankiewicz, A. Boileau, P. Stammet et al., Incremental value of circulating MiR-122-5p to predict outcome after out of hospital cardiac arrest, Theranostics, vol.7, issue.10, pp.2555-2564, 2017.

Y. Devaux, M. Vausort, G. P. Mccann, D. Kelly, O. Collignon et al., A panel of 4 microRNAs facilitates the prediction of left ventricular contractility after acute myocardial infarction, PLoS One, vol.8, issue.8, p.70644, 2013.

V. Auffret, G. Leurent, M. Gilard, J. P. Hacot, E. Filippi et al., Incidence, timing, predictors and impact of acute heart failure complicating ST-segment elevation myocardial infarction in patients treated by primary percutaneous coronary intervention, Int. J. Cardiol, vol.221, pp.433-442, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01372350

M. Vausort, A. Salgado-somoza, L. Zhang, P. Leszek, M. Scholz et al., Myocardial infarction-associated circular RNA predicting left ventricular dysfunction, J. Am. Coll. Cardiol, vol.68, issue.11, pp.1247-1248, 2016.

N. Townsend, L. Wilson, P. Bhatnagar, K. Wickramasinghe, M. Rayner et al., Cardiovascular disease in Europe: epidemiological update 2016, Eur Heart J, vol.37, pp.3232-3245, 2016.

E. J. Benjamin, M. J. Blaha, and S. E. Chiuve, Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association, Circulation, vol.135, pp.146-603, 2017.

A. J. Lansky, V. G. Ng, and A. Maehara, Gender and the extent of coronary atherosclerosis, plaque composition, and clinical outcomes in acute coronary syndromes, JACC Cardiovasc Imaging, vol.5, pp.62-72, 2012.

C. S. Lam, M. Mcentegart, and B. Claggett, Sex differences in clinical characteristics and outcomes after myocardial infarction: insights from the Valsartan in Acute Myocardial Infarction Trial (VALIANT), Eur J Heart Fail, vol.17, pp.301-313, 2015.

M. J. Valero-masa, J. Velasquez-rodriguez, and F. Diez-delhoyo, Sex differences in acute myocardial infarction: Is it only the age?, Int J Cardiol, vol.231, pp.36-41, 2017.

J. Berg, L. Bjorck, S. Nielsen, G. Lappas, and A. Rosengren, Sex differences in survival after myocardial infarction in Sweden, Heart, vol.103, pp.1625-1630, 1987.

A. Galli and F. Lombardi, Postinfarct Left Ventricular Remodelling: A Prevailing Cause of Heart Failure, Cardiol Res Pract, p.2579832, 2016.

D. L. Crabbe, K. Dipla, and S. Ambati, Gender differences in post-infarction hypertrophy in end-stage failing hearts, J Am Coll Cardiol, vol.41, pp.300-306, 2003.

J. H. Pope, T. P. Aufderheide, and R. Ruthazer, Missed diagnoses of acute cardiac ischemia in the emergency department, N Engl J Med, vol.342, pp.1163-70, 2000.

L. B. Daniels and A. S. Maisel, Cardiovascular biomarkers and sex: the case for women, Nat Rev Cardiol, vol.12, pp.588-96, 2015.

M. Fertin, E. Dubois, A. Belliard, P. Amouyel, F. Pinet et al., Usefulness of circulating biomarkers for the prediction of left ventricular remodeling after myocardial infarction, Am J Cardiol, vol.110, pp.277-83, 2012.

S. D. Wiviott, C. P. Cannon, and D. A. Morrow, Differential expression of cardiac biomarkers by gender in patients with unstable angina/non-ST-elevation myocardial infarction: a TACTICS-TIMI 18 (Treat Angina with Aggrastat and determine Cost of Therapy with an Invasive or Conservative Strategy-Thrombolysis In Myocardial Infarction 18) substudy, Circulation, vol.109, pp.580-586, 2004.

E. M. Hsich, M. V. Grau-sepulveda, and A. F. Hernandez, Relationship between sex, ejection fraction, and B-type natriuretic peptide levels in patients hospitalized with heart failure and associations with inhospital outcomes: findings from the Get With The Guideline-Heart Failure Registry, Am Heart J, vol.166, pp.1063-1071, 2013.

A. Boileau, T. Lalem, M. Vausort, L. Zhang, and Y. Devaux, A 3-gene panel improves the prediction of left ventricular dysfunction after acute myocardial infarction, Int J Cardiol, vol.254, pp.28-35, 2018.

R. Ubrich, P. Barthel, and B. Haller, Sex differences in long-term mortality among acute myocardial infarction patients: Results from the ISAR-RISK and ART studies, PLoS One, vol.12, p.186783, 2017.

V. Lundberg, B. Stegmayr, K. Asplund, M. Eliasson, and F. Huhtasaari, Diabetes as a risk factor for myocardial infarction: population and gender perspectives, J Intern Med, vol.241, pp.485-92, 1997.

I. Gustafsson, B. Brendorp, and M. Seibaek, Influence of diabetes and diabetes-gender interaction on the risk of death in patients hospitalized with congestive heart failure, J Am Coll Cardiol, vol.43, pp.771-778, 2004.

K. M. Eggers, T. Jernberg, and B. Lindahl, High-sensitivity cardiac troponin T, left ventricular function, and outcome in non-ST elevation acute coronary syndrome, Am Heart J, vol.197, pp.70-76, 2018.

S. T. Nauta, J. W. Deckers, R. T. Van-domburg, and K. M. Akkerhuis, Sex-related trends in mortality in hospitalized men and women after myocardial infarction between 1985 and 2008: equal benefit for women and men, Circulation, vol.126, pp.2184-2193, 2012.

M. Fertin, B. Hennache, and M. Hamon, Usefulness of serial assessment of B-type natriuretic peptide, troponin I, and C-reactive protein to predict left ventricular remodeling after acute myocardial infarction (from the REVE-2 study), Am J Cardiol, vol.106, pp.1410-1416, 2010.

S. Talwar, I. B. Squire, and P. F. Downie, Profile of plasma N-terminal proBNP following acute myocardial infarction; correlation with left ventricular systolic dysfunction, Eur Heart J, vol.21, pp.1514-1535, 2000.

G. Graham, Acute Coronary Syndromes in Women: Recent Treatment Trends and Outcomes, Clin Med Insights Cardiol, vol.10, pp.1-10, 2016.

E. J. Benjamin, M. J. Blaha, S. E. Chiuve, M. Cushman, S. R. Das et al., Heart disease and stroke Statistics-2017 update: a report from the American Heart Association, vol.135, pp.146-603, 2017.

N. Townsend, L. Wilson, P. Bhatnagar, K. Wickramasinghe, M. Rayner et al., Cardiovascular disease in Europe: epidemiological update, vol.37, pp.3232-3245, 2016.

H. Jneid, G. C. Fonarow, C. P. Cannon, A. F. Hernandez, I. F. Palacios et al., Sex differences in medical care and early death after acute myocardial infarction, Circulation, vol.118, issue.25, pp.2803-2810, 2008.

N. J. Pagidipati and E. D. Peterson, Acute coronary syndromes in women and men, Nat. Rev. Cardiol, vol.13, issue.8, pp.471-480, 2016.

V. Vaccarino, H. M. Krumholz, J. Yarzebski, J. M. Gore, and R. J. Goldberg, Sex differences in 2-year mortality after hospital discharge for myocardial infarction, Ann. Intern. Med, vol.134, issue.3, pp.173-181, 2001.

B. Ziaeian and G. C. Fonarow, Epidemiology and aetiology of heart failure, Nat. Rev. Cardiol, vol.13, issue.6, pp.368-378, 2016.

G. W. Stone, S. R. Dixon, C. L. Grines, D. A. Cox, J. G. Webb et al., Predictors of infarct size after primary coronary angioplasty in acute myocardial infarction from pooled analysis from four contemporary trials, Am. J. Cardiol, vol.100, issue.9, pp.1370-1375, 2007.

T. J. Cahill and R. K. Kharbanda, Heart failure after myocardial infarction in the era of primary percutaneous coronary intervention: mechanisms, incidence and identification of patients at risk, World J. Cardiol, vol.9, issue.5, pp.407-415, 2017.

B. Ibanez, S. James, S. Agewall, M. J. Antunes, C. Bucciarelli-ducci et al., ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC), Eur. Heart J, vol.39, issue.2, pp.119-177, 2017.

J. J. Mcmurray, M. Packer, A. S. Desai, J. Gong, M. P. Lefkowitz et al., Angiotensin-neprilysin inhibition versus enalapril in heart failure, N. Engl. J. Med, vol.371, issue.11, pp.993-1004, 2014.

Y. Devaux, Transcriptome of blood cells as a reservoir of cardiovascular biomarkers, Biochim. Biophys. Acta (BBA) Mol. Cell Res, vol.1864, issue.1, pp.209-216, 2017.

M. Vausort, D. R. Wagner, and Y. Devaux, Long noncoding RNAs in patients with acute myocardial infarction, Circ. Res, vol.115, issue.7, pp.668-677, 2014.

K. Higashimoto, H. Soejima, T. Saito, K. Okumura, and T. Mukai, Imprinting disruption of the CDKN1C/KCNQ1OT1 domain: the molecular mechanisms causing BeckwithWiedemann syndrome and cancer, Cytogenet. Genome Res, vol.113, issue.1-4, pp.306-312, 2006.

L. Korostowski, N. Sedlak, and N. Engel, The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart, PLoS Genet, vol.8, issue.9, 2012.

S. Matsuoka, M. C. Edwards, C. Bai, S. Parker, P. Zhang et al., p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene, Genes Dev, vol.9, issue.6, pp.650-662, 1995.

Y. Takagi, Adenovirus-mediated overexpression of a cyclin-dependent kinase inhibitor, p57Kip2, suppressed vascular smooth muscle cell proliferation, Hokkaido Igaky Zasshi, vol.77, issue.3, pp.221-230, 2002.

N. Nakano, K. Urasawa, Y. Takagi, T. Saito, S. Kaneta et al., Downregulation of cyclin-dependent kinase inhibitor; p57(kip2), is involved in the cell cycle progression of vascular smooth muscle cells, Biochem. Biophys. Res. Commun, vol.338, issue.3, pp.1661-1667, 2005.

I. Rodriguez, E. Coto, J. R. Reguero, P. Gonzalez, V. Andres et al., Role of the CDKN1A/p21, CDKN1C/p57, and CDKN2A/p16 genes in the risk of atherosclerosis and myocardial infarction, Cell Cycle, vol.6, issue.5, pp.620-625, 2007.

H. Landolsi, N. Missaoui, S. Brahem, S. Hmissa, M. Gribaa et al., The usefulness of p57(KIP2) immunohistochemical staining and genotyping test in the diagnosis of the hydatidiform mole, Pathol. Res. Pract, vol.207, issue.8, pp.498-504, 2011.

S. Sasaki, Y. Sasaki, T. Kunimura, A. Sekizawa, Y. Kojima et al., Clinical usefulness of Immunohistochemical staining of p57 kip2 for the differential diagnosis of complete mole, Biomed. Res. Int, vol.2015, 2015.

M. H. Khouja, M. Baekelandt, J. M. Nesland, and R. Holm, The clinical importance of Ki-67, p16, p14, and p57 expression in patients with advanced ovarian carcinoma, Int. J. Gynecol. Pathol, vol.26, issue.4, pp.418-425, 2007.

X. Y. Xu, W. Q. Wang, L. Zhang, Y. M. Li, M. Tang et al., Clinical implications of p57 KIP2 expression in breast cancer, Asian Pac, J. Cancer Prev, vol.13, issue.10, pp.5033-5036, 2012.

B. A. Rodriguez, Y. I. Weng, T. M. Liu, T. Zuo, P. Y. Hsu et al., Estrogenmediated epigenetic repression of the imprinted gene cyclin-dependent kinase inhibitor 1C in breast cancer cells, Carcinogenesis, vol.32, issue.6, pp.812-821, 2011.

A. Boileau, T. Lalem, M. Vausort, L. Zhang, and Y. Devaux, A 3-gene panel improves the prediction of left ventricular dysfunction after acute myocardial infarction, Int. J. Cardiol, vol.254, pp.28-35, 2018.

F. Beutner, D. Teupser, S. Gielen, L. M. Holdt, M. Scholz et al., Rationale and design of the Leipzig (LIFE) heart study: phenotyping and cardiovascular characteristics of patients with coronary artery disease, PLoS One, vol.6, issue.12, p.29070, 2011.

R. Burkhardt, H. Kirsten, F. Beutner, L. M. Holdt, A. Gross et al., Integration of genome-wide SNP data and gene-expression profiles reveals six novel loci and regulatory mechanisms for amino acids and acylcarnitines in whole blood, PLoS Genet, vol.11, issue.9, 2015.

H. Kirsten, H. Al-hasani, L. Holdt, A. Gross, F. Beutner et al., Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding locidagger, Hum. Mol. Genet, vol.24, issue.16, pp.4746-4763, 2015.

S. Talwar, I. B. Squire, P. F. Downie, A. M. Mccullough, M. C. Campton et al., Profile of plasma N-terminal proBNP following acute myocardial infarction; correlation with left ventricular systolic dysfunction, Eur. Heart J, vol.21, issue.18, pp.1514-1521, 2000.

O. Melander, A. S. Maisel, P. Almgren, J. Manjer, M. Belting et al., Plasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality, JAMA, vol.308, issue.14, pp.1469-1475, 2012.

C. L. Drum, W. K. Tan, S. P. Chan, L. S. Pakkiri, J. P. Chong et al., Thymosin beta-4 is elevated in women with heart failure with preserved ejection fraction, J. Am. Heart Assoc, vol.6, issue.6, 2017.

P. Ponikowski, A. A. Voors, S. D. Anker, H. Bueno, J. G. Cleland et al., ESC guidelines for the diagnosis and treatment of acute and chronic heart failure, Eur. J. Heart Fail, vol.18, issue.8, pp.891-975, 2016.

Y. Devaux, M. Vausort, G. P. Mccann, J. Zangrando, D. Kelly et al., MicroRNA-150: a novel marker of left ventricular remodeling after acute myocardial infarction, Circ. Cardiovasc. Genet, vol.6, issue.3, pp.290-298, 2013.

M. Vausort, A. Salgado-somoza, L. Zhang, P. Leszek, M. Scholz et al., Myocardial infarction-associated circular RNA predicting left ventricular dysfunction, J. Am. Coll. Cardiol, vol.68, issue.11, pp.1247-1248, 2016.

Y. Devaux, A. Salgado-somoza, J. Dankiewicz, A. Boileau, P. Stammet et al., Incremental value of circulating MiR-122-5p to predict outcome after out of hospital cardiac arrest, Theranostics, vol.7, issue.10, pp.2555-2564, 2017.

Y. Devaux, M. Vausort, G. P. Mccann, D. Kelly, O. Collignon et al., A panel of 4 microRNAs facilitates the prediction of left ventricular contractility after acute myocardial infarction, PLoS One, vol.8, issue.8, 2013.

E. W. Steyerberg, S. E. Bleeker, H. A. Moll, D. E. Grobbee, and K. G. Moons, Internal and external validation of predictive models: a simulation study of bias and precision in small samples, J. Clin. Epidemiol, vol.56, issue.5, pp.441-447, 2003.

T. J. Wang, M. G. Larson, D. Levy, E. P. Leip, E. J. Benjamin et al., Impact of age and sex on plasma natriuretic peptide levels in healthy adults, Am. J. Cardiol, vol.90, issue.3, pp.254-258, 2002.

R. S. Vasan, E. J. Benjamin, M. G. Larson, E. P. Leip, T. J. Wang et al., Plasma natriuretic peptides for community screening for left ventricular hypertrophy and systolic dysfunction: the Framingham heart study, JAMA, vol.288, issue.10, pp.1252-1259, 2002.

M. M. Redfield, R. J. Rodeheffer, S. J. Jacobsen, D. W. Mahoney, K. R. Bailey et al., Plasma brain natriuretic peptide concentration: impact of age and gender, J. Am. Coll. Cardiol, vol.40, issue.5, pp.976-982, 2002.

M. A. Cavasin, Z. Y. Tao, A. L. Yu, and X. P. Yang, Testosterone enhances early cardiac remodeling after myocardial infarction, causing rupture and degrading cardiac function, Am. J. Physiol. Heart Circ. Physiol, vol.290, issue.5, pp.2043-2050, 2006.

D. L. Crabbe, K. Dipla, S. Ambati, A. Zafeiridis, J. P. Gaughan et al., Gender differences in post-infarction hypertrophy in end-stage failing hearts, J. Am. Coll. Cardiol, vol.41, issue.2, pp.300-306, 2003.

P. A. Heidenreich, J. G. Trogdon, O. A. Khavjou, J. Butler, K. Dracup et al., Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association, Circulation, vol.123, issue.8, pp.933-944, 2011.

J. Vargas, J. A. Lima, W. E. Kraus, P. S. Douglas, and S. Rosenberg, Use of the Corus® CAD gene expression test for assessment of obstructive coronary artery disease likelihood in symptomatic non-diabetic patients, PLoS Curr, vol.5, 2013.

N. G. Frangogiannis, The inflammatory response in myocardial injury, repair, and remodelling, Nat. Rev. Cardiol, vol.11, issue.5, pp.255-265, 2014.

D. Mancini-dinardo, S. J. Steele, J. M. Levorse, R. S. Ingram, and S. M. Tilghman, Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes, Genes Dev, vol.20, issue.10, pp.1268-1282, 2006.

, cluster avec la FV et leur capacité à stratifier les patients d'une manière spécifique à chaque sexe méritent d'être également étudiées. Bibliographie 1. Cardiovascular disease in Europe 2016: an epidemiological update, Eur Heart J, vol.37, issue.42, pp.3182-3183, 2016.

M. Fertin, Usefulness of circulating biomarkers for the prediction of left ventricular remodeling after myocardial infarction, Am J Cardiol, vol.110, issue.2, pp.277-83, 2012.

C. S. Lam, Influence of sex and hormone status on circulating natriuretic peptides, J Am Coll Cardiol, vol.58, issue.6, pp.618-644, 2011.

N. Suthahar, Sex-specific associations of obesity and N-terminal pro-B-type natriuretic peptide levels in the general population, Eur J Heart Fail, 2018.

C. S. Lam, Sex differences in clinical characteristics and outcomes after myocardial infarction: insights from the Valsartan in Acute Myocardial Infarction Trial (VALIANT), Eur J Heart Fail, vol.17, issue.3, pp.301-313, 2015.

K. H. Humphries, Sex differences in cardiovascular disease -Impact on care and outcomes, Front Neuroendocrinol, vol.46, pp.46-70, 2017.

B. D. Johnson, Persistent chest pain predicts cardiovascular events in women without obstructive coronary artery disease: results from the NIH-NHLBI-sponsored Women's Ischaemia Syndrome Evaluation (WISE) study, Eur Heart J, vol.27, issue.12, pp.1408-1423, 2006.

S. E. Reis, Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study, Am Heart J, vol.141, issue.5, pp.735-776, 2001.

D. L. Crabbe, Gender differences in post-infarction hypertrophy in end-stage failing hearts, J Am Coll Cardiol, vol.41, issue.2, pp.300-306, 2003.

E. M. Hsich, Relationship between sex, ejection fraction, and B-type natriuretic peptide levels in patients hospitalized with heart failure and associations with inhospital outcomes: findings from the Get With The Guideline-Heart Failure Registry, Am Heart J, vol.166, issue.6, p.3, 2013.

L. B. Daniels and A. S. Maisel, Cardiovascular biomarkers and sex: the case for women, Nat Rev Cardiol, vol.12, issue.10, pp.588-96, 2015.

F. H. Netter, Atlas of human anatomy

C. M. Kramer, Multimodality imaging of myocardial injury and remodeling, J Nucl Med, vol.51, issue.1, pp.107-121, 2010.

J. Dean, Coronary microvascular dysfunction: sex-specific risk, diagnosis, and therapy, Nat Rev Cardiol, vol.12, issue.7, pp.406-420, 2015.

A. L. Beale, Sex Differences in Cardiovascular Pathophysiology: Why Women Are Overrepresented in Heart Failure With Preserved Ejection Fraction. Circulation, vol.138, pp.198-205, 2018.

V. H. Huxley, Sex and the cardiovascular system: the intriguing tale of how women and men regulate cardiovascular function differently, Adv Physiol Educ, vol.31, issue.1, pp.17-22, 2007.

, Cardiovascular diseases

A. Timmis, European Society of Cardiology: Cardiovascular Disease Statistics 2017, Eur Heart J, vol.39, issue.7, pp.508-579, 2018.

S. Yusuf, Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study, Lancet, vol.364, issue.9438, pp.937-52, 2004.

S. S. Mahmood, The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective, Lancet, vol.383, issue.9921, pp.999-1008, 2014.

G. Hu, The gender-specific impact of diabetes and myocardial infarction at baseline and during follow-up on mortality from all causes and coronary heart disease, J Am Coll Cardiol, vol.45, issue.9, pp.1413-1421, 2005.

E. L. Barrett-connor, Why is diabetes mellitus a stronger risk factor for fatal ischemic heart disease in women than in men? The Rancho Bernardo Study, Jama, vol.265, issue.5, pp.627-658, 1991.

S. M. Haffner, H. Miettinen, and M. P. Stern, Relatively more atherogenic coronary heart disease risk factors in prediabetic women than in prediabetic men, Diabetologia, vol.40, issue.6, pp.711-718, 1997.

R. Huxley, F. Barzi, and M. Woodward, Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies, Bmj, vol.332, issue.7533, pp.73-81, 2006.

K. Williams, Diabetes, abdominal adiposity, and atherogenic dyslipoproteinemia in women compared with men, Diabetes, vol.57, issue.12, pp.3289-96, 2008.

S. G. Wannamethee, Do women exhibit greater differences in established and novel risk factors between diabetes and non-diabetes than men? The British Regional Heart Study and British Women's Heart Health Study, Diabetologia, vol.55, issue.1, pp.80-87, 2012.

J. Stamler, R. Stamler, and J. D. Neaton, Blood pressure, systolic and diastolic, and cardiovascular risks. US population data, Arch Intern Med, vol.153, issue.5, pp.598-615, 1993.

D. Mozaffarian, Update: A Report From the American Heart Association. Circulation, vol.133, issue.4, pp.38-360, 2016.

J. Boggia, Ambulatory blood pressure monitoring in 9357 subjects from 11 populations highlights missed opportunities for cardiovascular prevention in women, Hypertension, vol.57, issue.3, pp.397-405, 2011.

D. Levy, The progression from hypertension to congestive heart failure, Jama, vol.275, pp.1557-62, 1920.

J. Stamler, D. Wentworth, and J. D. Neaton, Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT), Jama, vol.256, pp.2823-2831, 1920.

R. A. Kreisberg and S. Kasim, Cholesterol metabolism and aging, Am J Med, vol.82, issue.1b, pp.54-60, 1987.

D. J. Lerner and W. B. Kannel, Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population, Am Heart J, vol.111, issue.2, pp.383-90, 1986.

L. J. Shaw, Insights from the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study: Part I: gender differences in traditional and novel risk factors, symptom evaluation, and gender-optimized diagnostic strategies, J Am Coll Cardiol, vol.47, issue.3, pp.4-20, 2006.

S. Kenchaiah, Obesity and the risk of heart failure, N Engl J Med, vol.347, issue.5, pp.305-318, 2002.

R. Sturm and A. Hattori, Morbid obesity rates continue to rise rapidly in the United States, Int J Obes, vol.37, issue.6, pp.889-91, 2013.

C. S. Hayward, C. M. Webb, and P. Collins, Effect of sex hormones on cardiac mass, Lancet, vol.357, issue.9265, pp.1354-1360, 2001.

X. Song, Obesity attenuates gender differences in cardiovascular mortality, Cardiovasc Diabetol, vol.13, p.144, 2014.

E. Puymirat, Association of changes in clinical characteristics and management with improvement in survival among patients with ST-elevation myocardial infarction, Jama, vol.308, issue.10, pp.998-1006, 2012.

V. Vaccarino and J. D. Bremner, Behavioral, emotional and neurobiological determinants of coronary heart disease risk in women, Neurosci Biobehav Rev, vol.74, pp.297-309, 2017.

V. Regitz-zagrosek, ESC Guidelines on the management of cardiovascular diseases during pregnancy: the Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC), Eur Heart J, vol.32, issue.24, pp.3147-97, 2011.

M. A. Nickens, R. C. Long, and S. A. Geraci, Cardiovascular disease in pregnancy: (women's health series), South Med J, vol.106, issue.11, pp.624-654, 2013.

L. Mosca, Effectiveness-based guidelines for the prevention of cardiovascular disease in women--2011 update: a guideline from the american heart association, Circulation, vol.123, issue.11, pp.1243-62, 2011.

L. Bellamy, Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis, Lancet, vol.373, issue.9677, pp.1773-1782, 2009.

T. Muka, Association of Age at Onset of Menopause and Time Since Onset of Menopause With Cardiovascular Outcomes, Intermediate Vascular Traits, and AllCause Mortality: A Systematic Review and Meta-analysis, JAMA Cardiol, vol.1, issue.7, pp.767-776, 2016.

G. Albrektsen, Lifelong Gender Gap in Risk of Incident Myocardial Infarction: The Tromso Study, JAMA Intern Med, vol.176, issue.11, pp.1673-1679, 2016.

K. Thygesen, Third universal definition of myocardial infarction, Eur Heart J, vol.33, pp.2551-67, 1920.

M. T. Roe, Clinical and therapeutic profile of patients presenting with acute coronary syndromes who do not have significant coronary artery disease, The Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy (PURSUIT) Trial Investigators. Circulation, vol.102, pp.1101-1107, 2000.

R. Bugiardini, O. Manfrini, and G. M. De-ferrari, Unanswered questions for management of acute coronary syndrome: risk stratification of patients with minimal disease or normal findings on coronary angiography, Arch Intern Med, vol.166, issue.13, pp.1391-1396, 2006.

H. R. Reynolds, Mechanisms of myocardial infarction in women without angiographically obstructive coronary artery disease. Circulation, vol.124, pp.1414-1439, 2011.

J. A. Suwaidi, Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction, Circulation, vol.101, issue.9, pp.948-54, 2000.

R. Bugiardini, Endothelial function predicts future development of coronary artery disease: a study of women with chest pain and normal coronary angiograms, Circulation, vol.109, issue.21, pp.2518-2541, 2004.

M. E. Bertrand, Frequency of provoked coronary arterial spasm in 1089 consecutive patients undergoing coronary arteriography. Circulation, vol.65, pp.1299-306, 1982.

E. S. Spatz, The Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) Classification System: A Taxonomy for Young Women With Acute Myocardial Infarction, Circulation, vol.132, issue.18, pp.1710-1718, 2015.

V. Regitz-zagrosek and G. Kararigas, Mechanistic Pathways of Sex Differences in Cardiovascular Disease, Physiol Rev, vol.97, issue.1, pp.1-37, 2017.

K. Sakakura, Pathophysiology of atherosclerosis plaque progression, Heart Lung Circ, vol.22, issue.6, pp.399-411, 2013.

L. Gonzalez and B. L. Trigatti, Macrophage Apoptosis and Necrotic Core Development in Atherosclerosis: A Rapidly Advancing Field with Clinical Relevance to Imaging and Therapy, Can J Cardiol, vol.33, issue.3, pp.303-312, 2017.

A. J. Lansky, Gender and the extent of coronary atherosclerosis, plaque composition, and clinical outcomes in acute coronary syndromes, JACC Cardiovasc Imaging, issue.5, pp.62-72, 2012.

S. J. White, A. C. Newby, and T. W. Johnson, Endothelial erosion of plaques as a substrate for coronary thrombosis, Thromb Haemost, vol.115, issue.3, pp.509-528, 2016.

N. J. Pagidipati and E. D. Peterson, Acute coronary syndromes in women and men, Nat Rev Cardiol, vol.13, issue.8, pp.471-80, 2016.

M. J. Hung, P. Hu, and M. Y. Hung, Coronary artery spasm: review and update, Int J Med Sci, vol.11, issue.11, pp.1161-71, 2014.

T. Nishiguchi, Prevalence of spontaneous coronary artery dissection in patients with acute coronary syndrome, Eur Heart J Acute Cardiovasc Care, vol.5, issue.3, pp.263-70, 2016.

H. N. Rashid, Incidence and characterisation of spontaneous coronary artery dissection as a cause of acute coronary syndrome--A single-centre Australian experience, Int J Cardiol, vol.202, pp.336-344, 2016.

R. Ono and L. M. Falcao, Takotsubo cardiomyopathy systematic review: Pathophysiologic process, clinical presentation and diagnostic approach to Takotsubo cardiomyopathy, Int J Cardiol, vol.209, pp.196-205, 2016.

K. A. Bybee, Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome, Am J Cardiol, vol.94, issue.3, pp.343-349, 2004.

Y. J. Akashi, The clinical features of takotsubo cardiomyopathy, Qjm, vol.96, issue.8, pp.563-73, 2003.

K. Kothawade and C. N. Bairey-merz, Microvascular coronary dysfunction in women: pathophysiology, diagnosis, and management, Curr Probl Cardiol, vol.36, issue.8, pp.291-318, 2011.

E. Jones, W. Eteiba, and N. B. , Merz, Cardiac syndrome X and microvascular coronary dysfunction, Trends Cardiovasc Med, vol.22, issue.6, pp.161-169, 2012.

R. Twerenbold, Clinical Use of High-Sensitivity Cardiac Troponin in Patients With Suspected Myocardial Infarction, J Am Coll Cardiol, vol.70, issue.8, pp.996-1012, 2017.

B. Ibanez, ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC), Eur Heart J, vol.39, issue.2, pp.119-177, 2017.

S. Dey, Sex-related differences in the presentation, treatment and outcomes among patients with acute coronary syndromes: the Global Registry of Acute Coronary Events, Heart, vol.95, issue.1, pp.20-26, 2009.

N. A. Khan, Sex differences in acute coronary syndrome symptom presentation in young patients, JAMA Intern Med, vol.173, pp.1863-71, 1920.

J. G. Canto, Association of age and sex with myocardial infarction symptom presentation and in-hospital mortality, Jama, vol.307, issue.8, pp.813-835, 2012.

P. Kaul, Temporal trends in patient and treatment delay among men and women presenting with ST-elevation myocardial infarction, Am Heart J, vol.161, issue.1, pp.91-98, 2011.

D. B. Diercks, Gender differences in time to presentation for myocardial infarction before and after a national women's cardiovascular awareness campaign: a temporal analysis from the Can Rapid Risk Stratification of Unstable Angina Patients Suppress ADverse Outcomes with Early Implementation (CRUSADE) and the National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network-Get with the Guidelines (NCDR ACTION Registry-GWTG), Am Heart J, vol.160, issue.1, pp.80-87, 2010.

M. Roffi, ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC), Eur Heart J, vol.37, issue.3, pp.267-315, 2015.

R. Pelletier, Sex-related differences in access to care among patients with premature acute coronary syndrome, Cmaj, vol.186, issue.7, pp.497-504, 2014.

J. S. Hochman, Sex, clinical presentation, and outcome in patients with acute coronary syndromes. Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes IIb Investigators, N Engl J Med, vol.341, issue.4, pp.226-258, 1999.

H. Jneid, Sex differences in medical care and early death after acute myocardial infarction. Circulation, vol.118, pp.2803-2813, 2008.

E. Giannitsis and H. A. Katus, Cardiac troponin level elevations not related to acute coronary syndromes, Nat Rev Cardiol, issue.10, pp.623-657, 2013.

M. Mueller, Cardiac troponin T: from diagnosis of myocardial infarction to cardiovascular risk prediction, Circ J, vol.77, issue.7, pp.1653-61, 2013.

N. L. Mills, Implementation of a sensitive troponin I assay and risk of recurrent myocardial infarction and death in patients with suspected acute coronary syndrome, Jama, vol.305, issue.12, pp.1210-1216, 2011.

N. L. Mills, Implications of lowering threshold of plasma troponin concentration in diagnosis of myocardial infarction: cohort study, Bmj, vol.344, p.1533, 2012.

S. D. Wiviott, Differential expression of cardiac biomarkers by gender in patients with unstable angina/non-ST-elevation myocardial infarction: a TACTICS-TIMI 18 (Treat Angina with Aggrastat and determine Cost of Therapy with an Invasive or Conservative Strategy-Thrombolysis In Myocardial Infarction 18) substudy. Circulation, vol.109, pp.580-586, 2004.

F. S. Apple, R. Ler, and M. M. Murakami, Determination of 19 cardiac troponin I and T assay 99th percentile values from a common presumably healthy population, Clin Chem, vol.58, issue.11, pp.1574-81, 2012.

, High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study, Bmj, vol.350, p.626, 2015.

J. Lew, Sex-Based Differences in Cardiometabolic Biomarkers, Circulation, vol.135, issue.6, pp.544-555, 2017.

J. H. Pope, Missed diagnoses of acute cardiac ischemia in the emergency department, N Engl J Med, vol.342, issue.16, pp.1163-70, 2000.

V. Vaccarino, Sex-based differences in early mortality after myocardial infarction. National Registry of Myocardial Infarction 2 Participants, N Engl J Med, vol.341, issue.4, pp.217-242, 1999.

B. Ahmed and H. L. Dauerman, Women, bleeding, and coronary intervention, Circulation, vol.127, issue.5, pp.641-650, 2013.

S. Johansson, Mortality and morbidity trends after the first year in survivors of acute myocardial infarction: a systematic review, BMC Cardiovasc Disord, vol.17, issue.1, p.53, 2017.

M. J. Valero-masa, Sex differences in acute myocardial infarction: Is it only the age?, Int J Cardiol, vol.231, pp.36-41, 2017.

J. Berg, Sex differences in survival after myocardial infarction in Sweden, vol.103, pp.1625-1630, 1920.

K. M. Kvakkestad, Gender differences in all-cause, cardiovascular and cancer mortality during long-term follow-up after acute myocardial infarction; a prospective cohort study, BMC Cardiovasc Disord, vol.17, issue.1, p.75, 2017.

R. Ubrich, Sex differences in long-term mortality among acute myocardial infarction patients: Results from the ISAR-RISK and ART studies, PLoS One, vol.12, issue.10, p.186783, 2017.

M. Izadnegahdar, Do younger women fare worse? Sex differences in acute myocardial infarction hospitalization and early mortality rates over ten years, J Womens Health (Larchmt), vol.23, issue.1, pp.10-17, 2014.

E. R. Porrello, Transient regenerative potential of the neonatal mouse heart, Science, vol.331, issue.6020, pp.1078-80, 2011.

Y. Matsui, J. Morimoto, and T. Uede, Role of matricellular proteins in cardiac tissue remodeling after myocardial infarction, World J Biol Chem, vol.1, issue.5, pp.69-80, 2010.

Y. Ma, Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling, Pflugers Arch, vol.466, issue.6, pp.1113-1140, 2014.

L. Timmers, The innate immune response in reperfused myocardium, Cardiovasc Res, vol.94, issue.2, pp.276-83, 2012.

N. G. Frangogiannis, The mechanistic basis of infarct healing, Antioxid Redox Signal, vol.8, pp.1907-1946, 2006.

A. Saxena, IL-1 induces proinflammatory leukocyte infiltration and regulates fibroblast phenotype in the infarcted myocardium, J Immunol, vol.191, issue.9, pp.4838-4886, 2013.

V. Talman and H. Ruskoaho, Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration, Cell Tissue Res, vol.365, issue.3, pp.563-81, 2016.

I. E. Willems, The alpha-smooth muscle actin-positive cells in healing human myocardial scars, Am J Pathol, vol.145, issue.4, pp.868-75, 1994.

D. Vanhoutte, Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: a temporal and spatial window, Cardiovasc Res, vol.69, issue.3, pp.604-617, 2006.

J. Gonzalez-santamaria, Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction, Cardiovasc Res, vol.109, issue.1, pp.67-78, 2016.

S. W. Van-den-borne, Myocardial remodeling after infarction: the role of myofibroblasts, Nat Rev Cardiol, vol.7, issue.1, pp.30-37, 2010.

F. A. Flachskampf, Cardiac imaging after myocardial infarction, Eur Heart J, vol.32, issue.3, pp.272-83, 2011.

P. Zhang, Multiscale Characterization of Impact of Infarct Size on Myocardial Remodeling in an Ovine Infarct Model, Cells Tissues Organs, issue.5, pp.349-62, 0200.

M. A. Konstam, Left ventricular remodeling in heart failure: current concepts in clinical significance and assessment, JACC Cardiovasc Imaging, vol.4, issue.1, pp.98-108, 2011.

J. Heineke and J. D. Molkentin, Regulation of cardiac hypertrophy by intracellular signalling pathways, Nat Rev Mol Cell Biol, vol.7, issue.8, pp.589-600, 2006.

F. G. Spinale, Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function, Physiol Rev, vol.87, issue.4, pp.1285-342, 2007.

A. T. Yan, Characterization of the peri-infarct zone by contrast-enhanced cardiac magnetic resonance imaging is a powerful predictor of post-myocardial infarction mortality, Circulation, vol.114, issue.1, pp.32-41, 2006.

N. G. Frangogiannis, The inflammatory response in myocardial injury, repair, and remodelling, Nat Rev Cardiol, vol.11, issue.5, pp.255-65, 2014.

A. Madamanchi, Beta-adrenergic receptor signaling in cardiac function and heart failure, Mcgill J Med, vol.10, issue.2, pp.99-104, 2007.

G. Olivetti, Apoptosis in the failing human heart, N Engl J Med, vol.336, issue.16, pp.1131-1172, 1997.

K. Lindpaintner, Selective activation of cardiac angiotensinogen gene expression in post-infarction ventricular remodeling in the rat, J Mol Cell Cardiol, vol.25, issue.2, pp.133-176, 1993.

H. H. Sigusch, S. E. Campbell, and K. T. Weber, Angiotensin II-induced myocardial fibrosis in rats: role of nitric oxide, prostaglandins and bradykinin, Cardiovasc Res, vol.31, issue.4, pp.546-54, 1996.

A. S. Bhatt, A. P. Ambrosy, and E. J. Velazquez, Adverse Remodeling and Reverse Remodeling After Myocardial Infarction, Curr Cardiol Rep, vol.19, issue.8, p.71, 2017.

M. Maczewski, Late ventricular remodeling in non-reperfused acute myocardial infarction in humans is predicted by angiotensin II type 1 receptor density on blood platelets, Int J Cardiol, vol.127, issue.1, pp.57-63, 2008.

J. S. Burchfield, M. Xie, and J. A. Hill, Pathological ventricular remodeling: mechanisms: part 1 of 2. Circulation, vol.128, pp.388-400, 2013.

A. Galli and F. Lombardi, Postinfarct Left Ventricular Remodelling: A Prevailing Cause of Heart Failure, Cardiol Res Pract, p.2579832, 2016.

K. H. Darasz, Measurement of left ventricular volume after anterior myocardial infarction: comparison of magnetic resonance imaging, echocardiography, and radionuclide ventriculography, Int J Cardiovasc Imaging, vol.18, issue.2, pp.135-177, 2002.

M. Piro, Sex-related differences in myocardial remodeling, J Am Coll Cardiol, vol.55, issue.11, pp.1057-65, 2010.

P. G. Masci, Relationship between location and size of myocardial infarction and their reciprocal influences on post-infarction left ventricular remodelling, Eur Heart J, vol.32, issue.13, pp.1640-1648, 2011.

E. Canali, Impact of gender differences on myocardial salvage and postischaemic left ventricular remodelling after primary coronary angioplasty: new insights from cardiovascular magnetic resonance, Eur Heart J Cardiovasc Imaging, vol.13, issue.11, pp.948-53, 2012.

J. C. Wu, Influence of sex on ventricular remodeling after myocardial infarction in mice, J Am Soc Echocardiogr, vol.16, issue.11, pp.1158-62, 2003.

D. A. Brown, Susceptibility of the heart to ischaemia-reperfusion injury and exercise-induced cardioprotection are sex-dependent in the rat, J Physiol, vol.564, issue.2, pp.619-649, 2005.

M. S. Johnson, R. L. Moore, and D. A. Brown, Sex differences in myocardial infarct size are abolished by sarcolemmal KATP channel blockade in rat, Am J Physiol Heart Circ Physiol, vol.290, issue.6, pp.2644-2691, 2006.

M. Jain, Influence of gender on the response to hemodynamic overload after myocardial infarction, Am J Physiol Heart Circ Physiol, vol.283, issue.6, pp.2544-50, 2002.

M. Wang, 17-beta-Estradiol decreases p38 MAPK-mediated myocardial inflammation and dysfunction following acute ischemia, J Mol Cell Cardiol, vol.40, issue.2, pp.205-217, 2006.

S. A. Gabel, Estrogen receptor beta mediates gender differences in ischemia/reperfusion injury, J Mol Cell Cardiol, vol.38, issue.2, pp.289-97, 2005.

M. A. Cavasin, Testosterone enhances early cardiac remodeling after myocardial infarction, causing rupture and degrading cardiac function, Am J Physiol Heart Circ Physiol, vol.290, issue.5, pp.2043-50, 2006.

M. A. Cavasin, Gender differences in cardiac function during early remodeling after acute myocardial infarction in mice, Life Sci, vol.75, issue.18, pp.2181-92, 2004.

L. Fang, Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction, J Mol Cell Cardiol, vol.43, issue.5, pp.535-579, 2007.

B. Kuch, Gender specific differences in left ventricular adaptation to obesity and hypertension, J Hum Hypertens, vol.12, issue.10, pp.685-91, 1998.

G. G. Biondi-zoccai, Reduced post-infarction myocardial apoptosis in women: a clue to their different clinical course? Heart, vol.91, pp.99-101, 2005.

P. Ponikowski, ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure, Rev Esp Cardiol, vol.69, issue.12, p.1167, 2016.

D. S. Lee, Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the framingham heart study of the national heart, lung, and blood institute, Circulation, vol.119, issue.24, pp.3070-3077, 2009.

A. Mosterd and A. W. Hoes, Clinical epidemiology of heart failure. Heart, vol.93, issue.9, pp.1137-1183, 2007.

M. M. Redfield, Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic, Jama, vol.289, issue.2, pp.194-202, 2003.

G. S. Bleumink, Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study, Eur Heart J, vol.25, issue.18, pp.1614-1623, 2004.

F. Ceia, Prevalence of chronic heart failure in Southwestern Europe: the EPICA study, Eur J Heart Fail, vol.4, issue.4, pp.531-540, 2002.

T. E. Owan, Trends in prevalence and outcome of heart failure with preserved ejection fraction, N Engl J Med, vol.355, issue.3, pp.251-260, 2006.

, The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis, Eur Heart J, vol.33, issue.14, pp.1750-1757, 2012.

K. F. Adams and . Jr, Relationship of serum digoxin concentration to mortality and morbidity in women in the digitalis investigation group trial: a retrospective analysis, J Am Coll Cardiol, vol.46, issue.3, pp.497-504, 2005.

F. J. Charchar, Association of the human Y chromosome with cholesterol levels in the general population, Arterioscler Thromb Vasc Biol, vol.24, issue.2, pp.308-320, 2004.

F. J. Charchar, Y is there a risk to being male?, Trends Endocrinol Metab, vol.14, issue.4, pp.163-171, 2003.

F. J. Charchar, Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome, Lancet, vol.379, issue.9819, pp.915-922, 2012.

J. B. Berletch, Genes that escape from X inactivation, Hum Genet, vol.130, issue.2, pp.237-282, 2011.

D. Shungin, New genetic loci link adipose and insulin biology to body fat distribution, Nature, vol.518, issue.7538, pp.187-196, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01132692

E. Orlowska-baranowska, Association of the common genetic polymorphisms and haplotypes of the chymase gene with left ventricular mass in male patients with symptomatic aortic stenosis, PLoS One, vol.9, issue.5, p.96306, 2014.

H. Wu, Genetic variation and gender determine bradykinin type 1 receptor responses in human tissue: implications for the ACE-inhibitor-induced effects in patients with coronary artery disease, Clin Sci, vol.126, issue.6, pp.441-450, 2014.

G. Kararigas, Sex-dependent regulation of fibrosis and inflammation in human left ventricular remodelling under pressure overload, Eur J Heart Fail, vol.16, issue.11, pp.1160-1167, 2014.

E. W. Tobi, DNA methylation differences after exposure to prenatal famine are common and timing-and sex-specific, Hum Mol Genet, vol.18, issue.21, pp.4046-53, 2009.

A. D. Stein, Exposure to famine during gestation, size at birth, and blood pressure at age 59 y: evidence from the Dutch Famine, Eur J Epidemiol, vol.21, issue.10, pp.759-65, 2006.

A. M. Queiros, Sex-and estrogen-dependent regulation of a miRNA network in the healthy and hypertrophied heart, Int J Cardiol, vol.169, issue.5, pp.331-339, 2013.

W. H. Cleland, C. R. Mendelson, and E. R. Simpson, Aromatase activity of membrane fractions of human adipose tissue stromal cells and adipocytes, Endocrinology, vol.113, issue.6, pp.2155-60, 1983.

L. E. Carlson and B. B. Sherwin, Higher levels of plasma estradiol and testosterone in healthy elderly men compared with age-matched women may protect aspects of explicit memory, Menopause, vol.7, issue.3, pp.168-77, 2000.

A. M. Shearman, Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts, Circ Res, vol.98, issue.5, pp.590-592, 2006.

I. Peter, Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women, Am J Hypertens, vol.18, issue.11, pp.1388-95, 2005.

J. Nordmeyer, Upregulation of myocardial estrogen receptors in human aortic stenosis, Circulation, vol.110, pp.3270-3275, 1920.

S. Mahmoodzadeh, Estrogen receptor alpha up-regulation and redistribution in human heart failure, Faseb j, vol.20, issue.7, pp.926-960, 2006.

G. Olivetti, Gender differences and aging: effects on the human heart, J Am Coll Cardiol, vol.26, issue.4, pp.1068-79, 1995.

S. Guerra, Myocyte death in the failing human heart is gender dependent, Circ Res, vol.85, issue.9, pp.856-66, 1999.

C. Chen, Apoptosis and autophagy contribute to gender difference in cardiac ischemia-reperfusion induced injury in rats, Life Sci, issue.93, pp.265-70, 2013.

A. Iwakura, Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthasemediated activation of matrix metalloproteinase-9, Circulation, vol.113, issue.12, pp.1605-1619, 2006.

T. Y. Le, Role of androgens in sex differences in cardiac damage during myocardial infarction, Endocrinology, vol.155, issue.2, pp.568-75, 2014.

M. Wang, Role of endogenous testosterone in myocardial proinflammatory and proapoptotic signaling after acute ischemia-reperfusion, Am J Physiol Heart Circ Physiol, vol.288, issue.1, pp.221-227, 2005.

A. Kher, Sex differences in the myocardial inflammatory response to acute injury, Shock, vol.23, issue.1, pp.1-10, 2005.

P. R. Kramer, V. Winger, and S. F. , Kramer, 17beta-Estradiol utilizes the estrogen receptor to regulate CD16 expression in monocytes, Mol Cell Endocrinol, vol.279, issue.1-2, pp.16-25, 2007.

H. L. Jeanes, Oestrogen-mediated cardioprotection following ischaemia and reperfusion is mimicked by an oestrogen receptor (ER)alpha agonist and unaffected by an ER beta antagonist, J Endocrinol, vol.197, issue.3, pp.493-501, 2008.

S. Mahmoodzadeh, Nuclear factor-kappaB regulates estrogen receptor-alpha transcription in the human heart, J Biol Chem, vol.284, issue.37, pp.24705-24719, 2009.

R. D. Patten, 17 Beta-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload, J Card Fail, vol.14, issue.3, pp.245-53, 2008.

C. Westphal, Effects of estrogen, an ERalpha agonist and raloxifene on pressure overload induced cardiac hypertrophy, PLoS One, vol.7, issue.12, p.50802, 2012.

G. Kararigas, Sex-specific modification of progesterone receptor expression by 17beta-oestradiol in human cardiac tissues, Biol Sex Differ, vol.1, issue.1, p.2, 2010.

G. Kararigas, Transcriptome characterization of estrogen-treated human myocardium identifies myosin regulatory light chain interacting protein as a sexspecific element influencing contractile function, J Am Coll Cardiol, vol.59, issue.4, pp.410-417, 2012.

S. Mahmoodzadeh, 17beta-Estradiol inhibits matrix metalloproteinase-2 transcription via MAP kinase in fibroblasts, Cardiovasc Res, vol.85, issue.4, pp.719-747, 2010.

N. Tamura, Cardiac fibrosis in mice lacking brain natriuretic peptide, Proc Natl Acad Sci, vol.97, issue.8, pp.4239-4283, 2000.

Y. Ogawa, Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene, J Clin Invest, vol.93, issue.5, pp.1911-1932, 1994.

A. Jujic, A genetic variant of the atrial natriuretic peptide gene is associated with left ventricular hypertrophy in a non-diabetic population--the Malmo preventive project study, BMC Med Genet, vol.14, p.64, 2013.

T. Hendriks, Predictors of left ventricular remodeling after ST-elevation myocardial infarction, Int J Cardiovasc Imaging, vol.33, issue.9, pp.1415-1423, 2017.

J. D. Haeck, Comparison of usefulness of N-terminal pro-brain natriuretic peptide as an independent predictor of cardiac function among admission cardiac serum biomarkers in patients with anterior wall versus nonanterior wall ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention, Am J Cardiol, vol.105, issue.8, pp.1065-1074, 2010.

D. Kelly, Plasma tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9: novel indicators of left ventricular remodelling and prognosis after acute myocardial infarction, Eur Heart J, vol.29, issue.17, pp.2116-2124, 2008.

S. Talwar, Profile of plasma N-terminal proBNP following acute myocardial infarction; correlation with left ventricular systolic dysfunction, Eur Heart J, vol.21, issue.18, pp.1514-1535, 2000.

T. J. Wang, Impact of age and sex on plasma natriuretic peptide levels in healthy adults, Am J Cardiol, vol.90, issue.3, pp.254-262, 2002.

R. S. Vasan, Plasma natriuretic peptides for community screening for left ventricular hypertrophy and systolic dysfunction: the Framingham heart study, Jama, vol.288, issue.10, pp.1252-1261, 2002.

M. M. Redfield, Plasma brain natriuretic peptide concentration: impact of age and gender, J Am Coll Cardiol, vol.40, issue.5, pp.976-82, 2002.

M. Hamada, Plasma levels of atrial and brain natriuretic peptides in apparently healthy subjects: Effects of sex, age, and hemoglobin concentration, Int J Cardiol, vol.228, pp.599-604, 2017.

S. Maffei, Increase in circulating levels of cardiac natriuretic peptides after hormone replacement therapy in postmenopausal women, Clin Sci (Lond), vol.101, issue.5, pp.447-53, 2001.

C. M. Hwu, Increased concentrations of atrial and plasma atrial natriuretic peptide in castrated male rats, Life Sci, vol.52, issue.2, pp.205-217, 1993.

H. Mollmann, Ischemia triggers BNP expression in the human myocardium independent from mechanical stress, Int J Cardiol, vol.143, issue.3, pp.289-97, 2010.

K. L. Ellis, Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes, J Mol Cell Cardiol, vol.50, issue.4, pp.695-701, 2011.

T. Y. Li, Sex Differences of the Natriuretic Peptide Polymorphism Associated With Angiographic Coronary Atherosclerosis, Cardiol Res, vol.8, issue.1, pp.1-6, 2017.

A. Mayr, Cardiac troponin T and creatine kinase predict mid-term infarct size and left ventricular function after acute myocardial infarction: a cardiac MR study, J Magn Reson Imaging, vol.33, issue.4, pp.847-54, 2011.

J. Hallen, Cardiac troponin I for the prediction of functional recovery and left ventricular remodelling following primary percutaneous coronary intervention for ST-elevation myocardial infarction, Heart, vol.96, issue.23, pp.1892-1899, 2010.

T. Dohi, Utility of peak creatine kinase-MB measurements in predicting myocardial infarct size, left ventricular dysfunction, and outcome after first anterior wall acute myocardial infarction (from the INFUSE-AMI trial), Am J Cardiol, vol.115, issue.5, pp.563-70, 2015.

T. S. Hall, Cardiac troponin I for prediction of clinical outcomes and cardiac function through 3-month follow-up after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction, Am Heart J, vol.169, issue.2, pp.257-265, 2015.

M. Fertin, Usefulness of serial assessment of B-type natriuretic peptide, troponin I, and C-reactive protein to predict left ventricular remodeling after acute myocardial infarction (from the REVE-2 study), Am J Cardiol, vol.106, issue.10, pp.1410-1416, 2010.

S. L. Klein and K. L. Flanagan, Sex differences in immune responses, Nat Rev Immunol, vol.16, issue.10, pp.626-664, 2016.

S. Aoki, Elevated peripheral blood mononuclear cell count is an independent predictor of left ventricular remodeling in patients with acute myocardial infarction, J Cardiol, vol.57, issue.2, pp.202-209, 2011.

A. Bauters, White blood cell and peripheral blood mononuclear cell counts for the prediction of left ventricular remodeling after myocardial infarction, J Cardiol, vol.58, issue.2, pp.197-205, 2011.

A. Tamura, T. Watanabe, and M. Nasu, Association between neutrophil counts on admission and left ventricular function in patients successfully treated with primary coronary angioplasty for first anterior wall acute myocardial infarction, Am J Cardiol, vol.88, issue.6, pp.678-80, 2001.

Y. Maekawa, Prognostic significance of peripheral monocytosis after reperfused acute myocardial infarction:a possible role for left ventricular remodeling, J Am Coll Cardiol, vol.39, issue.2, pp.241-247, 2002.

H. Tsujioka, Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction, J Am Coll Cardiol, vol.54, issue.2, pp.130-138, 2009.

J. Nunez, Low lymphocyte count in acute phase of ST-segment elevation myocardial infarction predicts long-term recurrent myocardial infarction. Coron Artery Dis, vol.21, pp.1-7, 2010.

A. Borekci, Neutrophil to Lymphocyte Ratio Predicts Left Ventricular Remodeling in Patients with ST Elevation Myocardial Infarction after Primary Percutaneous Coronary Intervention, Korean Circ J, vol.46, issue.1, pp.15-22, 2016.

I. M. Seropian, Inflammatory markers in ST-elevation acute myocardial infarction, Eur Heart J Acute Cardiovasc Care, vol.5, issue.4, pp.382-95, 2016.

A. Khera, Race and gender differences in C-reactive protein levels, J Am Coll Cardiol, vol.46, issue.3, pp.464-473, 2005.

I. Guillen, Cytokine signaling during myocardial infarction: sequential appearance of IL-1 beta and IL-6, Am J Physiol, vol.269, issue.2, pp.229-264, 1995.

S. Orn, Increased interleukin-1beta levels are associated with left ventricular hypertrophy and remodelling following acute ST segment elevation myocardial infarction treated by primary percutaneous coronary intervention, J Intern Med, vol.272, issue.3, pp.267-76, 2012.

L. Karpinski, Serum levels of interleukin-6, interleukin-10 and C-reactive protein in relation to left ventricular function in patients with myocardial infarction treated with primary angioplasty, Kardiol Pol, vol.66, issue.12, pp.1279-85, 2008.

R. A. Weir, Interleukin-21--a biomarker of importance in predicting myocardial function following acute infarction? Cytokine, vol.60, pp.220-225, 2012.

L. B. Daniels and A. Bayes-genis, Using ST2 in cardiovascular patients: a review, Future Cardiol, vol.10, issue.4, pp.525-564, 2014.

R. A. Weir, Serum soluble ST2: a potential novel mediator in left ventricular and infarct remodeling after acute myocardial infarction, J Am Coll Cardiol, vol.55, issue.3, pp.243-50, 2010.

E. E. Coglianese, Distribution and clinical correlates of the interleukin receptor family member soluble ST2 in the Framingham Heart Study, Clin Chem, vol.58, issue.12, pp.1673-81, 2012.

N. H. Dayawansa, Role of MIF in myocardial ischaemia and infarction: insight from recent clinical and experimental findings, Clin Sci, vol.127, issue.3, pp.149-61, 2014.

W. Chan, Macrophage migration inhibitory factor for the early prediction of infarct size, J Am Heart Assoc, issue.2, p.226, 2013.

M. Kobusiak-prokopowicz, Kinetics of chemokines in acute myocardial infarction, Kardiol Pol, vol.62, issue.4, pp.315-321, 2005.

M. Kobusiak-prokopowicz, Chemokines and left ventricular function in patients with acute myocardial infarction, Eur J Intern Med, vol.18, issue.4, pp.288-94, 2007.

C. Jourdan-lesaux, J. Zhang, and M. L. Lindsey, Extracellular matrix roles during cardiac repair, Life Sci, vol.87, pp.391-400, 2010.

C. Manhenke, The relationship between markers of extracellular cardiac matrix turnover: infarct healing and left ventricular remodelling following primary PCI in patients with first-time STEMI, Eur Heart J, vol.35, issue.6, pp.395-402, 2014.

R. Eschalier, Extracellular matrix turnover biomarkers predict long-term left ventricular remodeling after myocardial infarction: insights from the REVE-2 study, Circ Heart Fail, issue.6, pp.1199-205, 2013.

M. Fertin, Serum MMP-8: a novel indicator of left ventricular remodeling and cardiac outcome in patients after acute myocardial infarction, PLoS One, vol.8, issue.8, p.71280, 2013.

R. A. De-boer, Galectin-3: a novel mediator of heart failure development and progression, Eur J Heart Fail, vol.11, issue.9, pp.811-818, 2009.

R. J. Perea, Utility of galectin-3 in predicting post-infarct remodeling after acute myocardial infarction based on extracellular volume fraction mapping, Int J Cardiol, vol.223, pp.458-464, 2016.

G. Di-tano, Galectin-3 predicts left ventricular remodelling after anterior-wall myocardial infarction treated by primary percutaneous coronary intervention, Heart, vol.103, issue.1, pp.71-77, 2017.

J. E. Ho, Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the community, J Am Coll Cardiol, vol.60, issue.14, pp.1249-56, 2012.

L. B. Daniels, Galectin-3 is independently associated with cardiovascular mortality in community-dwelling older adults without known cardiovascular disease: The Rancho Bernardo Study, Am Heart J, vol.167, issue.5, pp.674-82, 2014.

I. C. Gerling, Gene expression profiles of peripheral blood mononuclear cells reveal transcriptional signatures as novel biomarkers of cardiac remodeling in rats with aldosteronism and hypertensive heart disease, JACC Heart Fail, issue.1, pp.469-76, 2013.

J. A. Wingrove, Correlation of peripheral-blood gene expression with the extent of coronary artery stenosis, Circ Cardiovasc Genet, vol.1, issue.1, pp.31-39, 2008.

F. Azuaje, Y. Devaux, and D. R. Wagner, Integrative pathway-centric modeling of ventricular dysfunction after myocardial infarction, PLoS One, vol.5, issue.3, p.9661, 2010.

F. Azuaje, Transcriptional networks characterize ventricular dysfunction after myocardial infarction: A proof-of-concept investigation, J Biomed Inform, vol.43, issue.5, pp.812-819, 2010.

Y. Devaux, Integrated protein network and microarray analysis to identify potential biomarkers after myocardial infarction, Funct Integr Genomics, vol.10, issue.3, pp.329-366, 2010.

F. J. Azuaje, Information encoded in a network of inflammation proteins predicts clinical outcome after myocardial infarction, BMC Med Genomics, vol.4, p.59, 2011.

Y. Devaux, Transforming growth factor beta receptor 1 is a new candidate prognostic biomarker after acute myocardial infarction, BMC Med Genomics, vol.4, p.83, 2011.

E. Goretti, D. R. Wagner, and Y. Devaux, miRNAs as biomarkers of myocardial infarction: a step forward towards personalized medicine?, Trends Mol Med, vol.20, issue.12, pp.716-741, 2014.

A. Zampetaki, Prospective study on circulating MicroRNAs and risk of myocardial infarction, J Am Coll Cardiol, vol.60, issue.4, pp.290-299, 2012.

A. Bye, Circulating microRNAs predict future fatal myocardial infarction in healthy individuals -The HUNT study, J Mol Cell Cardiol, vol.97, pp.162-170, 2016.

Y. Devaux, Use of circulating microRNAs to diagnose acute myocardial infarction, Clin Chem, vol.58, issue.3, pp.559-67, 2012.

U. Grabmaier, Diagnostic and prognostic value of miR-1 and miR-29b on adverse ventricular remodeling after acute myocardial infarction -The SITAGRAMImiR analysis, Int J Cardiol, vol.244, pp.30-36, 2017.

C. Bauters, Circulating miR-133a and miR-423-5p fail as biomarkers for left ventricular remodeling after myocardial infarction, Int J Cardiol, vol.168, issue.3, pp.1837-1877, 2013.

S. Matsumoto, Circulating p53-responsive microRNAs are predictive indicators of heart failure after acute myocardial infarction, Circ Res, vol.113, issue.3, pp.322-328, 2013.

Y. Devaux, MicroRNA-150: a novel marker of left ventricular remodeling after acute myocardial infarction, Circ Cardiovasc Genet, vol.6, issue.3, pp.290-298, 2013.

X. Liu, Circulating MicroRNA-146a and MicroRNA-21 Predict Left Ventricular Remodeling after ST-Elevation Myocardial Infarction, Cardiology, vol.132, issue.4, pp.233-274, 2015.

E. Dubois-deruy, MicroRNAs regulating superoxide dismutase 2 are new circulating biomarkers of heart failure, vol.7, p.14747, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02267416

J. Viereck and T. Thum, Circulating Noncoding RNAs as Biomarkers of Cardiovascular Disease and Injury, Circ Res, vol.120, issue.2, pp.381-399, 2017.

N. Ishii, Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction, J Hum Genet, vol.51, issue.12, pp.1087-99, 2006.

J. Zangrando, Identification of candidate long non-coding RNAs in response to myocardial infarction, BMC Genomics, vol.15, p.460, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01739527

R. Kumarswamy, Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure, Circ Res, vol.114, issue.10, pp.1569-75, 2014.
URL : https://hal.archives-ouvertes.fr/hal-02267443

P. Han, A long noncoding RNA protects the heart from pathological hypertrophy, Nature, vol.514, issue.7520, pp.102-106, 2014.

J. Zhang, Long Noncoding RNA MHRT Protects Cardiomyocytes against H2O2-Induced Apoptosis, Biomol Ther (Seoul), vol.24, issue.1, pp.19-24, 2016.

Y. Yan, Circulating Long Noncoding RNA UCA1 as a Novel Biomarker of Acute Myocardial Infarction, Biomed Res Int, p.8079372, 2016.

M. Vausort, D. R. Wagner, and Y. Devaux, Long noncoding RNAs in patients with acute myocardial infarction, Circ Res, vol.115, issue.7, pp.668-77, 2014.

Y. Devaux, Transcriptome of blood cells as a reservoir of cardiovascular biomarkers, Biochim Biophys Acta, vol.1864, issue.1, pp.209-216, 2017.

M. Vausort, Myocardial Infarction-Associated Circular RNA Predicting Left Ventricular Dysfunction, J Am Coll Cardiol, vol.68, issue.11, pp.1247-1248, 2016.

O. Melander, Plasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality, Jama, vol.308, issue.14, pp.1469-75, 2012.

J. L. Januzzi and . Jr, Circulating Proneurotensin Concentrations and Cardiovascular Disease Events in the Community: The Framingham Heart Study, Arterioscler Thromb Vasc Biol, vol.36, issue.8, pp.1692-1699, 2016.

N. Wettersten, Usefulness of Proneurotensin to Predict Cardiovascular and All-Cause Mortality in a United States Population (from the Reasons for Geographic and Racial Differences in Stroke Study), Am J Cardiol, vol.122, issue.1, pp.26-32, 2018.

C. L. Drum, Thymosin Beta-4 Is Elevated in Women With Heart Failure With Preserved Ejection Fraction, J Am Heart Assoc, issue.6, 2017.

A. Albadri, Inflammatory biomarkers as predictors of heart failure in women without obstructive coronary artery disease: A report from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE), PLoS One, vol.12, issue.5, p.177684, 2017.

R. Burkhardt, Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood, PLoS Genet, vol.11, issue.9, p.1005510, 2015.

H. Kirsten, Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding locidagger, Hum Mol Genet, vol.24, issue.16, pp.4746-63, 2015.

F. J. Azuaje, Systems-based approaches to cardiovascular biomarker discovery, Circ Cardiovasc Genet, vol.5, issue.3, pp.360-367, 2012.

K. Higashimoto, Imprinting disruption of the CDKN1C/KCNQ1OT1 domain: the molecular mechanisms causing Beckwith-Wiedemann syndrome and cancer, Cytogenet Genome Res, vol.113, issue.1-4, pp.306-318, 2006.

S. Sasaki, Clinical Usefulness of Immunohistochemical Staining of p57 kip2 for the Differential Diagnosis of Complete Mole, Biomed Res Int, p.905648, 2015.

M. H. Khouja, The clinical importance of Ki-67, p16, p14, and p57 expression in patients with advanced ovarian carcinoma, Int J Gynecol Pathol, vol.26, issue.4, pp.418-443, 2007.

X. Y. Xu, Clinical implications of p57 KIP2 expression in breast cancer, Asian Pac J Cancer Prev, vol.13, issue.10, pp.5033-5039, 2012.

I. Rodriguez, Role of the CDKN1A/p21, CDKN1C/p57, and CDKN2A/p16 genes in the risk of atherosclerosis and myocardial infarction, Cell Cycle, vol.6, issue.5, pp.620-625, 2007.

Y. Takagi, Adenovirus-mediated overexpression of a cyclin-dependent kinase inhibitor, p57Kip2, suppressed vascular smooth muscle cell proliferation, Hokkaido Igaku Zasshi, vol.77, issue.3, pp.221-251, 2002.

N. Nakano, Downregulation of cyclin-dependent kinase inhibitor; p57(kip2), is involved in the cell cycle progression of vascular smooth muscle cells, Biochem Biophys Res Commun, vol.338, issue.3, pp.1661-1668, 2005.

B. A. Rodriguez, Estrogen-mediated epigenetic repression of the imprinted gene cyclin-dependent kinase inhibitor 1C in breast cancer cells, Carcinogenesis, vol.32, issue.6, pp.812-833, 2011.

K. Miyazono, A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1, Embo j, vol.10, issue.5, pp.1091-101, 1991.

J. Bristow, Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B, J Cell Biol, vol.122, issue.1, pp.265-78, 1993.

J. W. Petersen and J. Y. Douglas, Tenascin-X, collagen, and Ehlers-Danlos syndrome: tenascin-X gene defects can protect against adverse cardiovascular events, Med Hypotheses, vol.81, issue.3, pp.443-450, 2013.

L. Jing, Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming growth factor-beta1 and peroxisome proliferator-activated receptor gamma in alcoholic cardiomyopathy, Chin Med J (Engl), vol.124, issue.3, pp.390-395, 2011.

H. Takase and Y. Dohi, Kidney function crucially affects B-type natriuretic peptide (BNP), N-terminal proBNP and their relationship, Eur J Clin Invest, vol.44, issue.3, pp.303-311, 2014.

A. Gabet, National trends in rate of patients hospitalized for heart failure and heart failure mortality in France, Eur J Heart Fail, vol.17, issue.6, pp.583-90, 2000.

M. Mayr, MicroRNAs within the continuum of postgenomics biomarker discovery, Arterioscler Thromb Vasc Biol, vol.33, issue.2, pp.206-220, 2013.

M. A. Siemelink and T. Zeller, Biomarkers of coronary artery disease: the promise of the transcriptome, Curr Cardiol Rep, vol.16, issue.8, p.513, 2014.

M. R. Elashoff, Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients, BMC Med Genomics, vol.4, p.26, 2011.

J. Vargas, Use of the Corus(R) CAD Gene Expression Test for Assessment of Obstructive Coronary Artery Disease Likelihood in Symptomatic Non-Diabetic Patients, PLoS Curr, issue.5, 2013.

M. X. Pham, Gene-expression profiling for rejection surveillance after cardiac transplantation, N Engl J Med, vol.362, pp.1890-900, 1920.

M. G. Crespo-leiro, Clinical usefulness of gene-expression profile to rule out acute rejection after heart transplantation: CARGO II, Eur Heart J, vol.37, issue.33, pp.2591-601, 2016.

R. Pfister, Differential white blood cell count and incident heart failure in men and women in the EPIC-Norfolk study, Eur Heart J, vol.33, issue.4, pp.523-553, 2012.

Y. Nakada, Sex differences in clinical characteristics and long-term outcome in acute decompensated heart failure patients with preserved and reduced ejection fraction, Am J Physiol Heart Circ Physiol, vol.310, issue.7, pp.813-833, 2016.

H. L. Kim, Gender Difference in the Prognostic Value of N-Terminal Pro-B Type Natriuretic Peptide in Patients With Heart Failure-A Report From the Korean Heart Failure Registry (KorHF), Circ J, vol.81, issue.9, pp.1329-1336, 2017.

M. H. Hartman, The contemporary value of peak creatine kinase-MB after ST-segment elevation myocardial infarction above other clinical and angiographic characteristics in predicting infarct size, left ventricular ejection fraction, and mortality, Clin Cardiol, vol.40, issue.5, pp.322-328, 2017.

T. Omland, Impact of sex on the prognostic value of high-sensitivity cardiac troponin I in the general population: the HUNT study, Clin Chem, vol.61, issue.4, pp.646-56, 2015.

M. N. Lyngbakken, High-Sensitivity Troponin I, and the Risk of Cardiovascular Events (from the Nord-Trondelag Health Study), Am J Cardiol, vol.118, issue.6, pp.816-821, 2016.

V. Lundberg, Diabetes as a risk factor for myocardial infarction: population and gender perspectives, J Intern Med, vol.241, issue.6, pp.485-92, 1997.

I. Gustafsson, Influence of diabetes and diabetes-gender interaction on the risk of death in patients hospitalized with congestive heart failure, J Am Coll Cardiol, vol.43, issue.5, pp.771-778, 2004.

A. Juutilainen, Gender difference in the impact of type 2 diabetes on coronary heart disease risk. Diabetes Care, vol.27, pp.2898-904, 2004.

J. A. Clayton and F. S. Collins, Policy: NIH to balance sex in cell and animal studies, Nature, vol.509, issue.7500, pp.282-285, 2014.