Advances in the diagnosis and treatment of chronic lymphocytic leukemia, Clin Adv Hematol Oncol, vol.2, pp.448-454, 2004. ,
Chronic lymphocytic leukemia: recent advances in diagnosis and treatment, Oncologist, vol.11, pp.21-30, 2006. ,
Leukemia virus long terminal repeat activates NFkappaB pathway by a TLR3-dependent mechanism, Virology, vol.345, pp.390-403, 2006. ,
DOI : 10.1016/j.virol.2005.10.003
URL : https://doi.org/10.1016/j.virol.2005.10.003
Toll-like receptors in the induction of the innate immune response, Nature, vol.406, pp.782-787, 2000. ,
Mammalian Toll-like receptors, Curr Opin Immunol, vol.15, pp.5-11, 2003. ,
TLR signaling, Curr Top Microbiol Immunol, vol.311, pp.1-16, 2006. ,
DOI : 10.1007/3-540-32636-7_1
Toll-like receptor signalling, Nat Rev Immunol, vol.4, pp.499-511, 2004. ,
Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation, Leukemia, vol.11, pp.342-345, 1997. ,
Recognition of doublestranded RNA and activation of NF-kappaB by Toll-like receptor 3, Nature, vol.413, pp.732-738, 2001. ,
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1-and TLR2-deficient mice, Nat Med, vol.8, pp.878-884, 2002. ,
DOI : 10.1038/nm732
, Apoptosis Assay Methods : Methods for studying apoptosis in individual cells Disponible sur
Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4, J Biol Chem, vol.277, pp.15028-15034, 2002. ,
Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes, J Biol Chem, vol.273, pp.29210-29217, 1998. ,
High response rate in refractory and poor-risk multiple myeloma after allotransplantation using a nonmyeloablative conditioning regimen and donor 221 lymphocyte infusions, Blood, vol.97, pp.2574-2579, 2001. ,
DOI : 10.1182/blood.v97.9.2574
URL : http://www.bloodjournal.org/content/97/9/2574.full.pdf
Minimal GVHD following in-vitro T celldepleted allogeneic stem cell transplantation with reduced-intensity conditioning allowing subsequent infusions of donor lymphocytes in patients with hematological malignancies and solid tumors, Exp Hematol, vol.31, pp.865-872, 2003. ,
Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes, J Biol Chem, vol.276, pp.23382-23390, 2001. ,
Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells, Blood, vol.99, pp.2969-2976, 2002. ,
Regulation of, 2006. ,
, Akt/PKB by phosphatidylinositol 3-kinase-dependent and-independent pathways in Bcell chronic lymphocytic leukemia cells: role of protein kinase C(Tabeta et al.), J Leukoc Biol, vol.80, pp.1473-1479
The cyclin-dependent kinase inhibitor p27(Kip1) induces N-terminal proteolytic cleavage of cyclin A, Proc Natl Acad Sci U S A, vol.95, pp.15374-15381, 1998. ,
AKT1/PKBalpha is recruited to lipid rafts and activated downstream of PKC isotypes in CD3-induced T cell signaling, FEBS Lett, vol.541, pp.155-162, 2003. ,
DNA activates human immune cells through a CpG sequence-dependent manner, Immunology, vol.97, pp.699-705, 1999. ,
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition, Proc Natl Acad Sci U S A, vol.98, pp.9237-9242, 2001. ,
Leucine-rich repeats and pathogen recognition in Toll-like receptors, Trends Immunol, vol.24, pp.528-533, 2003. ,
Downregulation of the PI3K/Akt survival pathway in cells with deregulated expression of c-Myc, Apoptosis, vol.11, pp.1311-1319, 2006. ,
A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells, Blood, vol.101, pp.4500-4504, 2003. ,
TAK1-dependent signaling requires functional interaction with TAB2/TAB3, J Biol Chem, vol.282, pp.3918-3928, 2007. ,
Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine, Blood, vol.106, pp.2018-2025, 2005. ,
, , 2002.
, Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signaling, J Virol, vol.76, pp.8729-8736
A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis, Cancer, vol.48, pp.198-206, 1981. ,
Leucémie lymphoïde chronique. Source : Cancers : évaluation, traitement et surveillance, Andrieu J.M., Colonna P, 1997. ,
, Disponible sur
, , 2002.
, Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2, Science, vol.298, pp.1025-1029
Cutting Edge: CD19+ Pro-B Cells Can Give Rise to Dendritic Cells In Vitro, J Immunol, vol.161, pp.5795-5799, 1998. ,
Long-term follow-up of T-cell depletion for bone marrow transplantation, Lancet, vol.341, pp.51-52, 1993. ,
Stereotyped and specific gene expression programs in human innate immune responses to bacteria, Proc Natl Acad Sci, vol.223, 2002. ,
, U S A, vol.99, pp.972-977
) 2. Cytokines and chemokines, J Allergy Clin Immunol, vol.111, pp.460-475, 2003. ,
The Immune Response Modifier Imiquimod Requires STAT-1 for induction of Interferon, InterferonStimulated Genes, and Interleukin-6, Antimicrob Agents Chemother, vol.43, pp.856-861, 1999. ,
The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells, Blood, vol.102, pp.956-963, 2003. ,
Subcutaneous CAMPATH-1H in fludarabine-resistant/relapsed chronic lymphocytic and B-prolymphocytic leukaemia, Br J Haematol, vol.96, pp.617-619, 1997. ,
Isolation of lymphocytes, granulocytes and macrophages, Scand J Immunol Suppl, vol.5, pp.9-15, 1976. ,
Role of nonmyeloablative allogeneic stem-cell transplantation after failure of autologous transplantation in patients with lymphoproliferative malignancies, J Clin Oncol, vol.20, pp.4022-4031, 2002. ,
CD40-activated Bcell chronic lymphocytic leukemia cells for tumor immunotherapy: stimulation of allogeneic versus autologous T cells generates different types of effector cells, Blood, vol.93, 1992. ,
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor, Nat Cell Biol, vol.2, pp.346-351, 2000. ,
Chronic lymphocytic leukemia, Hematology Am Soc Hematol Educ Program, pp.163-183, 2004. ,
PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase, Oncogene, vol.13, pp.2517-2526, 1996. ,
Chronic lymphocytic leukaemia: a model for investigating potential new targets for the therapy of indolent Activation of Raf-1 Signaling by Protein Kinase C through a Mechanism Involving Raf Kinase Inhibitory Protein, J Biol Chem, vol.278, pp.13061-13068, 2002. ,
Development of a cell with dendritic morphology from a precursor of B lymphocyte lineage, J Immunol, vol.138, pp.2075-2081, 1987. ,
Role of chlamydial heat shock protein 60 in the stimulation of innate immune cells by Chlamydia pneumoniae, Eur J Immunol, vol.32, pp.2460-2470, 2002. ,
ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia, N Engl J Med, vol.348, pp.1764-1775, 2003. ,
Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia, Blood, vol.94, pp.1840-1847, 1999. ,
Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP), J Biol Chem, vol.279, pp.5405-5412, 2004. ,
Expression of toll-like receptors on B lymphocytes, Cell Immunol, vol.236, pp.140-145, 2005. ,
Cellular survival: a play in three Akts, Genes Dev, vol.13, pp.2905-2927, 1999. ,
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery, Cell, vol.91, pp.231-241, 1997. ,
CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells, Blood, vol.102, pp.2146-2155, 2003. ,
Cell cycle progression of chronic lymphocytic leukemia cells is controlled by cyclin D2, cyclin D3, cyclin-dependent kinase (cdk) 4 and the cdk inhibitor p27, Leukemia, vol.16, pp.327-334, 2002. ,
Immunostimulatory CpG-oligonucleotides induce functional high affinity IL-2 receptors on B-CLL cells: costimulation with IL-2 results in a highly immunogenic phenotype, Exp Hematol, vol.28, pp.558-568, 2000. ,
Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells, Blood, vol.95, pp.999-1006, 2000. ,
Mutational status of IgVH genes consistent with antigen-driven selection but not percent of mutations has prognostic impact in B-cell chronic lymphocytic leukemia, Clin Lymphoma, vol.5, pp.123-126, 2004. ,
Results of alemtuzumab-based reduced-intensity allogeneic transplantation for chronic lymphocytic leukemia: a British Society of Blood and Marrow Transplantation Study, Blood, vol.107, pp.1724-1730, 2006. ,
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain, Cell, vol.103, pp.351-361, 2000. ,
Interleukin-8 induces the accumulation of B-cell chronic lymphocytic leukemia cells by prolonging survival in an autocrine fashion, Blood, vol.87, pp.4382-4389, 1996. ,
Cytokine gene expression in B-cell chronic lymphocytic leukemia: evidence of constitutive interleukin-8 (IL-8) mRNA expression and secretion of biologically active IL-8 protein, Blood, vol.84, pp.220-228, 1994. ,
Immunostimulatory oligonucleotide-induced metaphase cytogenetics detect chromosomal aberrations in 80% of CLL patients: A study of 132 CLL cases with correlation to FISH, IgVH status, and CD38 expression, Blood, vol.108, pp.3152-3160, 2006. ,
Primary cutaneous CD30+ T-cell lymphoma responsive to topical imiquimod (Aldara), Br J Dermatol, vol.150, pp.1198-1201, 2004. ,
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA, Science, vol.303, pp.1529-1531, 2004. ,
The two faces of IL-6 on Th1/Th2 differentiation, Mol Immunol, vol.39, pp.531-536, 2002. ,
Is chronic lymphocytic leukemia one disease?, Haematologica, vol.87, pp.1233-1235, 2002. ,
CLL Biology and Prognosis, Hematology Am Soc Hematol Educ Program, pp.278-284, 2005. ,
Individual cell-by-cell quantitation of lymphocyte surface membrane Ig in normal and CLL lymphocyte and during ontogeny of mouse B lymphocytes by immunoperoxidase assay, Blood, vol.55, pp.93-100, 1980. ,
Chlorambucil in indolent chronic lymphocytic leukemia. French Cooperative Group on Chronic Lymphocytic Leukemia, N Engl J Med, vol.338, pp.1506-1514, 1998. ,
B-cell chronic lymphocytic leukemia: present status and future directions. French Cooperative Group on CLL, Blood, vol.78, pp.1901-1914, 1991. ,
Helenalin Triggers a CD95 Death Receptor-independent Apoptosis That Is Not Affected by Overexpression of Bcl-xL or Bcl-2, Cancer Res, vol.61, pp.5817-5823, 2001. ,
Imiquimod and resiquimod as novel immunomodulators, J Antimicrob Chemother, vol.48, pp.751-755, 2001. ,
gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias, Blood, vol.85, pp.1580-1589, 1995. ,
Genomic aberrations and survival in chronic lymphocytic leukemia, N Engl J Med, vol.343, pp.1910-1916, 2000. ,
The CD5+ B-cell, Int J Biochem Cell Biol, vol.36, pp.2105-2111, 2004. ,
DOI : 10.1016/j.biocel.2004.05.017
Three novel mammalian toll-like receptors: gene structure, expression, and evolution, Eur Cytokine Netw, vol.11, pp.362-371, 2000. ,
TNFalpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway, Cell, vol.103, pp.1071-1083, 2000. ,
DOI : 10.1016/s0092-8674(00)00210-5
URL : https://doi.org/10.1016/s0092-8674(00)00210-5
Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4, Circulation, vol.105, pp.685-690, 2002. ,
DOI : 10.1161/hc0602.103617
Toll-like receptor 9 can be expressed at the cell surface of distinct populations of tonsils and human peripheral blood mononuclear cells, Infect Immun, vol.72, pp.7202-7211, 2004. ,
Cutaneous T cell lymphoma reactive CD4+ cytotoxic T lymphocyte clones display a Th1 cytokine profile and use a fas-independent pathway for specific tumor cell lysis, J Invest Dermatol, vol.115, pp.74-80, 2000. ,
DOI : 10.1046/j.1523-1747.2000.00995.x
URL : https://doi.org/10.1046/j.1523-1747.2000.00995.x
Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia, Blood, vol.107, pp.885-891, 2006. ,
T-Independent immune response: new aspects of B cell biology, Science, vol.290, pp.89-92, 2000. ,
DOI : 10.1126/science.290.5489.89
Interleukin-6 and interleukin-10 levels in chronic lymphocytic leukemia: correlation with phenotypic characteristics and outcome, Blood, vol.97, pp.256-263, 2001. ,
DOI : 10.1182/blood.v97.1.256
URL : http://www.bloodjournal.org/content/97/1/256.full.pdf
Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response, Cell, vol.60, pp.397-403, 1990. ,
Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells, Int Immunol, vol.16, pp.1411-1422, 2004. ,
DOI : 10.1093/intimm/dxh142
URL : https://academic.oup.com/intimm/article-pdf/16/10/1411/2174147/dxh142.pdf
Early modifications in the expression of mitogen-activated protein kinase (MAPK/ERK), stress-activated kinases SAPK/JNK and p38, and their phosphorylated substrates following focal cerebral ischemia, Acta Neuropathol (Berl), vol.105, pp.425-437, 2003. ,
LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF, J Exp Med, vol.198, pp.1043-1055, 2003. ,
DOI : 10.1084/jem.20031023
URL : http://jem.rupress.org/content/198/7/1043.full.pdf
Chronic lymphocytic leukemia, Cancer Treat Rev, vol.22, pp.1-13, 1996. ,
Reduced natural killer T-cells in B-cell chronic lymphocytic leukaemia identified by three monoclonal antibodies: Leu-11, A10, AB8.28, Br J Haematol, vol.62, pp.151-154, 1986. ,
DOI : 10.1111/j.1365-2141.1986.tb02911.x
, Natural history of stage A chronic lymphocytic leukaemia untreated patients, Br J Haematol, vol.76, pp.45-57, 1990.
,
Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia, Blood, vol.109, pp.4944-4951, 2007. ,
The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling, Int Immunol, vol.16, pp.1143-1154, 2004. ,
DOI : 10.1093/intimm/dxh115
URL : https://academic.oup.com/intimm/article-pdf/16/8/1143/2572602/dxh115.pdf
Haemophilus influenzae porin induces Toll-like receptor 2-mediated cytokine production in human monocytes and mouse macrophages, Infect Immun, vol.72, pp.1204-1209, 2004. ,
DOI : 10.1128/iai.72.2.1204-1209.2004
URL : https://iai.asm.org/content/72/2/1204.full.pdf
CD40-dependent and-independent activation of human tonsil B cells by CpG oligodeoxynucleotides, Eur J Immunol, vol.33, pp.1576-1585, 2003. ,
DOI : 10.1002/eji.200323444
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.200323444
Antigen-specific CD4+ T-cell help is required to activate a memory CD8+ T cell to a fully functional tumor killer cell, Cancer Res, vol.62, pp.6438-6441, 2002. ,
Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from two phase III, randomized, vehicle-controlled studies, J Am Acad Dermatol, vol.50, pp.722-733, 2004. ,
, , 2002.
, Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: a doubleblind, randomized, vehicle-controlled study, J Am Acad Dermatol, vol.47, pp.390-398
The origin of B-cell chronic lymphocytic leukemia, Semin Oncol, vol.33, pp.150-156, 2006. ,
Effect of Campath-1H antibody on human hematopoietic progenitors in vitro, Blood, vol.82, pp.807-812, 1993. ,
Direct costimulation of tumor-reactive CTL by helper T cells potentiate their proliferation, survival, and effector function, Clin Cancer Res, vol.8, pp.922-931, 2002. ,
, , 2000.
Toll-like receptor 4MD-2 complex mediates the signal transduction induced by flavolipin, an amino acidcontaining lipid unique to Flavobacterium meningosepticum, J Immunol, vol.168, pp.2939-2943, 2002. ,
DOI : 10.4049/jimmunol.168.10.5376
URL : http://www.jimmunol.org/content/168/10/5376.1.full.pdf
The immunological synapse: a molecular machine controlling T cell activation, Science, vol.285, pp.221-227, 1999. ,
Measurement of immunoglobulins G, A, and M levels in B-lymphocytes culture, J Immunoassay Immunochem, vol.26, pp.303-311, 2005. ,
Stem-cell transplantation in chronic lymphocytic leukaemia, Best Pract Res Clin Haematol, vol.20, pp.513-527, 2007. ,
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation, J Exp Med, vol.203, 1999. ,
Cutting edge: the immunostimulatory activity of the lung surfactant protein-A 232 involves Toll-like receptor 4, J Immunol, vol.168, pp.5989-5992, 2002. ,
CXCL16 influences the nature and specificity of CpG-induced immune activation, J Immunol, vol.177, pp.1575-1580, 2006. ,
Specificity in Tolllike receptor signalling through distinct effector functions of TRAF3 and TRAF6, Nature, vol.439, pp.204-207, 2006. ,
Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin, J Immunol, vol.166, pp.15-19, 2001. ,
DOI : 10.4049/jimmunol.166.1.15
URL : http://www.jimmunol.org/content/166/1/15.full.pdf
CAMPATH-1 antibodies in stem-cell transplantation, Cytotherapy, vol.3, pp.145-164, 2001. ,
DOI : 10.1080/146532401753173981
Elevated serum thymidine kinase levels identify a subgroup at high risk of disease progression in early, nonsmoldering chronic lymphocytic leukemia, Blood, vol.93, pp.1732-1737, 1999. ,
Serum beta(2)-microglobulin and serum thymidine kinase are independent predictors of progression-free survival in chronic lymphocytic leukemia and immunocytoma, Leuk Lymphoma, vol.22, pp.439-447, 1996. ,
Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia, Blood, vol.94, pp.1848-1854, 1999. ,
Immunoglobulin V genes and CD38 expression in CLL, Blood, vol.95, pp.2455-2457, 2000. ,
CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease, Blood, vol.99, pp.1023-1029, 2002. ,
) bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia, Blood, vol.82, pp.1820-1828, 1993. ,
Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity, Proc Natl Acad Sci U S A, vol.101, pp.15313-15317, 2004. ,
DOI : 10.1073/pnas.0406837101
URL : http://www.pnas.org/content/101/43/15313.full.pdf
Induction of cytotoxic T-cell responses against immunoglobulin V region-derived peptides modified at human leukocyte antigen-A2 binding residues, Blood, vol.98, pp.2999-3005, 2001. ,
DOI : 10.1182/blood.v98.10.2999
URL : http://www.bloodjournal.org/content/98/10/2999.full.pdf
Lymphoma classification-from controversy to consensus: the R.E.A.L. and WHO Classification of lymphoid neoplasms, Ann Oncol, vol.11, pp.3-10, 2000. ,
DOI : 10.1093/annonc/11.suppl_1.s3
URL : https://academic.oup.com/annonc/article-pdf/11/suppl_1/S3/7724526/11-suppl_1-S3.pdf
A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group, Blood, vol.84, pp.1361-1392, 1994. ,
Mechanism and function of a newly identified CpG DNA motif in human primary B cells, J Immunol, vol.164, pp.944-953, 2000. ,
Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88, J Immunol, vol.174, pp.2942-2950, 2005. ,
DOI : 10.4049/jimmunol.174.5.2942
URL : http://www.jimmunol.org/content/174/5/2942.full.pdf
The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein, Cell, vol.52, pp.269-279, 1988. ,
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5, Nature, vol.410, pp.1099-1103, 2001. ,
DOI : 10.1038/35074106
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8, Science, vol.303, pp.1526-1529, 2004. ,
DOI : 10.1126/science.1093620
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway, Nat Immunol, vol.3, pp.196-200, 2002. ,
DOI : 10.1038/ni758
A Toll-like receptor recognizes bacterial DNA, Nature, vol.408, pp.740-745, 2000. ,
DOI : 10.1038/35047123
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection, J Exp Med, vol.199, pp.1641-1650, 2004. ,
The biochemistry of apoptosis, Nature, vol.407, pp.770-776, 2000. ,
DOI : 10.1038/35037710
Leukemias, myeloma, and other lymphoreticular neoplasms, Cancer, vol.75, pp.381-394, 1995. ,
,
Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages, Infect Immun, vol.69, pp.1477-1482, 2001. ,
Triggering the interferon response: the role of IRF-3 transcription factor, J Interferon Cytokine Res, vol.19, pp.1-13, 1999. ,
Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and-independent pathways, Proc Natl Acad Sci U S A, vol.101, pp.11416-11421, 2004. ,
DOI : 10.1073/pnas.0403555101
URL : http://europepmc.org/articles/pmc509215?pdf=render
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways, Nat Immunol, vol.4, pp.1223-1229, 2003. ,
The immune response of Drosophila, Nature, vol.426, pp.33-38, 2003. ,
URL : https://hal.archives-ouvertes.fr/hal-00095084
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction, Nature, vol.434, pp.1035-1040, 2005. ,
IRF-7 is the master regulator of type-I interferon-dependent immune responses, Nature, vol.434, pp.772-777, 2005. ,
Mammalian Toll-like receptors: to immunity and beyond, Clin Exp Immunol, vol.140, pp.395-407, 2005. ,
DOI : 10.1111/j.1365-2249.2005.02801.x
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809390
The adaptor molecule TIRAP 235 provides signalling specificity for Toll-like receptors, Nature, vol.420, pp.329-333, 2002. ,
DOI : 10.1038/nature01180
Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides, J Immunol, vol.168, pp.4531-4537, 2002. ,
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product, J Immunol, vol.162, pp.3749-3752, 1999. ,
Flow Cytometry and Cell Sorting: An Introduction Disponible sur, p.11, 2005. ,
Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death, J Biol Chem, vol.279, pp.49420-49429, 2004. ,
The central role of CD4(+) T cells in the antitumor immune response, J Exp Med, vol.188, pp.2357-2368, 1998. ,
CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia, Blood, vol.98, pp.181-186, 2001. ,
DOI : 10.1182/blood.v98.1.181
URL : http://www.bloodjournal.org/content/98/1/181.full.pdf
Toll receptors in innate immunity, Trends Cell Biol, vol.11, pp.304-311, 2001. ,
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling, Embo J, vol.22, pp.6277-6288, 2003. ,
Toll-like receptor control of the adaptive immune responses, Nat Immunol, vol.5, pp.987-995, 2004. ,
CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens, J Leukoc Biol, vol.69, pp.81-88, 2001. ,
, , p.236, 2005.
, lymphomas differ in their responsiveness to CpG oligodeoxynucleotides, Clin Cancer Res, vol.11, pp.1490-1499
Immunostimulatory oligodeoxynucleotides induce apoptosis of B cell chronic lymphocytic leukemia cells, J Leukoc Biol, vol.77, pp.378-387, 2005. ,
Innate immune recognition, Annu Rev Immunol, vol.20, pp.197-216, 2002. ,
Immuno biology, the immune system in health and disease, 2001. ,
Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4, J Immunol, vol.168, pp.5233-5239, 2002. ,
Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubicin, and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukaemia. The French Cooperative Group on CLL, Lancet, vol.347, pp.1432-1438, 1996. ,
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA, Nat Biotechnol, vol.23, pp.457-462, 2005. ,
Chromosome aberrations in B-cell chronic lymphocytic leukemia. Pathogenetic and clinical implications, Cancer Genet Cytogenet, vol.45, pp.143-160, 1990. ,
Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases, Mol Cell Biol, vol.17, pp.24-35, 1997. ,
C-Class CpG ODN: sequence requirements and characterization of immunostimulatory activities on mRNA level, Immunobiology, vol.209, pp.141-154, 2004. ,
Pleiotropic function of Toll-like receptors, Microbes Infect, vol.6, pp.1388-1394, 2004. ,
Chronic lymphocytic leukemia, Oncologist, vol.4, pp.352-369, 1999. ,
Signal transduction by the TCR for antigen, Curr Opin Immunol, vol.12, pp.242-249, 2000. ,
Apoptosis in cancer: cause and cure, Bioessays, vol.22, pp.1007-1017, 2000. ,
Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway, Oncogene, vol.15, pp.629-637, 1997. ,
Innate immune recognition of viral infection, Nat Immunol, vol.7, pp.131-137, 2006. ,
TLR signaling, Cell Death Differ, vol.13, pp.816-825, 2006. ,
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6, Nat Immunol, vol.5, pp.1061-1068, 2004. ,
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes, J Immunol, vol.167, pp.5887-5894, 2001. ,
,
Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type-and stimulus-specific fashion, J Biol Chem, vol.279, pp.47720-47725, 2004. ,
Interleukin 4 content in chronic lymphocytic leukaemia (CLL) B cells and blood CD8+ T cells from B-CLL patients: impact on clonal B-cell apoptosis, Br J Haematol, vol.112, pp.760-767, 2001. ,
Emerging information on the use of rituximab in chronic lymphocytic leukemia, Semin Oncol, vol.29, pp.70-74, 2002. ,
Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia, J Clin Oncol, vol.23, pp.4079-4088, 2005. ,
Long-term follow-up of patients with chronic lymphocytic leukemia (CLL) receiving fludarabine regimens as initial therapy, Blood, vol.92, pp.1165-1171, 1998. ,
Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells, J Immunol, vol.170, pp.4465-4474, 2003. ,
Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL, J Biol Chem, vol.279, pp.31664-31670, 2004. ,
Transplant-lite: induction of graft-versus-malignancy using fludarabine-based nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies, J Clin Oncol, vol.16, pp.2817-2824, 1998. ,
,
Nonablative allogeneic hematopoietic transplantation as adoptive immunotherapy for indolent lymphoma: low incidence of toxicity, acute graft-versus-host disease, and treatment-related mortality, Blood, vol.98, pp.3595-3599, 2001. ,
The CD5 B cell, Adv Immunol, vol.47, pp.117-185, 1989. ,
Use of CpG oligodeoxynucleotides as immune adjuvants, Immunol Rev, vol.199, pp.201-216, 2004. ,
,
Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients, Blood, vol.86, pp.2041-2050, 1995. ,
Protein kinase C alpha activates RAF-1 by direct phosphorylation, Nature, vol.364, pp.249-252, 1993. ,
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway, Genes Dev, vol.13, pp.2059-2071, 1999. ,
,
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells, p.239, 2007. ,
, Nature, vol.448, pp.484-487
CpG motifs in bacterial DNA and their immune effects, Annu Rev Immunol, vol.20, pp.709-760, 2002. ,
Therapeutic potential of Toll-like receptor 9 activation, Nat Rev Drug Discov, vol.5, pp.471-484, 2006. ,
Rescue of B cells from apoptosis by immune stimulatory CpG DNA, Springer Semin Immunopathol, vol.22, pp.55-61, 2000. ,
V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia, Blood, vol.100, pp.1410-1416, 2002. ,
TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function, Immunity, vol.21, pp.107-119, 2004. ,
Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis, Proc Natl Acad Sci U S A, vol.101, pp.1315-1320, 2004. ,
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus, Nat Immunol, vol.1, pp.398-401, 2000. ,
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation, Physiol Rev, vol.81, pp.807-869, 2001. ,
The protooncogene TCL1 is an Akt kinase coactivator, Mol Cell, vol.6, pp.395-407, 2000. ,
DOI : 10.1016/s1097-2765(00)00039-3
URL : https://doi.org/10.1016/s1097-2765(00)00039-3
TLR9 signals after translocating from the ER to CpG DNA in the lysosome, Nat Immunol, vol.5, pp.190-198, 2004. ,
Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction, J Biol Chem, vol.277, pp.47834-47843, 2002. ,
Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway, J Biol Chem, vol.271, pp.20608-20616, 1996. ,
NF-kappaB-mediated upregulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes, Proc Natl Acad Sci U S A, vol.96, pp.9136-9141, 1999. ,
Clusters de différenciation humains, Applications à la caractérisation des hémopathies, 1998. ,
Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators, J Immunol, vol.166, pp.5161-5167, 2001. ,
The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults, Cell, vol.86, pp.973-983, 1996. ,
Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients, Blood, vol.98, pp.2319-2325, 2001. ,
Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway, J Biol Chem, vol.280, pp.26152-26159, 2005. ,
IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase, Proc Natl Acad Sci U S A, vol.99, pp.5567-5572, 2002. ,
Protein kinase C-alpha overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal, Oncogene, vol.18, pp.6564-6572, 1999. ,
DOI : 10.1038/sj.onc.1203065
URL : https://www.nature.com/articles/1203065.pdf
Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products, J Biol Chem, vol.274, pp.33419-33425, 1999. ,
Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia, Blood, vol.100, pp.1404-1409, 2002. ,
Essential role of interferon 241 regulatory factor 3 in direct activation of RANTES chemokine transcription, Mol Cell Biol, vol.19, pp.959-966, 1999. ,
,
Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression, Mol Cell Biol, vol.27, pp.2240-2252, 2007. ,
Imiquimod therapy for molluscum contagiosum, J Cutan Med Surg, vol.4, pp.76-82, 2000. ,
Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation, J Exp Med, vol.194, pp.113-126, 2001. ,
Monoclonal antibodies in the treatment of chronic lymphocytic leukemia, Med Oncol, vol.21, pp.297-304, 2004. ,
The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease, Leukemia, vol.21, pp.110-120, 2007. ,
Transforming growth factor beta as endogenous growth inhibitor of chronic lymphocytic leukemia B cells, J Exp Med, vol.179, pp.999-1004, 1994. ,
,
Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions, Blood, vol.103, pp.3278-3281, 2004. ,
Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells, J Exp Med, vol.198, pp.513-520, 2003. ,
Recognition of single-stranded RNA viruses by Toll-like receptor, 2004. ,
, Proc Natl Acad Sci U S A, vol.101, pp.5598-5603
Cellular immune reconstitution after subcutaneous alemtuzumab (anti-CD52 monoclonal antibody, p.1, 2004. ,
, treatment as first-line therapy for B-cell chronic lymphocytic leukaemia, Leukemia, vol.18, p.242
Independent evolution of Toll and related genes in insects and mammals, Immunogenetics, vol.51, pp.92-98, 2000. ,
reviewer: Lee H.C.) Protein Reviews on the Web. The guide on CD38 ,
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1, Nature, vol.385, pp.540-544, 1997. ,
Expression of unmutated VH genes is a detrimental prognostic factor in chronic lymphocytic leukemia, Blood, vol.96, pp.377-379, 2000. ,
A distinct Toll-like receptor repertoire in human tonsillar B cells, directly activated by PamCSK, R-837 and CpG2006 stimulation, Immunology, vol.118, pp.539-548, 2006. ,
Impact of T-cell depletion on outcome of allogeneic bone-marrow transplantation for standard-risk leukaemias, Lancet, vol.2, pp.175-178, 1987. ,
Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent, J Immunol, vol.168, pp.1533-1537, 2002. ,
DOI : 10.4049/jimmunol.168.4.1533
URL : http://www.jimmunol.org/content/168/4/1533.full.pdf
Subcellular localization of Toll-like receptor 3 in human dendritic cells, J Immunol, vol.171, pp.3154-3162, 2003. ,
Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling, Biochem Biophys Res Commun, vol.293, pp.1364-1369, 2002. ,
, , 1994.
, D-type cyclin-dependent kinase activity in mammalian cells, Mol Cell Biol, vol.14, pp.2066-2076
ROS-dependent activation of the TRAF6ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity, Nat Immunol, vol.6, pp.587-592, 2005. ,
Immunotherapy of cytotoxic T cell-resistant tumors by T helper 2 cells: an eotaxin and STAT6-dependent process, J Exp Med, vol.197, pp.387-393, 2003. ,
The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL, Leukemia, vol.8, pp.1640-1645, 1994. ,
The danger model: a renewed sense of self, Science, vol.296, pp.301-305, 2002. ,
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1, Mol Cell, vol.21, pp.749-760, 2006. ,
Usefulness of CD79b expression in the diagnosis of B-cell chronic lymphoproliferative disorders, Am J Clin Pathol, vol.113, pp.805-813, 2000. ,
B cells as effectors, Curr Opin Immunol, vol.15, pp.354-361, 2003. ,
,
,
Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versustumor effects, Blood, vol.97, pp.3390-3400, 2001. ,
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts, Proc Natl Acad Sci U S A, vol.101, pp.233-238, 2004. ,
Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis, J Immunol, vol.163, pp.3920-3927, 1999. ,
Decoding the patterns of self and nonself by the innate immune system, Science, vol.296, pp.298-300, 2002. ,
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity, Nature, vol.388, pp.394-397, 1997. ,
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways, Mol Cell, vol.2, pp.253-258, 1998. ,
DOI : 10.1016/s1097-2765(00)80136-7
URL : https://doi.org/10.1016/s1097-2765(00)80136-7
Activation of Innate Defense against a Paramyxovirus Is Mediated by RIG-I and TLR7 and TLR8 in a Cell-Type-Specific Manner, J Virol, vol.79, pp.12944-12951, 2005. ,
,
In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells, J Clin Invest, vol.115, pp.755-764, 2005. ,
Induction of apoptosis by Toll-like receptor-7 agonist in tissue cultures, Br J Dermatol, vol.149, pp.9-14, 2003. ,
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation, Nat Immunol, vol.5, pp.503-507, 2004. ,
DOI : 10.1038/ni1061
Alloreactive donor lymphocytes (DLI) after allogeneic hematopoietic stem cell transplantation (HSCT): study of toxicity and efficacy, 2003. ,
, Bull Cancer, vol.90, pp.758-762
Allogeneic hematopoietic stem-cell transplantation for hematological malignancies, Bull Cancer, vol.88, pp.908-926, 2001. ,
CpG are efficient adjuvants for specific CTL induction against tumor antigenderived peptide, J Immunol, vol.168, pp.1212-1218, 2002. ,
DOI : 10.4049/jimmunol.168.3.1212
URL : http://www.jimmunol.org/content/168/3/1212.full.pdf
Imiquimod applied topically: a novel immune response modifier and new class of drug, Int J Immunopharmacol, vol.21, pp.1-14, 1999. ,
Generation of potent T(h)1 responses from patients with lymphoid malignancies after differentiation of B lymphocytes into dendritic-like cells, Int Immunol, vol.14, pp.741-750, 2002. ,
, Flow Cytometry and Sorting Part, vol.1, 1996.
Clinico-prognostic implications of simultaneous increased serum levels of soluble CD23 and beta2microglobulin in B-cell chronic lymphocytic leukemia, Eur J Haematol, vol.62, pp.117-122, 1999. ,
Clinicobiological implications of increased serum levels of interleukin-8 in B-cell chronic lymphocytic leukemia, Haematologica, vol.84, pp.208-211, 1999. ,
Bimodal effect of phorbol ester on B cell activation. Implication for the role of protein kinase C, J Biol Chem, vol.266, pp.4458-4463, 1991. ,
Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages, J Immunol, vol.165, pp.4632-4639, 2000. ,
Chronic lymphocytic leukemia: novel prognostic factors and their relevance for risk-adapted therapeutic strategies, Haematologica, vol.90, pp.391-399, 2005. ,
Chronic lymphocytic leukemia: present status, Ann Oncol, vol.6, pp.219-235, 1995. ,
Lymphocyte doubling time in chronic lymphocytic leukaemia: analysis of its prognostic significance, Br J Haematol, vol.62, pp.567-575, 1986. ,
Interleukin-10 and the interleukin-10 receptor, Annu Rev Immunol, vol.19, pp.683-765, 2001. ,
Bcl-2 protein expression and p53 gene mutation in chronic lymphocytic leukemia: correlation with in vitro sensitivity to chlorambucil and purine analogs, Haematologica, vol.82, pp.16-20, 1997. ,
Alemtuzumab therapy in B-cell lymphoproliferative disorders, Semin Oncol, vol.30, pp.493-501, 2003. ,
DOI : 10.1016/s0093-7754(03)00253-7
Cytometric bead array: a multiplexed assay platform with applications in various areas of biology, Clin Immunol, vol.110, pp.252-266, 2004. ,
Outcomes after alemtuzumab-containing reducedintensity allogeneic transplantation regimen for relapsed and refractory non-Hodgkin lymphoma, Blood, vol.104, pp.3865-3871, 2004. ,
DOI : 10.1182/blood-2004-03-1105
URL : http://www.bloodjournal.org/content/104/13/3865.full.pdf
, , 2004.
, Natl Cancer Inst, vol.96, pp.673-682
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties, Annu Rev Immunol, vol.7, pp.145-173, 1989. ,
TLR signalling and activation of IRFs: revisiting old friends from the NF-kappaB pathway, Trends Immunol, vol.26, pp.469-476, 2005. ,
Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells, J Immunol, vol.164, pp.5998-6004, 2000. ,
Toll-like receptor family and signalling pathway, Biochem Soc Trans, vol.28, pp.563-566, 2000. ,
A human B-lineage dendritic cell line, HBM-noda and its potential role in human T-cell leukemia/lymphoma virus type I infection, Pathol Int, vol.50, pp.280-290, 2000. ,
DOI : 10.1046/j.1440-1827.2000.01040.x
Gene induction pathways mediated by distinct IRFs during viral infection, 2001. ,
DOI : 10.1006/bbrc.2001.4913
, Biochem Biophys Res Commun, vol.283, pp.1150-1156
IDEC-C2B8 anti-CD20 (rituximab) immunotherapy in patients with low-grade non-Hodgkin's lymphoma and lymphoproliferative disorders: evaluation of response on 48 patients, Eur J Haematol, vol.62, pp.76-82, 1999. ,
Cell-free degradation of p27(kip1), a G1 cyclindependent kinase inhibitor, is dependent on CDK2 activity and the proteasome, Mol Cell Biol, vol.19, pp.1190-1201, 1999. ,
Myc pathways provoking cell suicide and cancer, Oncogene, vol.22, pp.9007-9021, 2003. ,
DOI : 10.1038/sj.onc.1207261
URL : https://www.nature.com/articles/1207261.pdf
Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors, J Biol Chem, vol.279, pp.19008-19017, 2004. ,
TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements, J Biol Chem, vol.280, pp.37107-37117, 2005. ,
DOI : 10.1074/jbc.m504951200
Advances in the biology and treatment of Bcell chronic lymphocytic leukemia, Blood, vol.85, pp.307-318, 1995. ,
Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia, Cancer, vol.98, pp.2657-2663, 2003. ,
Critical role of TRAF3 in the Toll-like receptor-dependent andindependent antiviral response, Nature, vol.439, pp.208-211, 2006. ,
Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex, J Immunol, vol.164, pp.558-561, 2000. ,
The extra domain A of fibronectin activates Toll-like receptor 4, J Biol Chem, vol.3, pp.10229-10233, 2001. ,
The Toll-IL-1 receptor adaptor family grows to five members, Trends Immunol, vol.24, pp.286-290, 2003. ,
ZAP-70 expression and prognosis in chronic lymphocytic leukaemia, Lancet, vol.363, pp.105-111, 2004. ,
Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45, J Cancer Res Clin Oncol, vol.130, pp.8-14, 2004. ,
PI3K-Akt pathway: its functions and alterations in human cancer, Apoptosis, vol.9, pp.667-676, 2004. ,
Guidelines on the diagnosis and management of chronic lymphocytic leukaemia, Br J Haematol, vol.125, pp.294-317, 2004. ,
,
Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors, Blood, vol.100, pp.1177-1184, 2002. ,
Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities, Blood, vol.89, pp.4153-4160, 1997. ,
Clonal CD8+ and CD52-T cells are induced in responding B cell lymphoma patients treated with Campath-1H (anti-CD52), Eur J Haematol, vol.58, pp.5-13, 1997. ,
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors, Proc Natl Acad Sci U S A, vol.97, pp.13766-13771, 2000. ,
Fluorescent dyes for lymphocyte migration and proliferation studies, Immunol Cell Biol, vol.77, pp.499-508, 1999. ,
Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein, J Biol Chem, vol.279, pp.7370-7377, 2004. ,
Tcl1 enhances Akt kinase activity and mediates its nuclear translocation, Proc Natl Acad Sci U S A, vol.97, pp.3028-3033, 2000. ,
,
Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181, Cancer Res, vol.66, pp.11590-11593, 2006. ,
Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance, Br J Cancer, vol.76, pp.935-938, 1997. ,
Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection, J Exp Med, vol.199, pp.1651-1658, 2004. ,
Marginal zone B cells, Annu Rev Immunol, vol.23, pp.161-196, 2005. ,
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene, Science, vol.282, pp.2085-2088, 1998. ,
Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia, p.249, 2000. ,
, Engl J Med, vol.343, pp.1750-1757
A review of the prognostic role of cytogenetic, phenotypic, morphologic, and immune function characteristics in chronic lymphocytic leukemia, Blood Cells, vol.12, pp.327-338, 1987. ,
Clinical staging of chronic lymphocytic leukemia, Blood, vol.46, pp.219-234, 1975. ,
The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis, J Invest Dermatol, vol.117, pp.333-340, 2001. ,
Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal, J Exp Med, vol.177, pp.925-935, 1993. ,
Tumor necrosis factor-alpha facilitates induction of CD80 (B7-1) and CD54 on human B cells by activated T cells: complex regulation by IL-4, IL-10, and CD40L, Cell Immunol, vol.161, pp.226-235, 1995. ,
Murine retroviruses activate B cells via interaction with toll-like receptor 4, Proc Natl Acad Sci U S A, vol.99, pp.2281-2286, 2002. ,
,
ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia, N Engl J Med, vol.351, pp.893-901, 2004. ,
CD4(+) regulatory T cells, Curr Opin Immunol, vol.13, pp.644-649, 2001. ,
The clinical and epidemiological burden of chronic lymphocytic leukaemia, Eur J Cancer Care (Engl), vol.13, pp.279-287, 2004. ,
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell, Nature, vol.393, pp.474-478, 1998. ,
, Cancer Statistics Review, 1975.
, Disponible sur
Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta, Blood, vol.100, pp.3741-3748, 2002. ,
Bcl2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome, Leukemia, vol.10, pp.456-459, 1996. ,
Chemoresistant or aggressive lymphoma predicts for a poor outcome following reduced-intensity allogeneic progenitor cell transplantation: an analysis from the Lymphoma Working Party of the European Group for Blood and Bone Marrow Transplantation, Blood, vol.100, pp.4310-4316, 2002. ,
A family of human receptors structurally related to Drosophila Toll, Proc Natl Acad Sci U S A, vol.95, pp.588-593, 1998. ,
DOI : 10.1073/pnas.95.2.588
URL : http://www.pnas.org/content/95/2/588.full.pdf
Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma, Nat Med, vol.4, pp.321-327, 1998. ,
Zeta chain and CD28 are poorly expressed on T lymphocytes from chronic lymphocytic leukemia, Leukemia, vol.10, pp.494-497, 1996. ,
Consensus protocol for the flow cytometric immunophenotyping of hematopoietic malignancies, Working Group on Flow Cytometry and Image Analysis. Leukemia, vol.10, pp.877-895, 1996. ,
Chronic lymphocytic leukemia, N Engl J Med, vol.333, pp.1052-1057, 1995. ,
Idiotypic vaccination for Bcell malignancies as a model for therapeutic cancer vaccines: from prototype protein to second generation vaccines, Haematologica, vol.87, pp.989-1001, 2002. ,
Phosphatidylinositol 3-kinasemediated regulation of IL-10 and IL-12 production in macrophages stimulated with CpG oligodeoxynucleotide, Molecular Immunology, vol.44, pp.1323-1330, 2007. ,
Classification of B-cells according to their differentiation status, their micro-anatomical localisation and their developmental lineage, Immunol Lett, vol.90, pp.179-186, 2003. ,
DOI : 10.1016/j.imlet.2003.09.007
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses, Annu Rev Immunol, vol.22, pp.531-562, 2004. ,
Imiquimod 5% cream: a new treatment option for basal cell carcinoma, Int J Dermatol, vol.41, pp.16-20, 2002. ,
DOI : 10.1111/j.1365-4632.2002.00020.x
Immunohistochemical analysis of CDw52 antigen expression in non-Hodgkin's lymphomas, J Clin Pathol, vol.47, pp.313-317, 1994. ,
DOI : 10.1136/jcp.47.4.313
URL : https://jcp.bmj.com/content/jclinpath/47/4/313.full.pdf
Prognostic importance of serum soluble CD23 level in chronic lymphocytic leukemia, Blood, vol.88, pp.4259-4264, 1996. ,
Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling, 2004. ,
, Nat Struct Mol Biol, vol.11, pp.1060-1067
Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation, J Immunol, vol.174, pp.27-30, 2005. ,
DOI : 10.4049/jimmunol.174.1.27
URL : http://www.jimmunol.org/content/jimmunol/174/1/27.full.pdf
Tumor-selective induction of apoptosis and the small-molecule immune response modifier imiquimod, J Natl Cancer Inst, vol.95, pp.1138-1149, 2003. ,
Immune modulation and apoptosis induction: two sides of the antitumoral activity of imiquimod, Apoptosis, vol.9, pp.291-298, 2004. ,
The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7-and TLR8independent fashion, J Invest Dermatol, vol.126, pp.1338-1347, 2006. ,
Death receptor-independent apoptosis in malignant melanoma induced by the small-molecule immune response modifier imiquimod, J Invest Dermatol, vol.122, pp.1266-1276, 2004. ,
Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes, Mol Cell Biol, vol.18, pp.790-798, 1998. ,
CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigenspecific T cells for adoptive immunotherapy, J Clin Invest, vol.100, pp.2757-2765, 1997. ,
, , 1999.
, Peptidoglycan-and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2, J Biol Chem, vol.274, pp.17406-17409
Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion, Immunity, vol.18, pp.523-533, 2003. ,
Prognosis at diagnosis: integrating molecular biologic insights into clinical practice for patients with CLL, Blood, vol.103, pp.1202-1210, 2004. ,
Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia, J Clin Oncol, vol.24, pp.4634-4641, 2006. ,
Activation of the MKK/ERK pathway during somatic cell mitosis: direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen, J Cell Biol, vol.142, pp.1533-1545, 1998. ,
Comparison of the activity of phorbol 12-myristate 13-acetate and the diglyceride glycerol 1-myristate 2-acetate, Carcinogenesis, vol.7, pp.677-679, 1986. ,
Triggering the interferon antiviral response through an IKK-related pathway, Science, vol.300, pp.1148-1151, 2003. ,
TAB1: an activator of the TAK1 MAPKKK in TGFbeta signal transduction, Science, vol.272, pp.1179-1182, 1996. ,
Efficacy of topical 5% imiquimod cream for the treatment of nodular basal cell carcinoma: comparison of dosing regimens, Arch Dermatol, vol.138, pp.1165-1171, 2002. ,
Treatment of early chronic lymphocytic leukemia: intermittent chlorambucil versus observation, Hematol Oncol, vol.6, pp.7-12, 1988. ,
Topically applied imiquimod inhibits vascular tumor growth in vivo, J Invest Dermatol, vol.121, pp.1205-1209, 2003. ,
,
Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways, J Biol Chem, vol.275, pp.4670-4678, 2000. ,
Nonmyeloablative stem cell transplantation for the treatment of cancer and life-threatening nonmalignant disorders: past accomplishments and future goals, Cancer Chemother Pharmacol, vol.48, pp.79-84, 2001. ,
Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4, J Immunol, vol.167, pp.2887-2894, 2001. ,
Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells, J Biol Chem, vol.278, pp.32552-32560, 2003. ,
The costimulation-regulated duration of PKB activation controls T cell longevity, Nat Immunol, vol.5, pp.150-158, 2004. ,
Activation of the c-Raf protein kinase by protein kinase C phosphorylation, Oncogene, vol.7, pp.2259-2262, 1992. ,
Regression of lymphomatous skin deposits in a chronic lymphocytic leukemia patient treated with the Toll-like receptor-7/8 agonist, imiquimod, Leuk Lymphoma, vol.46, pp.935-939, 2005. ,
Immunomodulatory effects of Toll-like receptor-7 activation on chronic lymphocytic leukemia cells, Leukemia, vol.20, pp.286-295, 2006. ,
Opposing actions of STAT-1 and STAT-3, Growth Factors, vol.23, pp.177-182, 2005. ,
A randomized, double-blind, vehicle-controlled study to assess 5% imiquimod cream for the treatment of multiple actinic keratoses, Arch Dermatol, vol.138, pp.1498-1502, 2002. ,
Differentiation and function of Th17 T cells, Curr Opin Immunol, vol.19, pp.281-286, 2007. ,
Role of A2A adenosine receptors in inflammation, Drug Development Research, vol.45, pp.103-112, 1998. ,
Evaluation of superficial basal cell carcinomas after treatment with imiquimod 5% cream or vehicle for apoptosis and lymphocyte phenotyping, Dermatol Surg, vol.29, pp.1181-1186, 2003. ,
Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis, J Biol Chem, vol.274, pp.5053-5060, 1999. ,
PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction, Nat Immunol, vol.4, pp.280-286, 2003. ,
,
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4, Nature, vol.416, pp.750-756, 2002. ,
IRAK-4 as the central TIR signaling mediator in innate immunity, Trends Immunol, vol.23, pp.503-506, 2002. ,
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection, Proc Natl Acad Sci U S A, vol.101, pp.3516-3521, 2004. ,
, , vol.2, p.1, 2000.
, MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway, Mol Cell, vol.5, pp.649-658
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors, Nature, vol.434, pp.243-249, 2005. ,
TOLL-LIKE RECEPTORS, Annual Review of Immunology, vol.21, pp.335-376, 2003. ,
Toll-like receptors; their physiological role and signal transduction system, Int Immunopharmacol, vol.1, pp.625-635, 2001. ,
TLR6: A novel member of an expanding toll-like receptor family, Gene, vol.231, pp.59-65, 1999. ,
DOI : 10.1016/s0378-1119(99)00098-0
Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins, J Immunol, vol.169, pp.10-14, 2002. ,
The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors, 2002. ,
, Curr Opin Immunol, vol.14, pp.111-116
T lymphocyte recruitment by interleukin-8 (IL-8). IL-8-induced degranulation of neutrophils releases potent chemoattractants for human T lymphocytes both in vitro and in vivo, J Clin Invest, vol.97, pp.1931-1941, 1996. ,
DOI : 10.1172/jci118625
URL : http://www.jci.org/articles/view/118625/files/pdf
Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4, J Exp Med, vol.195, pp.99-111, 2002. ,
DOI : 10.1084/jem.20001858
URL : http://jem.rupress.org/content/195/1/99.full.pdf
TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in Fas ligand-resistant melanoma cells and mediates CD4 T cell killing of target cells, J Immunol, vol.161, pp.2195-2200, 1998. ,
The immune response modifiers imiquimod and R-848 are potent activators of B lymphocytes, Cell Immunol, vol.203, pp.55-65, 2000. ,
DOI : 10.1006/cimm.2000.1673
,
Human cardiac inflammatory responses triggered by, 2005. ,
, Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent, Cell Microbiol, vol.7, pp.1117-1126
Immunoglobulin framework-derived peptides function as cytotoxic T-cell epitopes commonly expressed in B-cell malignancies, Nat Med, vol.6, pp.667-672, 2000. ,
DOI : 10.1038/76243
Endogenous ligands of Toll-like receptors, J Leukoc Biol, vol.76, pp.514-519, 2004. ,
Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival, Blood, vol.108, pp.4178-4186, 2006. ,
Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf, 1996. ,
, J Biol Chem, vol.271, pp.23512-23519
Recognition of gram-negative bacteria and endotoxin by the innate immune system, Curr Opin Immunol, vol.11, pp.19-22, 1999. ,
Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages, Proc Natl Acad Sci U S A, vol.96, pp.14459-14463, 1999. ,
DOI : 10.1073/pnas.96.25.14459
URL : https://www.pnas.org/content/pnas/96/25/14459.full.pdf
Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells, J Biol Chem, vol.276, pp.31332-31339, 2001. ,
HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway, J Biol Chem, vol.277, pp.15107-15112, 2002. ,
The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway, J Biol Chem, vol.277, pp.20847-20853, 2002. ,
DOI : 10.1074/jbc.m200425200
URL : http://www.jbc.org/content/277/23/20847.full.pdf
Control of translation and mRNA degradation by miRNAs and siRNAs, Genes Dev, vol.20, pp.515-524, 2006. ,
DOI : 10.1101/gad.1399806
URL : http://genesdev.cshlp.org/content/20/5/515.full.pdf
CD40 triggering of chronic lymphocytic leukemia B cells results in efficient alloantigen presentation and cytotoxic T lymphocyte induction by up-regulation of CD80 and CD86 costimulatory molecules, Leukemia, vol.11, pp.572-580, 1997. ,
Triggering TLR signaling in vaccination, Trends in Immunology, vol.27, pp.49-55, 2006. ,
Presence of multiple isotypes on the surface of human tonsillar lymphocytes, Eur J Immunol, vol.10, pp.186-191, 1980. ,
B-lymphocytes, innate immunity, and autoimmunity, Clin Immunol, vol.114, pp.17-26, 2005. ,
DOI : 10.1016/j.clim.2004.08.019
Efficacy of imiquimod for the expression of Bcl-2, Ki67, p53 and basal cell carcinoma apoptosis, Br J Dermatol, vol.151, pp.656-662, 2004. ,
Management of anogenital warts (condylomata acuminata), Eur J Dermatol, vol.11, pp.598-603, 2001. ,
European course on HPV associated pathology: guidelines for primary care physicians for the diagnosis and management of anogenital warts, Sex Transm Infect, vol.76, pp.162-168, 2000. ,
Prognostic significance of the cell cycle inhibitor p27Kip1 in chronic B-cell lymphocytic leukemia, Blood, vol.91, pp.4694-4700, 1998. ,
Idiotype-pulsed dendritic cells are able to induce antitumoral cytotoxic CD8 cells in chronic lymphocytic leukaemia, Br J Haematol, vol.120, pp.243-250, 2003. ,
DOI : 10.1046/j.1365-2141.2003.04075.x
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2141.2003.04075.x
Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity, Curr Opin Microbiol, vol.5, pp.62-69, 2002. ,
DOI : 10.1016/s1369-5274(02)00287-4
IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA, J Immunol, vol.172, pp.954-963, 2004. ,
DOI : 10.4049/jimmunol.172.2.954
URL : http://www.jimmunol.org/content/172/2/954.full.pdf
TAK1 is a ubiquitin-dependent kinase of MKK and IKK, Nature, vol.412, pp.346-351, 2001. ,
DOI : 10.1038/35085597
Unmethylated CpG motifs protect murine B lymphocytes against Fas-mediated apoptosis, Cell Immunol, vol.180, pp.162-167, 1997. ,
DOI : 10.1006/cimm.1997.1156
The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides, J Leukoc Biol, vol.68, pp.455-463, 2000. ,
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism, Nat Immunol, vol.2, pp.346-352, 2001. ,
DOI : 10.1038/86354
Loss of protein kinase C function induces an apoptotic response, Oncogene, vol.16, pp.1939-1944, 1998. ,
DOI : 10.1038/sj.onc.1201725
URL : https://www.nature.com/articles/1201725.pdf
,
ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile, Blood, vol.101, pp.4944-4951, 2003. ,
Interferon regulatory factor3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa, J Biol Chem, vol.278, pp.50923-50931, 2003. ,
Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18, 1996. ,
, LFA-1) on NK cells, J Clin Invest, vol.98, pp.2819-2826
,
Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses, J Immunol, vol.165, pp.7125-7132, 2000. ,
Efficient complement-mediated lysis of cells containing the CAMPATH-1 (CDw52) antigen, Mol Immunol, vol.30, pp.1089-1096, 1993. ,
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains, Nature, vol.408, pp.111-115, 2000. ,
DOI : 10.1038/35040600
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction, Science, vol.270, 1995. ,
, , 2003.
, MyD88-independent toll-like receptor signaling pathway, Science, vol.301, pp.640-643
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4, Nature, vol.420, pp.324-329, 2002. ,
TRAM is specifically involved in the Toll-like receptor 4mediated MyD88-independent signaling pathway, Nat Immunol, vol.4, pp.1144-1150, 2003. ,
DOI : 10.1038/ni986
Malignant lymphoma in Hawaii-Japanese: a retrospective morphologic survey, Hematol Oncol, vol.7, pp.219-232, 1989. ,
DOI : 10.1002/hon.2900070305
Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii, J Immunol, vol.165, pp.628-631, 2000. ,
Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and-independent pathways, J Immunol, vol.174, pp.6129-6136, 2005. ,
DOI : 10.4049/jimmunol.174.10.6129
URL : http://www.jimmunol.org/content/174/10/6129.full.pdf
Antigen presentation in an HLA-DR-restricted fashion by B-cell chronic lymphocytic leukemia cells, Blood, vol.72, pp.102-108, 1988. ,
T lymphocyte T cell-B cellactivating molecule/CD40-L molecules induce normal B cells or chronic lymphocytic leukemia B cells to express CD80 (B7/BB-1) and enhance their costimulatory activity, J Immunol, vol.153, pp.666-674, 1994. ,
CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry, J Immunol, vol.160, pp.5898-5906, 1998. ,
CpG DNA rescue of murine B lymphoma cells from anti-IgM-induced growth arrest and programmed cell death is associated with increased expression of c-myc and bcl-xL, J Immunol, vol.157, pp.4918-4925, 1996. ,
CpG DNA rescues B cells from apoptosis by activating NFkappaB and preventing mitochondrial membrane potential disruption via a chloroquine-sensitive pathway, Int Immunol, vol.11, pp.2015-2024, 1999. ,
DOI : 10.1093/intimm/11.12.2015
URL : https://academic.oup.com/intimm/article-pdf/11/12/2015/18317610/112015.pdf
Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex, Exp Cell Res, vol.247, pp.189-199, 1999. ,
Regulation of the Raf-1 kinase domain by phosphorylation, pp.14-17, 2000. ,
, Biochem J, vol.351, pp.151-159
Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2, J Immunol, vol.163, pp.1-5, 1999. ,
CD5 expression in human B-cell populations, Immunol Today, vol.20, pp.312-316, 1999. ,
Familial chronic lymphocytic leukaemia: a survey and review of published studies, Br J Haematol, vol.109, pp.794-799, 2000. ,
Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines, J Immunol, vol.168, pp.554-561, 2002. ,
Negative regulation of toll-like receptor-mediated signaling by Tollip, J Biol Chem, vol.277, pp.7059-7065, 2002. ,
Human blood dendritic cell-like B cells isolated by the 5G9 monoclonal antibody reactive with a novel 220-kDa antigen, J Immunol, vol.163, pp.1354-1362, 1999. ,
CD38 expressed on human monocytes: a coaccessory molecule in the superantigen-induced proliferation, Proc Natl Acad Sci U S A, vol.97, pp.2840-2845, 2000. ,
An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9, J Biol Chem, vol.274, pp.11549-11556, 1999. ,
Surface-antigen expression profiling (SEP) in B-cell chronic lymphocytic leukemia (B-CLL): Identification of markers with prognostic relevance, J Immunol Methods, vol.305, pp.20-32, 2005. ,
Established human papillomavirus type 16expressing tumors are effectively eradicated following vaccination with long peptides, J Immunol, vol.169, pp.350-358, 2002. ,