, Sodium bemiparin powder (MW 3600 Da) (ROVI Pharmaceutical Laboratories

). France, )and sodium tinzaparin

®. Eudragit and . Rs-30d, copolymer of ethyl acrylate, methyl methacrylate and a low content of a methacrylic acid ester with quaternary ammonium groups (trimethylammonioethyl methacrylate chloride)) (Evonik Industries, Essem, Germany) was used for its poly-cationic properties

®. Stachrom and . Heparin, Asnières-Sur-Seine, France)) contains the reagents (Antithrombin III, coagulation factor Xa and substrate), Diagnostica Stago

, Male Wistar rats (mean body weight 700±100 g, Janvier, Le Genest-Saint-Isle, France) and New Zealand rabbits (mean body weight of 2500±250 g

. L'arbresle, Proposal to waive in vivo bioequivalence requirements for the WHO model list of essential medicines immediate release, solid oral dosage forms, 2005.

A. El-mohdy, H. L. , and A. Safrany, Preparation of fast response superabsorbent hydrogels by radiation polymerization and crosslinking of N-isopropylacrylamide in solution, Radiation Physics and Chemistry, vol.77, issue.3, pp.273-279, 2008.

M. M. Abdel-mottaleb and A. Lamprecht, Standardized in vitro drug release test for colloidal drug carriers using modified USP dissolution apparatus I, Drug Development and Industrial Pharmacy, vol.37, issue.2, pp.178-184, 2011.

S. M. Agnihotri and P. R. Vavia, Diclofenac-loaded biopolymeric nanosuspensions for ophthalmic application, Nanomedicine: Nanotechnology, Biology and Medicine, vol.5, issue.1, pp.90-95, 2009.

Z. Ahmad and R. Pandey, Novel chemotherapy for tuberculosis: chemotherapeutic potential of econazole-and moxifloxacin-loaded PLG nanoparticles, International Journal of Antimicrobial Agents, vol.31, issue.2, pp.142-146, 2008.

M. Akazawa and K. Uchida, Photoresponsive dithienylethene-urea-based organogels with "reversed" behavior, Organic & Biomolecular Chemistry, vol.6, issue.9, pp.1544-1547, 2008.

N. Al-zoubi and H. S. Al-khatib, Sustained-release of buspirone HCl by co spraydrying with aqueous polymeric dispersions, European Journal of Pharmaceutics and Biopharmaceutics, vol.69, issue.2, pp.735-742, 2008.

A. Omari, M. M. , and N. H. Daraghmeh, Novel inclusion complex of ibuprofen tromethamine with cyclodextrins: Physico-chemical characterization, Journal of Pharmaceutical and Biomedical Analysis, vol.50, issue.3, pp.449-458, 2009.

J. Albers and R. Alles, Mechanism of drug release from polymethacrylate-based extrudates and milled strands prepared by hot-melt extrusion, European Journal of Pharmaceutics and Biopharmaceutics, vol.71, issue.2, pp.387-394, 2009.

B. Albertini and N. Passerini, Polymer-lipid based mucoadhesive microspheres prepared by spray-congealing for the vaginal delivery of econazole nitrate, European Journal of Pharmaceutical Sciences, vol.36, issue.4-5, pp.591-601, 2009.

J. Ali and S. Arora, Formulation and development of floating capsules of celecoxib: in vitro and in vivo evaluation, AAPS PharmSciTech, vol.8, issue.4, 2007.

G. L. Amidon and H. Lennernas, A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability, Pharmaceutical Research, vol.12, issue.3, pp.413-420, 1995.

J. A. Arancibia and M. A. Boldrini, Spectrofluorimetric determination of diclofenac in the presence of [alpha]-cyclodextrin, Talanta, vol.52, issue.2, pp.261-268, 2000.

J. L. Arias and M. Lopez-viota, Development of iron/ethylcellulose (core/shell) nanoparticles loaded with diclofenac sodium for arthritis treatment, International Journal of Pharmaceutics, vol.382, issue.2, pp.270-276, 2009.

C. S. Asbill and B. B. Michniak, Percutaneous penetration enhancers: local versus transdermal activity, Pharmaceutical Science & Technology Today, vol.3, issue.1, pp.36-41, 2000.

A. Avdeef, Solubility of sparingly-soluble ionizable drugs, Advanced Drug Delivery Reviews, vol.59, issue.7, pp.568-590, 2007.

A. Azeem and F. J. Ahmad, Nonionic Surfactant Vesicles as a Carrier for Transdermal Delivery of Frusemide, Journal of Dispersion Science and Technology, vol.29, issue.5, pp.723-730, 2008.

V. G. Babak and F. Baros, Dilational viscoelasticity and relaxation properties of interfacial electrostatic complexes between oppositely charged hydrophobic and hydrophilic polyelectrolytes, Colloids and Surfaces B: Biointerfaces, vol.65, issue.1, pp.43-49, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00320812

V. G. Babak and F. Baros, Dilational rheology and relaxation properties of the adsorption layers of electrostatic complexes between Eudragit RS and chitosan sulfate at the methylene chloride-water interface, Mendeleev Communications, vol.18, issue.1, pp.35-37, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00250196

E. L. Bakota and L. Aulisa, Enzymatic Cross-Linking of a Nanofibrous Peptide Hydrogel, Biomacromolecules, vol.12, issue.1, pp.82-87, 2011.

P. V. Balimane and S. Chong, Current methodologies used for evaluation of intestinal permeability and absorption, Journal of Pharmacological and Toxicological Methods, vol.44, issue.1, pp.301-312, 2000.

S. H. Bariya and M. C. Gohel, Microneedles: an emerging transdermal drug delivery system, Journal of Pharmacy and Pharmacology, vol.64, issue.1, pp.11-29, 2012.

B. W. Barry, Novel mechanisms and devices to enable successful transdermal drug delivery, European Journal of Pharmaceutical Sciences, vol.14, issue.2, pp.101-114, 2001.

M. Benna-zayani and N. Kbir-ariguib, Stabilisation of W/O/W double emulsion by polysaccharides as weak gels, Colloids and Surfaces A: Physicochemical and Engineering Aspects, vol.316, issue.1-3, pp.46-54, 2008.

H. A. Benson and S. Namjoshi, Proteins and peptides: Strategies for delivery to and across the skin, Journal of Pharmaceutical Sciences, vol.97, issue.9, pp.3591-3610, 2008.

C. A. Bergstrom and M. Strafford, Absorption classification of oral drugs based on molecular surface properties, Journal of Medicinal Chemistry, vol.46, issue.4, pp.558-570, 2003.

G. Betz and P. Nowbakht, Heparin penetration into and permeation through human skin from aqueous and liposomal formulations in vitro, International Journal of Pharmaceutics, vol.228, issue.1-2, pp.147-159, 2001.

U. Bhaskar and E. Sterner, Engineering of routes to heparin and related polysaccharides, Applied Microbiology and Biotechnology, vol.93, issue.1, pp.1-16, 2012.

R. L. Bick and E. P. Frenkel, Unfractionated Heparin, Low Molecular Weight Heparins, and Pentasaccharide: Basic Mechanism of Actions, Pharmacology, and Clinical Use, Hematology/Oncology Clinics of North America, vol.19, issue.1, pp.1-51, 2005.

N. Blagden and M. De-matas, Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates, Advanced Drug Delivery Reviews, vol.59, issue.7, pp.617-630, 2007.

J. Blanchette and N. Kavimandan, Principles of transmucosal delivery of therapeutic agents, Biomedicine & Pharmacotherapy, vol.58, issue.3, pp.142-151, 2004.

R. Bodmeier and X. Guo, The influence of buffer species and strength on diltiazem HCl release from beads coated with the aqueous cationic polymer dispersions, eudragit RS, RL 30D, Pharmaceutical Research, vol.13, issue.1, pp.52-56, 1996.

G. Bonacucina and M. Cespi, Rheological, adhesive and release characterisation of semisolid Carbopol/tetraglycol systems, International Journal of Pharmaceutics, vol.307, issue.2, pp.129-140, 2006.

F. P. Bonina and L. Montenegro, Effects of some non-toxic penetration enhancers on in vitro heparin skin permeation from gel vehicles, International Journal of Pharmaceutics, vol.111, issue.2, pp.191-196, 1994.

C. Bucolo and A. Maltese, Enhanced ocular anti-inflammatory activity of ibuprofen carried by an eudragit RS100® nanoparticle suspension, Ophthalmic Research, vol.34, issue.5, pp.319-323, 2002.

V. Bühler, Kollicoat grades: Functional Polymers for the Pharmaceutical Industry, 2007.

H. Bunjes, Lipid nanoparticles for the delivery of poorly water-soluble drugs, Journal of Pharmacy and Pharmacology, vol.62, issue.11, pp.1637-1645, 2010.

J. M. Butler and J. B. Dressman, The developability classification system: Application of biopharmaceutics concepts to formulation development, Journal of Pharmaceutical Sciences, vol.99, issue.12, pp.4940-4954, 2010.

J. A. Camargo, Systèmes injectables biodegradables pour la libération prolongée d'ivermectine. Nancy, p.213, 2010.

R. Castelli and F. Porro, The heparins and cancer: review of clinical trials and biological properties, Vascular Medicine, vol.9, issue.3, pp.205-213, 2004.

M. R. Cesarone and G. Belcaro, Local heparin, superficial vein thrombosis, Angiology, vol.58, 2007.

M. R. Cesarone and G. Belcaro, Topical heparin: New observations, Angiology, vol.58, 2007.

G. Cevc, Lipid vesicles and other colloids as drug carriers on the skin, Advanced Drug Delivery Reviews, vol.56, issue.5, pp.675-711, 2004.

S. Chandran and P. Ravi, Development and in vitro evaluation of oral controlled release formulations of celecoxib using optimization techniques, Yakugaku Zasshi, vol.126, issue.7, pp.505-514, 2006.

P. Chattopadhyay and R. B. Gupta, Supercritical CO2 based production of magnetically responsive micro-and nanoparticles for drug targeting, Industrial & Engineering Chemistry Research, vol.41, issue.24, pp.6049-6058, 2002.

G. Chawla and A. K. Bansal, Improved dissolution of a poorly water soluble drug in solid dispersions with polymeric and non-polymeric hydrophilic additives, Acta Pharmaceutica, vol.58, issue.3, pp.257-274, 2008.

D. Chen and R. Tsay, Stabilization and sustained-release effect of Misoprostol with Methacrylate copolymer, International Journal of Pharmaceutics, vol.203, issue.1-2, pp.141-148, 2000.

H. Chen and C. Khemtong, Nanonization strategies for poorly water-soluble drugs, Drug Discovery Today, vol.16, pp.354-360, 2011.

B. Chuasuwan and V. Binjesoh, Biowaiver monographs for immediate release solid oral dosage forms: Diclofenac sodium and diclofenac potassium, Journal of Pharmaceutical Sciences, vol.98, issue.4, pp.1206-1219, 2009.

J. ;. Clement, . Application-d'ivermectine-en-pour, . On-:-conséquences, . Léchage, and . Bovins-sur-les-populations.-d'-ostertagia-ostertagi-et-cooperia-oncophora-toulouse, , 2005.

D. Cosco and C. Celia, Colloidal carriers for the enhanced delivery through the skin, Expert Opinion on Drug Delivery, vol.5, issue.7, pp.737-755, 2008.

P. Couvreur and C. Vauthier, Nanotechnology: Intelligent design to treat complex disease, Pharmaceutical Research, vol.23, issue.7, pp.1417-1450, 2006.
DOI : 10.1007/s11095-006-0284-8

C. Damgé and P. Maincent, Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats, Journal of Controlled Release, vol.117, issue.2, pp.163-170, 2007.

A. Dashevsky and K. Kolter, Compression of pellets coated with various aqueous polymer dispersions, International Journal of Pharmaceutics, vol.279, issue.2, pp.19-26, 2004.
DOI : 10.1016/j.ijpharm.2004.03.019

A. Dashevsky and K. Wagner, Physicochemical and release properties of pellets coated with Kollicoat® SR 30 D, a new aqueous polyvinyl acetate dispersion for extended release, International Journal of Pharmaceutics, vol.290, issue.1-2, pp.15-23, 2005.

A. A. Date and V. B. Patravale, Current strategies for engineering drug nanoparticles, pp.222-235, 2004.
DOI : 10.1016/j.cocis.2004.06.009

J. R. Day and R. C. Landis, Heparin is much more than just an anticoagulant, Journal of Cardiothoracic and Vascular Anesthesia, vol.18, issue.1, pp.93-100, 2004.
DOI : 10.1053/j.jvca.2003.10.021

A. Denet and R. Vanbever, Skin electroporation for transdermal and topical delivery, Advanced Drug Delivery Reviews, vol.56, issue.5, pp.659-674, 2004.
DOI : 10.1016/j.addr.2003.10.027

V. ;. Dictionnary and . Vidal-vidal-dictionnary, , 2007.

M. Dittgen and M. Durrani, Acrylic polymers -A review of pharmaceutical applications, Stp Pharma Sciences, vol.7, issue.6, pp.403-437, 1997.

M. Dittgen and M. Durrani, Acrylic polymers -A review of pharmaceutical applications, S.T.P. Pharma Sciences, vol.7, issue.6, pp.403-437, 1997.

A. Dokoumetzidis and P. Macheras, A century of dissolution research: From Noyes and Whitney to the Biopharmaceutics Classification System, International Journal of Pharmaceutics, vol.321, issue.1-2, pp.1-11, 2006.

A. Dolenc and J. Kristl, Advantages of celecoxib nanosuspension formulation and transformation into tablets, International Journal of Pharmaceutics, vol.376, issue.1-2, pp.204-212, 2009.
DOI : 10.1016/j.ijpharm.2009.04.038

G. Dollo and P. L. Corre, Spray-dried redispersible oil-in-water emulsion to improve oral bioavailability of poorly soluble drugs, European Journal of Pharmaceutical Sciences, vol.19, issue.4, pp.273-280, 2003.

D. Douroumis and A. Fahr, Nano-and micro-particulate formulations of poorly water-soluble drugs by using a novel optimized technique, European Journal of Pharmaceutics and Biopharmaceutics, vol.63, issue.2, pp.173-175, 2006.

P. R. Duchowicz and A. Talevi, Application of descriptors based on Lipinskiâ??s rules in the QSPR study of aqueous solubilities, Medicinal Chemistry, vol.15, issue.11, pp.3711-3719, 2007.

P. R. Duchowicz and A. Talevi, New QSPR study for the prediction of aqueous solubility of drug-like compounds, Medicinal Chemistry, vol.16, issue.17, pp.7944-7955, 2008.

G. Edwards, Ivermectin: does P-glycoprotein play a role in neurotoxicity?, Filaria Journal, vol.2, issue.1, p.8, 2003.

U. Fagerholm, Evaluation and suggested improvements of the Biopharmaceutics Classification System (BCS), Journal of Pharmacy and Pharmacology, vol.59, issue.6, pp.751-757, 2007.
DOI : 10.1211/jpp.59.6.0001

J. Fareed and W. Jeske, Low-molecular-weight heparins: pharmacologic profile and product differentiation, The American Journal of Cardiology, vol.82, issue.5, pp.3-10, 1998.
DOI : 10.1016/s0002-9149(98)00105-2

M. Ferstl and A. Strasser, Nanofibers Resulting from Cooperative Electrostatic and Hydrophobic Interactions between Peptides and Polyelectrolytes of Opposite Charge, Langmuir, vol.27, issue.23, pp.14450-14459, 2011.

B. Forslind, The skin: Upholder of physiological homeostasis. A physiological and (bio)physical study program, Thrombosis Research, vol.80, issue.1, pp.1-22, 1995.

A. Fortuna and G. Alves, Optimization of a parallel artificial membrane permeability assay for the fast and simultaneous prediction of human intestinal absorption and plasma protein binding of drug candidates: Application to dibenz[b,f]azepine-5-carboxamide derivatives, Journal of Pharmaceutical Sciences, vol.101, issue.2, pp.530-540, 2012.

M. F. Francis and M. Cristea, Engineering polysaccharide-based polymeric micelles to enhance permeability of cyclosporin a across Caco-2 cells, Pharmaceutical Research, vol.22, issue.2, pp.209-219, 2005.

C. Freitas and R. H. Müller, Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle (SLNâ"¢) dispersions, International Journal of Pharmaceutics, vol.168, issue.2, pp.221-229, 1998.

J. Fricke and T. Tillotson, Aerogels: production, characterization, and applications, Thin Solid Films, vol.297, issue.2, pp.212-223, 1997.

M. A. Frohoff-hülsmann and A. Schmitz, Aqueous ethyl cellulose dispersions containing plasticizers of different water solubility and hydroxypropyl methylcellulose as coating material for diffusion pellets: I. Drug release rates from coated pellets, International Journal of Pharmaceutics, vol.177, issue.1, pp.69-82, 1999.

V. Gallardo and M. E. Morales, An experimental investigation of the stability of ethylcellulose latex: Correlation between zeta potential and sedimentation, European Journal of Pharmaceutical Sciences, vol.26, issue.2, pp.170-175, 2005.

Y. Gao and R. A. Carr, A pH-dilution method for estimation of biorelevant drug solubility along the gastrointestinal tract: Application to physiologically based pharmacokinetic modeling, Molecular Pharmaceutics, vol.7, issue.5, pp.1516-1526, 2010.

A. N. Ghebremeskel and C. Vemavarapu, Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: Stability testing of selected solid dispersions, Pharmaceutical Research, vol.23, issue.8, pp.1928-1936, 2006.

H. S. Gill and M. R. Prausnitz, Coated microneedles for transdermal delivery, Journal of Controlled Release, vol.117, issue.2, pp.227-237, 2007.

B. Glaessl and F. Siepmann, Characterisation of quaternary polymethacrylate films containing tartaric acid, metoprolol free base or metoprolol tartrate, European Journal of Pharmaceutics and Biopharmaceutics, vol.73, issue.3, pp.366-372, 2009.

A. Glomme and J. März, Comparison of a miniaturized shake-flask solubility method with automated potentiometric acid/base titrations and calculated solubilities, Journal of Pharmaceutical Sciences, vol.94, issue.1, pp.1-16, 2005.

D. A. Godwin and M. R. Player, Synthesis and investigation of urea compounds as transdermal penetration enhancers, International Journal of Pharmaceutics, vol.167, issue.2, pp.165-175, 1998.

E. Gray and B. Mulloy, Heparin and low-molecular-weight heparin, Thrombosis and Haemostasis, vol.99, issue.5, pp.807-818, 2008.

M. C. Gres and B. Julian, Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: Comparison with the parental Caco-2 cell line, Pharmaceutical Research, vol.15, issue.5, pp.726-733, 1998.

H. X. Guo and J. Heinämäki, Stable aqueous film coating dispersion of zein, Journal of Colloid and Interface Science, vol.322, issue.2, pp.478-484, 2008.

J. Hadgraft, Skin, the final frontier, International Journal of Pharmaceutics, vol.224, issue.2, pp.1-18, 2001.

M. Hamidi and A. Azadi, Hydrogel nanoparticles in drug delivery, Advanced Drug Delivery Reviews, vol.60, issue.15, pp.1638-1649, 2008.

K. Hanabusa and M. Matsumoto, Low Molecular Weight Gelators for Organic Fluids: Gelation Using a Family of Cyclo(dipeptide)s, Journal of Colloid and Interface Science, vol.224, issue.2, pp.231-244, 2000.

C. He and S. W. Kim, In situ gelling stimuli-sensitive block copolymer hydrogels for drug delivery, Journal of Controlled Release, vol.127, issue.3, pp.189-207, 2008.

L. A. Hergert and G. M. Escandar, Spectrofluorimetric study of the [beta]-cyclodextrin-ibuprofen complex and determination of ibuprofen in pharmaceutical preparations and serum, Talanta, vol.60, issue.2-3, pp.235-246, 2003.

G. R. Hetzel and C. Sucker, The heparins: all a nephrologist should know, Nephrology Dialysis Transplantation, vol.20, issue.10, pp.2036-2042, 2005.

J. Hirsh, Heparins, Fibrinolysis, vol.9, issue.0, pp.66-68, 1995.

J. Hirsh and R. Raschke, Heparin and Low-Molecular-Weight Heparin, Chest, vol.126, issue.3, pp.188-203, 2004.

J. Hirsh and T. E. Warkentin, Heparin and Low-Molecular-Weight Heparin Mechanisms of Action, Pharmacokinetics, Dosing, Monitoring, Efficacy, and Safety, Chest, vol.119, issue.1, pp.64-94, 2001.

V. Hoffart and A. Lamprecht, Oral bioavailability of a low molecular weight heparin using a polymeric delivery system, Journal of Controlled Release, vol.113, issue.1, pp.38-42, 2006.

M. A. Holgado and A. Iruin, Development and in vitro evaluation of a controlled release formulation to produce wide dose interval morphine tablets, European Journal of Pharmaceutics and Biopharmaceutics, vol.70, issue.2, pp.544-549, 2008.

M. Homar and N. Ubrich, Influence of polymers on the bioavailability of microencapsulated celecoxib, Journal of Microencapsulation, vol.24, issue.7, pp.621-633, 2007.

D. Hoppensteadt and J. M. Walenga, Heparin, low-molecular-weight heparins, and heparin pentasaccharide: Basic and clinical differentiation, Hematology/Oncology Clinics of North America, vol.17, issue.1, pp.313-341, 2003.

J. Hu and K. P. Johnston, Nanoparticle Engineering Processes for Enhancing the Dissolution Rates of Poorly Water Soluble Drugs, Drug Development and Industrial Pharmacy, vol.30, issue.3, pp.233-245, 2004.

A. J. Humberstone and W. N. Charman, Lipid-based vehicles for the oral delivery of poorly water soluble drugs, Advanced Drug Delivery Reviews, vol.25, issue.1, pp.103-128, 1997.

J. Jacobsen and S. Bjerregaard, Cyclodextrin inclusion complexes of antimycotics intended to act in the oral cavity â?" drug supersaturation, toxicity on TR146 cells and release from a delivery system, European Journal of Pharmaceutics and Biopharmaceutics, vol.48, issue.3, pp.217-224, 1999.

S. Janssens and H. N. De-armas, The use of a new hydrophilic polymer, Kollicoat IR®, in the formulation of solid dispersions of Itraconazole, European Journal of Pharmaceutical Sciences, vol.30, issue.3-4, pp.288-294, 2007.

L. Javot and T. Lecompte, Encapsulation of low molecular weight heparins: Influence on the anti-Xa/anti-IIa ratio, Journal of Controlled Release, vol.139, issue.1, pp.8-14, 2009.

M. D. Joshi and R. H. Müller, Lipid nanoparticles for parenteral delivery of actives, European Journal of Pharmaceutics and Biopharmaceutics, vol.71, issue.2, pp.161-172, 2009.

B. K. Kang and S. K. Chon, Controlled release of paclitaxel from microemulsion containing PLGA and evaluation of anti-tumor activity in vitro and in vivo, International Journal of Pharmaceutics, vol.286, issue.2, pp.147-156, 2004.

E. Karavas and G. Ktistis, Effect of hydrogen bonding interactions on the release mechanism of felodipine from nanodispersions with polyvinylpyrrolidone, European Journal of Pharmaceutics and Biopharmaceutics, vol.63, issue.2, pp.103-114, 2006.

R. Katzenschlager and A. Ugurluoglu, Liposomal heparin-spraygel in comparison with subcutaneous low molecular weight heparin in patients with superficial venous thrombosis. A randomized, controlled, open multicentre study, Journal fur Kardiologie, vol.10, issue.9, pp.375-378, 2003.

Y. Kawabata and K. Wada, Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: Basic approaches and practical applications, International Journal of Pharmaceutics, vol.420, issue.1, pp.1-10, 2011.

K. Kawakami, Modification of physicochemical characteristics of active pharmaceutical ingredients and application of supersaturatable dosage forms for improving bioavailability of poorly absorbed drugs, Advanced Drug Delivery Reviews, vol.64, issue.6, pp.480-495, 2012.

F. Kesisoglou and S. Panmai, Nanosizing -Oral formulation development and biopharmaceutical evaluation, Advanced Drug Delivery Reviews, vol.59, issue.7, pp.631-644, 2007.
DOI : 10.1016/j.addr.2007.05.003

I. A. Khan and K. Anjum, A comparative study of interaction of ibuprofen with biocompatible polymers, Colloids and Surfaces B: Biointerfaces, vol.88, issue.1, pp.72-77, 2011.

R. Khonkarn and S. Mankhetkorn, PEG-OCL micelles for quercetin solubilization and inhibition of cancer cell growth, European Journal of Pharmaceutics and Biopharmaceutics, vol.79, issue.2, pp.268-275, 2011.

P. Kocbek and S. Baumgartner, Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly soluble drugs, International Journal of Pharmaceutics, vol.312, issue.1-2, pp.179-186, 2006.

K. Kokjohn and M. Bradley, Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria, International Journal of Dermatology, vol.42, pp.11-17, 2003.

P. N. Kotiyan and P. R. Vavia, Eudragits: Role as crystallization inhibitors in drugin-adhesive transdermal systems of estradiol, European Journal of Pharmaceutics and Biopharmaceutics, vol.52, issue.2, pp.173-180, 2001.

H. Kranz and S. Gutsche, Evaluation of the drug release patterns and long term stability of aqueous and organic coated pellets by using blends of enteric and gastrointestinal insoluble polymers, International Journal of Pharmaceutics, vol.380, issue.2, pp.112-119, 2009.

A. Krumme, Measuring crystallization kinetics of high density polyethylene by improved hot-stage polarized light microscopy, Polymer Testing, vol.23, issue.1, pp.29-34, 2004.
DOI : 10.1016/s0142-9418(03)00058-8

M. S. Ku, Use of the biopharmaceutical classification system in early drug development, AAPS Journal, vol.10, issue.1, pp.208-212, 2008.

T. Kuuva and R. Lantto, Rheological properties of laccase-induced sugar beet pectin gels, Food Hydrocolloids, vol.17, issue.5, pp.679-684, 2003.
DOI : 10.1016/s0268-005x(03)00034-1

H. I. Labouta and L. K. El-khordagui, Polymethacrylate microparticles gel for topical drug delivery, Pharmaceutical Research, vol.27, issue.10, pp.2106-2118, 2010.
DOI : 10.1007/s11095-010-0212-9

J. E. Lai-cheong and J. A. Mcgrath, Structure and function of skin, hair and nails, Medicine, vol.37, issue.5, pp.223-226, 2009.
DOI : 10.1016/j.mpmed.2013.04.017

URL : https://kclpure.kcl.ac.uk/portal/en/publications/structure-and-function-of-skin-hair-and-nails(e14982c8-dbb1-4b07-9c7b-95e19e3004d3).html

S. Laihonen and U. W. Gedde, Crystallization kinetics and morphology of poly(propylene-stat-ethylene) fractions, Polymer, vol.38, issue.2, pp.361-369, 1997.
DOI : 10.1016/s0032-3861(96)00502-2

A. Lamprecht and N. Ubrich, Biodegradable monodispersed nanoparticles prepared by pressure homogenization-emulsification, International Journal of Pharmaceutics, vol.184, issue.1, pp.97-105, 1999.
DOI : 10.1016/s0378-5173(99)00107-6

S. S. Lanke and J. G. Strom, Enhancement of transdermal delivery of heparin by various physical and chemical enhancement techniques, Critical Reviews in Therapeutic Drug Carrier Systems, vol.26, issue.6, pp.581-606, 2009.

S. S. Lanke and C. S. Kolli, Enhanced transdermal delivery of low molecular weight heparin by barrier perturbation, International Journal of Pharmaceutics, vol.365, issue.1-2, pp.26-33, 2009.

M. A. Lassoued and F. Khemiss, Comparative Study of Two In Vitro Methods for Assessing Drug Absorption: Sartorius SM 16750 Apparatus Versus Everted Gut Sac, Journal of Pharmacy and Pharmaceutical Sciences, vol.14, issue.1, pp.117-127, 2011.

L. Le and J. Kost, Combined Effect of Low-Frequency Ultrasound and Iontophoresis: Applications for Transdermal Heparin Delivery, Pharmaceutical Research, vol.17, issue.9, pp.1151-1154, 2000.

J. Lee and K. Park, Microemulsion formulation of clonixic acid: solubility enhancement and pain reduction, Journal of Pharmacy and Pharmacology, vol.54, issue.1, pp.43-49, 2002.
DOI : 10.1211/0022357021771904

H. Lennernas, Human intestinal permeability, Journal of Pharmaceutical Sciences, vol.87, issue.4, pp.403-410, 1998.

L. Verger, M. , and L. Fluckiger, Preparation and characterization of nanoparticles containing an antihypertensive agent, European Journal of Pharmaceutics and Biopharmaceutics, vol.46, issue.2, pp.137-143, 1998.

C. Leuner and J. Dressman, Improving drug solubility for oral delivery using solid dispersions, European Journal of Pharmaceutics and Biopharmaceutics, vol.50, issue.1, pp.47-60, 2000.

J. Li and Y. Zhai, Methoxy poly(ethylene glycol)-block-poly(D,L-lactic acid) copolymer nanoparticles as carriers for transdermal drug delivery, Polymer International, vol.57, issue.2, pp.268-274, 2008.

X. Li and Y. Yue, An oil-free microemulsion for intravenous delivery of diallyl trisulfide: Formulation and evaluation, International Journal of Pharmaceutics, vol.407, issue.2, pp.158-166, 2011.

A. Y. Lin and N. A. Muhammad, Study of crystallization of endogenous surfactant in Eudragit NE30D-free films and its influence on drug-release properties of controlled-release diphenhydramine HCl pellets coated with Eudragit NE30D, AAPS pharmSci, 2001.

S. Y. Lin and C. L. Cheng, Solid state interaction studies of drug-polymers (II): Warfarin-Eudragit E, RL or S resins, European Journal of Pharmaceutical Sciences, vol.1, issue.6, pp.313-322, 1994.

S. Y. Lin and H. L. Yu, Microscopic Fourier transform infrared/differential scanning calorimetry system used to study the different thermal behaviors of polymethacrylate copolymers of Eudragits RS, RL, E 30D, or E, Journal of Applied Polymer Science, vol.78, issue.4, pp.829-835, 2000.

M. Lindenberg and S. Kopp, Classification of orally administered drugs on the World Health Organization Model list of Essential Medicines according to the biopharmaceutics classification system, European Journal of Pharmaceutics and Biopharmaceutics, vol.58, issue.2, pp.265-278, 2004.

C. A. Lipinski and F. Lombardo, Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings, Advanced Drug Delivery Reviews, vol.46, pp.3-26, 2001.

A. Lippacher and R. H. Müller, Liquid and semisolid SLNâ"¢ dispersions for topical application: Rheological characterization, European Journal of Pharmaceutics and Biopharmaceutics, vol.58, issue.3, pp.561-567, 2004.

R. Löbenberg and G. L. Amidon, Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards, European Journal of Pharmaceutics and Biopharmaceutics, vol.50, issue.1, pp.3-12, 2000.

C. Loira-pastoriza and A. Sapin-minet, Low molecular weight heparin gels, based on nanoparticles, for topical delivery, International Journal of Pharmaceutics, vol.426, issue.1-2, pp.256-262, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01491900

A. Lucarz and G. Brand, Current considerations about Merkel cells, European Journal of Cell Biology, vol.86, issue.5, pp.243-251, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00493442

M. J. Lucero and J. García, A rheological study of semisolid preparations of Eudragit ®, International Journal of Pharmaceutics, vol.116, issue.1, pp.31-37, 1995.

M. J. Lucero-muñoz and J. Garcia-andréu, Influencia de la hidroxipropilmetilcelulosa sobre la reologia de sistemas poliméricos de Eudragit®, Ciencia y Tecnologia Pharmaceutica, vol.8, issue.1, pp.17-22, 1998.

W. D. Ma and H. Xu, Temperature-responsive, Pluronic-g-poly(acrylic acid) copolymers in situ gels for ophthalmic drug delivery: Rheology, in vitro drug release, and in vivo resident property, Drug Development and Industrial Pharmacy, vol.34, issue.3, pp.258-266, 2008.

J. L. Manzoori and H. Abdolmohammad-zadeh, Study on the inclusion complex between [beta]-cyclodextrin and celecoxib by spectrofluorimetry and its analytical application, Il Farmaco, vol.60, issue.6-7, pp.575-581, 2005.

H. Matsuda and K. Kaburagi, Prediction of solubilities of pharmaceutical compounds in water + co-solvent systems using an activity coefficient model, Fluid Phase Equilibria, vol.290, issue.2, pp.153-157, 2009.

J. W. Mcginity and . Ed, Aqueous polymeric coatings for pharmaceutical dosage forms. Drugs and the Pharmaceutical sciences, 1989.

S. Mehta and G. Kaur, Incorporation of Antitubercular Drug Isoniazid in Pharmaceutically Accepted Microemulsion: Effect on Microstructure and Physical Parameters, Pharmaceutical Research, vol.25, issue.1, pp.227-236, 2008.

E. Merisko-liversidge and G. G. Liversidge, Nanosizing: a formulation approach for poorly-water-soluble compounds, European Journal of Pharmaceutical Sciences, vol.18, issue.2, pp.113-120, 2003.

B. Mishra and B. B. Patel, Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery, Nanomedicine: Nanotechnology, Biology and Medicine, vol.6, issue.1, pp.9-24, 2009.

S. Mitragotri and J. Kost, Transdermal delivery of heparin and low-molecular weight heparin using low-frequency ultrasound, Pharmaceutical Research, vol.18, issue.8, pp.1151-1156, 2001.

S. Mitragotri and J. Kost, Low-frequency sonophoresis: A review, Advanced Drug Delivery Reviews, vol.56, issue.5, pp.589-601, 2004.

A. R. Mohammed and N. Weston, Liposome formulation of poorly water soluble drugs: Optimisation of drug loading and ESEM analysis of stability, International Journal of Pharmaceutics, vol.285, issue.1-2, pp.23-34, 2004.

C. Moreau and V. Siguret, Pharmacogénétique et antivitamine K aujourd'hui: un débat ouvert, La Revue de Médecine Interne, vol.31, issue.5, pp.361-368, 2010.

M. Morgen and C. Bloom, Polymeric Nanoparticles for Increased Oral Bioavailability and Rapid Absorption Using Celecoxib as a Model of a LowSolubility, High-Permeability Drug, Pharmaceutical Research, vol.29, issue.2, pp.427-440, 2012.

T. A. Morris, Heparin and low molecular weight heparin: background and pharmacology, Clinics in Chest Medicine, vol.24, issue.1, pp.39-47, 2003.

R. H. Müller and S. Heinemann, Fat emulsions for parenteral nutrition. III: Lipofundin MCT/LCT regimens for total parenteral nutrition (TPN) with low electrolyte load, International Journal of Pharmaceutics, vol.101, issue.3, pp.175-189, 1994.

R. H. Müller and C. Jacobs, Nanosuspensions as particulate drug formulations in therapy: Rationale for development and what we can expect for the future, Advanced Drug Delivery Reviews, vol.47, issue.1, pp.3-19, 2001.

S. P. Mulye and S. A. Jamadar, Improvement in physicochemical properties of ezetimibe using a crystal engineering technique, Powder Technology, vol.222, issue.0, pp.131-138, 2011.

S. Murdan, Drug delivery to the nail following topical application, International Journal of Pharmaceutics, vol.236, issue.2, pp.1-26, 2002.

R. H. Neubert, Potentials of new nanocarriers for dermal and transdermal drug delivery, European Journal of Pharmaceutics and Biopharmaceutics, vol.77, issue.1, pp.1-2, 2011.

E. M. Niazy, Differences in penetration-enhancing effect of Azone through excised rabbit, rat, hairless mouse, guinea pig and human skins, International Journal of Pharmaceutics, vol.130, issue.2, pp.225-230, 1996.

T. M. Niers and C. P. Klerk, Mechanisms of heparin induced anti-cancer activity in experimental cancer models, Critical Reviews in Oncology/Hematology, vol.61, issue.3, pp.195-207, 2007.

F. L. Nordström and A. C. Rasmuson, Prediction of solubility curves and melting properties of organic and pharmaceutical compounds, European Journal of Pharmaceutical Sciences, vol.36, issue.2-3, pp.330-344, 2009.

E. Nutescu and I. Chuatrisorn, Drug and dietary interactions of warfarin and novel oral anticoagulants: an update, Journal of Thrombosis and Thrombolysis, vol.31, issue.3, pp.326-343, 2011.

Y. Ohya and S. Takeda, Evaluation of polyanion-coated biodegradable polymeric micelles as drug delivery vehicles, Journal of Controlled Release, vol.155, issue.1, pp.104-110, 2011.

D. M. Omari and A. Sallam, Lactic acid-induced modifications in films of Eudragit RL and RS aqueous dispersions, International Journal of Pharmaceutics, vol.274, issue.2, pp.85-96, 2004.

A. Paavola and I. Kilpeläinen, Controlled release injectable liposomal gel of ibuprofen for epidural analgesia, International Journal of Pharmaceutics, vol.199, issue.1, pp.85-93, 2000.

S. Pacini and T. Punzi, Transdermal delivery of heparin using pulsed current iontophoresis, Pharmaceutical Research, vol.23, issue.1, pp.114-120, 2006.

A. Pal and Y. K. Ghosh, Molecular mechanism of physical gelation of hydrocarbons by fatty acid amides of natural amino acids, Tetrahedron, vol.63, issue.31, pp.7334-7348, 2007.

R. Pandey and Z. Ahmad, Nano-encapsulation of azole antifungals: Potential applications to improve oral drug delivery, International Journal of Pharmaceutics, vol.301, issue.1-2, pp.268-276, 2005.

H. J. Park and M. S. Kim, Solid-State Carbon NMR Characterization and Investigation of Intrinsic Dissolution Behavior of Fluconazole Polymorphs, Anhydrate Forms I and II, Chemical & Pharmaceutical Bulletin, vol.58, issue.9, pp.1243-1247, 2010.

M. Pedersen and S. Bjerregaard, An econazole B-cyclodextrin inclusion complex: an unusual dissolution rate, supersaturation, and biological efficacy example, International Journal of Pharmaceutics, vol.165, issue.1, pp.57-68, 1998.

M. Pedersen and M. Edelsten, Formation and antimycotic effect of cyclodextrin inclusion complexes of econazole and miconazole, International Journal of Pharmaceutics, vol.90, issue.3, pp.247-254, 1993.

R. Pignatello and C. Bucolo, Eudragit RS100® nanosuspensions for the ophthalmic controlled delivery of ibuprofen, European Journal of Pharmaceutical Sciences, vol.16, issue.1-2, pp.53-61, 2002.

G. F. Pineo and R. D. Hull, Vitamin K Antagonists and Direct Thrombin Inhibitors: Present and Future, Hematology/Oncology Clinics of North America, vol.19, issue.1, pp.69-85, 2005.

H. Potthast and J. B. Dressman, Biowaiver monographs for immediate release solid oral dosage forms: Ibuprofen, Journal of Pharmaceutical Sciences, vol.94, issue.10, pp.2121-2131, 2005.

C. W. Pouton, Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system, European Journal of Pharmaceutical Sciences, vol.29, pp.278-287, 2006.

J. Powell, Skin physiology, Women's Health Medicine, vol.3, issue.3, pp.130-133, 2006.

M. R. Prausnitz, Microneedles for transdermal drug delivery, Advanced Drug Delivery Reviews, vol.56, issue.5, pp.581-587, 2004.

M. R. Prausnitz and E. R. Edelman, TRANSDERMAL DELIVERY OF HEPARIN BY SKIN ELECTROPORATION, Bio-Technology, vol.13, issue.11, pp.1205-1209, 1995.

E. Ragazzi and A. Chinellato, Heparin: Pharmacological potentials from atherosclerosis to asthma, General Pharmacology: The Vascular System, vol.26, issue.4, pp.697-701, 1995.

R. A. Rajewski and V. J. Stella, Pharmaceutical applications of cyclodextrins .2. In vivo drug delivery, Journal of Pharmaceutical Sciences, vol.85, issue.11, pp.1142-1169, 1996.

E. Rinaki and G. Valsami, Quantitative biopharmaceutics classification system: The central role of dose/solubility ratio, Pharmaceutical Research, vol.20, issue.12, pp.1917-1925, 2003.

J. E. Riviere and M. C. Heit, Electrically-Assisted Transdermal Drug Delivery, Pharmaceutical Research, vol.14, issue.6, pp.687-697, 1997.

K. Saga, Structure and function of human sweat glands studied with histochemistry and cytochemistry, Progress in Histochemistry and Cytochemistry, vol.37, issue.4, pp.323-386, 2002.

N. M. Sangeetha and U. Maitra, Supramolecular gels: Functions and uses, Chemical Society Reviews, vol.34, issue.10, pp.821-836, 2005.

N. Sarisuta and M. Kumpugdee, Physico-chemical characterization of interactions between erythromycin and various film polymers, International Journal of Pharmaceutics, vol.186, issue.2, pp.109-118, 1999.

J. Scala-bertola, Développement de formes orales d'héparine et de formes à libération prolongée de warfarine: une réponse à l'amélioration de la prévention de laa thrombose? Nancy, 2009.

S. Schmid and C. C. Müller-goymann, Interactions during aqueous film coating of ibuprofen with Aquacoat ECD, International Journal of Pharmaceutics, vol.197, issue.1-2, pp.35-39, 2000.
DOI : 10.1016/s0378-5173(99)00397-x

C. Schmidt and R. Bodmeier, Incorporation of polymeric nanoparticles into solid dosage forms, Journal of Controlled Release, vol.57, issue.2, pp.115-125, 1999.
DOI : 10.1016/s0168-3659(98)00108-4

P. Shah and V. Jogani, Role of Caco-2 cell monolayers in prediction of intestinal drug absorption, Biotechnology Progress, vol.22, issue.1, pp.186-198, 2006.

N. Shan and M. J. Zaworotko, The role of cocrystals in pharmaceutical science, Drug Discovery Today, vol.13, pp.440-446, 2008.

A. Shikhar and M. M. Bommana, Formulation development of Carbamazepineâ?"Nicotinamide co-crystals complexed with γ-cyclodextrin using supercritical fluid process, The Journal of Supercritical Fluids, vol.55, issue.3, pp.1070-1078, 2010.
DOI : 10.1016/j.supflu.2010.09.009

W. S. Shim and J. Kim, Biodegradability and biocompatibility of a pH-and thermo-sensitive hydrogel formed from a sulfonamide-modified poly(ε-caprolactoneco-lactide)â?"poly(ethylene glycol)â?"poly(ε-caprolactone-co-lactide) block copolymer, Biomaterials, vol.27, issue.30, pp.5178-5185, 2006.

F. Siepmann and S. Muschert, How to improve the storage stability of aqueous polymeric film coatings, Journal of Controlled Release, vol.126, issue.1, pp.26-33, 2008.

B. Singh and S. Kumar, Synthesis and characterization of psyllium-NVP based drug delivery system through radiation crosslinking polymerization, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, vol.266, pp.3417-3430, 2008.

J. Slager and A. J. Domb, Biopolymer stereocomplexes, Advanced Drug Delivery Reviews, vol.55, issue.4, pp.549-583, 2003.
DOI : 10.1016/s0169-409x(03)00042-5

Y. Song and C. Kim, Topical delivery of low-molecular-weight heparin with surface-charged flexible liposomes, Biomaterials, vol.27, issue.2, pp.271-280, 2006.

S. Stegemann and F. Leveiller, When poor solubility becomes an issue: From early stage to proof of concept, European Journal of Pharmaceutical Sciences, vol.31, issue.5, pp.249-261, 2007.

R. J. Stenekes and H. Talsma, Formation of dextran hydrogels by crystallization, Biomaterials, vol.22, issue.13, pp.1891-1898, 2001.

R. G. Strickley, Solubilizing excipients in oral and injectable formulations, Pharmaceutical Research, vol.21, issue.2, pp.201-230, 2004.
DOI : 10.1023/b:pham.0000016235.32639.23

M. Stuart and K. Box, Chasing equilibrium: Measuring the intrinsic solubility of weak acids and bases, Analytical Chemistry, vol.77, issue.4, pp.983-990, 2005.

S. J. Sun and M. H. Wang, Study on warfarin plasma concentration and its correlation with international normalized ratio, Journal of Pharmaceutical and Biomedical Analysis, vol.42, issue.2, pp.218-222, 2006.
DOI : 10.1016/j.jpba.2006.03.019

Y. M. Sun and S. C. Hsu, Transport properties of ionic drugs in the ammonio methacrylate copolymer membranes, Pharmaceutical Research, vol.18, issue.3, pp.304-310, 2001.

M. Suzuki and K. Hanabusa, Polymer organogelators that make supramolecular organogels through physical cross-linking and self-assembly, Chemical Society Reviews, vol.39, issue.2, pp.455-463, 2010.
DOI : 10.1039/b910604a

E. I. Taha and S. Al-saidan, Preparation and in vitro characterization of selfnanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate, International Journal of Pharmaceutics, vol.285, issue.2, pp.109-119, 2004.

R. Takano and K. Sugano, Oral absorption of poorly water-soluble drugs: Computer simulation of fraction absorbed in humans from a miniscale dissolution test, Pharmaceutical Research, vol.23, issue.6, pp.1144-1156, 2006.

S. Tamburic and D. Q. Craig, An investigation into the rheological, dielectric and mucoadhesive properties of poly(acrylic acid) gel systems, Journal of Controlled Release, vol.37, issue.1-2, pp.59-68, 1995.

A. S. Tatavarti and S. W. Hoag, Microenvironmental pH modulation based release enhancement of a weakly basic drug from hydrophilic matrices, Journal of Pharmaceutical Sciences, vol.95, issue.7, pp.1459-1468, 2006.

M. E. Taub and L. Kristensen, Optimized conditions for MDCK permeability and turbidimetric solubility studies using compounds representative of BCS classes I-IV, European Journal of Pharmaceutical Sciences, vol.15, issue.4, pp.331-340, 2002.
DOI : 10.1016/s0928-0987(02)00015-5

S. Tavelin and V. Milovic, A conditionally immortalized epithelial cell line for studies of intestinal drug transport, Journal of Pharmacology and Experimental Therapeutics, vol.290, issue.3, pp.1212-1221, 1999.

Z. Teksin and P. Seo, Comparison of Drug Permeabilities and BCS Classification: Three Lipid-Component PAMPA System Method versus Caco-2 Monolayers, The AAPS Journal, vol.12, issue.2, pp.238-241, 2010.

P. Terech and R. G. Weiss, Low Molecular Mass Gelators of Organic Liquids and the Properties of Their Gels, Chemical Reviews, vol.97, issue.8, pp.3133-3160, 1997.

. Tewa-tagne, Séchage par atomisation de nanoparticules polymériques, 2007.

V. Torchilin, Micellar Nanocarriers: Pharmaceutical Perspectives, Pharmaceutical Research, vol.24, issue.1, pp.1-16, 2007.
DOI : 10.1007/s11095-006-9132-0

E. Touitou and B. Godin, Enhanced delivery of drugs into and across the skin by ethosomal carriers, Drug Development Research, vol.50, issue.3-4, pp.406-415, 2000.

H. Trommer and R. H. Neubert, Overcoming the Stratum Corneum: The Modulation of Skin Penetration, Skin Pharmacology and Physiology, vol.19, issue.2, pp.106-121, 2006.

J. Turner and D. Maddalena, Bioavailability Prediction Based on Molecular Structure for a Diverse Series of Drugs, Pharmaceutical Research, vol.21, issue.1, pp.68-82, 2004.

J. V. Turner and B. D. Glass, Prediction of drug bioavailability based on molecular structure, Analytica Chimica Acta, vol.485, issue.1, pp.89-102, 2003.
DOI : 10.1016/s0003-2670(03)00406-9

I. F. Uchegbu and S. P. Vyas, Non-ionic surfactant based vesicles (niosomes) in drug delivery, International Journal of Pharmaceutics, vol.172, issue.2, pp.33-70, 1998.
DOI : 10.1016/s0378-5173(98)00169-0

C. Valenta and B. G. Auner, The use of polymers for dermal and transdermal delivery, European Journal of Pharmaceutics and Biopharmaceutics, vol.58, issue.2, pp.279-289, 2004.

S. R. Van-tomme and G. Storm, In situ gelling hydrogels for pharmaceutical and biomedical applications, International Journal of Pharmaceutics, vol.355, issue.1-2, pp.1-18, 2008.

S. R. Van-tomme and M. J. Van-steenbergen, Self-gelling hydrogels based on oppositely charged dextran microspheres, Biomaterials, vol.26, issue.14, pp.2129-2135, 2005.

C. Vecchio and A. Frisinghelli, Topically applied heparins for the treatment of vascular disorders: A comprehensive review, Clinical Drug Investigation, vol.28, issue.10, pp.603-614, 2008.

L. Vera-cabrera and M. P. Campos-rivera, In Vitro Activity of ACH-702, a New Isothiazoloquinolone, against Nocardia brasiliensis Compared with Econazole and the Carbapenems Imipenem and Meropenem Alone or in Combination with Clavulanic Acid, Antimicrobial Agents and Chemotherapy, vol.54, issue.5, pp.2191-2193, 2010.

P. Verma and K. Pathak, Nanosized ethanolic vesicles loaded with econazole nitrate for the treatment of deep fungal infections through topical gel formulation, Nanomedicine: Nanotechnology, Biology and Medicine, vol.8, issue.4, pp.489-496, 2011.

J. C. Villanova and E. Ayres, Acrylic polymers derived from high solid emulsions as excipients to pharmaceutical applications: synthesis and characterization, Polymer Bulletin, vol.68, issue.4, pp.931-948, 2012.
DOI : 10.1007/s00289-011-0583-z

A. Vintiloiu and J. C. Leroux, Organogels and their use in drug delivery -A review, Journal of Controlled Release, vol.125, issue.3, pp.179-192, 2008.

R. B. Walker and E. W. Smith, The role of percutaneous penetration enhancers, Advanced Drug Delivery Reviews, vol.18, issue.3, pp.295-301, 1996.

I. Walters-;-marcel-dekker, S. Wan, and Y. Sun, Improved Bioavailability of Poorly Water-Soluble Drug Curcumin in Cellulose Acetate Solid Dispersion, AAPS PharmSciTech, pp.1-8, 2002.

J. C. Weaver and R. Vanbever, Heparin Alters Transdermal Transport Associated with Electroporation, Biochemical and Biophysical Research Communications, vol.234, issue.3, pp.637-640, 1997.

R. R. Wickett and M. O. Visscher, Structure and function of the epidermal barrier, American Journal of Infection Control, vol.34, issue.10, pp.98-110, 2006.

A. C. Williams and B. W. Barry, Penetration enhancers, Advanced Drug Delivery Reviews, vol.56, issue.5, pp.603-618, 2004.

W. Iii, R. O. , and J. Liu, Influence of processing and curing conditions on beads coated with an aqueous dispersion of cellulose acetate phthalate, European Journal of Pharmaceutics and Biopharmaceutics, vol.49, issue.3, pp.243-252, 2000.

S. Wittaya-areekul and C. Prahsarn, Development and in vitro evaluation of chitosan-Eudragit RS 30D composite wound dressings, AAPS PharmSciTech, vol.7, issue.1, 2006.

C. B. Wu and J. W. Mcginity, Influence of an enteric polymer on drug release rates of theophylline from pellets coated with Eudragit (R) RS 30D, Pharmaceutical Development and Technology, vol.8, issue.1, pp.103-110, 2003.

C. Y. Wu and L. Z. Benet, Predicting drug disposition via application of BCS: Transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system, Pharmaceutical Research, vol.22, issue.1, pp.11-23, 2005.

G. L. Xiong and D. Quan, Effects of penetration enhancers on in vitro percutaneous absorption of low molecular weight heparin through human skin, Journal of Controlled Release, vol.42, issue.3, pp.289-296, 1996.

J. M. Xu and S. Chen, The Synthesis of Amide Dendritic Gelators and its Selfassembly Behavior in MMA, Journal of Macromolecular Science Part a-Pure and Applied Chemistry, vol.48, issue.11, pp.896-903, 2011.

G. Yan and S. K. Li, Evaluation of constant current alternating current iontophoresis for transdermal drug delivery, Journal of Controlled Release, vol.110, issue.1, pp.141-150, 2005.

M. Yazdanian and K. Briggs, The "High Solubility" Definition of the Current FDA Guidance on Biopharmaceutical Classification System May Be Too Strict for Acidic Drugs, Pharmaceutical Research, vol.21, issue.2, pp.293-299, 2004.

G. Yordanov, Influence of the preparation method on the physicochemical properties of econazole-loaded poly(butyl cyanoacrylate) colloidal nanoparticles, Colloids and Surfaces A: Physicochemical and Engineering Aspects, issue.0, 2012.

Y. Piemi, M. P. , and D. Korner, Positively and negatively charged submicron emulsions for enhanced topical delivery of antifungal drugs, Journal of Controlled Release, vol.58, issue.2, pp.177-187, 1999.

M. Zacchigna and G. D. Luca, Improvement of warfarin biopharmaceutics by conjugation with poly(ethylene glycol), European Journal of Pharmaceutical Sciences, vol.23, issue.4-5, pp.379-384, 2004.

N. M. Zaki and P. Artursson, A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery, Molecular Pharmaceutics, vol.7, issue.5, pp.1478-1487, 2010.

G. Zingone and F. Rubessa, Preformulation study of the inclusion complex warfarin-[beta]-cyclodextrin, International Journal of Pharmaceutics, vol.291, issue.1-2, pp.3-10, 2005.

C. Loira-pastoriza, A. Sapin-minet, R. Diab, J. L. Grossiord, and P. Maincent, Low molecular weight heparin gels, based on nanoparticles, for topical delivery, International Journal of Pharmaceutics, vol.426, issue.1-2, pp.256-262, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01491900

C. Poster, A. Sapin-minet, R. Diab, J. L. Grossiord, and P. Maincent, Heparin gels based on nanoparticle suspension for topical application, 2010.