, « glutathione metabolism » comprenant notamment les protéines Gpx1, Gss, Gstm2, Gstm4, Lap3 ; « regulation of actin cytoskeleton
Nous avons également observé la présence d'un réseau d'interaction comprenant diverses histones (H1, H2 et H3) comme mentionné ci-dessus, Un réseau central est constitué de protéines impliquées dans la voie « Glucose metabolism » notamment Eno2, Pgam1, Pkm, Pygl, Txnrd2, ainsi que dans le processus biologique « oxidation-reduction » comme Gpx1, Mdh2, Prdx2, Prdx5, Pygl, Txnrd1 et Txnrd2. De manière intéressante, ces 7 réseaux interagissent directement les uns avec les autres, ou indirectement via d'autres protéines ,
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, ANNEXE 2 : Morphologie, cytologie, histologie, fonction et structure de l'appareil respiratoire et régions utilisées dans le modèle dosimétrique de la Commission internationale de protection radiologique, 1994.
, Justification de l'exposition des rats à un aérosol nanostructuré de, ANNEXE, vol.3
, Aux Etats-Unis, le NIOSH a proposé en 2011 une VLEP pondérée sur 10h par jour et 40h par semaine de 0,3 mg/m 3 pour le TiO 2 ultrafin, 2011.
, En estimant une durée moyenne de vie au travail de 40 ans, avec environ 45 semaines travaillées par an, et 40h de travail par semaine
, Concernant certains paramètres respiratoires chez l'Homme : ? La fréquence respiratoire (Fr) représente la rapidité de respiration, Elle comprend environ, vol.12, issue.20
, ? Le volume courant VC (également appelé volume tidal) représente l'amplitude de respiration, c'est à dire le volume d'air inspiré ou expiré à chaque mouvement respiratoire. Au repos, le volume courant moyen est de 500 ml
, Ainsi le débit ventilatoire au repos est d'environ 6 à 10 L/min (= Fr x VC)
, En prenant la valeur par défaut du modèle MPPD de 7,5 L/min, le volume respiré tout au long de la carrière d'un Homme serait
TiO 2 respirée au cours de la carrière d'un Homme serait, p.3 ,
, En supposant que 10 % de la quantité respirée soit déposée dans les poumons chez l'Homme (modèle de la CIPR, 1994), cela correspondrait à une quantité déposée de 972 mg, mg/m 3 soit 9720 mg
, Cette quantité peut ensuite être normalisée par différents paramètres : ? Normalisation par poids corporel : En estimant le poids moyen d'un Homme à 70 kg et une quantité déposée de 972 mg (au cours de sa carrière), Pour un rat de poids moyen de 0,3 kg, cela correspond à une quantité déposée de 4,2 mg sur 1 mois
, En estimant la masse moyenne d'un poumon humain à 700 g et une quantité déposée de 972 mg (au cours de sa carrière)
, En estimant la surface alvéolaire totale moyenne des poumons chez l'Homme à 102 m 2 et une quantité déposée de 972 mg (au cours de sa carrière)
, Détermination de la concentration en aérosol de TiO 2 à utiliser par inhalation chez le rat
241 ml/min (Hsieh, 1999) ; le volume respiré sur 1 mois (6 h par jour, 5 jours par semaine, pendant 4 semaines) est de 1735,2 L soit environ 1,7 m 3 . Ainsi la concentration en aérosol (mg/m 3 ) : ? a été estimée à 9,6 mg/m 3 (environ 10 mg/m 3 ) en supposant 10 % de dépôt chez le rat et en tenant compte de la normalisation par masse de poumon : En effet, la quantité déposée au niveau pulmonaire est estimée à 1,7 mg sur 1 mois. Elle correspondant à une quantité respirée sur 1 mois de 17 mg ,
, mg/m 3 ) en se basant sur 20 % de dépôt chez le rat et une normalisation par surface alvéolaire : En effet, la quantité déposée au niveau alvéolaire est estimée à 3,8 mg sur 1 mois. Elle correspond à une quantité respirée sur 1 mois de 5 x 3,8 soit 19 mg
, Abbreviations: BALF, bronchoalveolar lavage fluid
Database for Annotation, Visualization and Integrated Discovery; d0, d3 and d180, immediately, 3 and 180 post-exposure days respectively ,
, EBC, exhaled breath condensate; EMMS, Electro-Medical Measurement System; GO BP, gene ontology biological processes
, International Agency for Research on Cancer; KEGG, Kyoto Encyclopedia of Genes and Genomes
, Multidimensional Protein Identification Technology
Organization for Economic Co-operation and Development; PBS, phosphate buffered saline ,
, ROS, reactive oxygen species; TiO2, titanium dioxide Abbreviations: BALF, bronchoalveolar lavage fluid
Database for Annotation, Visualization and Integrated Discovery; d0, d3 and d180, immediately, 3 and 180 post-exposure days respectively ,
, EBC, exhaled breath condensate; EMMS, Electro-Medical Measurement System; GO BP, gene ontology biological processes
, International Agency for Research on Cancer; KEGG, Kyoto Encyclopedia of Genes and Genomes
, Multidimensional Protein Identification Technology
Organization for Economic Co-operation and Development; PBS, phosphate buffered saline ,
, ROS