Étude par spectrométrie de masse des aérosols associés à la fumée de cigarette

Abstract : The cigarette smokes are complex mixtures, composed of a gaseous phase and a particulate phase. They are generated by the combustion and the pyrolysis of the cigarette ingredients (tobacco, additive and paper). The toxic effects of cigarette smoke are directly correlated with its chemical composition as well as the morphology of the aerosol itself. The aim of this thesis is to increase our knowledge of the chemical composition of the particulate matter of the cigarette smoke inhaled by an active smoker (MSS). The used approach is a non-targeted analysis ensuring the detection of as many as possible of the cigarette smoke constituents. A prior to this study was the establishment of a repeatable method of smoking cigarettes and collecting the gas phase and the particulate phase. This method has been validated by the monitoring of tracer compounds: BTEX (benzene, toluene, ethylbenzene, ortho- meta- and para-xylene) for the gas phase and the nicotine for the particulate phase. Non-targeted analysis of the particulate matter is carried out without pretreatment by laser desorption/ionization (LDI) or by electrospray ionization (ESI) after extraction. A Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) was systematically used. The very high resolution and the very high accuracy measurement achieved by this instrument are required for the examination of such extremely complex samples. The complementarity of LDI and ESI ionization for the analysis of the particle cigarette smoke compounds was established. The ESI analyses evidenced polar compounds and components with a pyridine group and LDI ensured the detection of poly-condensed heteroaromatic species. All the results obtained in this study showed the influence of the morphology of the cigarette, of its origin and the presence of flavoring agents (cloves) on the chemical composition of the particulate matter of the MSS
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Theses
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http://docnum.univ-lorraine.fr/ulprive/DDOC_T_2018_0284_KAMISSOKO.pdf
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https://hal.univ-lorraine.fr/tel-02129950
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Submitted on : Wednesday, May 15, 2019 - 2:24:07 PM
Last modification on : Thursday, May 16, 2019 - 1:37:10 AM

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  • HAL Id : tel-02129950, version 1

Citation

Adama Kamissoko. Étude par spectrométrie de masse des aérosols associés à la fumée de cigarette. Chimie analytique. Université de Lorraine, 2018. Français. ⟨NNT : 2018LORR0284⟩. ⟨tel-02129950⟩

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