, En effet, la diminution de l'absorbance due à la conversion du NADH en NAD + est proportionnelle à l'activité ASAT dans l'échantillon

, La solution de contrôle, les réactifs ainsi que 12 ?L de chaque échantillon de sérum à doser ont été ajoutés à l'automate. La calibration de l'automate et le dosage des sérums ont été ensuite programmés via un microordinateur intégré au système. Les différentes lectures de l'absorbance de NADH,H + ont été réalisées grâce à un spectrophotomètre intégré à l'automate. Les résultats du dosage des transaminases sont déduits par l'automate. Ces dosages ont été réalisés en collaboration avec le laboratoire de biochimie-biologie moléculaire-nutrition et métabolisme du, Les mesures sont réalisées avec un automate multiparamétrique, Olympus AU 2700

. Calcul and . Homa-ir,

, La relation entre glycémie et insulinémie est bien connue et a conduit à l'élaboration de l'indice HOMA (Homeostasis Model Assessment), indice qui permet de mettre en évidence une résistance à l'insuline qui est un facteur de risque de diabète de type 2

, Après avoir dosé le glucose et l'insuline, il est ainsi possible de calculer l'indice HOMA-IR

, Un résultat trop élevé de l'indice HOMA indique la présence d'une résistance à l'insuline

L. Homa-est-basé-sur-une-formule-mathématique, présentée ci-dessous, permettant d'évaluer la résistance à l'insuline de manière simple et fiable

?. Glucose,

, Les techniques de coloration ont été réalisées au Service d'Anatomopathologie à l'Hôpital Central, Nancy. ?Xylène (VWR Prolabo

, ?Tous les produits sont fournis par VWR Prolabo

, ?Eau ammoniacale : ammoniaque (Merck), eau stérile (versyleine fresenius) (VWR Prolabo

, ?Fuchsine Ponceau : fuchsine acide 1 % (RAL avec 100mL de Ponceau de Xylidine à 1%

, ?Acide phosphomolybdique (Merck, Darmstadt, Deutschland). ?Bleu d'Aniline (VWR Prolabo

-. Appareil-d'électrophorèse-mini and . Ii,

, ? Gel de séparation : acrylamide : bisacrylamide (29:1) (Bio-Rad Laboratories), tampon Tris-HCl 0,125 M, vol.6

, ? Tampon de migration : Tris 250 mM contenant glycine 1,92 mM et SDS 1% (p/v) pH~8,3 (ne pas ajuster avec HCl)

. ?-tampon-laemmli-x2-;-sigma-aldrich,

. ?-marqueurs-de-poids-moléculaires, Low Molecular Weight ; LMW -Amersham Pharmacia

, Déshybridation de membrane après western blotting (stripping)

, Principe: Les membranes ayant déjà été incubées avec des anticorps primaires et secondaires peuvent être ré-incubées avec un autre anticorps après avoir été déshybridées

, ? Tampon de déshybridation : Pour 1 litre, 100 mM 2-mercaptoethanol 7 ml, 2 % SDS 20g, 62,5mM Tris HCL pH 6, vol.7, p.57

, Tris 200 mM 24,2g, NaCl 1,5 M 87,5g, pH 7,4 à ajuster avec HCl qsp H2O MilliQ. Conserver à 4°C

N. , Si le volume d'échantillon excède 700 µl, charger les échantillons successivement en gardant la même colonne et centrifuger comme ci-dessus. Jeter l'éluat après chaque étape de centrifugation

, Ajouter 700 µL de tampon RW1 sur la mini-colonne. Centrifuger pendant 15sec à vitesse ?8000 g pour laver la colonne

, Laver la colonne avec 500 µL de tampon RPE. Centrifuger pendant 15sec à vitesse ?8000 g

, Ajouter encore 500 µL de tampon RPE à la colonne. Centrifuger pendant 2 min à vitesse ?8000 g

, Transférer la colonne dans un nouveau tube collecteur de 2 mL et recentrifuger 1 min à vitesse maximale (16000 g) pour sécher la membrane

N. , Enlever délicatement la colonne du tube pour éviter tout contact entre la membrane et le produit d'écoulement. S'assurer que le tube soit bien vide

, Transférer la colonne dans un nouveau tube collecteur de 1,5 mL, Centrifuger 1min à vitesse ?8000 g pour éluer l'ARN

N. , Si le taux d'ARN attendu est >30 µg, répéter l'étape d'élution avec un second volume d'eau

, Doser les ARN afin d'obtenir la concentration de chaque échantillons

?. Kit,

, Préparer le volume à utiliser, à savoir 10 µl de ?-Mercaptoéthanol par ml de tampon RLT

, Ajouter de l'éthanol au tampon RPE avant utilisation soit 44 ml d'éthanol 96-100 % Rnase-free dans les 11 ml de tampon RPE

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