Exploration du traitement de l’information visuelle au stade précoce et intégratif chez les patients souffrant de schizophrénie avec hallucinations visuelles

Abstract : Visual hallucinations (VH) are a common psychotic symptom present in eye disease, neurological disorders and psychiatric disorders. Cognitive models of VH postulate the disruption of both bottom-up visual information processing and late top-down processes to explain the emergence of VH. In the first part of our work, we have reviewed the common characteristics between pathologies characterized by VH. We have found that structural or functional abnormalities of the retina were systematically present, but few studies have explored the link between these abnormalities and VH. Hence, we have explored the retinal functions in schizophrenia patients with or without VH. We have found photoreceptors and retinal ganglion cells abnormalities in patients with schizophrenia and abnormalities of the rod system specifically in patients with VH. Abnormalities of sensory processing are a necessary but insufficient condition to explain the occurrence of VH. Thus, we have explored the influence of emotion processing in healthy hallucinations prone subjects and schizophrenia patients in an emotional priming task requiring the treatment of ambiguous stimuli. We expose intermediate results which show that the manipulation of an emotional primer can influence the perception of ambiguous stimuli in healthy hallucinations prone subjects. These results need replications in a new research protocol. Our results allow us to discuss the adaptation of a model of VH in schizophrenia.
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Florent Bernardin. Exploration du traitement de l’information visuelle au stade précoce et intégratif chez les patients souffrant de schizophrénie avec hallucinations visuelles. Neurosciences [q-bio.NC]. Université de Lorraine, 2019. Français. ⟨NNT : 2019LORR0039⟩. ⟨tel-02327952⟩

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