A. Aburima, S. Wraith, . Raslan, . Law, E. M. Magwenzi et al., « CAMP Signaling Regulates Platelet Myosin Light Chain (MLC) Phosphorylation and Shape Change through Targeting the RhoA-Rho Kinase-MLC Phosphatase Signaling Pathway, Blood, vol.122, pp.3533-3578, 2013.

W. Aburima and W. Naseem, « CGMP Signaling Inhibits Platelet Shape Change through Regulation of the RhoA-Rho Kinase-MLC Phosphatase Signaling Pathway, Journal of Thrombosis and Haemostasis: JTH, vol.15, pp.1668-78, 2017.

K. Akbar, . Funk, . Cancelas, . Shang, . Chen et al., « Genetic and Pharmacologic Evidence That Rac1 GTPase Is Involved in Regulation of Platelet Secretion and Aggregation, Journal of Thrombosis and Haemostasis, vol.5, pp.1747-55, 2007.

C. Allahverdian, . Boukais, . Francis, and . Bochaton-piallat, Smooth Muscle Cell Fate and Plasticity in Atherosclerosis, vol.114, pp.540-50, 2018.

K. Alshbool, . Vemana, L. Conlon, and . Khasawneh, The Regulator of G-Protein Signaling 18 Regulates Platelet Aggregation, Hemostasis and Thrombosis, vol.462, pp.378-82, 2015.

J. Althoff, . Troidl, . Tang, . Wang, . Wirth et al., Procontractile G Protein-Mediated Signaling Pathways Antagonistically Regulate Smooth Muscle Differentiation in Vascular Remodeling, vol.209, pp.2277-90, 2012.

. Antoniak, . Cardenas, . Buczek, . Church, . Mackman et al., Protease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation, vol.136, pp.258-68, 2017.

S. Arciniegas and A. Schor, « Transforming Growth Factor Beta 1 Promotes the Differentiation of Endothelial Cells into Smooth Muscle-like Cells in Vitro », Journal of Cell Science, vol.103, issue.2, pp.521-550, 1992.

. Argmann, . Edwards, . Sawyez, . Neil, . Hegele et al., « Regulation of Macrophage Cholesterol Efflux through Hydroxymethylglutaryl-CoA Reductase Inhibition: A ROLE FOR RhoA IN ABCA1-MEDIATED CHOLESTEROL EFFLUX », Journal of Biological Chemistry, vol.280, pp.22212-22233, 2005.

J. E. Aslan, « Platelet Rho GTPase Regulation in Physiology and Disease, Platelets, vol.30, pp.17-22, 2019.

L. Badimon, . Padró, and . Vilahur, « Atherosclerosis, Platelets and Thrombosis in Acute Ischaemic Heart Disease, European Heart Journal: Acute Cardiovascular Care, vol.1, pp.60-74, 2012.

D. Bi, . Nishimura, . Niiro, . Hirano, and . Kanaide, « Contractile Properties of the Cultured Vascular Smooth Muscle Cells: The Crucial Role Played by RhoA in the Regulation of Contractility, Circulation Research, vol.96, pp.890-97, 2005.

H. Bishop, « Rho GTPases and Their Effector Proteins, The Biochemical Journal, vol.348, pp.241-55, 2000.

. Borissoff, . Spronk, and C. Heeneman, « Is Thrombin a Key Player in the "coagulation-Atherogenesis" Maze?, Cardiovascular Research, vol.82, pp.392-403, 2009.

O. Bouchard, . Keith, . Lavoie, . Gissel, . Fung et al., « Microparticles Formed during Storage of Red Blood Cell Units Support Thrombin Generation, Journal of Trauma and Acute Care Surgery, vol.84, pp.598-605, 2018.

. Burkhart, . Vaudel, . Gambaryan, . Radau, . Walter et al., The First Comprehensive and Quantitative Analysis of Human Platelet Protein Composition Allows the Comparative Analysis of Structural and Functional Pathways, vol.120, p.15, 2012.

L. Burnier, R. Fontana, . Kwak, and . Et-angelillo-scherrer, Cell-Derived Microparticles in Haemostasis and Vascular Medicine, vol.101, pp.439-51, 2009.

P. Byzova, Activation of ?V?3 on Vascular Cells Controls Recognition of Prothrombin, vol.143, pp.2081-92, 1998.

Z. Cai and . Li, « Rho-GTPase and Atherosclerosis: Pleiotropic Effects of Statins », Journal of the American Heart Association, vol.4, 2015.

C. Carbone, . Heurtebise-chrétien, . Prieur, . Quillard, . Goueffic et al., « Leukocyte RhoA Exchange Factor Arhgef1 Mediates Vascular Inflammation and Atherosclerosis », Journal of Clinical Investigation, vol.127, pp.4516-4542, 2017.

. Cesarman-maus and H. Et, « Molecular Mechanisms of Fibrinolysis, British Journal of Haematology, vol.129, pp.307-328, 2005.

. Chen, . Singer, . Sternweis, and . Sprang, « Structure of the P115RhoGEF RgRGS Domain-G?13/I1 Chimera Complex Suggests Convergent Evolution of a GTPase Activator, Nature Structural & Molecular Biology, vol.12, issue.2, p.191, 2005.

Z. Cherfils, Regulation of Small GTPases by GEFs, GAPs, and GDIs, vol.93, pp.269-309, 2013.

. Cintorino, D. Vindigni, . Vecchio, . Tosi, . Frezzotti et al., « Expression of Actin Isoforms and Intermediate Filament Proteins in Childhood Orbital Rhabdomyosarcomas », Journal of Submicroscopic Cytology and Pathology, vol.21, pp.409-428, 1989.

M. Coenen and . Cosemans, « Platelet Interaction with Activated Endothelium: Mechanistic Insights from Microfluidics ». Blood, vol.130, pp.2819-2847, 2017.

. Coughlin, « Thrombin Signalling and Protease-Activated Receptors », Nature, vol.407, issue.6801, pp.258-64, 2000.

. Coughlin, Protease-Activated Receptors in Hemostasis, Thrombosis and Vascular Biology, vol.3, pp.1800-1814, 2005.

A. Dash and . Siess, « Integrin Alpha IIb Beta 3-Mediated Translocation of CDC42Hs to the Cytoskeleton in Stimulated Human Platelets, The Journal of Biological Chemistry, vol.270, pp.17321-17347, 1995.

D. Sotomayor, D. Pérez-guerrero, . Herrera, and M. Et, « Effect of simvastatin on vascular smooth muscle responsiveness: involvement of Ca2+ homeostasis, European Journal of Pharmacology, vol.415, issue.2, pp.217-241, 2001.

E. Denis and . Wagner, Platelet Adhesion Receptors and Their Ligands in Mouse Models of Thrombosis ». Arteriosclerosis, Thrombosis, and Vascular Biology, vol.27, pp.728-767, 2007.

. Dewerchin, . Liang, . Moons, . Carmeliet, C. Castellino et al., « Blood Coagulation Factor X Deficiency Causes Partial Embryonic Lethality and Fatal Neonatal Bleeding in Mice, Thrombosis and Haemostasis, vol.83, issue.2, pp.185-90, 2000.

. Dong, . Liao, . Fang, . Lee, . Yan et al., « Increased Rho Kinase Activity in Congestive Heart Failure, European Journal of Heart Failure, vol.14, pp.965-73, 2012.

W. Duluc, « Rho GTPases in the Regulation of Pulmonary Vascular Barrier Function, Cell and Tissue Research, vol.355, pp.675-85, 2014.

. Dzau, E. Braun-dullaeus, and . Sedding, Vascular Proliferation and Atherosclerosis: New Perspectives and Therapeutic Strategies, vol.8, pp.1249-56, 2002.

. Eckly, . Hechler, . Freund, . Zerr, . Cazenave et al., Mechanisms Underlying FeCl3-Induced Arterial Thrombosis ». Journal of Thrombosis and Haemostasis: JTH 9, vol.4, pp.779-89, 2011.

. Elvers, . Beck, . Fotinos, . Ziegler, and . Gawaz, « The GRAF Family Member Oligophrenin1 Is a RhoGAP with BAR Domain and Regulates Rho GTPases in Platelets, Cardiovascular Research, vol.94, pp.526-562, 2012.

G. Faix, « Staying in Shape with Formins, Developmental Cell, vol.10, pp.693-706, 2006.

. Farrehi, . Ozaki, . Carmeliet, and . Fay, « Regulation of Arterial Thrombolysis by Plasminogen Activator Inhibitor-1 in Mice, Circulation, vol.97, pp.1002-1010, 1998.

V. Félétou and . Verbeuren, « The Thromboxane/Endoperoxide Receptor (TP): The Common Villain », Journal of Cardiovascular Pharmacology, vol.55, pp.317-349, 2010.

. Feske, . Sorond, . Henderson, . Seto, . Hitomi et al., « Increased Leukocyte ROCK Activity in Patients after Acute Ischemic Stroke, Brain Research, vol.1257, pp.89-93, 2009.

F. Fitch-tewfik, « Platelet Granule Exocytosis: A Comparison with Chromaffin Cells », Frontiers in Endocrinology, vol.4, p.77, 2013.

P. Flevaris, . Stojanovic, . Gong, W. Chishti, and . Du, « A Molecular Switch That Controls Cell Spreading and Retraction, The Journal of Cell Biology, vol.179, pp.553-65, 2007.

. Flynn, . Byrne, . Baglin, . Weissberg, and . Bennett, « Thrombin Generation by Apoptotic Vascular Smooth Muscle Cells, Blood, vol.89, pp.4378-84, 1997.

G. A. Fritsma, « Platelet Structure and Function », vol.28, pp.125-131, 2015.

A. Fukuda, . Nogi, and . Goto, « Evaluation of Mouse Red Blood Cell and Platelet Counting with an Automated Hematology Analyzer », Journal of Veterinary Medical Science, vol.79, pp.1707-1718, 2017.

L. Fukumoto, . Rabkin, . Hill, . Enomoto, . Hirouchi et al., « Statins Alter Smooth Muscle Cell Accumulation and Collagen Content in Established Atheroma of Watanabe Heritable Hyperlipidemic Rabbits, Circulation, vol.103, pp.993-99, 2001.

. Gachet, « P2 Receptors, Platelet Function and Pharmacological Implications, Thrombosis and Haemostasis, vol.99, pp.466-72, 2008.

. Galis, . Kranzhöfer, . Fenton, and . Libby, « Thrombin Promotes Activation of Matrix Metalloproteinase-2 Produced by Cultured Vascular Smooth Muscle Cells, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.17, pp.483-89, 1997.

. Gao, . Smith, . Ker, . Campbell, . Cheng et al., « Role of RhoA-Specific Guanine Exchange Factors in Regulation of Endomitosis in Megakaryocytes, Developmental Cell, vol.22, pp.573-84, 2012.

. Goggs, . Harper, . Pope, . Savage, . Williams et al., « RhoG Protein Regulates Platelet Granule Secretion and Thrombus Formation in Mice », Journal of Biological Chemistry, vol.288, pp.34217-34246, 2013.

. Goggs, . Savage, . Mellor, and . Poole, « The Small GTPase Rif Is Dispensable for Platelet Filopodia Generation in Mice ». Édité par Pontus Aspenstrom, PLoS ONE, vol.8, issue.1, 2013.

W. Goggs, . Mellor, and . Poole, « Platelet Rho GTPases-a Focus on Novel Players, Roles and Relationships, vol.466, pp.431-473, 2015.

C. Gratzinger, . Engelhardt, and . Madri, Platelet Endothelial Cell Adhesion Molecule-1, 2003.

, Modulates Endothelial Cell Motility through the Small G-Protein Rho ». The FASEB Journal, vol.17, pp.1458-69

F. Gresele and S. Momi, Matrix Metalloproteinases and Platelet Function, vol.147, pp.133-65, 2017.

B. Guilluy, . Toumaniantz, . Rolli-derkinderen, . Retailleau, . Loufrani et al., « The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure », Nature Medicin, vol.16, pp.183-90, 2010.

. Hall, « Rho Family GTPases, Biochemical Society Transactions, vol.40, pp.1378-82, 2012.

R. Heasman, « Mammalian Rho GTPases: New Insights into Their Functions from in Vivo Studies », Nature Reviews Molecular Cell Biology, vol.9, pp.690-701, 2008.

S. Heerkens, . Ryding, . Brooker, . Mullins, . Austin et al., « ?V Integrins Are Necessary for Eutrophic Inward Remodeling of Small Arteries in Hypertension, Hypertension, vol.47, issue.2, pp.281-87, 2006.

. Heiman, . Meadow, S. Gupta, E. Khan, D. Vaughan et al., Complete Plasminogen Activator Inhibitor 1 Deficiency, 2017.

B. Hemker, The Generation of Thrombin in Whole Plasma. Biochemical Possibilities and Physiological Realities ». Verhandelingen -Koninklijke Academie Voor Geneeskunde Van Belgie, vol.47, pp.321-360, 1985.

K. Hensch, . Druey, . Tansey, and . Khasawneh, RGS10 Negatively Regulates Platelet Activation and Thrombogenesis, vol.11, p.11, 2016.

. Hernández-perera, . Pérez-sala, . Soria, and . Lamas, « Involvement of Rho GTPases in the Transcriptional Inhibition of Preproendothelin-1 Gene Expression by Simvastatin in Vascular Endothelial Cells, Circulation Research, vol.87, pp.616-638, 2000.

. Hirsch, . Bosco, . Tropel, . Laffargue, . Calvez et al., « Resistance to Thromboembolism in PI3Kgamma-Deficient Mice, FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, vol.15, pp.2019-2040, 2001.

R. Hodge, « Regulating Rho GTPases and Their Regulators », Nature Reviews. Molecular Cell Biology, vol.17, pp.496-510, 2016.

P. Hordijk, VE-Cadherin Modulates Endothelial Permeability, 1999.

. Huang, . Bi, . Su, . Huang, . Miao et al., « Enhancing autophagy protects platelets in immune thrombocytopenia patients, Annals of Translational Medicine, vol.7, p.7, 2019.

. Ikeda, . Shimpo, . Ohki, . Inaba, . Takahashi et al., « Fluvastatin Inhibits Matrix Metalloproteinase-1 Expression in Human Vascular Endothelial Cells, Hypertension, vol.36, pp.325-354, 2000.

J. , « The Growing Complexity of Platelet Aggregation, Blood, vol.109, pp.5087-95, 2007.

D. Jacobson, . Birukov, . Ye, . Grigoryev, . Girgis et al., « Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin, American Journal of Respiratory cell and Molecular Biology, vol.30, p.5, 2004.

S. Jeong, . Kim, . Eo, . Rhim, and . Kim, Multiple Signaling Pathways Contribute to the Thrombin-Induced Secretory Phenotype in Vascular Smooth Muscle Cells, vol.19, pp.549-55, 2015.

M. Jin, . Thomas, D. Kim, and . Kunapuli, « RhoA Downstream of G(q) and G(12/13) Pathways Regulates Protease-Activated Receptor-Mediated Dense Granule Release in Platelets, Biochemical Pharmacology, vol.77, pp.835-879, 2009.

T. Johnson and . Malik, « Thrombin-Induced Lung Vascular Injury. Roles of Fibrinogen and Fibrinolysis ». The American Review of Respiratory Disease 128, vol.1, pp.38-44, 1983.

K. Jurk, Platelets: Physiology and Biochemistry, vol.31, pp.381-92, 2005.

E. Kakar and . Lip, « Hypertension: endothelial dysfunction, the prothrombotic state and antithrombotic therapy, Expert Review of Cardiovascular Therapy, vol.5, pp.441-50, 2007.

P. Korff and . Schorpp-kistner, « MiR-663 and the MiRaculous Vascular Smooth Muscle Phenotypic Switch, Circulation Research, vol.113, pp.1102-1107, 2013.

P. Kouklis, . Konstantoulaki, . Vogel, E. B. Broman, and . Malik, « Cdc42 Regulates the Restoration of Endothelial Barrier Function, Circulation Research, vol.94, issue.2, pp.159-66, 2004.

S. Kulkarni, M. Dopheide, L. Yap, . Ravanat, . Freund et al., « A Revised Model of Platelet Aggregation », Journal of Clinical Investigation, vol.105, pp.783-91, 2000.

. Kurz, . Main, and . Sandusky, « Rat Model of Arterial Thrombosis Induced by Ferric Chloride, Thrombosis Research, vol.60, pp.269-80, 1990.

R. Lacolley and . Avolio, Smooth Muscle Cell and Arterial Aging: Basic and Clinical Aspects, vol.114, pp.513-541, 2018.

R. Lacolley, L. Nicoletti, and . Michel, « The Vascular Smooth Muscle Cell in Arterial Pathology: A Cell That Can Take on Multiple Roles, Cardiovascular Research, vol.95, issue.2, pp.194-204, 2012.

R. Lacolley, . Segers, and . Laurent, « Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease », Physiological Reviews, vol.97, pp.1555-1617, 2017.

L. Laufs, « Post-Transcriptional Regulation of Endothelial Nitric Oxide Synthase MRNA Stability by Rho GTPase », Journal of Biological Chemistry, vol.273, pp.24266-71, 1998.

. Law, . Deguzman, . Heiser, . Ministri-madrid, . Killeen et al., « Integrin Cytoplasmic Tyrosine Motif Is Required for Outside-in AlphaIIbbeta3 Signalling and Platelet Function », Nature, vol.401, pp.808-819, 1999.

E. Lecompte and . Salignac, « New complete blood count parameter to evaluate iron status of haemodialysis patients, Nephrologie & Therapeutique, vol.2, issue.5, pp.327-332, 2006.

K. Leng, . Ren, and . Shattil, RhoA and the Function of Platelet Integrin AlphaIIbbeta3, vol.91, pp.4206-4221, 1998.

C. Lhermusier and . Payrastre, Platelet Membrane Phospholipid Asymmetry: From the Characterization of a Scramblase Activity to the Identification of an Essential Protein Mutated in Scott Syndrome, Journal of Thrombosis and Haemostasis, vol.9, pp.1883-91, 2011.

N. Li and . Gupta, « Ferric Chloride-Induced Murine Thrombosis Models », Journal of Visualized Experiments, p.115, 2016.

G. Y. Lip and . Blann, Association of Platelet Function in Hypertensive Patients with Left Ventricular Hypertrophy, vol.10, pp.71-72, 1999.

T. Littlewood and M. Bennett, « Apoptotic Cell Death in Atherosclerosis, Current Opinion in Lipidology, vol.14, pp.469-75, 2003.

. Liu, . Itoh, . Louie, . Kubota, and . Kent, « The Signaling Protein Rho Is Necessary for Vascular Smooth Muscle Migration and Survival but Not for Proliferation, Surgery, vol.132, issue.2, pp.317-342, 2002.

P. Loirand, « The role of Rho protein signaling in hypertension », Nature Reviews Cardiology, vol.7, pp.637-647, 2010.

. Lu, . Hsu, . Huang, . Tu, . Huang et al., Journal of Thrombosis and Haemostasis, vol.15, pp.2053-64, 2017.

E. Ma and . Dorling, The Roles of Thrombin and Protease-Activated Receptors in Inflammation, vol.34, pp.63-72, 2012.

Q. Ma and . Plow, Platelet Integrin ?IIb?3: Activation Mechanisms, vol.5, pp.1345-52, 2007.

G. Mallat, . Sauzeau, . Brun, . Silvestre, . Esposito et al., « Rho-Associated Protein Kinase Contributes to Early Atherosclerotic Lesion Formation in Mice, Circulation Research, vol.93, pp.884-88, 2003.

X. Mao, . Said, . Louis, . Max, . Bourhim et al., « Cyclic Stretch-Induced Thrombin Generation by Rat Vascular Smooth Muscle Cells Is Mediated by the Integrin ?v?3 Pathway, Cardiovascular Research, vol.96, pp.513-536, 2012.

M. Mariano, . Pallas, . Abad, . Lloret, and . Lopez-galvez, Coagulation Factor XII Congenital Deficiency in Women with Recurrent Miscarriage, International Journal of Clinical Medicine, vol.02, pp.469-72, 2011.

. Martin, . Weiss, . Metharom, . Schmeckpeper, O. Hynes et al., « Thrombin Stimulates Smooth Muscle Cell Differentiation From Peripheral Blood Mononuclear Cells via Protease-Activated Receptor-1, RhoA, and Myocardin, Circulation Research, vol.105, pp.214-232, 2009.

C. Marx, . Lenting, . Rupin, . Vallez, and D. Verbeuren, « Altered thrombus formation in von Willebrand factor-deficient mice expressing von Willebrand factor variants vith defective binding to collagen or GPIIbIIIa, pp.603-612, 2008.

. Mccarty, . Larson, . Auger, . Kalia, P. Atkinson et al., « Rac1 Is Essential for Platelet Lamellipodia Formation and Aggregate Stability under Flow », Journal of Biological Chemistry, vol.280, pp.39474-84, 2005.

. Mcnamara, . Sarembock, . Bachhuber, . Stouffer, . Ragosta et al., Thrombin and Vascular Smooth Muscle Cell Proliferation: Implications for Atherosclerosis and Restenosis ». Seminars in Thrombosis and Hemostasis, vol.22, pp.139-183, 1996.

. Mcnamara, . Sarembock, . Gimple, . Fenton, . Coughlin et al., « Thrombin Stimulates Proliferation of Cultured Rat Aortic Smooth Muscle Cells by a Proteolytically Activated Receptor, Journal of Clinical Investigation, vol.91, pp.94-98, 1993.

. Mcvey, . Boswell, . Mumford, . Kemball-cook, and T. Et, « Factor VII Deficiency and the FVII Mutation Database, Human Mutation, vol.17, pp.3-17, 2001.

. Membré, . Bounameaux, . Boehlen, . Genné, . Pouplard et al., « Heparin-Induced Thrombocytopenia Associated with Interleukin-8-Dependent Platelet Activation in a Patient with Antiphospholipid Syndrome, European Journal of Haematology, vol.79, pp.550-53, 2007.

L. Michel and . Lacolley, Smooth Muscle Cells and Vascular Diseases, vol.95, pp.135-172, 2012.

. Miyata, . Shimokawa, . Kandabashi, . Higo, . Morishige et al., « Rho-Kinase Is Involved in Macrophage-Mediated Formation of Coronary Vascular Lesions in Pigs in Vivo, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.20, pp.2351-58, 2000.

E. Monroe and . Hoffman, « What Does It Take to Make the Perfect Clot?, Thrombosis, and Vascular Biology, vol.26, pp.41-48, 2006.

H. Monroe and . Roberts, Platelets and Thrombin Generation ». Arteriosclerosis, Thrombosis, and Vascular Biology, vol.22, pp.1381-89, 2002.

Z. Nagy, V. Wynne, . Kriegsheim, . Gambaryan, and . Smolenski, Cyclic Nucleotide-Dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets, vol.290, pp.29974-83, 2015.

E. Napolitano and . Siragusa, « Coronary Artery Stenosis Treatment in Aging Patients with Inherited Factor VII Deficiency: Where Do We Stand?, Transfusion and Apheresis Science: Official Journal of the World Apheresis Association: Official Journal of the European Society for Haemapheresis, vol.56, pp.867-69, 2017.

C. Navarrete, . Legendre, . Marx, J. Hu, D. Lenting et al., « A Murine Model to Characterize the Antithrombotic Effect of Molecules Targeting Human von Willebrand Factor, Blood, vol.120, pp.2723-2755, 2012.

. Nguyen, . Frye, . Eskin, R. Patterson, and . Mcintire, « Cyclic Strain Increases Protease-Activated Receptor-1 Expression in Vascular Smooth Muscle Cells, Hypertension, vol.38, pp.1038-1081, 2001.

. Nishioka, . Horiuchi, . Tabuchi, . Yoshioka, . Shirakawa et al., « Small GTPase Rho Regulates Thrombin-Induced Platelet Aggregation, Biochemical and Biophysical Research Communications, vol.280, pp.970-75, 2001.

E. Noda-heiny and . Sobel, « Vascular smooth muscle cell migration mediated by thrombin and urokinase receptor, American Journal of Physiology-Cell Physiology, vol.268, pp.1195-1201, 1995.

. Nygaard, . Herfindal, . Asrud, . Bjørnstad, . Kopperud et al., « Epac1-Deficient Mice Have Bleeding Phenotype and Thrombocytes with Decreased GPIb? Expression, Scientific Reports, vol.7, issue.1, p.8725, 2017.

S. Offermanns, « Activation of Platelet Function Through G Protein-Coupled Receptors, Circulation Research, vol.99, pp.1293-1304, 2006.

G. Ory, « Rho GTPases and Exocytosis: What Are the Molecular Links?, Seminars in Cell & Developmental Biology, vol.22, pp.27-32, 2011.

S. Palta and . Palta, « Overview of the Coagulation System, Indian Journal of Anaesthesia, vol.58, pp.515-538, 2014.

A. Pan, R. Spina, . Cleary, . Wakelam, . Page et al., « P-Rex and Vav Rac-GEFs in Platelets Control Leukocyte Recruitment to Sites of Inflammation, Blood, vol.125, pp.1146-58, 2015.

. Pathak, . Zhao, . Monroe, . Roberts, . Sheridan et al., « Thrombin Generation in Vascular Tissue, Journal of Thrombosis and Haemostasis, vol.4, pp.60-67, 2006.

L. Pearce, . Edwards, . English, and . Geary, « Differential Effects of Rho-Kinase Inhibition on Artery Wall Mass and Remodeling », Journal of Vascular Surgery, vol.39, pp.223-251, 2004.

E. Pérez-gómez and . Bover, The new coagulation cascade and its possible influence on the delicate balance between thrombosis and hemorrhage, vol.60, pp.1217-1236, 2007.

T. Petrache, . Crow, G. Neuss, and . Garcia, « Central Involvement of Rho Family GTPases in TNF-?-Mediated Bovine Pulmonary Endothelial Cell Apoptosis, Biochemical and Biophysical Research Communications, vol.306, issue.1, pp.244-293, 2003.

E. Pleines, . Elvers, . Hagedorn, . Eliautou, . Bender et al., « Multiple Alterations of Platelet Functions Dominated by Increased Secretion in Mice Lacking Cdc42 in Platelets, Blood, vol.115, pp.3364-73, 2010.

. Pleines, . Hagedorn, . Gupta, . May, . Chakarova et al., « Megakaryocyte-Specific RhoA Deficiency Causes Macrothrombocytopenia and Defective Platelet Activation in Hemostasis and Thrombosis, Blood, vol.119, pp.1054-63, 2012.

E. W. Pula and . Poole, « Critical Roles for the Actin Cytoskeleton and Cdc42 in Regulating Platelet Integrin ? 2 ? 1 », Platelets, vol.19, pp.199-210, 2008.

H. Qasim, . Karim, . Hernandez, . Lozano, E. Z. Khasawneh et al., « Arhgef1 Plays a Vital Role in Platelet Function and Thrombogenesis », Journal of the American Heart Association, vol.8, p.9, 2019.

F. Reed and . Polgár, « Molecular Mechanisms of Platelet Exocytosis: Insights into the "Secrete, Life of Thrombocytes ». Blood, vol.96, pp.3334-3376, 2000.

. Rodgers, « Vascular Smooth Muscle Cells Synthesize, Secrete and Express Coagulation Factor V », Biochimica et Biophysica Acta (BBA) -Molecular Cell Research, vol.968, pp.17-23, 1988.

W. Rolfe, . World, . Campbell, and . Campbell, Atherosclerosis, vol.183, pp.1-16, 2005.

. Ruggeri, « The Role of von Willebrand Factor in Thrombus Formation, Thrombosis Research, vol.120, pp.5-9, 2007.

C. Sartore, . Faggin, . Franch, A. Puato, and . Pauletto, « Contribution of Adventitial Fibroblasts to Neointima Formation and Vascular Remodeling: From Innocent Bystander to Active Participant, Circulation Research, vol.89, pp.1111-1132, 2001.

. Sawada, . Itoh, . Ueyama, . Yamashita, C. Doi et al., « Inhibition of Rho-Associated Kinase Results in Suppression of Neointimal Formation of Balloon-Injured Arteries, Circulation, vol.101, pp.2030-2063, 2000.

. Schecter, . Spirn, . Rossikhina, . Giesen, . Bogdanov et al., « Release of Active Tissue Factor by Human Arterial Smooth Muscle Cells, Circulation Research, vol.87, issue.2, pp.126-158, 2000.

, The endothelium in regulating vascular leakage and leukocyte extravasation

. Schmeck, . Brunsch, . Seybold, . Krüll, . Eichel-streiber et al., « Rho Protein Inhibition Blocks Cyclooxygenase-2 Expression by Proinflammatory Mediators in Endothelial Cells, Inflammation, vol.27, issue.2, pp.89-95, 2003.

. Schoenwaelder, . Hughan, . Boniface, . Fernando, . Holdsworth et al., RhoA Sustains Integrin ? IIb ? 3 Adhesion Contacts under High Shear, Journal of Biological Chemistry, vol.277, pp.14738-14784, 2002.

. Schrör, . Bretschneider, . Fischer, . Fischer, . Pape et al., « Thrombin Receptors in Vascular Smooth Muscle Cells -Function and Regulation by Vasodilatory Prostaglandins, Thrombosis and Haemostasis, vol.103, pp.884-90, 2010.

. Seasholtz, . Zhang, . Morissette, Y. Howes, and . Brown, « Increased Expression and Activity of RhoA Are Associated with Increased DNA Synthesis and Reduced P27(Kip1) Expression in the Vasculature of Hypertensive Rats, Circulation Research, vol.89, pp.488-95, 2001.

K. Shibata, . Seki, . Kusaba, . Takemiya, . Koga et al., « Rho-Kinase Inhibition Reduces Neointima Formation after Vascular Injury by Enhancing Bax Expression and Apoptosis, Journal of Cardiovascular Pharmacology, vol.42, 2003.

L. Shiu, . Marganski, . Usami, . Schwartz, . Wang et al., « Rho Mediates the Shear-Enhancement of Endothelial Cell Migration and Traction Force Generation », Biophysical Journal, vol.86, pp.2558-65, 2004.

. Siegel-axel, . Runge, . Seipel, and . Et-riessen, « Effects of Cerivastatin on Human Arterial Smooth Muscle Cell Growth and Extracellular Matrix Expression at Varying Glucose and Low-Density Lipoprotein Levels », Journal of Cardiovascular Pharmacology, vol.41, pp.422-455, 2003.

. Stewart, « Regulator of G protein signaling 6 (RGS6), a multifarious and pleiotropic modulator of G protein coupled receptor signaling in brain, 2014.

. Suzuki, . Shin, . Wang, . Min, . Poncz et al., RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy and Platelet Generation ». Édité par Kathleen Freson, PLoS ONE, vol.8, issue.7, 2013.

Y. Suzuki, . Yamamoto, . Wada, . Ito, . Nakano et al., « Agonist-Induced Regulation of Myosin Phosphatase Activity in Human Platelets Through Activation of Rho-Kinase, pp.3408-3425, 1999.

. Tai, . Herzog, . Margaritis, . Arruda, . Chu et al., « A Viable Mouse Model of Factor X Deficiency Provides Evidence for Maternal Transfer of Factor X », Journal of Thrombosis and Haemostasis: JTH, vol.6, issue.2, pp.339-384, 2008.

M. Taubman, . Rosenfield, . Guha, . Nichtberger, and . Nemerson, « Agonist-mediated tissue factor expression in cultured vascular smooth muscle cells. Role of Ca2+ mobilization and protein kinase C activation, Journal of Clinical Investigation, vol.91, issue.2, pp.547-52, 1993.

E. Tsopanoglou and . Maragoudakis, « Thrombin's central role in angiogenesis and pathophysiological processes, European Cytokine Network, vol.20, pp.171-79, 2009.

. Van-nieuw-amerongen, . Koolwijk, . Versteilen, and . Van-hinsbergh, « Involvement of RhoA/Rho Kinase Signaling in VEGF-Induced Endothelial Cell Migration and Angiogenesis in Vitro, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.23, issue.2, pp.211-228, 2003.

. Van-wetering, « Rac Induces Loss of VE-Cadherin Function, J. Cell. Sci, pp.1837-1883, 2002.

. Versteeg, L. Heemskerk, and . Reitsma, New Fundamentals in Hemostasis, vol.93, pp.327-58, 2013.

P. Vidwan, . Pathak, . Sheth, M. Huang, A. Monroe et al., « Activation of Protease-Activated Receptors 3 and 4 Accelerates Tissue Factor-Induced Thrombin Generation on the Surface of Vascular Smooth Muscle Cells ». Arteriosclerosis, Thrombosis, and Vascular Biology 30, vol.12, pp.2587-96, 2010.

. Vouret-craviari, . Boquet, . Pouysségur, and . Van-obberghen-schilling, « Regulation of the Actin Cytoskeleton by Thrombin in Human Endothelial Cells: Role of Rho Proteins in Endothelial Barrier Function, Molecular Biology of the Cell, vol.9, pp.2639-53, 1998.

B. Wang, Aging and Atherosclerosis. Mechanisms, Functional Consequences, and Potential Therapeutics for Cellular Senescence, vol.111, pp.245-259, 2012.

G. Wang, . Yue, . Zhou, and . Chu, « On-Line Optical Determination of Floc Size of Fe(III) Coagulants », Journal of Environmental Sciences, vol.17, pp.921-946, 2005.

. Wetering, . Van-den, . Berk, . Van-buul, . Mul et al., « VCAM-1-Mediated Rac Signaling Controls Endothelial Cell-Cell Contacts and Leukocyte Transmigration, American Journal of Physiology-Cell Physiology, vol.285, issue.2, pp.343-52, 2003.

. Williams, . Harper, . Goggs, . Walsh, . Offermanns et al., « Leukemia-Associated Rho Guanine-Nucleotide Exchange Factor Is Not Critical for RhoA Regulation, yet Is Important for Platelet Activation and Thrombosis in Mice, Journal of Thrombosis and Haemostasis, vol.13, pp.2102-2109, 2015.

R. Wojciak-stothard, « Rho GTPases and the Regulation of Endothelial Permeability, Vascular Pharmacology, vol.39, pp.187-99, 2002.

L. Wong, . Smith, W. Sisko, and . Cai, « Statins Suppress THP-1 Cell Migration and Secretion of Matrix Metalloproteinase 9 by Inhibiting Geranylgeranylation », Journal of Leukocyte Biology, vol.69, pp.959-62, 2001.

J. Woodcock-mitchell, J. J. Mitchell, . Low, . Kieny, . Sengel et al., « Alpha-Smooth Muscle Actin Is Transiently Expressed in Embryonic Rat Cardiac and Skeletal Muscles ». Differentiation, Research in Biological Diversity, vol.39, pp.161-66, 1988.

R. Worth, . Song, and . Campbell, « Vascular Smooth Muscle Cell Phenotypic Modulation in Culture Is Associated with Reorganisation of Contractile and Cytoskeletal Proteins, Cell Motility and the Cytoskeleton, vol.49, pp.130-175, 2001.

B. Worthylake, « Leukocyte Transendothelial Migration: Orchestrating the Underlying Molecular Machinery, Current Opinion in Cell Biology, vol.13, pp.569-77, 2001.

. Yamakawa, . Tanaka, . Numaguchi, . Yamakawa, . Motley et al., « Involvement of Rho-Kinase in Angiotensin II-Induced Hypertrophy of Rat Vascular Smooth Muscle Cells, Hypertension, vol.35, pp.313-331, 2000.

. Yang, . Wu, . Jiang, . Mortensen, . Austin et al., Signaling through Gi Family Members in Platelets. Redundancy and Specificity in the Regulation of Adenylyl Cyclase and Other Effectors, The Journal of Biological Chemistry, vol.277, pp.46035-46077, 2002.

C. Yu, Megakaryopoiesis and Thrombopoiesis: An Update on Cytokines and Lineage Surface Markers », Methods in Molecular Biology, vol.788, pp.291-303, 2012.

N. Zeidan, . Albinsson, . Malmqvist, . Swärd, and . Hellstrand, Stretch-Induced Contractile Differentiation of Vascular Smooth Muscle: Sensitivity to Actin Polymerization Inhibitors, vol.284, pp.1387-96, 2003.

. Ziniel, . Desai, . Cass, . Gatto, . Oldfield et al., « Characterization of Potential Drug Targets Farnesyl Diphosphate Synthase and Geranylgeranyl Diphosphate Synthase in Schistosoma Mansoni, Antimicrobial Agents and Chemotherapy, vol.57, pp.5969-76, 2013.

B. Zlamal, « Acquired Immune Thrombocytopenia: An Update on Pathophysiology, Diagnosis and Management, Annals of Blood, vol.3, p.0, 2018.

T. Zou, . Kostadima, . Astle, . Radhakrishnan, and T. Simon, SNP in Human ARHGEF3 Promoter Is Associated with DNase Hypersensitivity, Transcript Level and Platelet Function, and Arhgef3 KO Mice Have Increased Mean Platelet Volume », vol.12, p.5, 2017.

T. Zou, . Yin, . Xiang, . Xavier-ferrucio, . Zhang et al., « Leukaemia-Associated Rho Guanine Nucleotide Exchange Factor (LARG) Plays an Agonist Specific Role in Platelet Function through RhoA Activation, Thrombosis and Haemostasis, vol.116, pp.506-522, 2016.