. .. References, Role of ABC transporters in the pathogenesis of Alzheimer's disease, ACS Chem Neurosci, vol.3, pp.820-831, 2012.

K. K. Ade, Y. Wan, M. Chen, B. Gloss, and N. Calakos, An Improved BAC Transgenic Fluorescent Reporter Line for Sensitive and Specific Identification of Striatonigral Medium Spiny Neurons, Front Syst Neurosci, vol.5, p.32, 2011.

N. Ahmad, J. Girardet, S. Akbar, M. Lanhers, C. Paris et al., Lactoferrin and its hydrolysate bind directly to the oleate-activated form of the lipolysis stimulated lipoprotein receptor, FEBS J, vol.279, pp.4361-4373, 2012.

S. Akbar, A. Pinçon, M. Lanhers, T. Claudepierre, C. Corbier et al., Expression profile of hepatic genes related to lipid homeostasis in LSR heterozygous mice contributes to their increased response to high-fat diet, Physiological Genomics, vol.48, pp.928-935, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01594183

M. Andersson, P. G. Elmberger, C. Edlund, K. Kristensson, and G. Dallner, Rates of cholesterol, ubiquinone, dolichol and dolichyl-P biosynthesis in rat brain slices, FEBS Lett, vol.269, pp.15-18, 1990.

R. Apfel, D. Benbrook, E. Lernhardt, M. A. Ortiz, G. Salbert et al., A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily, Mol Cell Biol, vol.14, pp.7025-7035, 1994.

P. S. Aranda, D. M. Lajoie, and C. L. Jorcyk, Bleach gel: a simple agarose gel for analyzing RNA quality, Electrophoresis, vol.33, pp.366-369, 2012.

A. F. Arnsten, Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks, Biol Psychiatry, vol.69, pp.89-99, 2011.

R. Baeta-corral and L. Giménez-llort, Persistent hyperactivity and distinctive strategy features in the Morris water maze in 3xTg-AD mice at advanced stages of disease, Behav Neurosci, vol.129, pp.129-137, 2015.

Z. Balazs, U. Panzenboeck, A. Hammer, A. Sovic, O. Quehenberger et al., Uptake and transport of high-density lipoprotein (HDL) and HDL-associated alpha-tocopherol by an in vitro blood-brain barrier model, J Neurochem, vol.89, pp.939-950, 2004.

K. R. Bales, Y. Du, D. Holtzman, B. Cordell, and S. M. Paul, Neuroinflammation and Alzheimer's disease: critical roles for cytokine/Abeta-induced glial activation, NF-kappaB, and apolipoprotein E, Neurobiol Aging, vol.21, pp.427-432, 2000.

M. Baranowski, Biological role of liver X receptors, J Physiol Pharmacol, vol.59, issue.7, pp.31-55, 2008.

C. A. Barnes, Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat, J Comp Physiol Psychol, vol.93, pp.74-104, 1979.

P. J. Barrett, Y. Song, W. D. Van-horn, E. J. Hustedt, J. M. Schafer et al., The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol, Science, vol.336, pp.1168-1171, 2012.

U. Beffert, A. Durudas, E. J. Weeber, P. C. Stolt, K. M. Giehl et al., Functional dissection of Reelin signaling by sitedirected disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity, J Neurosci, vol.26, pp.2041-2052, 2006.

U. Beffert, E. J. Weeber, A. Durudas, S. Qiu, I. Masiulis et al., Modulation of Synaptic Plasticity and Memory by Reelin Involves Differential Splicing of the Lipoprotein Receptor Apoer2, vol.47, pp.567-579, 2005.

N. Belhaj, F. Desor, C. Gleizes, F. M. Denis, E. Arab-tehrany et al., Anxiolytic-like effect of a salmon phospholipopeptidic complex composed of polyunsaturated fatty acids and bioactive peptides, Mar Drugs, vol.11, pp.4294-4317, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01272922

J. Be?towski and A. Semczuk, Liver X receptor (LXR) and the reproductive system--a potential novel target for therapeutic intervention, Pharmacol Rep, vol.62, pp.15-27, 2010.

J. M. Berg, J. L. Tymoczko, and L. Stryer, The Complex Regulation of Cholesterol Biosynthesis Takes Place at Several Levels, 2002.

X. Bi, A. P. Yong, J. Zhou, C. E. Ribak, and G. Lynch, Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice, Proc Natl Acad Sci, vol.98, pp.8832-8837, 2001.

B. E. Bihain and F. T. Yen, Free fatty acids activate a high-affinity saturable pathway for degradation of low-density lipoproteins in fibroblasts from a subject homozygous for familial hypercholesterolemia, Biochemistry, vol.31, pp.4628-4636, 1992.

B. E. Bihain and F. T. Yen, The lipolysis stimulated receptor: a gene at last, Curr Opin Lipidol, vol.9, pp.221-224, 1998.

I. Björkhem, Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain, J Intern Med, vol.260, pp.493-508, 2006.

I. Björkhem, Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain, J Intern Med, vol.260, pp.493-508, 2006.

I. Björkhem, L. Starck, U. Andersson, D. Lütjohann, S. Von-bahr et al., Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S-and 27-hydroxycholesterol, J Lipid Res, vol.42, pp.366-371, 2001.

B. Ingemar and &. Steve, Brain Cholesterol: Long Secret Life Behind a Barrier, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.24, pp.806-815, 2004.

R. C. Block, E. R. Dorsey, C. A. Beck, J. T. Brenna, and I. Shoulson, Altered cholesterol and fatty acid metabolism in Huntington disease, J Clin Lipidol, vol.4, pp.17-23, 2010.

E. Boda, A. Pini, E. Hoxha, R. Parolisi, and F. Tempia, Selection of reference genes for quantitative real-time RT-PCR studies in mouse brain, J Mol Neurosci, vol.37, pp.238-253, 2009.

C. Bodo, C. Fernandes, and M. Krause, Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice, Sci Rep, vol.7, p.5365, 2017.

N. Bogdanovic, L. Bretillon, E. G. Lund, U. Diczfalusy, L. Lannfelt et al., On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterolcatabolic enzyme CYP46 in glial cells, Neurosci Lett, vol.314, pp.45-48, 2001.

R. Bohuslavova, N. Dodd, I. Macova, T. Chumak, M. Horak et al., Pax2-Islet1 Transgenic Mice Are Hyperactive and Have Altered Cerebellar Foliation, Mol Neurobiol, vol.54, pp.1352-1368, 2017.

D. D. Bojanic, P. T. Tarr, G. D. Gale, D. J. Smith, D. Bok et al., Differential expression and function of ABCG1 and ABCG4 during development and aging, J Lipid Res, vol.51, pp.169-181, 2010.

D. D. Bojanic, P. T. Tarr, G. D. Gale, D. J. Smith, D. Bok et al., Differential expression and function of ABCG1 and ABCG4 during development and aging, J Lipid Res, vol.51, pp.169-181, 2010.

I. Borghini, F. Barja, D. Pometta, and R. W. James, Characterization of subpopulations of lipoprotein particles isolated from human cerebrospinal fluid, Biochim Biophys Acta, vol.1255, pp.192-200, 1995.

J. K. Boyles, R. E. Pitas, E. Wilson, R. W. Mahley, and J. M. Taylor, Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system, J Clin Invest, vol.76, pp.1501-1513, 1985.

M. S. Brown and J. L. Goldstein, A receptor-mediated pathway for cholesterol homeostasis, Science, vol.232, pp.34-47, 1986.

M. S. Brown, J. Herz, and J. L. Goldstein, LDL-receptor structure. Calcium cages, acid baths and recycling receptors, Nature, vol.388, pp.629-630, 1997.

E. Y. Bryleva, M. A. Rogers, C. C. Chang, F. Buen, B. T. Harris et al., ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD, Proc Natl Acad Sci, vol.107, pp.3081-3086, 2010.

M. Buttini, E. Masliah, G. Yu, J. J. Palop, S. Chang et al., Cellular Source of Apolipoprotein E4 Determines Neuronal Susceptibility to Excitotoxic Injury in Transgenic Mice, Am J Pathol, vol.177, pp.563-569, 2010.

R. Chandra, Y. Wang, R. A. Shahid, S. R. Vigna, N. J. Freedman et al., Immunoglobulin-like domain containing receptor 1 mediates fatstimulated cholecystokinin secretion, J Clin Invest, vol.123, pp.3343-3352, 2013.

Y. Charnay, A. Imhof, P. G. Vallet, D. Hakkoum, A. Lathuiliere et al., Clusterin expression during fetal and postnatal CNS development in mouse, Neuroscience, vol.155, pp.714-724, 2008.

E. I. De-chaves, A. E. Rusiñol, D. E. Vance, R. B. Campenot, and J. E. Vance, Role of lipoproteins in the delivery of lipids to axons during axonal regeneration, J Biol Chem, vol.272, pp.30766-30773, 1997.

A. Chawla, J. J. Repa, R. M. Evans, and D. J. Mangelsdorf, Nuclear receptors and lipid physiology: opening the X-files, Science, vol.294, pp.1866-1870, 2001.

J. Chen, X. Zhang, H. Kusumo, L. G. Costa, and M. Guizzetti, Cholesterol efflux is differentially regulated in neurons and astrocytes: implications for brain cholesterol homeostasis, Biochim Biophys Acta, vol.1831, pp.263-275, 2013.

J. Chen, X. Zhang, H. Kusumo, L. G. Costa, and M. Guizzetti, Cholesterol efflux is differentially regulated in neurons and astrocytes: implications for brain cholesterol homeostasis, Biochim Biophys Acta, vol.1831, pp.263-275, 2013.

S. R. Cheruku, Z. Xu, R. Dutia, P. Lobel, and J. Storch, Mechanism of cholesterol transfer from the Niemann-Pick type C2 protein to model membranes supports a role in lysosomal cholesterol transport, J Biol Chem, vol.281, pp.31594-31604, 2006.

W. Chung, P. B. Verghese, C. Chakraborty, J. Joung, B. T. Hyman et al., Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes, Proc Natl Acad Sci, vol.113, pp.10186-10191, 2016.

T. Claudel, M. D. Leibowitz, C. Fiévet, A. Tailleux, B. Wagner et al., Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor, Proc Natl Acad Sci U S A, vol.98, pp.2610-2615, 2001.

T. Claudepierre and F. W. Pfrieger, , 2003.

, Med Sci (Paris), vol.19, pp.601-605

T. Claudepierre and F. W. Pfrieger, , 2003.

, Med Sci (Paris), vol.19, pp.601-605

R. Daneman, L. Zhou, D. Agalliu, J. D. Cahoy, A. Kaushal et al., The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells, PLoS ONE, vol.5, 2010.

G. D'arcangelo, R. Homayouni, L. Keshvara, D. S. Rice, M. Sheldon et al., Reelin is a ligand for lipoprotein receptors, Neuron, vol.24, pp.471-479, 1999.

P. Davidsson, J. Hulthe, B. Fagerberg, and G. Camejo, Proteomics of apolipoproteins and associated proteins from plasma high-density lipoproteins, Arterioscler Thromb Vasc Biol, vol.30, pp.156-163, 2010.

J. P. Davies and Y. A. Ioannou, Topological analysis of Niemann-Pick C1 protein reveals that the membrane orientation of the putative sterol-sensing domain is identical to those of 3-hydroxy-3-methylglutaryl-CoA reductase and sterol regulatory element binding protein cleavage-activating protein, J Biol Chem, vol.275, pp.24367-24374, 2000.

R. A. Debose-boyd, M. S. Brown, W. P. Li, A. Nohturfft, J. L. Goldstein et al., Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi, Cell, vol.99, pp.703-712, 1999.

R. F. Degrella and R. D. Simoni, Intracellular transport of cholesterol to the plasma membrane, J Biol Chem, vol.257, pp.14256-14262, 1982.

R. B. Demattos, R. P. Brendza, J. E. Heuser, M. Kierson, J. R. Cirrito et al., Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice, Neurochem Int, vol.39, pp.415-425, 2001.

D. Paolo, G. Kim, and T. , Linking lipids to Alzheimer's disease: cholesterol and beyond, Nat Rev Neurosci, vol.12, pp.284-296, 2011.

M. Díaz, N. Fabelo, I. Ferrer, and R. Marín, Lipid raft aging" in the human frontal cortex during nonpathological aging: gender influences and potential implications in Alzheimer's disease, Neurobiol Aging, vol.67, pp.42-52, 2018.

M. Didic, O. Felician, E. J. Barbeau, J. Mancini, C. Latger-florence et al., Impaired visual recognition memory predicts Alzheimer's disease in amnestic mild cognitive impairment, Dement Geriatr Cogn Disord, vol.35, pp.291-299, 2013.

J. M. Dietschy and S. D. Turley, Cholesterol metabolism in the brain, Curr Opin Lipidol, vol.12, pp.105-112, 2001.

F. Djelti, Toxicité neuronale du cholestérol et physiopathologie de la maladie d'Alzheimer : analyse in vivo des conséquences de l'inhibition de la cholestérol-24-hydroxylase. thesis, 2005.

F. Djelti, J. Braudeau, E. Hudry, M. Dhenain, J. Varin et al., CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease, vol.138, pp.2383-2398, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01779044

M. Dokmanovic-chouinard, W. K. Chung, J. Chevre, E. Watson, J. Yonan et al., Positional Cloning of "Lisch-like, PLoS Genet, vol.4, 2008.

S. B. Dumanis, H. Cha, J. M. Song, J. H. Trotter, M. Spitzer et al., ApoE receptor 2 regulates synapse and dendritic spine formation, PLoS ONE, vol.6, 2011.

R. Ehehalt, P. Keller, C. Haass, C. Thiele, and K. Simons, Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts, J Cell Biol, vol.160, pp.113-123, 2003.

A. Eichinger, A. Nasreen, H. J. Kim, and A. Skerra, Structural insight into the dual ligand specificity and mode of high density lipoprotein association of apolipoprotein D, J Biol Chem, vol.282, pp.31068-31075, 2007.

M. Eisenstein, Genetics: finding risk factors, Nature, vol.475, pp.20-22, 2011.

A. El-hajj, F. T. Yen, T. Oster, C. Malaplate, L. Pauron et al., Age-related changes in regiospecific expression of Lipolysis Stimulated Receptor (LSR) in mice brain, PLOS ONE, vol.14, p.218812, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02269337

G. A. Elder, A. Ragnauth, N. Dorr, S. Franciosi, J. Schmeidler et al., Increased locomotor activity in mice lacking the lowdensity lipoprotein receptor, Behav Brain Res, vol.191, pp.256-265, 2008.

K. Elhabazi, A. Dicko, F. Desor, A. Dalal, C. Younos et al., Preliminary study on immunological and behavioural effects of Thymus broussonetii Boiss., an endemic species in Morocco, J Ethnopharmacol, vol.103, pp.413-419, 2006.

D. A. Elliott, C. S. Weickert, and B. Garner, Apolipoproteins in the brain: implications for neurological and psychiatric disorders, Clin Lipidol, vol.51, pp.555-573, 2010.

A. El-sayed and H. Harashima, Endocytosis of Gene Delivery Vectors: From Clathrin-dependent to Lipid Raft-mediated Endocytosis, Molecular Therapy, vol.21, pp.1118-1130, 2013.

N. A. Elshourbagy, M. S. Boguski, W. S. Liao, L. S. Jefferson, J. I. Gordon et al., Expression of rat apolipoprotein A-IV and A-I genes: mRNA induction during development and in response to glucocorticoids and insulin, PNAS, vol.82, pp.8242-8246, 1985.

P. J. Espenshade and A. L. Hughes, Regulation of sterol synthesis in eukaryotes, Annu Rev Genet, vol.41, pp.401-427, 2007.

A. M. Fagan, G. Bu, Y. Sun, A. Daugherty, and D. M. Holtzman, Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein, J Biol Chem, vol.271, pp.30121-30125, 1996.

A. M. Fagan and D. M. Holtzman, Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid-beta deposition in vivo, Microsc Res Tech, vol.50, pp.297-304, 2000.

A. M. Fagan, D. M. Holtzman, G. Munson, T. Mathur, D. Schneider et al., Unique Lipoproteins Secreted by Primary Astrocytes From Wild Type, apoE (?/?), and Human apoE Transgenic Mice, J Biol Chem, vol.274, pp.30001-30007, 1999.

A. M. Fagan, B. A. Murphy, S. N. Patel, J. F. Kilbridge, W. C. Mobley et al., Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury, Exp Neurol, vol.151, pp.314-325, 1998.

Q. W. Fan, I. Iosbe, H. Asou, K. Yanagisawa, and M. Michikawa, Expression and regulation of apolipoprotein E receptors in the cells of the central nervous system in culture: A review, J Am Aging Assoc, vol.24, pp.1-10, 2001.

A. Faure, L. Verret, B. Bozon, N. El-tannir-el-tayara, M. Ly et al., Impaired neurogenesis, neuronal loss, and brain functional deficits in the APPxPS1-Ki mouse model of Alzheimer's disease, Neurobiol Aging, vol.32, pp.407-418, 2011.

L. Fester, L. Zhou, A. Bütow, C. Huber, R. Von-lossow et al., Cholesterol-promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus, Hippocampus, vol.19, pp.692-705, 2009.

M. Filali, R. Lalonde, and S. Rivest, Anomalies in social behaviors and exploratory activities in an APPswe/PS1 mouse model of Alzheimer's disease, Physiol Behav, vol.104, pp.880-885, 2011.

S. M. Fleming, N. A. Tetreault, C. K. Mulligan, C. B. Hutson, E. Masliah et al., Olfactory deficits in mice overexpressing human wildtype alphasynuclein, Eur J Neurosci, vol.28, pp.247-256, 2008.

C. Frank, S. Rufini, V. Tancredi, R. Forcina, D. Grossi et al., Cholesterol depletion inhibits synaptic transmission and synaptic plasticity in rat hippocampus, Exp Neurol, vol.212, pp.407-414, 2008.

J. D. Fryer, R. B. Demattos, L. M. Mccormick, M. A. O'dell, M. L. Spinner et al., The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice, J Biol Chem, vol.280, pp.25754-25759, 2005.

M. Fujiyoshi, M. Tachikawa, S. Ohtsuki, S. Ito, Y. Uchida et al., Amyloid-? peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier, J Neurochem, vol.118, pp.407-415, 2011.

H. Fukumoto, A. Deng, M. C. Irizarry, M. L. Fitzgerald, and G. W. Rebeck, Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels, J Biol Chem, vol.277, pp.48508-48513, 2002.

S. M. Fullerton, W. J. Strittmatter, and W. D. Matthew, Peripheral sensory nerve defects in apolipoprotein E knockout mice, Exp Neurol, vol.153, pp.156-163, 1998.

U. Fünfschilling, W. J. Jockusch, N. Sivakumar, W. Möbius, K. Corthals et al., Critical time window of neuronal cholesterol synthesis during neurite outgrowth, J Neurosci, vol.32, pp.7632-7645, 2012.

U. Fünfschilling, G. Saher, L. Xiao, W. Möbius, and K. Nave, Survival of adult neurons lacking cholesterol synthesis in vivo, BMC Neurosci, vol.8, p.1, 2007.

P. Gamba, M. Guglielmotto, G. Testa, D. Monteleone, C. Zerbinati et al., Up-regulation of ?-amyloidogenesis in neuron-like human cells by both 24-and 27-hydroxycholesterol: protective effect of Nacetyl-cysteine, Aging Cell, vol.13, pp.561-572, 2014.

P. Gamba, E. Staurenghi, G. Testa, S. Giannelli, B. Sottero et al., A Crosstalk Between Brain Cholesterol Oxidation and Glucose Metabolism in Alzheimer's Disease, Front Neurosci, vol.13, 2019.

J. C. Garza, M. Guo, W. Zhang, and X. Lu, Leptin increases adult hippocampal neurogenesis in vivo and in vitro, J Biol Chem, vol.283, pp.18238-18247, 2008.

I. C. Gelissen, T. Hochgrebe, M. R. Wilson, S. B. Easterbrook-smith, W. Jessup et al., Apolipoprotein J (clusterin) induces cholesterol export from macrophage-foam cells: a potential anti-atherogenic function?, Biochem J, vol.331, pp.231-237, 1998.

J. L. Goldstein, R. A. Debose-boyd, and M. S. Brown, Protein sensors for membrane sterols, Cell, vol.124, pp.35-46, 2006.

Y. Gong, J. N. Lee, P. C. Lee, J. L. Goldstein, M. S. Brown et al., Sterolregulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake, Cell Metab, vol.3, pp.15-24, 2006.

C. Goritz, D. H. Mauch, and F. W. Pfrieger, Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron, Mol Cell Neurosci, vol.29, pp.190-201, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00094057

D. Goti, A. Hrzenjak, S. Levak-frank, S. Frank, D. R. Van-der-westhuyzen et al., Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL-associated vitamin E, J Neurochem, vol.76, pp.498-508, 2001.

M. O. Grimm, T. L. Rothhaar, and T. Hartmann, The role of APP proteolytic processing in lipid metabolism, Exp Brain Res, vol.217, pp.365-375, 2012.

R. M. Hagen, S. Rodriguez-cuenca, and A. Vidal-puig, An allostatic control of membrane lipid composition by SREBP1, FEBS Letters, Gothenburg Special Issue: Molecules of Life, vol.584, pp.2689-2698, 2010.

B. H. Han, R. B. Demattos, L. L. Dugan, J. S. Kim-han, R. P. Brendza et al., Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia, Nat Med, vol.7, pp.338-343, 2001.

M. Hao and F. R. Maxfield, Characterization of rapid membrane internalization and recycling, J Biol Chem, vol.275, pp.15279-15286, 2000.

F. M. Harris, I. Tesseur, W. J. Brecht, Q. Xu, K. Mullendorff et al., Astroglial Regulation of Apolipoprotein E Expression in Neuronal Cells IMPLICATIONS FOR ALZHEIMER'S DISEASE, J Biol Chem, vol.279, pp.3862-3868, 2004.

L. Harrison, S. C. Schriever, A. Feuchtinger, E. Kyriakou, P. Baumann et al., Fluorescent blood-brain barrier tracing shows intact leptin transport in obese mice, International Journal of Obesity, vol.43, p.1305, 2019.

C. M. Hawes, H. Wiemer, S. R. Krueger, and B. Karten, Pre-synaptic defects of NPC1-deficient hippocampal neurons are not directly related to plasma membrane cholesterol, J Neurochem, vol.114, pp.311-322, 2010.

H. Hayashi, R. B. Campenot, D. E. Vance, and J. E. Vance, Apolipoprotein Econtaining lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1, J Neurosci, vol.27, pp.1933-1941, 2007.

S. Heino, S. Lusa, P. Somerharju, C. Ehnholm, V. M. Olkkonen et al., Dissecting the role of the Golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface, Proc Natl Acad Sci U S A, vol.97, pp.8375-8380, 2000.

M. Herbsleb, K. Birkenkamp-demtroder, T. Thykjaer, C. Wiuf, A. K. Hein et al., Increased cell motility and invasion upon knockdown of lipolysis stimulated lipoprotein receptor (LSR) in SW780 bladder cancer cells, BMC Med Genomics, vol.1, p.31, 2008.

J. Herz, Apolipoprotein E receptors in the nervous system, Curr Opin Lipidol, vol.20, pp.190-196, 2009.

J. Herz and Y. Chen, Reelin, lipoprotein receptors and synaptic plasticity, Nat Rev Neurosci, vol.7, pp.850-859, 2006.

J. Herz, D. E. Clouthier, and R. E. Hammer, LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation, Cell, vol.71, pp.411-421, 1992.

D. A. Hicks, N. N. Nalivaeva, and A. J. Turner, Lipid Rafts and Alzheimer's Disease: Protein-Lipid Interactions and Perturbation of Signaling, Front Physiol, vol.3, 2012.

V. Hirsch-reinshagen, S. Zhou, B. L. Burgess, L. Bernier, S. A. Mcisaac et al., Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain, J Biol Chem, vol.279, pp.41197-41207, 2004.

H. Hoe, A. Pocivavsek, G. Chakraborty, Z. Fu, S. Vicini et al., Apolipoprotein E receptor 2 interactions with the N-methyl-Daspartate receptor, J Biol Chem, vol.281, pp.3425-3431, 2006.

C. A. Hornick, D. Y. Hui, and J. G. Delamatre, A role for retrosomes in intracellular cholesterol transport from endosomes to the plasma membrane, Am J Physiol, vol.273, pp.1075-1081, 1997.

J. D. Horton, J. L. Goldstein, and M. S. Brown, SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver, J Clin Invest, vol.109, pp.1125-1131, 2002.

Z. Huang, C. Cheng, L. Jiang, Z. Yu, F. Cao et al., Intraventricular apolipoprotein ApoJ infusion acts protectively in Traumatic Brain Injury, J Neurochem, vol.136, pp.1017-1025, 2016.

M. J. Ignatius, P. J. Gebicke-härter, J. H. Skene, J. W. Schilling, K. H. Weisgraber et al., Expression of apolipoprotein E during nerve degeneration and regeneration, Proc Natl Acad Sci, vol.83, pp.1125-1129, 1986.

E. Ikonen, Cellular cholesterol trafficking and compartmentalization, Nat Rev Mol Cell Biol, vol.9, pp.125-138, 2008.

A. Imhof, Y. Charnay, P. G. Vallet, B. Aronow, E. Kovari et al., Sustained astrocytic clusterin expression improves remodeling after brain ischemia, Neurobiol Dis, vol.22, pp.274-283, 2006.

A. K. Indra, X. Warot, J. Brocard, J. M. Bornert, J. H. Xiao et al., Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifeninducible Cre-ER(T) and Cre-ER(T2) recombinases, Nucleic Acids Res, vol.27, pp.4324-4327, 1999.

N. Iwamoto, T. Higashi, and M. Furuse, Localization of angulin-1/LSR and tricellulin at tricellular contacts of brain and retinal endothelial cells in vivo, Cell Struct Funct, vol.39, pp.1-8, 2014.

H. Jahn, Memory loss in Alzheimer's disease, Dialogues Clin Neurosci, vol.15, pp.445-454, 2013.

D. J. Jeske and J. M. Dietschy, Regulation of rates of cholesterol synthesis in vivo in the liver and carcass of the rat measured using [3H]water, J Lipid Res, vol.21, pp.364-376, 1980.

C. W. Joyce, G. S. Shelness, M. A. Davis, R. G. Lee, K. Skinner et al., ACAT1 and ACAT2 membrane topology segregates a serine residue essential for activity to opposite sides of the endoplasmic reticulum membrane, Mol Biol Cell, vol.11, pp.3675-3687, 2000.

M. R. Kaplan and R. D. Simoni, Transport of cholesterol from the endoplasmic reticulum to the plasma membrane, J Cell Biol, vol.101, pp.446-453, 1985.

J. M. Karasinska, F. Rinninger, D. Lütjohann, P. Ruddle, S. Franciosi et al., Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function, J Neurosci, vol.29, pp.3579-3589, 2009.

B. Karten, R. B. Campenot, D. E. Vance, and J. E. Vance, The Niemann-Pick C1 protein in recycling endosomes of presynaptic nerve terminals, J Lipid Res, vol.47, pp.504-514, 2006.

B. Karten, D. E. Vance, R. B. Campenot, and J. E. Vance, Cholesterol accumulates in cell bodies, but is decreased in distal axons, of Niemann-Pick C1-deficient neurons, J Neurochem, vol.83, pp.1154-1163, 2002.

B. Karten, D. E. Vance, R. B. Campenot, and J. E. Vance, Trafficking of cholesterol from cell bodies to distal axons in Niemann Pick C1-deficient neurons, J Biol Chem, vol.278, pp.4168-4175, 2003.

M. A. Katzman and T. Sternat, A Review of OROS Methylphenidate (Concerta®) in the Treatment of Attention-Deficit/Hyperactivity Disorder, CNS Drugs, vol.28, pp.1005-1033, 2014.

C. H. Kawas, M. M. Corrada, R. Brookmeyer, A. Morrison, S. M. Resnick et al., Visual memory predicts Alzheimer's disease more than a decade before diagnosis, Neurology, vol.60, pp.1089-1093, 2003.

M. A. Kennedy, G. C. Barrera, K. Nakamura, A. Baldán, P. Tarr et al., ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation, Cell Metab, vol.1, pp.121-131, 2005.

J. Kim, J. M. Castellano, H. Jiang, J. M. Basak, M. Parsadanian et al., Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance, Neuron, vol.64, pp.632-644, 2009.

W. S. Kim, A. S. Rahmanto, A. Kamili, K. Rye, G. J. Guillemin et al., Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation, J Biol Chem, vol.282, pp.2851-2861, 2007.

W. S. Kim, C. S. Weickert, and B. Garner, Role of ATP-binding cassette transporters in brain lipid transport and neurological disease, J Neurochem, vol.104, pp.1145-1166, 2008.

W. S. Kim, J. Wong, C. S. Weickert, M. J. Webster, S. Bahn et al., Apolipoprotein-D expression is increased during development and maturation of the human prefrontal cortex, J Neurochem, vol.109, pp.1053-1066, 2009.

A. Kirova, R. B. Bays, and S. Lagalwar, Working Memory and Executive Function Decline across Normal Aging, Mild Cognitive Impairment, and Alzheimer's Disease, Biomed Res Int, 2015.

R. C. Klein, B. E. Mace, S. D. Moore, and P. M. Sullivan, Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2, Neuroscience, vol.171, pp.1265-1272, 2010.

J. Knoferle, S. Y. Yoon, D. Walker, L. Leung, A. K. Gillespie et al., Apolipoprotein E4 Produced in GABAergic Interneurons Causes Learning and Memory Deficits in Mice, J Neurosci, vol.34, pp.14069-14078, 2014.

S. Koch, N. Donarski, K. Goetze, M. Kreckel, H. J. Stuerenburg et al., Characterization of four lipoprotein classes in human cerebrospinal fluid, J Lipid Res, vol.42, pp.1143-1151, 2001.

M. Koenigs and J. Grafman, The functional neuroanatomy of depression: distinct roles for ventromedial and dorsolateral prefrontal cortex, Behav Brain Res, vol.201, pp.239-243, 2009.

E. Kojro, G. Gimpl, S. Lammich, W. Marz, and F. Fahrenholz, Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10, Proc Natl Acad Sci, vol.98, pp.5815-5820, 2001.

Z. Korade and A. K. Kenworthy, Lipid rafts, cholesterol, and the brain, Neuropharmacology, vol.55, pp.1265-1273, 2008.

Z. Korade, L. Xu, R. Shelton, and N. A. Porter, Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome, J Lipid Res, vol.51, pp.3259-3269, 2010.

J. Kosacka, M. Gericke, M. Nowicki, J. Kacza, J. Borlak et al., Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures, Neuroscience, vol.162, pp.282-291, 2009.

M. J. Ladu, M. T. Falduto, A. M. Manelli, C. A. Reardon, G. S. Getz et al., Isoform-specific binding of apolipoprotein E to beta-amyloid, J Biol Chem, vol.269, pp.23403-23406, 1994.

M. J. Ladu, C. Reardon, L. Van-eldik, A. M. Fagan, G. Bu et al., Lipoproteins in the central nervous system, Ann N Y Acad Sci, vol.903, pp.167-175, 2000.

Y. Lange, J. Ye, M. Rigney, and T. L. Steck, Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol, J Lipid Res, vol.40, pp.2264-2270, 1999.

M. D. Ledesma, M. G. Martin, and C. G. Dotti, Lipid changes in the aged brain: effect on synaptic function and neuronal survival, Prog Lipid Res, vol.51, pp.23-35, 2012.

C. Y. Lee, W. Tse, J. D. Smith, and G. E. Landreth, Apolipoprotein E promotes ?-amyloid trafficking and degradation by modulating microglial cholesterol levels, J Biol Chem, vol.287, pp.2032-2044, 2012.

M. Leger, A. Quiedeville, V. Bouet, B. Haelewyn, M. Boulouard et al., Object recognition test in mice, Nature Protocols, vol.8, pp.2531-2537, 2013.
URL : https://hal.archives-ouvertes.fr/hal-02135259

V. Leoni, C. Mariotti, L. Nanetti, E. Salvatore, F. Squitieri et al., Whole body cholesterol metabolism is impaired in Huntington's disease, Neurosci Lett, vol.494, pp.245-249, 2011.

V. Leoni, A. Solomon, and M. Kivipelto, Links between ApoE, brain cholesterol metabolism, tau and amyloid beta-peptide in patients with cognitive impairment, Biochem Soc Trans, vol.38, pp.1021-1025, 2010.

V. Leoni, A. Solomon, A. Lövgren-sandblom, L. Minthon, K. Blennow et al., Diagnostic power of 24S-hydroxycholesterol in cerebrospinal fluid: candidate marker of brain health, J Alzheimers Dis, vol.36, pp.739-747, 2013.

B. Leuner and E. Gould, Structural Plasticity and Hippocampal Function, Annu Rev Psychol, vol.61, pp.111-114, 2010.

O. Levi, D. Lütjohann, A. Devir, K. Von-bergmann, T. Hartmann et al., Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation, J Neurochem, vol.95, pp.987-997, 2005.

D. A. Lewis and G. Gonzalez-burgos, Pathophysiologically based treatment interventions in schizophrenia, Nat Med, vol.12, pp.1016-1022, 2006.

M. Li and B. J. Snider, Chapter 1 -Gene Therapy Methods and Their Applications in Neurological Disorders, Gene Therapy in Neurological Disorders, pp.3-39, 2018.

Y. Li, W. Lu, M. P. Marzolo, and G. Bu, Differential Functions of Members of the Low Density Lipoprotein Receptor Family Suggested by Their Distinct Endocytosis Rates, J Biol Chem, vol.276, pp.18000-18006, 2001.

W. S. Liang, K. Chen, W. Lee, K. Sidhar, J. J. Corneveaux et al., Association between GAB2 haplotype and higher glucose metabolism in Alzheimer's disease-affected brain regions in cognitively normal APOE?4 carriers, Neuroimage, vol.54, pp.1896-1902, 2011.

Y. Liang, Y. Pertzov, J. M. Nicholas, S. M. Henley, S. Crutch et al., Visual short-term memory binding deficit in familial Alzheimer's disease, Cortex, vol.78, pp.150-164, 2016.

A. Linetti, A. Fratangeli, E. Taverna, P. Valnegri, M. Francolini et al., Cholesterol reduction impairs exocytosis of synaptic vesicles, J Cell Sci, vol.123, pp.595-605, 2010.

M. F. Linton, R. Gish, S. T. Hubl, E. Bütler, C. Esquivel et al., Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation, J Clin Invest, vol.88, pp.270-281, 1991.

L. Liscum and N. J. Munn, Intracellular cholesterol transport, Biochim Biophys Acta, pp.19-37, 1438.

B. Liu, S. D. Turley, D. K. Burns, A. M. Miller, J. J. Repa et al., Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/-mouse, Proc Natl Acad Sci, vol.106, pp.2377-2382, 2009.

C. Liu, J. Hu, N. Zhao, J. Wang, N. Wang et al., Astrocytic LRP1 Mediates Brain A? Clearance and Impacts Amyloid Deposition, J Neurosci, vol.37, pp.4023-4031, 2017.

C. Liu, T. Kanekiyo, H. Xu, and G. Bu, Apolipoprotein E and Alzheimer disease: risk, mechanisms, and therapy, Nature reviews Neurology, vol.9, p.106, 2013.

Q. Liu, J. Trotter, J. Zhang, M. M. Peters, H. Cheng et al., Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration, J Neurosci, vol.30, pp.17068-17078, 2010.

Y. Liu, B. P. Chen, .. Lu, M. Zhu, Y. Stemerman et al., Shear stress activation of SREBP1 in endothelial cells is mediated by integrins, Arterioscler Thromb Vasc Biol, vol.22, pp.76-81, 2002.

K. J. Livak and T. D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method, Methods, vol.25, pp.402-408, 2001.

P. Lledo, F. T. Merkle, and A. Alvarez-buylla, Origin and function of olfactory bulb interneuron diversity, Trends Neurosci, vol.31, pp.392-400, 2008.

S. Lo, K. Scearce-levie, and M. Sheng, Characterization of Social Behaviors in caspase-3 deficient mice, 2016.

C. G. Lyketsos, M. C. Carrillo, J. M. Ryan, A. S. Khachaturian, P. Trzepacz et al., Neuropsychiatric symptoms in Alzheimer's disease, Alzheimers Dement, vol.7, pp.532-539, 2011.

M. Madra and S. L. Sturley, Niemann-Pick type C pathogenesis and treatment: from statins to sugars, Clin Lipidol, vol.5, pp.387-395, 2010.

R. W. Mahley, Central Nervous System Lipoproteins, Arterioscler Thromb Vasc Biol, vol.36, pp.1305-1315, 2016.

R. W. Mahley, T. L. Innerarity, S. C. Rall, and K. H. Weisgraber, Plasma lipoproteins: apolipoprotein structure and function, J Lipid Res, vol.25, pp.1277-1294, 1984.

R. W. Mahley, K. H. Weisgraber, and Y. Huang, Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease, Proc Natl Acad Sci, vol.103, pp.5644-5651, 2006.

T. Mailman, M. Hariharan, and B. Karten, Inhibition of neuronal cholesterol biosynthesis with lovastatin leads to impaired synaptic vesicle release even in the presence of lipoproteins or geranylgeraniol, J Neurochem, vol.119, pp.1002-1015, 2011.

M. Mainardi, M. Spinelli, F. Scala, A. Mattera, S. Fusco et al., Loss of Leptin-Induced Modulation of Hippocampal Synaptic Trasmission and Signal Transduction in High-Fat Diet-Fed Mice, Front Cell Neurosci, vol.11, 2017.

C. J. Mann, J. Khallou, O. Chevreuil, A. A. Troussard, L. M. Guermani et al., Mechanism of activation and functional significance of the lipolysis-stimulated receptor. Evidence for a role as chylomicron remnant receptor, Biochemistry, vol.34, pp.10421-10431, 1995.

C. J. Mann, A. A. Troussard, F. T. Yen, N. Hannouche, J. Najib et al., Inhibitory effects of specific apolipoprotein C-III isoforms on the binding of triglyceride-rich lipoproteins to the lipolysis-stimulated receptor, J Biol Chem, vol.272, pp.31348-31354, 1997.

M. Martin, C. G. Dotti, and M. D. Ledesma, Brain cholesterol in normal and pathological aging, Biochim Biophys Acta, vol.1801, pp.934-944, 2010.

S. Martin and R. G. Parton, Lipid droplets: a unified view of a dynamic organelle, Nat Rev Mol Cell Biol, vol.7, pp.373-378, 2006.

A. Matsuda, K. Nagao, M. Matsuo, N. Kioka, and K. Ueda, (S)-hydroxycholesterol is actively eliminated from neuronal cells by ABCA1, Journal of Neurochemistry, vol.126, pp.93-101, 2013.

D. H. Mauch, K. Nägler, S. Schumacher, C. Göritz, E. C. Müller et al., CNS synaptogenesis promoted by glia-derived cholesterol, Science, vol.294, pp.1354-1357, 2001.
URL : https://hal.archives-ouvertes.fr/hal-02882619

S. Meaney, K. Bodin, U. Diczfalusy, and I. Björkhem, On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function, J Lipid Res, vol.43, pp.2130-2135, 2002.

P. Merino-serrais, R. Loera-valencia, P. Rodriguez-rodriguez, C. Parrado-fernandez, M. A. Ismail et al., -Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons, Cereb Cortex, vol.29, pp.429-446, 2019.

S. Mesli, S. Javorschi, A. M. Bérard, M. Landry, H. Priddle et al., Distribution of the lipolysis stimulated receptor in adult and embryonic murine tissues and lethality of LSR-/-embryos at 12.5 to 14.5 days of gestation, Eur J Biochem, vol.271, pp.3103-3114, 2004.

B. Möckel, H. Zinke, R. Flach, B. Weiss, H. Weiler-güttler et al., Expression of apolipoprotein A-I in porcine brain endothelium in vitro, J Neurochem, vol.62, pp.788-798, 1994.

P. Morell and H. Jurevics, Origin of cholesterol in myelin, Neurochem Res, vol.21, pp.463-470, 1996.

C. D. Morrison and H. Münzberg, Capricious Cre: The Devil Is in the Details, Endocrinology, vol.153, pp.1005-1007, 2012.

M. Mulder, P. J. Jansen, B. J. Janssen, W. D. Van-de-berg, H. Van-der-boom et al., Lowdensity lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus, Neurobiol Dis, vol.16, pp.212-219, 2004.

P. Narvekar, M. Diaz, A. Krones-herzig, U. Hardeland, D. Strzoda et al., Liver-specific loss of lipolysis-stimulated lipoprotein receptor triggers systemic hyperlipidemia in mice, Diabetes, vol.58, pp.1040-1049, 2009.

A. B. Nelson, G. B. Hang, B. A. Grueter, V. Pascoli, C. Luscher et al., A comparison of striatal-dependent behaviors in wildtype and hemizygous Drd1a and Drd2 BAC transgenic mice, J Neurosci, vol.32, pp.9119-9123, 2012.

S. Niu, O. Yabut, and G. D'arcangelo, The Reelin Signaling Pathway Promotes Dendritic Spine Development in Hippocampal Neurons, J Neurosci, vol.28, pp.10339-10348, 2008.

L. Nobis and M. Husain, Apathy in Alzheimer's disease. Current Opinion in Behavioral Sciences, Apathy and Motivation, vol.22, pp.7-13, 2018.

A. Nohturfft, D. Yabe, J. L. Goldstein, M. S. Brown, and P. J. Espenshade, Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes, Cell, vol.102, pp.315-323, 2000.

K. Nordengen, B. Kirsebom, K. Henjum, P. Selnes, B. Gísladóttir et al., Glial activation and inflammation along the Alzheimer's disease continuum, J Neuroinflammation, vol.16, p.46, 2019.

M. J. Nowaczyk and M. B. Irons, Smith-Lemli-Opitz syndrome: phenotype, natural history, and epidemiology, Am J Med Genet C Semin Med Genet, vol.160, pp.250-262, 2012.

S. Okamoto, K. Kimura, and M. Saito, Anorectic effect of leptin is mediated by hypothalamic corticotropin-releasing hormone, but not by urocortin, in rats, Neurosci Lett, vol.307, pp.179-182, 2001.

J. De-oliveira, M. A. Hort, E. L. Moreira, V. Glaser, R. M. Ribeiro-do-valle et al., Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress, Neuroscience, vol.197, pp.99-106, 2011.

S. Ollila, M. T. Hyvönen, and I. Vattulainen, Polyunsaturation in lipid membranes: dynamic properties and lateral pressure profiles, J Phys Chem B, vol.111, pp.3139-3150, 2007.

Y. Oomura, N. Hori, T. Shiraishi, K. Fukunaga, H. Takeda et al., Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats, Peptides, vol.27, pp.2738-2749, 2006.

N. Osada, Y. Kosuge, T. Kihara, K. Ishige, and Y. Ito, Apolipoprotein Edeficient mice are more vulnerable to ER stress after transient forebrain ischemia, Neurochem Int, vol.54, pp.403-409, 2009.

A. Papassotiropoulos, D. Lütjohann, M. Bagli, S. Locatelli, F. Jessen et al., 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia, J Psychiatr Res, vol.36, pp.27-32, 2002.

P. Papatheodorou, J. E. Carette, G. W. Bell, C. Schwan, G. Guttenberg et al., Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT), PNAS, vol.108, pp.16422-16427, 2011.

G. M. Pasinetti, S. A. Johnson, T. Oda, I. Rozovsky, and C. E. Finch, Clusterin (SGP-2): a multifunctional glycoprotein with regional expression in astrocytes and neurons of the adult rat brain, J Comp Neurol, vol.339, pp.387-400, 1994.

K. B. Peake and J. E. Vance, Defective cholesterol trafficking in Niemann-Pick Cdeficient cells, FEBS Lett, vol.584, pp.2731-2739, 2010.

G. Pennetta and M. A. Welte, Emerging Links between Lipid Droplets and Motor Neuron Diseases, Dev Cell, vol.45, pp.427-432, 2018.

A. M. Petrov, M. R. Kasimov, and A. L. Zefirov, Brain Cholesterol Metabolism and Its Defects: Linkage to Neurodegenerative Diseases and Synaptic Dysfunction, Acta Naturae, vol.8, pp.58-73, 2016.

F. W. Pfrieger and N. Ungerer, Cholesterol metabolism in neurons and astrocytes, Prog Lipid Res, vol.50, pp.357-371, 2011.
URL : https://hal.archives-ouvertes.fr/hal-02878162

A. Pinçon, M. H. Thomas, M. Huguet, A. Allouche, J. C. Colin et al., Increased susceptibility of dyslipidemic LSR+/-mice to amyloid stress is associated with changes in cortical cholesterol levels, J Alzheimers Dis, vol.45, pp.195-204, 2015.

A. Pinçon, M. H. Thomas, M. Huguet, A. Allouche, J. C. Colin et al., Increased susceptibility of dyslipidemic LSR+/-mice to amyloid stress is associated with changes in cortical cholesterol levels, J Alzheimers Dis, vol.45, pp.195-204, 2015.

R. E. Pitas, J. K. Boyles, S. H. Lee, D. Hui, and K. H. Weisgraber, Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain, J Biol Chem, vol.262, pp.14352-14360, 1987.

R. E. Pitas, J. K. Boyles, S. H. Lee, D. Hui, and K. H. Weisgraber, Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain, J Biol Chem, vol.262, pp.14352-14360, 1987.

A. Pocivavsek, M. P. Burns, and G. W. Rebeck, Low Density Lipoprotein Receptors Regulate Microglial Inflammation Through C-Jun N-Terminal Kinase, Glia, vol.57, pp.444-453, 2009.

J. Popp, P. Lewczuk, H. Kölsch, S. Meichsner, W. Maier et al., Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease, J Neurochem, vol.123, pp.310-316, 2012.

J. Popp, S. Meichsner, H. Kölsch, P. Lewczuk, W. Maier et al., Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease, Biochem Pharmacol, vol.86, pp.37-42, 2013.

J. R. Prasanthi, A. Huls, S. Thomasson, A. Thompson, E. Schommer et al., Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells, Mol Neurodegener, vol.4, p.1, 2009.

G. Quan, C. Xie, J. M. Dietschy, and S. D. Turley, Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse, Brain Res Dev Brain Res, vol.146, pp.87-98, 2003.

T. Rahman, A. Y. Taha, B. J. Song, S. K. Orr, Z. Liu et al., The very low density lipoprotein receptor is not necessary for maintaining brain polyunsaturated fatty acid concentrations, Prostaglandins Leukot Essent Fatty Acids, vol.82, pp.141-145, 2010.

A. Rapp, B. Gmeiner, and M. Hüttinger, Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes, Biochimie, vol.88, pp.473-483, 2006.

E. Rassart, A. Bedirian, S. Do-carmo, O. Guinard, J. Sirois et al., Biochim Biophys Acta, vol.1482, pp.185-198, 2000.

D. K. Reaves, K. D. Fagan-solis, K. Dunphy, S. D. Oliver, D. W. Scott et al., The Role of Lipolysis Stimulated Lipoprotein Receptor in Breast Cancer and Directing Breast Cancer Cell Behavior, PLOS ONE, vol.9, 2014.

G. W. Rebeck, Cholesterol efflux as a critical component of Alzheimer's disease pathogenesis, J Mol Neurosci, vol.23, pp.219-224, 2004.

S. S. Reddy, T. E. Connor, E. J. Weeber, and W. Rebeck, Similarities and differences in structure, expression, and functions of VLDLR and ApoER2, 2011.

, Mol Neurodegener, vol.6, p.30

A. Rigotti, B. Trigatti, J. Babitt, M. Penman, S. Xu et al., Scavenger receptor BI--a cell surface receptor for high density lipoprotein, Curr Opin Lipidol, vol.8, pp.181-188, 1997.

F. Rizzi and S. Bettuzzi, The clusterin paradigm in prostate and breast carcinogenesis, Endocr Relat Cancer, vol.17, pp.1-17, 2010.

P. S. Roheim, M. Carey, T. Forte, and G. L. Vega, Apolipoproteins in human cerebrospinal fluid, Proc Natl Acad Sci, vol.76, pp.4646-4649, 1979.

P. S. Roheim, M. Carey, T. Forte, and G. L. Vega, Apolipoproteins in human cerebrospinal fluid, Proc Natl Acad Sci, vol.76, pp.4646-4649, 1979.

T. T. Rohn, Proteolytic cleavage of apolipoprotein E4 as the keystone for the heightened risk associated with Alzheimer's disease, Int J Mol Sci, vol.14, pp.14908-14922, 2013.

P. Ru, T. M. Williams, A. Chakravarti, and D. Guo, Tumor Metabolism of Malignant Gliomas, Cancers, vol.5, pp.1469-1484, 2013.

J. Ruiz, D. Kouiavskaia, M. Migliorini, S. Robinson, E. L. Saenko et al., The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor, J Lipid Res, vol.46, pp.1721-1731, 2005.

D. W. Russell, R. W. Halford, D. M. Ramirez, R. Shah, and T. Kotti, Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain, Annu Rev Biochem, vol.78, pp.1017-1040, 2009.

M. Ruthirakuhan, N. Herrmann, D. Vieira, D. Gallagher, and K. L. Lanctôt, The Roles of Apathy and Depression in Predicting Alzheimer Disease: A Longitudinal Analysis in Older Adults With Mild Cognitive Impairment, The American Journal of Geriatric Psychiatry, vol.27, pp.873-882, 2019.

K. Saito, V. Dubreuil, Y. Arai, M. Wilsch-bräuninger, D. Schwudke et al., Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis, Proc Natl Acad Sci, vol.106, pp.8350-8355, 2009.

M. Saito, E. P. Benson, M. Saito, and A. Rosenberg, Metabolism of cholesterol and triacylglycerol in cultured chick neuronal cells, glial cells, and fibroblasts: Accumulation of esterified cholesterol in serum-free culture, Journal of Neuroscience Research, vol.18, pp.319-325, 1987.

K. Sakai, O. Tiebel, M. C. Ljungberg, M. Sullivan, H. Lee et al., A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins, Brain Res, vol.1276, pp.11-21, 2009.

M. Sano, K. L. Bell, D. Galasko, J. E. Galvin, R. G. Thomas et al., A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease, Neurology, vol.77, pp.556-563, 2011.

C. B. Saper and B. B. Lowell, The hypothalamus, Current Biology, vol.24, pp.1111-1116, 2014.

J. R. Sarna, M. Larouche, H. Marzban, R. V. Sillitoe, D. E. Rancourt et al., Patterned Purkinje cell degeneration in mouse models of Niemann-Pick type C disease, J Comp Neurol, vol.456, pp.279-291, 2003.

B. Sauer and N. Henderson, Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1, Proc Natl Acad Sci, vol.85, pp.5166-5170, 1988.

F. Schroeder, A. M. Gallegos, B. P. Atshaves, S. M. Storey, A. L. Mcintosh et al., Recent advances in membrane microdomains: rafts, caveolae, and intracellular cholesterol trafficking, Exp Biol Med (Maywood), vol.226, pp.873-890, 2001.

D. J. Selkoe, Clearing the brain's amyloid cobwebs, Neuron, vol.32, pp.177-180, 2001.

D. J. Selkoe, Alzheimer's disease is a synaptic failure, Science, vol.298, pp.789-791, 2002.

A. Sen, D. L. Alkon, and T. J. Nelson, Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilon, J Biol Chem, vol.287, pp.15947-15958, 2012.

Y. Seo, H. Kim, and K. Kang, Microglial involvement in the development of olfactory dysfunction, J Vet Sci, vol.19, pp.319-330, 2018.

N. Sever, B. Song, D. Yabe, J. L. Goldstein, M. S. Brown et al., Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol, J Biol Chem, vol.278, pp.52479-52490, 2003.

M. Shafaati, A. Marutle, H. Pettersson, A. Lövgren-sandblom, M. Olin et al., Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation, J Lipid Res, vol.52, pp.1004-1010, 2011.

H. Sheng, D. T. Laskowitz, G. B. Mackensen, M. Kudo, R. D. Pearlstein et al., Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse, Stroke, vol.30, pp.1118-1124, 1999.

N. E. Shepardson, G. M. Shankar, and D. J. Selkoe, Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies, Arch Neurol, vol.68, pp.1239-1244, 2011.

H. Shimada, S. Satohisa, T. Kohno, T. Konno, K. Takano et al., Downregulation of lipolysis-stimulated lipoprotein receptor promotes cell invasion via claudin-1-mediated matrix metalloproteinases in human endometrial cancer, Oncol Lett, vol.14, pp.6776-6782, 2017.

H. Shimada, S. Satohisa, T. Kohno, S. Takahashi, T. Hatakeyama et al., The roles of tricellular tight junction protein lipolysis-stimulated lipoprotein receptor in malignancy of human endometrial cancer cells, Oncotarget, vol.7, pp.27735-27752, 2016.

A. Simonsen, R. Lippé, S. Christoforidis, J. M. Gaullier, A. Brech et al., EEA1 links PI(3)K function to Rab5 regulation of endosome fusion, Nature, vol.394, pp.494-498, 1998.

S. Sipione, D. Rigamonti, M. Valenza, C. Zuccato, L. Conti et al., Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses, Hum Mol Genet, vol.11, pp.1953-1965, 2002.

D. E. Sleat, J. A. Wiseman, M. El-banna, S. M. Price, L. Verot et al., Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport, Proc Natl Acad Sci, vol.101, pp.5886-5891, 2004.

M. Slezak, C. Göritz, A. Niemiec, J. Frisén, P. Chambon et al., Transgenic mice for conditional gene manipulation in astroglial cells, Glia, vol.55, pp.1565-1576, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00188914

K. M. Smith, R. M. Lawn, and J. N. Wilcox, Cellular localization of apolipoprotein D and lecithin:cholesterol acyltransferase mRNA in rhesus monkey tissues by in situ hybridization, J Lipid Res, vol.31, pp.995-1004, 1990.

M. Söderberg, C. Edlund, K. Kristensson, and G. Dallner, Lipid compositions of different regions of the human brain during aging, J Neurochem, vol.54, pp.415-423, 1990.

F. Sohet, C. Lin, R. N. Munji, S. Y. Lee, N. Ruderisch et al., LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation, J Cell Biol, vol.208, pp.703-711, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01575779

B. Song, N. B. Javitt, and R. A. Debose-boyd, Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol, Cell Metab, vol.1, pp.179-189, 2005.

S. Sonnino and A. Prinetti, Membrane domains and the "lipid raft" concept, Curr Med Chem, vol.20, pp.4-21, 2013.

D. L. Sparks, S. W. Scheff, J. C. Hunsaker, H. Liu, T. Landers et al., Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol, Exp Neurol, vol.126, pp.88-94, 1994.

G. Staneva, C. Chachaty, C. Wolf, and P. J. Quinn, Comparison of the liquidordered bilayer phases containing cholesterol or 7-dehydrocholesterol in modeling Smith-Lemli-Opitz syndrome, J Lipid Res, vol.51, pp.1810-1822, 2010.

S. E. Starkstein, R. Jorge, R. Mizrahi, and R. G. Robinson, A prospective longitudinal study of apathy in Alzheimer's disease, J Neurol Neurosurg Psychiatry, vol.77, pp.8-11, 2006.

C. C. Steinmetz, I. Buard, T. Claudepierre, K. Nägler, and F. W. Pfrieger, Regional variations in the glial influence on synapse development in the mouse CNS, J Physiol, vol.577, pp.249-261, 2006.
URL : https://hal.archives-ouvertes.fr/hal-02881680

C. Stenger, M. Hanse, D. Pratte, M. Mbala, S. Akbar et al., Up-regulation of hepatic lipolysis stimulated lipoprotein receptor by leptin: a potential lever for controlling lipid clearance during the postprandial phase, FASEB J, vol.24, pp.4218-4228, 2010.

C. Stenger, A. Pinçon, M. Hanse, L. Royer, A. Comte et al., Brain region-specific immunolocalization of the lipolysis-stimulated lipoprotein receptor (LSR) and altered cholesterol distribution in aged LSR+/-mice, J Neurochem, vol.123, pp.467-476, 2012.

N. Sternberg, Bacteriophage P1 site-specific recombination: III. Strand exchange during recombination at lox sites, Journal of Molecular Biology, vol.150, pp.603-608, 1981.

R. Streicher, J. Kotzka, D. Müller-wieland, G. Siemeister, M. Munck et al., SREBP-1 mediates activation of the low density lipoprotein receptor promoter by insulin and insulin-like growth factor-I, J Biol Chem, vol.271, pp.7128-7133, 1996.

S. Stukas, J. Robert, M. Lee, I. Kulic, M. Carr et al., Intravenously injected human apolipoprotein A-I rapidly enters the central nervous system via the choroid plexus, J Am Heart Assoc, vol.3, 1156.

T. Sugase, T. Takahashi, S. Serada, M. Fujimoto, T. Ohkawara et al., Lipolysis-stimulated lipoprotein receptor overexpression is a novel predictor of poor clinical prognosis and a potential therapeutic target in gastric cancer, Oncotarget, vol.9, pp.32917-32928, 2018.

E. V. Sullivan, Cognitive Functions of the Cerebellum, Neuropsychol Rev, vol.20, pp.227-228, 2010.

. Sun, The role of transporters ABCG1/4 and ABCA1 in brain cholesterol metabolism, 2014.

S. Suzuki, K. Kiyosue, S. Hazama, A. Ogura, M. Kashihara et al., Brain-Derived Neurotrophic Factor Regulates Cholesterol Metabolism for Synapse Development, J Neurosci, vol.27, pp.6417-6427, 2007.

L. Svennerholm and C. G. Gottfries, Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II), J Neurochem, vol.62, pp.1039-1047, 1994.

I. Tabas, Consequences of cellular cholesterol accumulation: basic concepts and physiological implications, J Clin Invest, vol.110, pp.905-911, 2002.

M. Tachikawa, M. Watanabe, S. Hori, M. Fukaya, S. Ohtsuki et al., Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain, J Neurochem, vol.95, pp.294-304, 2005.

A. R. Tall, Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteins, J Intern Med, vol.263, pp.256-273, 2008.

J. Tan and G. Evin, ?-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis, J Neurochem, vol.120, pp.869-880, 2012.

P. T. Tarr and P. A. Edwards, ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2, J Lipid Res, vol.49, pp.169-182, 2008.

G. Testa, P. Gamba, U. Badilli, S. Gargiulo, M. Maina et al., Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols, PLoS ONE, vol.9, p.96795, 2014.

K. Thanopoulou, A. Fragkouli, F. Stylianopoulou, and S. Georgopoulos, Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model, Proc Natl Acad Sci, vol.107, pp.20816-20821, 2010.

V. Theendakara, C. A. Peters-libeu, P. Spilman, K. S. Poksay, D. E. Bredesen et al., Direct Transcriptional Effects of Apolipoprotein E, J Neurosci, vol.36, pp.685-700, 2016.

I. Tooyama, T. Kawamata, H. Akiyama, H. Kimura, S. K. Moestrup et al., Subcellular localization of the low density lipoprotein receptor-related protein (alpha 2-macroglobulin receptor) in human brain, Brain Res, vol.691, pp.235-238, 1995.

D. Del-toro, X. Xifró, A. Pol, S. Humbert, F. Saudou et al., Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease, J Neurochem, vol.115, pp.153-167, 2010.

M. Trommsdorff, M. Gotthardt, T. Hiesberger, J. Shelton, W. Stockinger et al., Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2, Cell, vol.97, pp.689-701, 1999.

A. A. Troussard, J. Khallou, C. J. Mann, P. André, D. K. Strickland et al., Inhibitory effect on the lipolysis-stimulated receptor of the 39-kDa receptor-associated protein, J Biol Chem, vol.270, pp.17068-17071, 1995.

J. Z. Tsien, D. F. Chen, D. Gerber, C. Tom, E. H. Mercer et al., Subregion-and cell type-restricted gene knockout in mouse brain, Cell, vol.87, pp.1317-1326, 1996.

S. D. Turley, D. K. Burns, and J. M. Dietschy, Preferential utilization of newly synthesized cholesterol for brain growth in neonatal lambs, Am J Physiol, vol.274, pp.1099-1105, 1998.

M. Ujiie, D. L. Dickstein, D. A. Carlow, and W. A. Jefferies, Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model, Microcirculation, vol.10, pp.463-470, 2003.

T. Umeda, T. Tomiyama, E. Kitajima, T. Idomoto, S. Nomura et al., Hypercholesterolemia accelerates intraneuronal accumulation of A? oligomers resulting in memory impairment in Alzheimer's disease model mice, Life Sci, vol.91, pp.1169-1176, 2012.

M. Valenza, D. Rigamonti, D. Goffredo, C. Zuccato, S. Fenu et al., Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease, J Neurosci, vol.25, pp.9932-9939, 2005.

J. E. Vance, Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases, Dis Model Mech, vol.5, pp.746-755, 2012.

M. T. Vanier and G. Millat, Niemann-Pick disease type C, Clin Genet, vol.64, pp.269-281, 2003.
URL : https://hal.archives-ouvertes.fr/inserm-00410410

C. J. Vaughan and A. M. Gotto, Update on statins, Circulation, vol.110, pp.886-892, 2003.

R. P. Vaz, A. Cardoso, P. Serrão, P. A. Pereira, and M. D. Madeira, Chronic stress leads to long-lasting deficits in olfactory-guided behaviors, and to neuroplastic changes in the nucleus of the lateral olfactory tract, Horm Behav, vol.98, pp.130-144, 2018.

N. D. Volkow, G. Wang, J. H. Newcorn, S. H. Kollins, T. L. Wigal et al., Motivation Deficit in ADHD is Associated with Dysfunction of the Dopamine Reward Pathway, Mol Psychiatry, vol.16, pp.1147-1154, 2011.

S. E. Wahrle, H. Jiang, M. Parsadanian, J. Legleiter, X. Han et al., ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE, J Biol Chem, vol.279, pp.40987-40993, 2004.

S. E. Wahrle, H. Jiang, M. Parsadanian, J. Legleiter, X. Han et al., ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE, J Biol Chem, vol.279, pp.40987-40993, 2004.

N. Wang, L. Yvan-charvet, D. Lütjohann, M. Mulder, T. Vanmierlo et al., ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain, FASEB J, vol.22, pp.1073-1082, 2008.

N. Wang, L. Yvan-charvet, D. Lütjohann, M. Mulder, T. Vanmierlo et al., ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain, FASEB J, vol.22, pp.1073-1082, 2008.

K. Watanabe, E. Watson, M. L. Cremona, E. J. Millings, J. H. Lefkowitch et al., ILDR2: An Endoplasmic Reticulum Resident Molecule Mediating Hepatic Lipid Homeostasis, PLoS One, vol.8, 2013.

E. J. Weeber, U. Beffert, C. Jones, J. M. Christian, E. Forster et al., Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning, J Biol Chem, vol.277, pp.39944-39952, 2002.

G. K. Wicher and H. Aldskogius, Adult motor neurons show increased susceptibility to axotomy-induced death in mice lacking clusterin, Eur J Neurosci, vol.21, pp.2024-2028, 2005.

T. E. Wilens, Mechanism of Action of Agents Used in Attention-Deficit/Hyperactivity Disorder, J Clin Psychiatry, vol.67, pp.32-37, 2006.

P. J. Willy, K. Umesono, E. S. Ong, R. M. Evans, R. A. Heyman et al., LXR, a nuclear receptor that defines a distinct retinoid response pathway, Genes Dev, vol.9, pp.1033-1045, 1995.

T. S. Wingo, D. J. Cutler, A. P. Wingo, N. Le, G. D. Rabinovici et al., Association of Early-Onset Alzheimer Disease With Elevated Low-density Lipoprotein Cholesterol Levels and Rare Genetic Coding Variants of APOB, JAMA Neurol, 2019.

S. K. Woody and L. Zhao, Clusterin (APOJ) in Alzheimer's Disease: An Old Molecule with a New Role, 2016.

L. Wu and S. L. Gonias, The low-density lipoprotein receptor-related protein-1 associates transiently with lipid rafts, J Cell Biochem, vol.96, pp.1021-1033, 2005.

D. Wüstner, M. Mondal, I. Tabas, and F. R. Maxfield, Direct observation of rapid internalization and intracellular transport of sterol by macrophage foam cells, Traffic, vol.6, pp.396-412, 2005.

A. R. Wyatt, J. J. Yerbury, and M. R. Wilson, Structural characterization of clusterin-chaperone client protein complexes, J Biol Chem, vol.284, pp.21920-21927, 2009.

Z. Xie, M. E. Harris-white, P. A. Wals, S. A. Frautschy, C. E. Finch et al., Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro, J Neurochem, vol.93, pp.1038-1046, 2005.

F. Xu, M. P. Vitek, C. A. Colton, M. L. Previti, N. Gharkholonarehe et al., Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice, J Neurosci, vol.28, pp.5312-5320, 2008.

Q. Xu, A. Bernardo, D. Walker, T. Kanegawa, R. W. Mahley et al., Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus, J Neurosci, vol.26, pp.4985-4994, 2006.

S. Xu, S. Zhou, D. Xia, J. Xia, G. Chen et al., Defects of synaptic vesicle turnover at excitatory and inhibitory synapses in Niemann-Pick C1-deficient neurons, Neuroscience, vol.167, pp.608-620, 2010.

X. Xu, R. Bittman, G. Duportail, D. Heissler, C. Vilcheze et al., Effect of the structure of natural sterols and sphingolipids on the formation of ordered sphingolipid/sterol domains (rafts). Comparison of cholesterol to plant, fungal, and disease-associated sterols and comparison of sphingomyelin, cerebrosides, and ceramide, J Biol Chem, vol.276, pp.33540-33546, 2001.

M. Yang and J. N. Crawley, Simple behavioral assessment of mouse olfaction, Curr Protoc Neurosci Chapter, 2009.

N. Yassine, A. Lazaris, C. Dorner-ciossek, O. Després, L. Meyer et al., Detecting spatial memory deficits beyond blindness in tg2576 Alzheimer mice, Neurobiol Aging, vol.34, pp.716-730, 2013.

S. Ye, Y. Huang, K. Müllendorff, L. Dong, G. Giedt et al., Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target, Proc Natl Acad Sci, vol.102, pp.18700-18705, 2005.

F. T. Yen, C. J. Mann, L. M. Guermani, N. F. Hannouche, N. Hubert et al., Identification of a lipolysisstimulated receptor that is distinct from the LDL receptor and the LDL receptor-related protein, Biochemistry, vol.33, pp.1172-1180, 1994.

F. T. Yen, M. Masson, N. Clossais-besnard, P. André, J. M. Grosset et al., Molecular cloning of a lipolysis-stimulated remnant receptor expressed in the liver, J Biol Chem, vol.274, pp.13390-13398, 1999.

F. T. Yen, O. Roitel, L. Bonnard, V. Notet, D. Pratte et al., Lipolysis stimulated lipoprotein receptor: a novel molecular link between hyperlipidemia, weight gain, and atherosclerosis in mice, J Biol Chem, vol.283, pp.25650-25659, 2008.

F. T. Yen, O. Roitel, L. Bonnard, V. Notet, D. Pratte et al., Lipolysis stimulated lipoprotein receptor: a novel molecular link between hyperlipidemia, weight gain, and atherosclerosis in mice, J Biol Chem, vol.283, pp.25650-25659, 2008.

N. Zelcer and P. Tontonoz, Liver X receptors as integrators of metabolic and inflammatory signaling, J Clin Invest, vol.116, pp.607-614, 2006.

J. Zhang and Q. Liu, Cholesterol metabolism and homeostasis in the brain, Protein Cell, vol.6, pp.254-264, 2015.

J. Zhao, Y. Deng, Z. Jiang, and H. Qing, Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRs, Front Aging Neurosci, vol.8, p.58, 2016.

Y. Zou, D. Lu, L. Liu, H. Zhang, and Y. Zhou, Olfactory dysfunction in Alzheimer's disease, Neuropsychiatr Dis Treat, vol.12, pp.869-875, 2016.