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, Sarcomere organization (GO:0045214)

, GO:0060048) Cardiac muscle cell action potential (GO:0086001) Regulation of protein complex disassembly (GO:0043244) Regulation of heart rate by cardiac conduction (GO:0086091) Cardiac muscle tissue development, Cardiac muscle contraction, p.48738

, Regulation of extracellular matrix assembly (GO:1901203) TORC1 signaling

, Protein ubiquitination (GO:0016567) Regulation of autophagy of mitochondrion (GO:1903146) Regulation of autophagy, p.10506

B. Overexpressed, GO Biological Processes Negative Log10

, Enrichr overexpressed GO biological processes enriched in mitochondrial energy metabolism for the overexpressed sub-cluster 4 genes in Mtr cKO, Supplementary Figure S3

, Mitochondrion distribution (GO:0048311)

, Glycogen metabolic process, p.5977

, Mitochondrion localization (GO:0051646)

, ATP biosynthetic process, p.6754

, Mitochondrion organization (GO:0007005) Glycolytic process (GO:0006096)

, ATP generation from ADP, p.6757

, Glycolytic process through G6P (GO:0061620) Ubiquinone metabolic process, p.6743

. Gluconeogenesis, , p.6094

, ATP metabolic process, p.46034

, GO Biological process Negative Log10

, PANTHER Gene ontology term enrichment and pathway analysis for the upregulated genes (Sub-cluster 4 and sub-cluster 3) in the hearts of Mtr cKO. Shown in the bar graph are the dysregulated reactome pathways associated with the upregulated genes in sub-cluster 3 and sub-cluster 4 in the hearts of Mtr cKO. Majority of these dysregulated pathways are linked to response to cellular stress, cardiac remodelling and myocardial bioenergetics. The analysis of pathways was performed using Panther classification system, Supplementary Figure S4

, Citric acid cycle (TCA cycle) (R-MMU-71403) Glycogen metabolism

, Response to heat stress (R-MMU-3371556) Glucose metabolism

. Vegfa-vegfr2 and . Pathway,

, Signaling by VEGF (R-MMU-194138)

, Signaling by Rho GTPases (R-MMU-194315) Response to cell stress

, Signaling by GPCR (R-MMU-372790)

I. Complex and . Biogenesis, , p.97031

E. Mitochondrial and . Go, , p.6120

A. Mitochondrial and . Synthesis, GO:0042775) Mitochondrial translation (GO:0032543) Heart contraction

, Fatty acid catabolic process (GO:0009062) short-chain fatty acid metabolism (GO:0019626) Heart process

, Cardiac muscle Relaxation (GO:0055119) Blood circulation (GO:0008015)

A. Biosynthesis, , p.71616

, Mitochondrial transport (GO:0006839)

, Cobalamin metabolic process (GO:0009235)

, V Cardiac muscle tissue development (GO:0003229) Cardiac muscle tissue development (GO:0048738) Fatty acid beta-oxidation, p.6635

, NADH dehydrogenase activity

C. Acetyl-coa and . Activity, , p.3988

, ATPase regulator activity, p.60590

, Nitric-oxide synthase binding (GO:0050998) Cadherin binding

, Actin binding (GO:0003779)

, Nucleosomal DNA binding

, NAD(P)H oxidase activity, p.16174

, Mitochondrion, p.5739

, Mitochondrial inner membrane (GO:0005743) Mitochondrial matrix (GO:0005759)

, Mitochondrial respiratory chain complex I (GO:0005747) Actin cytoskeleton

, Contractile actin filament bundle (GO:0097517) Stress fiber

, Cytoskeleton, p.5856

. Myofibril, , p.30016

, Endoplasmic reticulum lumen (GO:0005788) Focal adhesion (GO:0005925)

, Nucleolus, p.5730

, Nuclear proteasome complex, p.31595

, RISC-loading complex

, Actin-based cell projection (GO:0098858) Myosin filament

, Mitochondrial gene expression (GO:0140053)

, NADH dehydrogenase complex assembly, p.10257

, Mitochondrial ATP synthesis ETC, p.42775

, Mitochondrial translational elongation, p.70125

, GO:0070126) Cardiac muscle cell action potential (GO:0098901) Respiratory electron transport chain (GO:0022904) Regulation of heart contraction (GO:0008016) Regulation of heart rate, Mitochondrial translational termination, p.86091

, Mitochondrial electron transport

, Negative regulation of muscle hypertrophy (GO:0014741) Response to increased oxygen levels (GO:0036296) Glucose homeostasis