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Optimisation physico-chimique de films fonctionnalisés pour des applications cardio-vasculaires

Abstract : Implantable medical devices (IMD) dedicated to the cardiovascular system, such as stents, are associated with a high long-term risk of thrombosis and/or restenosis. These complications are due to endothelial lesions, protein adsorption or coagulation leading to vessel occlusion. In this physiopathological context, nitric oxide (NO), an endogenous mediator involved in vascular homeostasis, plays a key role. The aim of this project is to develop a surface coating on the IMD that releases NO on a long-term period to improve its vascular tolerance and limit the occurrence of side effects. For this purpose, a multilayered film alternating cationic and anionic polymers and gold nanoparticles (AuNPs) functionalized by S-nitrosothiol (RSNO) NO donors is developed, from the surface functionalization to its biological evaluation in terms of biocompatibility. Chapter 1 provides a review of the literature on the creation of biomaterials with biological activity through the release or generation of NO. This review allows the selection of a surface functionalization strategy in relation to the expected therapeutic effect. Chapter 2 is dedicated to the NO reservoir and it defines the conditions of construction of multilayered films combining the enrichment in AuNP and the stability of the film as well as the strategies of functionalization by NO. The chapter 3 focuses on the interaction between multilayer films and the blood compartment. The hemocompatibility of the surface is enhanced by the addition of poly(ethylene glycol) (PEG) creating a non-hemolytic, non-cytotoxic, antithrombotic interface and limiting protein adsorption. Thus, all these works define the strategy for creating an active and hemocompatible coating applicable to a cardiovascular IMD.
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Submitted on : Wednesday, October 27, 2021 - 11:48:14 AM
Last modification on : Thursday, October 28, 2021 - 4:08:40 AM

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  • HAL Id : tel-03405464, version 1

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Jordan Beurton. Optimisation physico-chimique de films fonctionnalisés pour des applications cardio-vasculaires. Médecine humaine et pathologie. Université de Lorraine, 2021. Français. ⟨NNT : 2021LORR0139⟩. ⟨tel-03405464⟩

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