Predictive model of the prostate motion in the context of radiotherapy: A biomechanical approach relying on urodynamic data and mechanical testing

Abstract : In this paper, a biomechanical approach relying on urodynamic data and mechanical tests is proposed for an accurate prediction of the motion of the pelvic organs in the context of the prostate radiotherapy. As a first step, an experimental protocol is elaborated to characterize the mechanical properties of the bladder and rectum wall tissues; uniaxial tensile tests are performed on porcine substrates. In a second step, the parameters of Ogden-type hyperelastic constitutive models are identified; their relevance in the context of the implementation of a human biomechanical model is verified by means of preliminary Finite Elements (FE) simulations against human urodynamic data. In a third step, the identified constitutive equations are employed for the simulations of the motion and interactions of the pelvic organs due to concomitant changes of the distension volumes of the urinary bladder and rectum. The effectiveness of the developed biomechanical model is demonstrated in investigating the motion of the bladder, rectum and prostate organs; the results in terms of displacements are shown to be in good agreement with measurements inherent to a deceased person, with a relative error close to 6%.
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Journal of mechanical behavior of biomedical materials, Elsevier, 2015, 49, pp.30 - 42. 〈10.1016/j.jmbbm.2015.04.016〉
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https://hal.univ-lorraine.fr/hal-01432037
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Soumis le : mercredi 11 janvier 2017 - 14:30:05
Dernière modification le : jeudi 15 mars 2018 - 17:16:06

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Mohamed Boubaker, Mohamed Haboussi, Jean-François Ganghoffer, Pierre Aletti. Predictive model of the prostate motion in the context of radiotherapy: A biomechanical approach relying on urodynamic data and mechanical testing. Journal of mechanical behavior of biomedical materials, Elsevier, 2015, 49, pp.30 - 42. 〈10.1016/j.jmbbm.2015.04.016〉. 〈hal-01432037〉

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