A complete CFD model for nano-aerosol dynamics is presented and discussed. It consists in an Eulerian “diffusion-inertia” equation including a coagulation source term which is rewritten in terms of moments. Deposition phenomenon is taken into account by means of a boundary condition on the flux of moments at walls. The moment transformation allows good computational performances and makes thus the model tractable for industrial and occupational health applications. The implementation of this approach into a computational fluid dynamics code is assessed for simple cases by comparison with sectional approach results and experimental data. These comparisons show that the method of moments does not induce particular bias and that numerical results are in agreement with available experimental data.