Skip to Main content Skip to Navigation
Journal articles

Prenatal caffeine exposure induces a poor quality of articular cartilage in male adult offspring rats via cholesterol accumulation in cartilage

Abstract : Epidemiological investigations indicate that osteoarthritis is associated with intrauterine growth retardation (IUGR) and abnormal cholesterol metabolism. Our previous studies showed that prenatal caffeine exposure (PCE) induced chondrogenesis retardation in IUGR offspring rats. The current study sought to investigate the effects of PCE on male IUGR offspring rats' articular cartilage, and the mechanisms associated with abnormal cholesterol metabolism. Based on the results from both male fetal and adult fed a high-fat diet (HFD) studies of rats that experienced PCE (120 mg/kg. d), the results showed a poor quality of articular cartilage and cholesterol accumulation in the adult PCE group. Meanwhile, the serum total cholesterol and low-density lipoprotein-cholesterol concentrations were increased in adult PCE offspring. We also observed lower expression of insulin-like growth factor1 (IGF1) and impaired cholesterol efflux in adult articular cartilage. Furthermore, the expression of cartilage functional genes, components of the IGF1 signaling pathway and cholesterol efflux pathway related genes were decreased in PCE fetal cartilage. In conclusion, PCE induced a poor quality of articular cartilage in male adult offspring fed a HFD. This finding was shown to be due to cholesterol accumulation in the cartilage, which may have resulted from intrauterine reduced activity of the IGF1 signaling pathway.
Complete list of metadatas

https://hal.univ-lorraine.fr/hal-01451910
Contributor : Imopa Ul <>
Submitted on : Wednesday, February 1, 2017 - 3:10:08 PM
Last modification on : Tuesday, October 13, 2020 - 10:47:41 AM

Links full text

Identifiers

Collections

Citation

Hanwen Luo, Jing Li, Hong Cao, Yang Tan, Jacques Magdalou, et al.. Prenatal caffeine exposure induces a poor quality of articular cartilage in male adult offspring rats via cholesterol accumulation in cartilage. Scientific Reports, Nature Publishing Group, 2015, 5, ⟨10.1038/srep17746⟩. ⟨hal-01451910⟩

Share

Metrics

Record views

160