Skip to Main content Skip to Navigation
Journal articles

Respective interest of T2 mapping and diffusion tensor imaging in assessing porcine knee cartilage with MR at 3 Teslas

Abstract : Non-invasive quantitative assessment of articular cartilage integrity is essential for early detection and evaluation of osteoarthritis (OA) and for the follow-up of stem-cell-driven cartilage engineering. In this study, we investigated the feasibility of exploiting diffusion tensor imaging (DTI) on porcine knee joints with a clinical magnetic resonance (MR) scanner to extract micro-structural information in order to complement biochemical information quantified by T2 maps. We propose an MR protocol for quantifying T2 and cartilage microstructure with diffusion MR on a clinical scanner. Preliminary results were obtained on four pig knee joints using a 3 T GE clinical MRI scanner and an 8-channel knee coil array. The measured cartilage volume, T2 values, apparent diffusion coefficient and fractional anisotropy (FA) of femoral and tibial cartilage were respectively 9.8/2.3 mm2, 67.0/56.1 ms, 1.3/1.3×10-3 mm2/s and 0.4/0.3. This new protocol has the potential to be combined in vivo with quantitative assessment of both cartilage degradation and restoration in osteoarthritis.
Complete list of metadatas

https://hal.univ-lorraine.fr/hal-01471903
Contributor : Imopa Ul <>
Submitted on : Monday, February 20, 2017 - 1:10:44 PM
Last modification on : Thursday, January 7, 2021 - 3:58:03 PM

Identifiers

  • HAL Id : hal-01471903, version 1
  • PUBMED : 23798647

Collections

Citation

Bailiang Chen, Emilie Roeder, Pierre Vuissoz, Pierre Gillet, Jacques Felblinger, et al.. Respective interest of T2 mapping and diffusion tensor imaging in assessing porcine knee cartilage with MR at 3 Teslas. Bio-Medical Materials and Engineering, IOS Press, 2013, 23, pp.263-72. ⟨hal-01471903⟩

Share

Metrics

Record views

99