Osteoarthritis: rationale for a new paradigm shift involving transforming growth factor-β1
Résumé
Introduction
Osteoarthritis (OA) in no longer
considered as a disease of articular
cartilage only. In more recent times,
researchers opine that OA could be
a disease of joint as well. Clinical
and basic studies now question this
notion. Indeed, current evidence indicates
OA may be a disease involving
abnormal bone tissue modelling or
remodelling caused by alterations in
mesenchymal stem cell (MSC) recruitment
and differentiation. Biological
factors produced by OA osteoblasts
have been shown to affect chondrocyte
function, causing alterations in
MSC recruitment/differentiation.
One such factor may be transforming
growth factor-β1 (TFG-β1). The
aim of this review was to discuss the
rationale for a new paradigm shift
involving TFG-β1 in OA.
Conclusion
Recent studies have contributed to a
shift in researchers’ understanding of
OA and the causative events that lead
to it.