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Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction

Abstract : The biosynthesis of diazobenzofluorene kinamycins requires a hitherto uncharacterized B-ring contraction. Via detailed genetic and enzymatic analyses we unambiguously characterized the conserved pairs of oxidases, AlpJ and AlpK homologs, as nature's machinery for benzofluorenone formation, which paves the way for the investigation of the following diazo assembly.
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https://hal.univ-lorraine.fr/hal-01475728
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Submitted on : Friday, February 24, 2017 - 10:05:51 AM
Last modification on : Friday, February 5, 2021 - 3:43:01 AM

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Bin Wang, Jinwei Ren, Liyuan Li, Fang Fan, Guohui Pan, et al.. Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction. Chemical Communications, Royal Society of Chemistry, 2015, 51 (42), pp.8845 - 8848. ⟨10.1039/c5cc01986a⟩. ⟨hal-01475728⟩

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