Synthesis and antiproliferative studies of 5-aryl-2-(3-thienylamino)-1,3,4-thiadiazoles - Université de Lorraine
Journal Articles Bioorganic and Medicinal Chemistry Letters Year : 2014

Synthesis and antiproliferative studies of 5-aryl-2-(3-thienylamino)-1,3,4-thiadiazoles

Abstract

A series of 5-aryl-2-(3-thienylamino)-1,3,4-thiadiazoles 3a-m were synthesized in good yields in two steps starting from thiophen-3-isothiocyanates. Those compounds as well as the thiosemicarbazide intermediates 2a-m were screened for their antiproliferative activity against a panel of six cancer cell lines. Among them, two 5-aryl-2-(3-thienylamino)-1,3,4-thiadiazoles (3f and 3i) have shown very interesting results with IC50 < 10 mu M on three cell lines.
No file

Dates and versions

hal-01494566 , version 1 (23-03-2017)

Identifiers

Cite

Germain Revelant, Charlene Gadais, Veronique Mathieu, Gilbert Kirsch, Stéphanie Hesse. Synthesis and antiproliferative studies of 5-aryl-2-(3-thienylamino)-1,3,4-thiadiazoles. Bioorganic and Medicinal Chemistry Letters, 2014, 24 (12), pp.2724-2727. ⟨10.1016/j.bmcl.2014.04.043⟩. ⟨hal-01494566⟩
41 View
0 Download

Altmetric

Share

More