HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Anticancer activity of ruthenium(II) polypyridine complexes bearing pyrrolidine substituents

Abstract : A set of homoleptic ruthenium polypyridine (bipyridine and terpyridine) complexes flanked with several electron-donating pyrrolidine moieties has been characterized and the anticancer activity was evaluated toward human lung adenocarcinoma epithelial (A549) and murine colon carcinoma (CT26). Good antiproliferative effects were observed with an IC50 ranging from ca. 4 to 21 mu M against both cell lines. Dependence was found between the cytotoxicity, the lipophilicity and the Ru-II/Ru-III oxidation potential. All the studied compounds interacted quite well with albumin while the interaction with DNA was marginal. The biological studies revealed that the ruthenium complexes induced the ROS overproduction which might be one but not the only way of cell death induction.
Document type :
Journal articles
Complete list of metadata

Contributor : Srsmc Ul Connect in order to contact the contributor
Submitted on : Monday, March 27, 2017 - 4:47:31 PM
Last modification on : Monday, December 13, 2021 - 1:14:06 PM




Olga Mazuryk, Michal Lomzik, David Martineau, Marc Beley, Malgorzata Brindell, et al.. Anticancer activity of ruthenium(II) polypyridine complexes bearing pyrrolidine substituents. Inorganica Chimica Acta, Elsevier, 2016, 443, pp.86-90. ⟨10.1016/j.ica.2015.12.021⟩. ⟨hal-01496645⟩



Record views