Mesoporous silica thin films for molecular sieving and electrode surface protection against biofouling

Abstract : Electrode fouling is a major challenge for the long term use of sensors in real samples as it leads to the decay of the electroanalytical signal and is often caused by the formation of an inhibiting layer formed by biomolecules. We demonstrate here that ordered and vertically aligned mesoporous silica generated at the surface of an indium tin oxide electrode by electrochemically assisted self-assembly act as a molecular sieve and a protective layer for the electrode surface. They indeed prevent the adsorption of size excluded large undesired molecules (e.g. haemoglobin) while allowing the detection of small redox active molecules likely to reach the electrode surface through the film (e.g. propranolol) with almost no loss of sensitivity. At a bare electrode, the oxidation of propranolol is completely inhibited in the presence of 5 mu M haemoglobin. At a modified electrode, the sensitivity for propranolol in the absence of haemoglobin is (72.8 +/- 2.9) mA mol(-1) (R-2= 0.992, N= 7) and it remains similar in the presence of 5 mu M haemoglobin with a value of (67.4 +/- 7.2) mA mol(-1) (R-2= 0.992, N= 7).
Document type :
Journal articles
Complete list of metadatas

Cited literature [21 references]  Display  Hide  Download

https://hal.univ-lorraine.fr/hal-01504773
Contributor : Lcpme Ul <>
Submitted on : Wednesday, June 26, 2019 - 9:21:08 AM
Last modification on : Wednesday, June 26, 2019 - 11:29:44 AM

File

47-postprint.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Maria Serrano, Christelle Despas, Grégoire Herzog, Alain Walcarius. Mesoporous silica thin films for molecular sieving and electrode surface protection against biofouling. Electrochemistry Communications, Elsevier, 2015, 52, pp.34-36. ⟨10.1016/j.elecom.2015.01.010⟩. ⟨hal-01504773⟩

Share

Metrics

Record views

149

Files downloads

31